PTPRE (protein tyrosine phosphatase receptor type E)

Download as csv Download as pdf

Log in to bookmark this gene

Bookmark This Gene

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 5791
• Gene name: Protein tyrosine phosphatase receptor type E
• Gene symbol: PTPRE
• Synonyms (NCBI Gene): HPTPE, PTPE, R-PTP-EPSILON
• Chromosome: 10
• Chromosome location: 10q26.2
• Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic tran

miRNA Show/Hide all (176)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017960	hsa-miR-335-5p	Microarray	18185580
MIRT024574	hsa-miR-215-5p	Microarray	19074876
MIRT024574	hsa-miR-215-5p	Microarray	19074876
MIRT026595	hsa-miR-192-5p	Microarray	19074876
MIRT616055	hsa-miR-6763-3p	HITS-CLIP	19536157
MIRT616054	hsa-miR-3679-3p	HITS-CLIP	19536157
MIRT616053	hsa-miR-4446-5p	HITS-CLIP	19536157
MIRT616058	hsa-miR-4704-3p	HITS-CLIP	23824327
MIRT616055	hsa-miR-6763-3p	HITS-CLIP	23824327
MIRT616054	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT616053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT616058	hsa-miR-4704-3p	HITS-CLIP	23824327
MIRT616055	hsa-miR-6763-3p	HITS-CLIP	23824327
MIRT616054	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT616053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT616058	hsa-miR-4704-3p	HITS-CLIP	23824327
MIRT616055	hsa-miR-6763-3p	HITS-CLIP	23824327
MIRT616054	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT616053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT616058	hsa-miR-4704-3p	HITS-CLIP	23824327
MIRT616055	hsa-miR-6763-3p	HITS-CLIP	23824327
MIRT616054	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT616053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT616060	hsa-miR-3126-3p	HITS-CLIP	23824327
MIRT616059	hsa-miR-1298-3p	HITS-CLIP	23824327
MIRT616058	hsa-miR-4704-3p	HITS-CLIP	23824327
MIRT616057	hsa-miR-4490	HITS-CLIP	23824327
MIRT616056	hsa-miR-4774-5p	HITS-CLIP	23824327
MIRT616055	hsa-miR-6763-3p	HITS-CLIP	23824327
MIRT616054	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT616053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT491132	hsa-miR-6871-5p	PAR-CLIP	23592263
MIRT491131	hsa-miR-1827	PAR-CLIP	23592263
MIRT491130	hsa-miR-6878-5p	PAR-CLIP	23592263
MIRT491129	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT491128	hsa-miR-8085	PAR-CLIP	23592263
MIRT491127	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT491125	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT491126	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT491124	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT491123	hsa-miR-3175	PAR-CLIP	23592263
MIRT491122	hsa-miR-30c-1-3p	PAR-CLIP	23592263
MIRT491121	hsa-miR-30c-2-3p	PAR-CLIP	23592263
MIRT491120	hsa-miR-6788-5p	PAR-CLIP	23592263
MIRT491119	hsa-miR-6734-5p	PAR-CLIP	23592263
MIRT616055	hsa-miR-6763-3p	HITS-CLIP	19536157
MIRT616054	hsa-miR-3679-3p	HITS-CLIP	19536157
MIRT616053	hsa-miR-4446-5p	HITS-CLIP	19536157
MIRT616058	hsa-miR-4704-3p	HITS-CLIP	23824327
MIRT616055	hsa-miR-6763-3p	HITS-CLIP	23824327
MIRT616054	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT616053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT616058	hsa-miR-4704-3p	HITS-CLIP	23824327
MIRT616055	hsa-miR-6763-3p	HITS-CLIP	23824327
MIRT616054	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT616053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT616058	hsa-miR-4704-3p	HITS-CLIP	23824327
MIRT616055	hsa-miR-6763-3p	HITS-CLIP	23824327
MIRT616054	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT616053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT616058	hsa-miR-4704-3p	HITS-CLIP	23824327
MIRT616055	hsa-miR-6763-3p	HITS-CLIP	23824327
MIRT616054	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT616053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT616060	hsa-miR-3126-3p	HITS-CLIP	23824327
MIRT616059	hsa-miR-1298-3p	HITS-CLIP	23824327
MIRT616058	hsa-miR-4704-3p	HITS-CLIP	23824327
MIRT616057	hsa-miR-4490	HITS-CLIP	23824327
MIRT616056	hsa-miR-4774-5p	HITS-CLIP	23824327
MIRT616055	hsa-miR-6763-3p	HITS-CLIP	23824327
MIRT616054	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT616053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT491132	hsa-miR-6871-5p	PAR-CLIP	23592263
MIRT491131	hsa-miR-1827	PAR-CLIP	23592263
MIRT491130	hsa-miR-6878-5p	PAR-CLIP	23592263
MIRT491129	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT491128	hsa-miR-8085	PAR-CLIP	23592263
MIRT491127	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT491125	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT491126	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT491124	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT491123	hsa-miR-3175	PAR-CLIP	23592263
MIRT491122	hsa-miR-30c-1-3p	PAR-CLIP	23592263
MIRT491121	hsa-miR-30c-2-3p	PAR-CLIP	23592263
MIRT491120	hsa-miR-6788-5p	PAR-CLIP	23592263
MIRT491119	hsa-miR-6734-5p	PAR-CLIP	23592263
MIRT1276021	hsa-miR-1256	CLIP-seq
MIRT1276022	hsa-miR-181a	CLIP-seq
MIRT1276023	hsa-miR-181b	CLIP-seq
MIRT1276024	hsa-miR-181c	CLIP-seq
MIRT1276025	hsa-miR-181d	CLIP-seq
MIRT1276026	hsa-miR-374a	CLIP-seq
MIRT1276027	hsa-miR-374b	CLIP-seq
MIRT1276028	hsa-miR-4262	CLIP-seq
MIRT1276029	hsa-miR-4291	CLIP-seq
MIRT1276030	hsa-miR-4420	CLIP-seq
MIRT1276031	hsa-miR-4528	CLIP-seq
MIRT1276032	hsa-miR-4720-5p	CLIP-seq
MIRT1276033	hsa-miR-4799-3p	CLIP-seq
MIRT1276034	hsa-miR-543	CLIP-seq
MIRT1276035	hsa-miR-545	CLIP-seq
MIRT1276036	hsa-miR-124	CLIP-seq
MIRT1276037	hsa-miR-1252	CLIP-seq
MIRT1276038	hsa-miR-1253	CLIP-seq
MIRT1276039	hsa-miR-143	CLIP-seq
MIRT1276040	hsa-miR-3115	CLIP-seq
MIRT1276041	hsa-miR-3136-5p	CLIP-seq
MIRT1276042	hsa-miR-3155	CLIP-seq
MIRT1276043	hsa-miR-3155b	CLIP-seq
MIRT1276044	hsa-miR-3177-3p	CLIP-seq
MIRT1276045	hsa-miR-3180-5p	CLIP-seq
MIRT1276046	hsa-miR-3714	CLIP-seq
MIRT1276047	hsa-miR-3910	CLIP-seq
MIRT1276048	hsa-miR-3934	CLIP-seq
MIRT1276049	hsa-miR-4261	CLIP-seq
MIRT1276050	hsa-miR-4303	CLIP-seq
MIRT1276051	hsa-miR-4434	CLIP-seq
MIRT1276052	hsa-miR-4439	CLIP-seq
MIRT1276053	hsa-miR-4477b	CLIP-seq
MIRT1276054	hsa-miR-4496	CLIP-seq
MIRT1276055	hsa-miR-4513	CLIP-seq
MIRT1276056	hsa-miR-4516	CLIP-seq
MIRT1276057	hsa-miR-4682	CLIP-seq
MIRT1276058	hsa-miR-4699-5p	CLIP-seq
MIRT1276059	hsa-miR-4729	CLIP-seq
MIRT1276060	hsa-miR-4770	CLIP-seq
MIRT1276061	hsa-miR-484	CLIP-seq
MIRT1276062	hsa-miR-494	CLIP-seq
MIRT1276063	hsa-miR-506	CLIP-seq
MIRT1276064	hsa-miR-552	CLIP-seq
MIRT1276065	hsa-miR-940	CLIP-seq
MIRT1276066	hsa-miR-943	CLIP-seq
MIRT1276022	hsa-miR-181a	CLIP-seq
MIRT1276023	hsa-miR-181b	CLIP-seq
MIRT1276024	hsa-miR-181c	CLIP-seq
MIRT1276025	hsa-miR-181d	CLIP-seq
MIRT1276028	hsa-miR-4262	CLIP-seq
MIRT1276034	hsa-miR-543	CLIP-seq
MIRT2457461	hsa-miR-1537	CLIP-seq
MIRT2457462	hsa-miR-185	CLIP-seq
MIRT1276046	hsa-miR-3714	CLIP-seq
MIRT2457463	hsa-miR-4306	CLIP-seq
MIRT2457464	hsa-miR-4484	CLIP-seq
MIRT2457465	hsa-miR-4644	CLIP-seq
MIRT2457466	hsa-miR-4717-3p	CLIP-seq
MIRT2457467	hsa-miR-4802-3p	CLIP-seq
MIRT2457468	hsa-miR-548an	CLIP-seq
MIRT2604616	hsa-miR-146a	CLIP-seq
MIRT2604617	hsa-miR-146b-5p	CLIP-seq
MIRT2457461	hsa-miR-1537	CLIP-seq
MIRT2457462	hsa-miR-185	CLIP-seq
MIRT2604618	hsa-miR-2682	CLIP-seq
MIRT1276046	hsa-miR-3714	CLIP-seq
MIRT2604619	hsa-miR-4251	CLIP-seq
MIRT2457463	hsa-miR-4306	CLIP-seq
MIRT2457464	hsa-miR-4484	CLIP-seq
MIRT2604620	hsa-miR-449c	CLIP-seq
MIRT2457465	hsa-miR-4644	CLIP-seq
MIRT2457466	hsa-miR-4717-3p	CLIP-seq
MIRT2604621	hsa-miR-4738-3p	CLIP-seq
MIRT2457467	hsa-miR-4802-3p	CLIP-seq
MIRT2457468	hsa-miR-548an	CLIP-seq
MIRT2604622	hsa-miR-589	CLIP-seq
MIRT2689095	hsa-miR-125a-3p	CLIP-seq
MIRT2457461	hsa-miR-1537	CLIP-seq
MIRT2457462	hsa-miR-185	CLIP-seq
MIRT2689096	hsa-miR-296-3p	CLIP-seq
MIRT1276048	hsa-miR-3934	CLIP-seq
MIRT2457463	hsa-miR-4306	CLIP-seq
MIRT2457464	hsa-miR-4484	CLIP-seq
MIRT2457465	hsa-miR-4644	CLIP-seq
MIRT2457466	hsa-miR-4717-3p	CLIP-seq
MIRT2457467	hsa-miR-4802-3p	CLIP-seq
MIRT2457468	hsa-miR-548an	CLIP-seq
MIRT2689097	hsa-miR-760	CLIP-seq
MIRT2689098	hsa-miR-764	CLIP-seq

Gene ontology (GO) Show/Hide all (20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	IBA
GO:0004725	Function	Protein tyrosine phosphatase activity	IEA
GO:0005001	Function	Transmembrane receptor protein tyrosine phosphatase activity	IEA
GO:0005001	Function	Transmembrane receptor protein tyrosine phosphatase activity	TAS	2170109
GO:0005515	Function	Protein binding	IPI	10980613
GO:0005634	Component	Nucleus	IDA	10980613
GO:0005737	Component	Cytoplasm	IDA	8618876, 10980613
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	IDA	10980613
GO:0005886	Component	Plasma membrane	IEA
GO:0006470	Process	Protein dephosphorylation	TAS	2170109
GO:0007165	Process	Signal transduction	IBA
GO:0007185	Process	Cell surface receptor protein tyrosine phosphatase signaling pathway	IEA
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0033003	Process	Regulation of mast cell activation	IEA
GO:0042802	Function	Identical protein binding	IEA
GO:0046627	Process	Negative regulation of insulin receptor signaling pathway	IEA
GO:0046627	Process	Negative regulation of insulin receptor signaling pathway	ISS

Other IDs

• MIM: 600926
• HGNC: 9669
• e!Ensembl: ENSG00000132334

Protein

• UniProt ID: P23469
• Protein name: Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48)
• Protein function: Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity). ; Isoform 2 acts as a negati
• PDB: 2JJD , 6D3F , 6D4D , 6D4F
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00102	Y_phosphatase	159 → 393	Protein-tyrosine phosphatase	Domain
  PF00102	Y_phosphatase	451 → 688	Protein-tyrosine phosphatase	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in giant cell tumor (osteoclastoma rich in multinucleated osteoclastic cells). {ECO:0000269|PubMed:8610169}.
• Sequence:

  MEPLCPLLLVGFSLPLARALRGNETTADSNETTTTSGPPDPGASQPLLAWLLLPLLLLLL
  VLLLAAYFFRFRKQRKAVVSTSDKKMPNGILEEQEQQRVMLLSRSPSGPKKYFPIPVEHL
  EEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQ
  LDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERK
  EEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTS
  WPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQK
  VDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTH
  FDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTD
  YINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYW
  PTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGI
  PAEGKGMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQ
  AVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYANFK

• Sequence length: 700

Related Genes

No strongly related genes found yet for PTPRE.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to PTPRE.