Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	5700
Gene name	Proteasome 26S subunit, ATPase 1
Gene symbol	PSMC1
Synonyms (NCBI Gene)	NEDGTHP26S4RPT2S4p56
Chromosome	14
Chromosome location	14q32.11
Summary	The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits a

188 Show/Hide all (188)

miRTarBase ID	miRNA	Experiments	Reference
MIRT028792	hsa-miR-26b-5p	Microarray	19088304
MIRT051203	hsa-miR-16-5p	CLASH	23622248
MIRT038229	hsa-miR-342-5p	CLASH	23622248
MIRT649822	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT649821	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT649820	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT649819	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT649818	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT649817	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT649816	hsa-miR-1200	HITS-CLIP	23824327
MIRT649815	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT649814	hsa-miR-580-3p	HITS-CLIP	23824327
MIRT649813	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT649812	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT649822	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT649821	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT649820	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT649819	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT649818	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT649817	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT649816	hsa-miR-1200	HITS-CLIP	23824327
MIRT649815	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT649814	hsa-miR-580-3p	HITS-CLIP	23824327
MIRT649813	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT649812	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT649822	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT649821	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT649820	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT649819	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT649818	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT649817	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT649816	hsa-miR-1200	HITS-CLIP	23824327
MIRT649815	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT649814	hsa-miR-580-3p	HITS-CLIP	23824327
MIRT649813	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT649812	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT649822	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT649821	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT649820	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT649819	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT649818	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT649817	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT649816	hsa-miR-1200	HITS-CLIP	23824327
MIRT649815	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT649814	hsa-miR-580-3p	HITS-CLIP	23824327
MIRT649813	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT649812	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT1270291	hsa-miR-1265	CLIP-seq
MIRT1270292	hsa-miR-1285	CLIP-seq
MIRT1270293	hsa-miR-1292	CLIP-seq
MIRT1270294	hsa-miR-2052	CLIP-seq
MIRT1270295	hsa-miR-2277-3p	CLIP-seq
MIRT1270296	hsa-miR-3145-5p	CLIP-seq
MIRT1270297	hsa-miR-3187-5p	CLIP-seq
MIRT1270298	hsa-miR-326	CLIP-seq
MIRT1270299	hsa-miR-330-5p	CLIP-seq
MIRT1270300	hsa-miR-378g	CLIP-seq
MIRT1270301	hsa-miR-3941	CLIP-seq
MIRT1270302	hsa-miR-4307	CLIP-seq
MIRT1270303	hsa-miR-4471	CLIP-seq
MIRT1270304	hsa-miR-4486	CLIP-seq
MIRT1270305	hsa-miR-4502	CLIP-seq
MIRT1270306	hsa-miR-4639-5p	CLIP-seq
MIRT1270307	hsa-miR-4643	CLIP-seq
MIRT1270308	hsa-miR-466	CLIP-seq
MIRT1270309	hsa-miR-4672	CLIP-seq
MIRT1270310	hsa-miR-4789-3p	CLIP-seq
MIRT1270311	hsa-miR-487b	CLIP-seq
MIRT1270312	hsa-miR-508-5p	CLIP-seq
MIRT1270313	hsa-miR-548c-3p	CLIP-seq
MIRT1270314	hsa-miR-612	CLIP-seq
MIRT1270292	hsa-miR-1285	CLIP-seq
MIRT1270294	hsa-miR-2052	CLIP-seq
MIRT1270296	hsa-miR-3145-5p	CLIP-seq
MIRT1270297	hsa-miR-3187-5p	CLIP-seq
MIRT1270298	hsa-miR-326	CLIP-seq
MIRT1270299	hsa-miR-330-5p	CLIP-seq
MIRT2079451	hsa-miR-361-3p	CLIP-seq
MIRT1270300	hsa-miR-378g	CLIP-seq
MIRT1270301	hsa-miR-3941	CLIP-seq
MIRT1270302	hsa-miR-4307	CLIP-seq
MIRT1270304	hsa-miR-4486	CLIP-seq
MIRT2079452	hsa-miR-4494	CLIP-seq
MIRT1270307	hsa-miR-4643	CLIP-seq
MIRT1270308	hsa-miR-466	CLIP-seq
MIRT1270309	hsa-miR-4672	CLIP-seq
MIRT2079453	hsa-miR-4771	CLIP-seq
MIRT1270310	hsa-miR-4789-3p	CLIP-seq
MIRT1270311	hsa-miR-487b	CLIP-seq
MIRT1270312	hsa-miR-508-5p	CLIP-seq
MIRT1270314	hsa-miR-612	CLIP-seq
MIRT1270291	hsa-miR-1265	CLIP-seq
MIRT1270292	hsa-miR-1285	CLIP-seq
MIRT1270293	hsa-miR-1292	CLIP-seq
MIRT2305757	hsa-miR-1972	CLIP-seq
MIRT1270294	hsa-miR-2052	CLIP-seq
MIRT1270296	hsa-miR-3145-5p	CLIP-seq
MIRT1270297	hsa-miR-3187-5p	CLIP-seq
MIRT1270298	hsa-miR-326	CLIP-seq
MIRT1270299	hsa-miR-330-5p	CLIP-seq
MIRT2079451	hsa-miR-361-3p	CLIP-seq
MIRT1270300	hsa-miR-378g	CLIP-seq
MIRT1270301	hsa-miR-3941	CLIP-seq
MIRT1270302	hsa-miR-4307	CLIP-seq
MIRT1270303	hsa-miR-4471	CLIP-seq
MIRT1270304	hsa-miR-4486	CLIP-seq
MIRT1270306	hsa-miR-4639-5p	CLIP-seq
MIRT1270307	hsa-miR-4643	CLIP-seq
MIRT1270308	hsa-miR-466	CLIP-seq
MIRT1270309	hsa-miR-4672	CLIP-seq
MIRT2305758	hsa-miR-4717-5p	CLIP-seq
MIRT1270310	hsa-miR-4789-3p	CLIP-seq
MIRT1270311	hsa-miR-487b	CLIP-seq
MIRT1270312	hsa-miR-508-5p	CLIP-seq
MIRT1270313	hsa-miR-548c-3p	CLIP-seq
MIRT1270314	hsa-miR-612	CLIP-seq
MIRT1270291	hsa-miR-1265	CLIP-seq
MIRT1270292	hsa-miR-1285	CLIP-seq
MIRT1270293	hsa-miR-1292	CLIP-seq
MIRT2602956	hsa-miR-150	CLIP-seq
MIRT2602957	hsa-miR-188-5p	CLIP-seq
MIRT2305757	hsa-miR-1972	CLIP-seq
MIRT2602958	hsa-miR-204	CLIP-seq
MIRT1270294	hsa-miR-2052	CLIP-seq
MIRT2602959	hsa-miR-211	CLIP-seq
MIRT1270295	hsa-miR-2277-3p	CLIP-seq
MIRT2602960	hsa-miR-3127-5p	CLIP-seq
MIRT1270296	hsa-miR-3145-5p	CLIP-seq
MIRT1270297	hsa-miR-3187-5p	CLIP-seq
MIRT1270298	hsa-miR-326	CLIP-seq
MIRT1270299	hsa-miR-330-5p	CLIP-seq
MIRT2079451	hsa-miR-361-3p	CLIP-seq
MIRT1270300	hsa-miR-378g	CLIP-seq
MIRT1270301	hsa-miR-3941	CLIP-seq
MIRT2602961	hsa-miR-4270	CLIP-seq
MIRT1270302	hsa-miR-4307	CLIP-seq
MIRT2602962	hsa-miR-4441	CLIP-seq
MIRT2602963	hsa-miR-4461	CLIP-seq
MIRT1270303	hsa-miR-4471	CLIP-seq
MIRT1270304	hsa-miR-4486	CLIP-seq
MIRT1270305	hsa-miR-4502	CLIP-seq
MIRT1270306	hsa-miR-4639-5p	CLIP-seq
MIRT1270307	hsa-miR-4643	CLIP-seq
MIRT1270308	hsa-miR-466	CLIP-seq
MIRT1270309	hsa-miR-4672	CLIP-seq
MIRT2305758	hsa-miR-4717-5p	CLIP-seq
MIRT1270310	hsa-miR-4789-3p	CLIP-seq
MIRT1270311	hsa-miR-487b	CLIP-seq
MIRT1270312	hsa-miR-508-5p	CLIP-seq
MIRT2602964	hsa-miR-539	CLIP-seq
MIRT1270313	hsa-miR-548c-3p	CLIP-seq
MIRT2602965	hsa-miR-580	CLIP-seq
MIRT1270314	hsa-miR-612	CLIP-seq
MIRT1270291	hsa-miR-1265	CLIP-seq
MIRT1270292	hsa-miR-1285	CLIP-seq
MIRT1270293	hsa-miR-1292	CLIP-seq
MIRT2602956	hsa-miR-150	CLIP-seq
MIRT2602957	hsa-miR-188-5p	CLIP-seq
MIRT2602958	hsa-miR-204	CLIP-seq
MIRT1270294	hsa-miR-2052	CLIP-seq
MIRT2602959	hsa-miR-211	CLIP-seq
MIRT1270295	hsa-miR-2277-3p	CLIP-seq
MIRT2602960	hsa-miR-3127-5p	CLIP-seq
MIRT1270296	hsa-miR-3145-5p	CLIP-seq
MIRT1270297	hsa-miR-3187-5p	CLIP-seq
MIRT1270298	hsa-miR-326	CLIP-seq
MIRT1270299	hsa-miR-330-5p	CLIP-seq
MIRT2079451	hsa-miR-361-3p	CLIP-seq
MIRT1270300	hsa-miR-378g	CLIP-seq
MIRT1270301	hsa-miR-3941	CLIP-seq
MIRT2602961	hsa-miR-4270	CLIP-seq
MIRT1270302	hsa-miR-4307	CLIP-seq
MIRT2602962	hsa-miR-4441	CLIP-seq
MIRT2602963	hsa-miR-4461	CLIP-seq
MIRT1270303	hsa-miR-4471	CLIP-seq
MIRT1270304	hsa-miR-4486	CLIP-seq
MIRT1270305	hsa-miR-4502	CLIP-seq
MIRT1270306	hsa-miR-4639-5p	CLIP-seq
MIRT1270307	hsa-miR-4643	CLIP-seq
MIRT1270308	hsa-miR-466	CLIP-seq
MIRT1270309	hsa-miR-4672	CLIP-seq
MIRT1270310	hsa-miR-4789-3p	CLIP-seq
MIRT1270311	hsa-miR-487b	CLIP-seq
MIRT1270312	hsa-miR-508-5p	CLIP-seq
MIRT2602964	hsa-miR-539	CLIP-seq
MIRT1270313	hsa-miR-548c-3p	CLIP-seq
MIRT2602965	hsa-miR-580	CLIP-seq
MIRT1270314	hsa-miR-612	CLIP-seq

26 Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000502	Component	Proteasome complex	IDA	17323924
GO:0000502	Component	Proteasome complex	IEA
GO:0000502	Component	Proteasome complex	NAS	8811196, 29636472
GO:0003723	Function	RNA binding	HDA	22658674
GO:0005515	Function	Protein binding	IPI	9452483, 16189514, 16990800, 19060904, 19490896, 22901813, 23455924, 25416956, 26496610, 27342858, 28514442, 29128334, 29636472, 31515488, 32296183, 32814053, 33961781, 35271311, 37776851
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005838	Component	Proteasome regulatory particle	IEA
GO:0008540	Component	Proteasome regulatory particle, base subcomplex	IBA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0022624	Component	Proteasome accessory complex	IEA
GO:0022624	Component	Proteasome accessory complex	ISS
GO:0036402	Function	Proteasome-activating activity	IBA
GO:0036402	Function	Proteasome-activating activity	ISS	1429620
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IBA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	NAS	19489727
GO:1901800	Process	Positive regulation of proteasomal protein catabolic process	IEA

MIM	HGNC	e!Ensembl
602706	9547	ENSG00000100764

P62191

Protein name

26S proteasome regulatory subunit 4 (P26s4) (26S proteasome AAA-ATPase subunit RPT2) (Proteasome 26S subunit ATPase 1)

Protein function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which

PDB

5GJQ , 5GJR , 5L4G , 5LN3 , 5M32 , 5T0C , 5T0G , 5T0H , 5T0I , 5T0J , 5VFP , 5VFQ , 5VFR , 5VFS , 5VFT , 5VFU , 5VGZ , 5VHF , 5VHH , 5VHI , 5VHJ , 5VHM , 5VHN , 5VHO , 5VHP , 5VHQ , 5VHR , 5VHS , 6MSB , 6MSD , 6MSG , 6MSH , 6MSJ , 6MSK , 6WJD , 6WJN , 7QXN , 7QXP , 7QXU , 7QXW , 7QXX , 7QY7 , 7QYA , 7QYB , 7W37 , 7W38 , 7W39 , 7W3A , 7W3B , 7W3C , 7W3F

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00004	AAA	222 → 355	ATPase family associated with various cellular activities (AAA)	Domain
PF16450	Prot_ATP_ID_OB	109 → 163	Proteasomal ATPase OB C-terminal domain	Domain
PF17862	AAA_lid_3	377 → 421	AAA+ lid domain	Domain

Sequence

MGQSQSGGHGPGGGKKDDKDKKKKYEPPVPTRVGKKKKKTKGPDAASKLPLVTPHTQCRL
KLLKLERIKDYLLMEEEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSVGTLEEIIDDNH
AIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAP
QETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVA
NQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSG
GEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKT
KKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFK
KSKENVLYKKQEGTPEGLYL

Sequence length

440

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Proteasome	Activation of NF-kappaB in B cells
Alzheimer disease	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Parkinson disease	Cross-presentation of soluble exogenous antigens (endosomes)
Amyotrophic lateral sclerosis	Autodegradation of Cdh1 by Cdh1:APC/C
Huntington disease	SCF-beta-TrCP mediated degradation of Emi1
Spinocerebellar ataxia	APC/C:Cdc20 mediated degradation of Securin
Prion disease	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Pathways of neurodegeneration - multiple diseases	Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Human papillomavirus infection	Vpu mediated degradation of CD4
Epstein-Barr virus infection	Vif-mediated degradation of APOBEC3G
Viral carcinogenesis	SCF(Skp2)-mediated degradation of p27/p21
	Degradation of beta-catenin by the destruction complex
	Downstream TCR signaling
	Separation of Sister Chromatids
	FCERI mediated NF-kB activation
	Autodegradation of the E3 ubiquitin ligase COP1
	Regulation of ornithine decarboxylase (ODC)
	ABC-family proteins mediated transport
	AUF1 (hnRNP D0) binds and destabilizes mRNA
	Asymmetric localization of PCP proteins
	Degradation of AXIN
	Degradation of DVL
	N-glycan trimming in the ER and Calnexin/Calreticulin cycle
	Hedgehog ligand biogenesis
	Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
	Dectin-1 mediated noncanonical NF-kB signaling
	CLEC7A (Dectin-1) signaling
	Degradation of GLI1 by the proteasome
	GLI3 is processed to GLI3R by the proteasome
	Hedgehog 'on' state
	Regulation of RAS by GAPs
	TNFR2 non-canonical NF-kB pathway
	NIK-->noncanonical NF-kB signaling
	Defective CFTR causes cystic fibrosis
	MAPK6/MAPK4 signaling
	UCH proteinases
	Ub-specific processing proteases
	CDT1 association with the CDC6:ORC:origin complex
	Orc1 removal from chromatin
	CDK-mediated phosphorylation and removal of Cdc6
	G2/M Checkpoints
	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
	Ubiquitin-dependent degradation of Cyclin D
	The role of GTSE1 in G2/M progression after G2 checkpoint
	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
	RUNX1 regulates transcription of genes involved in differentiation of HSCs
	Regulation of RUNX2 expression and activity
	Regulation of RUNX3 expression and activity
	Regulation of PTEN stability and activity
	Neddylation
	Interleukin-1 signaling
	Antigen processing: Ubiquitination & Proteasome degradation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss	Pathogenic	rs2503963172	RCV002291329	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal. Show/Hide Unknown Diseases (7)
BIPOLAR DISORDER	—	GWAS catalog	30217971	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIRK-AHARONI SYNDROME	—	Disgenet, HPO Disgenet, HPO	35861243	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	39046104	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	30217971	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDER	—	GWAS catalog	35861243	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDERS	—	Disgenet	35861243	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate cancer	Uncertain significance	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (21)
Acute pancreatitis	Pancreatitis	BEFREE	28984787		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anemia Hemolytic	Hemolytic anemia	Pubtator	36639418	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	39342401	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ataxia Telangiectasia	Ataxia Telangiectasia	BEFREE	19147735		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ataxia Telangiectasia	Ataxia telangiectasia	Pubtator	19147735	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
B-Cell Lymphomas	B-Cell Lymphoma	BEFREE	30651846		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	34329194	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	11765912		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cognition Disorders	Cognitive disorder	BEFREE	30890645		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	39342401	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
PSMB1	[]	54	["Proteasome","Parkinson disease","Spinocerebellar ataxia","Prion disease","Regulation of PTEN stability and activity","Ub-specific processing proteases","Neddylation","Separation of Sister Chromatids","ABC-family proteins mediated transport","Regulation of RAS by GAPs","SCF(Skp2)-mediated degradation of p27\/p21","Orc1 removal from chromatin"]	2	["GenCC (Neurodevelopmental disorder)","ClinVar (Neurodevelopmental disorder)"]
PSMC3	[]	55	["Proteasome","Parkinson disease","Spinocerebellar ataxia","Prion disease","Epstein-Barr virus infection","Regulation of PTEN stability and activity","Ub-specific processing proteases","Neddylation","Separation of Sister Chromatids","ABC-family proteins mediated transport","Regulation of RAS by GAPs","SCF(Skp2)-mediated degradation of p27\/p21"]	2	["GenCC (Neurodevelopmental disorder)","GWAS catalog (Neurodevelopmental disorder)"]
PSMC2	[]	55	["Proteasome","Parkinson disease","Spinocerebellar ataxia","Prion disease","Epstein-Barr virus infection","Regulation of PTEN stability and activity","Ub-specific processing proteases","Neddylation","Separation of Sister Chromatids","ABC-family proteins mediated transport","Regulation of RAS by GAPs","SCF(Skp2)-mediated degradation of p27\/p21"]	0	[]
PSMC4	[]	55	["Proteasome","Parkinson disease","Spinocerebellar ataxia","Prion disease","Epstein-Barr virus infection","Regulation of PTEN stability and activity","Ub-specific processing proteases","Neddylation","Separation of Sister Chromatids","ABC-family proteins mediated transport","Regulation of RAS by GAPs","SCF(Skp2)-mediated degradation of p27\/p21"]	0	[]
PSMC5	[]	55	["Proteasome","Parkinson disease","Spinocerebellar ataxia","Prion disease","Epstein-Barr virus infection","Regulation of PTEN stability and activity","Ub-specific processing proteases","Neddylation","Separation of Sister Chromatids","ABC-family proteins mediated transport","Regulation of RAS by GAPs","SCF(Skp2)-mediated degradation of p27\/p21"]	0	[]

PSMC1 (proteasome 26S subunit, ATPase 1)

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