PTGR2 (prostaglandin reductase 2)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 145482
• Gene name: Prostaglandin reductase 2
• Gene symbol: PTGR2
• Synonyms (NCBI Gene): HEL-S-298, PGR2, ZADH1
• Chromosome: 14
• Chromosome location: 14q24.3
• Summary: This gene encodes an enzyme involved in the metabolism of prostaglandins. The encoded protein catalyzes the NADPH-dependent conversion of 15-keto-prostaglandin E2 to 15-keto-13,14-dihydro-prostaglandin E2. This protein may also be involved in regulating a

miRNA Show/Hide all (225)

miRTarBase ID	miRNA	Experiments	Reference
MIRT042357	hsa-miR-484	CLASH	23622248
MIRT720527	hsa-miR-4747-3p	HITS-CLIP	19536157
MIRT720526	hsa-miR-6778-3p	HITS-CLIP	19536157
MIRT720525	hsa-miR-744-5p	HITS-CLIP	19536157
MIRT720524	hsa-miR-5580-5p	HITS-CLIP	19536157
MIRT720523	hsa-miR-1908-5p	HITS-CLIP	19536157
MIRT720522	hsa-miR-663a	HITS-CLIP	19536157
MIRT720521	hsa-miR-6787-5p	HITS-CLIP	19536157
MIRT720520	hsa-miR-2355-5p	HITS-CLIP	19536157
MIRT642655	hsa-miR-6854-5p	HITS-CLIP	23824327
MIRT642654	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT642653	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT642652	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT642651	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT642650	hsa-miR-3666	HITS-CLIP	23824327
MIRT642649	hsa-miR-4295	HITS-CLIP	23824327
MIRT642648	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT642647	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT642646	hsa-miR-3655	HITS-CLIP	23824327
MIRT642645	hsa-miR-3135b	HITS-CLIP	23824327
MIRT642644	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT642643	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT642642	hsa-miR-3652	HITS-CLIP	23824327
MIRT642641	hsa-miR-4430	HITS-CLIP	23824327
MIRT642640	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT514557	hsa-miR-6758-5p	PAR-CLIP	23446348
MIRT514556	hsa-miR-6856-5p	PAR-CLIP	23446348
MIRT514555	hsa-miR-6890-5p	PAR-CLIP	23446348
MIRT514554	hsa-miR-1273f	PAR-CLIP	23446348
MIRT514553	hsa-miR-4755-3p	PAR-CLIP	23446348
MIRT514552	hsa-miR-193b-5p	PAR-CLIP	23446348
MIRT514551	hsa-miR-548s	PAR-CLIP	23446348
MIRT514550	hsa-miR-4701-5p	PAR-CLIP	23446348
MIRT514549	hsa-miR-588	PAR-CLIP	23446348
MIRT514548	hsa-miR-4435	PAR-CLIP	23446348
MIRT514547	hsa-miR-3187-3p	PAR-CLIP	23446348
MIRT514546	hsa-miR-3170	PAR-CLIP	23446348
MIRT514545	hsa-miR-6855-5p	PAR-CLIP	23446348
MIRT514544	hsa-miR-5096	PAR-CLIP	23446348
MIRT720527	hsa-miR-4747-3p	HITS-CLIP	19536157
MIRT720526	hsa-miR-6778-3p	HITS-CLIP	19536157
MIRT720525	hsa-miR-744-5p	HITS-CLIP	19536157
MIRT720524	hsa-miR-5580-5p	HITS-CLIP	19536157
MIRT720523	hsa-miR-1908-5p	HITS-CLIP	19536157
MIRT720522	hsa-miR-663a	HITS-CLIP	19536157
MIRT720521	hsa-miR-6787-5p	HITS-CLIP	19536157
MIRT720520	hsa-miR-2355-5p	HITS-CLIP	19536157
MIRT642655	hsa-miR-6854-5p	HITS-CLIP	23824327
MIRT642654	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT642653	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT642652	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT642651	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT642650	hsa-miR-3666	HITS-CLIP	23824327
MIRT642649	hsa-miR-4295	HITS-CLIP	23824327
MIRT642648	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT642647	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT642646	hsa-miR-3655	HITS-CLIP	23824327
MIRT642645	hsa-miR-3135b	HITS-CLIP	23824327
MIRT642644	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT642643	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT642642	hsa-miR-3652	HITS-CLIP	23824327
MIRT642641	hsa-miR-4430	HITS-CLIP	23824327
MIRT642640	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT514557	hsa-miR-6758-5p	PAR-CLIP	23446348
MIRT514556	hsa-miR-6856-5p	PAR-CLIP	23446348
MIRT514555	hsa-miR-6890-5p	PAR-CLIP	23446348
MIRT514554	hsa-miR-1273f	PAR-CLIP	23446348
MIRT514553	hsa-miR-4755-3p	PAR-CLIP	23446348
MIRT514552	hsa-miR-193b-5p	PAR-CLIP	23446348
MIRT514551	hsa-miR-548s	PAR-CLIP	23446348
MIRT514550	hsa-miR-4701-5p	PAR-CLIP	23446348
MIRT514549	hsa-miR-588	PAR-CLIP	23446348
MIRT514548	hsa-miR-4435	PAR-CLIP	23446348
MIRT514547	hsa-miR-3187-3p	PAR-CLIP	23446348
MIRT514546	hsa-miR-3170	PAR-CLIP	23446348
MIRT514545	hsa-miR-6855-5p	PAR-CLIP	23446348
MIRT514544	hsa-miR-5096	PAR-CLIP	23446348
MIRT1273263	hsa-miR-1179	CLIP-seq
MIRT1273264	hsa-miR-513c	CLIP-seq
MIRT1273265	hsa-miR-514b-5p	CLIP-seq
MIRT1273266	hsa-miR-106a	CLIP-seq
MIRT1273267	hsa-miR-106b	CLIP-seq
MIRT1273268	hsa-miR-1200	CLIP-seq
MIRT1273269	hsa-miR-1227	CLIP-seq
MIRT1273270	hsa-miR-1245	CLIP-seq
MIRT1273271	hsa-miR-143	CLIP-seq
MIRT1273272	hsa-miR-145	CLIP-seq
MIRT1273273	hsa-miR-17	CLIP-seq
MIRT1273274	hsa-miR-181a	CLIP-seq
MIRT1273275	hsa-miR-181b	CLIP-seq
MIRT1273276	hsa-miR-181c	CLIP-seq
MIRT1273277	hsa-miR-181d	CLIP-seq
MIRT1273278	hsa-miR-1910	CLIP-seq
MIRT1273279	hsa-miR-1913	CLIP-seq
MIRT1273280	hsa-miR-20a	CLIP-seq
MIRT1273281	hsa-miR-20b	CLIP-seq
MIRT1273282	hsa-miR-2114	CLIP-seq
MIRT1273283	hsa-miR-3180-5p	CLIP-seq
MIRT1273284	hsa-miR-324-3p	CLIP-seq
MIRT1273285	hsa-miR-3545-3p	CLIP-seq
MIRT1273286	hsa-miR-361-3p	CLIP-seq
MIRT1273287	hsa-miR-3663-5p	CLIP-seq
MIRT1273288	hsa-miR-4262	CLIP-seq
MIRT1273289	hsa-miR-4313	CLIP-seq
MIRT1273290	hsa-miR-4324	CLIP-seq
MIRT1273291	hsa-miR-4421	CLIP-seq
MIRT1273292	hsa-miR-4438	CLIP-seq
MIRT1273293	hsa-miR-4635	CLIP-seq
MIRT1273294	hsa-miR-4643	CLIP-seq
MIRT1273295	hsa-miR-466	CLIP-seq
MIRT1273296	hsa-miR-4680-5p	CLIP-seq
MIRT1273297	hsa-miR-4707-3p	CLIP-seq
MIRT1273298	hsa-miR-4715-3p	CLIP-seq
MIRT1273299	hsa-miR-4722-3p	CLIP-seq
MIRT1273300	hsa-miR-4762-3p	CLIP-seq
MIRT1273301	hsa-miR-4762-5p	CLIP-seq
MIRT1273302	hsa-miR-4766-5p	CLIP-seq
MIRT1273303	hsa-miR-4770	CLIP-seq
MIRT1273304	hsa-miR-4789-3p	CLIP-seq
MIRT1273305	hsa-miR-487a	CLIP-seq
MIRT1273306	hsa-miR-495	CLIP-seq
MIRT1273307	hsa-miR-505	CLIP-seq
MIRT1273308	hsa-miR-5095	CLIP-seq
MIRT1273264	hsa-miR-513c	CLIP-seq
MIRT1273265	hsa-miR-514b-5p	CLIP-seq
MIRT1273309	hsa-miR-515-3p	CLIP-seq
MIRT1273310	hsa-miR-516b	CLIP-seq
MIRT1273311	hsa-miR-519d	CLIP-seq
MIRT1273312	hsa-miR-519e	CLIP-seq
MIRT1273313	hsa-miR-520d-5p	CLIP-seq
MIRT1273314	hsa-miR-520g	CLIP-seq
MIRT1273315	hsa-miR-520h	CLIP-seq
MIRT1273316	hsa-miR-524-5p	CLIP-seq
MIRT1273317	hsa-miR-543	CLIP-seq
MIRT1273318	hsa-miR-544b	CLIP-seq
MIRT1273319	hsa-miR-548ad	CLIP-seq
MIRT1273320	hsa-miR-616	CLIP-seq
MIRT1273321	hsa-miR-93	CLIP-seq
MIRT1273322	hsa-miR-105	CLIP-seq
MIRT1273323	hsa-miR-1915	CLIP-seq
MIRT1273324	hsa-miR-3671	CLIP-seq
MIRT1273325	hsa-miR-4726-3p	CLIP-seq
MIRT1273326	hsa-miR-607	CLIP-seq
MIRT2306566	hsa-miR-3672	CLIP-seq
MIRT2604157	hsa-miR-122	CLIP-seq
MIRT1273269	hsa-miR-1227	CLIP-seq
MIRT1273270	hsa-miR-1245	CLIP-seq
MIRT2604158	hsa-miR-129-5p	CLIP-seq
MIRT2604159	hsa-miR-1303	CLIP-seq
MIRT2604160	hsa-miR-130a	CLIP-seq
MIRT2604161	hsa-miR-130b	CLIP-seq
MIRT1273271	hsa-miR-143	CLIP-seq
MIRT2604162	hsa-miR-144	CLIP-seq
MIRT1273272	hsa-miR-145	CLIP-seq
MIRT2604163	hsa-miR-150	CLIP-seq
MIRT2604164	hsa-miR-1538	CLIP-seq
MIRT1273279	hsa-miR-1913	CLIP-seq
MIRT2604165	hsa-miR-1972	CLIP-seq
MIRT2604166	hsa-miR-301a	CLIP-seq
MIRT2604167	hsa-miR-301b	CLIP-seq
MIRT2604168	hsa-miR-3065-5p	CLIP-seq
MIRT2604169	hsa-miR-3140-3p	CLIP-seq
MIRT2604170	hsa-miR-3149	CLIP-seq
MIRT1273283	hsa-miR-3180-5p	CLIP-seq
MIRT1273284	hsa-miR-324-3p	CLIP-seq
MIRT2604171	hsa-miR-34b	CLIP-seq
MIRT1273285	hsa-miR-3545-3p	CLIP-seq
MIRT1273287	hsa-miR-3663-5p	CLIP-seq
MIRT2604172	hsa-miR-3913-3p	CLIP-seq
MIRT2604173	hsa-miR-421	CLIP-seq
MIRT1273292	hsa-miR-4438	CLIP-seq
MIRT2604174	hsa-miR-454	CLIP-seq
MIRT2604175	hsa-miR-455-5p	CLIP-seq
MIRT1273293	hsa-miR-4635	CLIP-seq
MIRT2604176	hsa-miR-4639-3p	CLIP-seq
MIRT2604177	hsa-miR-4645-3p	CLIP-seq
MIRT2604178	hsa-miR-4650-5p	CLIP-seq
MIRT1273296	hsa-miR-4680-5p	CLIP-seq
MIRT1273297	hsa-miR-4707-3p	CLIP-seq
MIRT2604179	hsa-miR-4708-5p	CLIP-seq
MIRT1273298	hsa-miR-4715-3p	CLIP-seq
MIRT2604180	hsa-miR-4735-5p	CLIP-seq
MIRT2604181	hsa-miR-4738-3p	CLIP-seq
MIRT2604182	hsa-miR-4745-3p	CLIP-seq
MIRT1273301	hsa-miR-4762-5p	CLIP-seq
MIRT2604183	hsa-miR-4763-5p	CLIP-seq
MIRT1273303	hsa-miR-4770	CLIP-seq
MIRT2604184	hsa-miR-4775	CLIP-seq
MIRT1273308	hsa-miR-5095	CLIP-seq
MIRT2604185	hsa-miR-511	CLIP-seq
MIRT2604186	hsa-miR-548g	CLIP-seq
MIRT2604187	hsa-miR-550a	CLIP-seq
MIRT2604188	hsa-miR-590-3p	CLIP-seq
MIRT2604157	hsa-miR-122	CLIP-seq
MIRT1273269	hsa-miR-1227	CLIP-seq
MIRT2604158	hsa-miR-129-5p	CLIP-seq
MIRT2604159	hsa-miR-1303	CLIP-seq
MIRT2604160	hsa-miR-130a	CLIP-seq
MIRT2604161	hsa-miR-130b	CLIP-seq
MIRT1273271	hsa-miR-143	CLIP-seq
MIRT1273272	hsa-miR-145	CLIP-seq
MIRT2604166	hsa-miR-301a	CLIP-seq
MIRT2604167	hsa-miR-301b	CLIP-seq
MIRT2604168	hsa-miR-3065-5p	CLIP-seq
MIRT2604170	hsa-miR-3149	CLIP-seq
MIRT1273283	hsa-miR-3180-5p	CLIP-seq
MIRT1273285	hsa-miR-3545-3p	CLIP-seq
MIRT1273287	hsa-miR-3663-5p	CLIP-seq
MIRT2604173	hsa-miR-421	CLIP-seq
MIRT1273292	hsa-miR-4438	CLIP-seq
MIRT2604174	hsa-miR-454	CLIP-seq
MIRT1273293	hsa-miR-4635	CLIP-seq
MIRT2604176	hsa-miR-4639-3p	CLIP-seq
MIRT1273296	hsa-miR-4680-5p	CLIP-seq
MIRT2604179	hsa-miR-4708-5p	CLIP-seq
MIRT1273298	hsa-miR-4715-3p	CLIP-seq
MIRT2604180	hsa-miR-4735-5p	CLIP-seq
MIRT2604181	hsa-miR-4738-3p	CLIP-seq
MIRT1273301	hsa-miR-4762-5p	CLIP-seq
MIRT1273303	hsa-miR-4770	CLIP-seq
MIRT2604184	hsa-miR-4775	CLIP-seq
MIRT1273308	hsa-miR-5095	CLIP-seq
MIRT2604185	hsa-miR-511	CLIP-seq
MIRT2604186	hsa-miR-548g	CLIP-seq
MIRT2604188	hsa-miR-590-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006693	Process	Prostaglandin metabolic process	IBA
GO:0006693	Process	Prostaglandin metabolic process	IDA	19000823
GO:0006693	Process	Prostaglandin metabolic process	IEA
GO:0008270	Function	Zinc ion binding	IDA	19000823
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016628	Function	Oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	IEA
GO:0047522	Function	15-oxoprostaglandin 13-reductase [NAD(P)+] activity	IBA
GO:0047522	Function	15-oxoprostaglandin 13-reductase [NAD(P)+] activity	IDA	19000823
GO:0047522	Function	15-oxoprostaglandin 13-reductase [NAD(P)+] activity	IEA

Other IDs

• MIM: 608642
• HGNC: 20149
• e!Ensembl: ENSG00000140043

Protein

• UniProt ID: Q8N8N7
• Protein name: Prostaglandin reductase 2 (PRG-2) (EC 1.3.1.48) (15-oxoprostaglandin 13-reductase) (Zinc-binding alcohol dehydrogenase domain-containing protein 1)
• Protein function: Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2 (PubMed:19000823). Overexpression represses transcriptional activity of P
• PDB: 2VNA , 2W4Q , 2W98 , 2ZB4 , 2ZB7 , 2ZB8
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00107	ADH_zinc_N	166 → 305	Zinc-binding dehydrogenase	Family
  PF16884	ADH_N_2	4 → 117	N-terminal domain of oxidoreductase	Family

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:15004468}.
• Sequence:

  MIVQRVVLNSRPGKNGNPVAENFRMEEVYLPDNINEGQVQVRTLYLSVDPYMRCRMNEDT
  GTDYITPWQLSQVVDGGGIGIIEESKHTNLTKGDFVTSFYWPWQTKVILDGNSLEKVDPQ
  LVDGHLSYFLGAIGMPGLTSLIGIQEKGHITAGSNKTMVVSGAAGACGSVAGQIGHFLGC
  SRVVGICGTHEKCILLTSELGFDAAINYKKDNVAEQLRESCPAGVDVYFDNVGGNISDTV
  ISQMNENSHIILCGQISQYNKDVPYPPPLSPAIEAIQKERNITRERFLVLNYKDKFEPGI
  LQLSQWFKEGKLKIKETVINGLENMGAAFQSMMTGGNIGKQIVCISEEISL

• Sequence length: 351

Pathways

KEGG Pathway:

Arachidonic acid metabolism

Related Genes

No strongly related genes found yet for PTGR2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to PTGR2.