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Gene Gene information from NCBI Gene database.
Entrez ID 23475
Gene name Quinolinate phosphoribosyltransferase
Gene symbol QPRT
Synonyms (NCBI Gene)
HEL-S-90nQPRTase
Chromosome 16
Chromosome location 16p11.2
Summary This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has
miRNA miRNA information provided by mirtarbase database.
579 Show/Hide all (579)
miRTarBase ID miRNA Experiments Reference
MIRT017727 hsa-miR-335-5p Microarray 18185580
MIRT029367 hsa-miR-26b-5p Microarray 19088304
MIRT042601 hsa-miR-423-3p CLASH 23622248
MIRT036528 hsa-miR-1226-3p CLASH 23622248
MIRT635243 hsa-miR-500b-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
23 Show/Hide all (23)
GO ID Ontology Definition Evidence Reference
GO:0004514 Function Nicotinate-nucleotide diphosphorylase (carboxylating) activity IBA
GO:0004514 Function Nicotinate-nucleotide diphosphorylase (carboxylating) activity IDA 3409840, 9473669, 17868694, 24038671
GO:0004514 Function Nicotinate-nucleotide diphosphorylase (carboxylating) activity IEA
GO:0004514 Function Nicotinate-nucleotide diphosphorylase (carboxylating) activity TAS
GO:0005515 Function Protein binding IPI 25464930, 32296183
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606248 9755 ENSG00000103485
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q15274
Protein name Nicotinate-nucleotide pyrophosphorylase [carboxylating] (EC 2.4.2.19) (Quinolinate phosphoribosyltransferase [decarboxylating]) (QAPRTase) (QPRTase)
Protein function Involved in the catabolism of quinolinic acid (QA).
PDB 2JBM , 4KWV , 4KWW , 5AYX , 5AYY , 5AYZ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01729 QRPTase_C 114 → 284 Quinolinate phosphoribosyl transferase, C-terminal domain Domain
PF02749 QRPTase_N 29 → 112 Quinolinate phosphoribosyl transferase, N-terminal domain Domain
Sequence
Sequence length 297
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Nicotinate and nicotinamide metabolism Nicotinate metabolism
Metabolic pathways  
Biosynthesis of cofactors