Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Transcription factors Other IDs Associated diseases
Entrez ID	5693
Gene name	Proteasome 20S subunit beta 5
Gene symbol	PSMB5
Synonyms (NCBI Gene)	LMPXMB1
Chromosome	14
Chromosome location	14q11.2
Summary	The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta

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miRTarBase ID	miRNA	Experiments	Reference
MIRT021543	hsa-miR-142-3p	Microarray	17612493
MIRT031323	hsa-miR-18a-5p	Sequencing	20371350
MIRT046973	hsa-miR-221-3p	CLASH	23622248
MIRT044149	hsa-miR-30e-5p	CLASH	23622248
MIRT042548	hsa-miR-423-3p	CLASH	23622248
MIRT654676	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT654675	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT654674	hsa-miR-361-3p	HITS-CLIP	23824327
MIRT654673	hsa-miR-4287	HITS-CLIP	23824327
MIRT654672	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT666802	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT654697	hsa-miR-1470	HITS-CLIP	23824327
MIRT654696	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT654694	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT654695	hsa-miR-5193	HITS-CLIP	23824327
MIRT654693	hsa-miR-3183	HITS-CLIP	23824327
MIRT654692	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT654691	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT654690	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT654689	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT654688	hsa-miR-1248	HITS-CLIP	23824327
MIRT654687	hsa-miR-4469	HITS-CLIP	23824327
MIRT654686	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT654685	hsa-miR-3605-3p	HITS-CLIP	23824327
MIRT654684	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT654683	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT654682	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT654681	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT654680	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT654679	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT654678	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT654677	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT654676	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT654675	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT654674	hsa-miR-361-3p	HITS-CLIP	23824327
MIRT654673	hsa-miR-4287	HITS-CLIP	23824327
MIRT654672	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT654671	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT636306	hsa-miR-651-3p	HITS-CLIP	23824327
MIRT636305	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT137935	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT654670	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT654669	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT636303	hsa-miR-7159-3p	HITS-CLIP	23824327
MIRT636302	hsa-miR-4482-3p	HITS-CLIP	23824327
MIRT654668	hsa-miR-488-3p	HITS-CLIP	23824327
MIRT636306	hsa-miR-651-3p	HITS-CLIP	23824327
MIRT636305	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT636304	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT137935	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT636303	hsa-miR-7159-3p	HITS-CLIP	23824327
MIRT636302	hsa-miR-4482-3p	HITS-CLIP	23824327
MIRT630293	hsa-miR-5197-5p	HITS-CLIP	23824327
MIRT630292	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT630291	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT630290	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT630289	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT630288	hsa-miR-3666	HITS-CLIP	23824327
MIRT630287	hsa-miR-4295	HITS-CLIP	23824327
MIRT630286	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT630285	hsa-miR-183-5p	HITS-CLIP	23824327
MIRT630284	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT630283	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT630282	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT630281	hsa-miR-767-5p	HITS-CLIP	23824327
MIRT630280	hsa-miR-3135b	HITS-CLIP	23824327
MIRT630279	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT630278	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT630277	hsa-miR-593-5p	HITS-CLIP	23824327
MIRT630276	hsa-miR-3652	HITS-CLIP	23824327
MIRT630275	hsa-miR-4430	HITS-CLIP	23824327
MIRT630274	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT021543	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT021543	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT726853	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT726854	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT726852	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT726851	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT654676	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT654675	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT654674	hsa-miR-361-3p	HITS-CLIP	23824327
MIRT654673	hsa-miR-4287	HITS-CLIP	23824327
MIRT654672	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT666802	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT654697	hsa-miR-1470	HITS-CLIP	23824327
MIRT654696	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT654694	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT654695	hsa-miR-5193	HITS-CLIP	23824327
MIRT654693	hsa-miR-3183	HITS-CLIP	23824327
MIRT654692	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT654691	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT654690	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT654689	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT654688	hsa-miR-1248	HITS-CLIP	23824327
MIRT654687	hsa-miR-4469	HITS-CLIP	23824327
MIRT654686	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT654685	hsa-miR-3605-3p	HITS-CLIP	23824327
MIRT654684	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT654683	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT654682	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT654681	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT654680	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT654679	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT654678	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT654677	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT654676	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT654675	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT654674	hsa-miR-361-3p	HITS-CLIP	23824327
MIRT654673	hsa-miR-4287	HITS-CLIP	23824327
MIRT654672	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT654671	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT636306	hsa-miR-651-3p	HITS-CLIP	23824327
MIRT636305	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT137935	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT654670	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT654669	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT636303	hsa-miR-7159-3p	HITS-CLIP	23824327
MIRT636302	hsa-miR-4482-3p	HITS-CLIP	23824327
MIRT654668	hsa-miR-488-3p	HITS-CLIP	23824327
MIRT636306	hsa-miR-651-3p	HITS-CLIP	23824327
MIRT636305	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT636304	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT137935	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT636303	hsa-miR-7159-3p	HITS-CLIP	23824327
MIRT636302	hsa-miR-4482-3p	HITS-CLIP	23824327
MIRT630293	hsa-miR-5197-5p	HITS-CLIP	23824327
MIRT630292	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT630291	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT630290	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT630289	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT630288	hsa-miR-3666	HITS-CLIP	23824327
MIRT630287	hsa-miR-4295	HITS-CLIP	23824327
MIRT630286	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT630285	hsa-miR-183-5p	HITS-CLIP	23824327
MIRT630284	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT630283	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT630282	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT630281	hsa-miR-767-5p	HITS-CLIP	23824327
MIRT630280	hsa-miR-3135b	HITS-CLIP	23824327
MIRT630279	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT630278	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT630277	hsa-miR-593-5p	HITS-CLIP	23824327
MIRT630276	hsa-miR-3652	HITS-CLIP	23824327
MIRT630275	hsa-miR-4430	HITS-CLIP	23824327
MIRT630274	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT1270254	hsa-miR-103a	CLIP-seq
MIRT1270255	hsa-miR-107	CLIP-seq
MIRT1270256	hsa-miR-1184	CLIP-seq
MIRT1270257	hsa-miR-1205	CLIP-seq
MIRT1270258	hsa-miR-1265	CLIP-seq
MIRT1270259	hsa-miR-2392	CLIP-seq
MIRT1270260	hsa-miR-3121-3p	CLIP-seq
MIRT1270261	hsa-miR-3143	CLIP-seq
MIRT1270262	hsa-miR-3158-5p	CLIP-seq
MIRT1270263	hsa-miR-324-5p	CLIP-seq
MIRT1270264	hsa-miR-3605-5p	CLIP-seq
MIRT1270265	hsa-miR-4436b-5p	CLIP-seq
MIRT1270266	hsa-miR-4490	CLIP-seq
MIRT1270267	hsa-miR-4493	CLIP-seq
MIRT1270268	hsa-miR-4534	CLIP-seq
MIRT1270269	hsa-miR-4660	CLIP-seq
MIRT1270270	hsa-miR-4666-3p	CLIP-seq
MIRT1270271	hsa-miR-4731-3p	CLIP-seq
MIRT1270272	hsa-miR-4801	CLIP-seq
MIRT1270273	hsa-miR-4802-5p	CLIP-seq
MIRT1270274	hsa-miR-548a-5p	CLIP-seq
MIRT1270275	hsa-miR-548ab	CLIP-seq
MIRT1270276	hsa-miR-548ak	CLIP-seq
MIRT1270277	hsa-miR-548b-5p	CLIP-seq
MIRT1270278	hsa-miR-548c-5p	CLIP-seq
MIRT1270279	hsa-miR-548d-5p	CLIP-seq
MIRT1270280	hsa-miR-548h	CLIP-seq
MIRT1270281	hsa-miR-548i	CLIP-seq
MIRT1270282	hsa-miR-548j	CLIP-seq
MIRT1270283	hsa-miR-548w	CLIP-seq
MIRT1270284	hsa-miR-548y	CLIP-seq
MIRT1270285	hsa-miR-559	CLIP-seq
MIRT1270286	hsa-miR-646	CLIP-seq
MIRT1270287	hsa-miR-765	CLIP-seq
MIRT1270258	hsa-miR-1265	CLIP-seq
MIRT1270259	hsa-miR-2392	CLIP-seq
MIRT1270260	hsa-miR-3121-3p	CLIP-seq
MIRT1270265	hsa-miR-4436b-5p	CLIP-seq
MIRT1270267	hsa-miR-4493	CLIP-seq
MIRT1270270	hsa-miR-4666-3p	CLIP-seq
MIRT2079441	hsa-miR-1208	CLIP-seq
MIRT1270258	hsa-miR-1265	CLIP-seq
MIRT1270259	hsa-miR-2392	CLIP-seq
MIRT1270260	hsa-miR-3121-3p	CLIP-seq
MIRT1270263	hsa-miR-324-5p	CLIP-seq
MIRT1270264	hsa-miR-3605-5p	CLIP-seq
MIRT2079442	hsa-miR-3657	CLIP-seq
MIRT1270265	hsa-miR-4436b-5p	CLIP-seq
MIRT1270268	hsa-miR-4534	CLIP-seq
MIRT2079443	hsa-miR-4645-3p	CLIP-seq
MIRT2079444	hsa-miR-4669	CLIP-seq
MIRT2079445	hsa-miR-4704-3p	CLIP-seq
MIRT1270271	hsa-miR-4731-3p	CLIP-seq
MIRT1270272	hsa-miR-4801	CLIP-seq
MIRT1270273	hsa-miR-4802-5p	CLIP-seq
MIRT2079446	hsa-miR-556-3p	CLIP-seq
MIRT1270286	hsa-miR-646	CLIP-seq
MIRT1270287	hsa-miR-765	CLIP-seq
MIRT2079447	hsa-miR-892a	CLIP-seq
MIRT1270254	hsa-miR-103a	CLIP-seq
MIRT1270255	hsa-miR-107	CLIP-seq
MIRT1270256	hsa-miR-1184	CLIP-seq
MIRT1270257	hsa-miR-1205	CLIP-seq
MIRT2079441	hsa-miR-1208	CLIP-seq
MIRT1270258	hsa-miR-1265	CLIP-seq
MIRT1270259	hsa-miR-2392	CLIP-seq
MIRT1270260	hsa-miR-3121-3p	CLIP-seq
MIRT1270261	hsa-miR-3143	CLIP-seq
MIRT1270262	hsa-miR-3158-5p	CLIP-seq
MIRT1270263	hsa-miR-324-5p	CLIP-seq
MIRT1270264	hsa-miR-3605-5p	CLIP-seq
MIRT2079442	hsa-miR-3657	CLIP-seq
MIRT2305737	hsa-miR-376c	CLIP-seq
MIRT1270265	hsa-miR-4436b-5p	CLIP-seq
MIRT1270266	hsa-miR-4490	CLIP-seq
MIRT1270267	hsa-miR-4493	CLIP-seq
MIRT1270268	hsa-miR-4534	CLIP-seq
MIRT2079443	hsa-miR-4645-3p	CLIP-seq
MIRT1270269	hsa-miR-4660	CLIP-seq
MIRT1270270	hsa-miR-4666-3p	CLIP-seq
MIRT2079444	hsa-miR-4669	CLIP-seq
MIRT2079445	hsa-miR-4704-3p	CLIP-seq
MIRT1270271	hsa-miR-4731-3p	CLIP-seq
MIRT2305738	hsa-miR-4789-3p	CLIP-seq
MIRT1270272	hsa-miR-4801	CLIP-seq
MIRT1270273	hsa-miR-4802-5p	CLIP-seq
MIRT1270274	hsa-miR-548a-5p	CLIP-seq
MIRT1270275	hsa-miR-548ab	CLIP-seq
MIRT1270276	hsa-miR-548ak	CLIP-seq
MIRT1270277	hsa-miR-548b-5p	CLIP-seq
MIRT1270278	hsa-miR-548c-5p	CLIP-seq
MIRT1270279	hsa-miR-548d-5p	CLIP-seq
MIRT1270280	hsa-miR-548h	CLIP-seq
MIRT1270281	hsa-miR-548i	CLIP-seq
MIRT1270282	hsa-miR-548j	CLIP-seq
MIRT1270283	hsa-miR-548w	CLIP-seq
MIRT1270284	hsa-miR-548y	CLIP-seq
MIRT2079446	hsa-miR-556-3p	CLIP-seq
MIRT1270285	hsa-miR-559	CLIP-seq
MIRT1270286	hsa-miR-646	CLIP-seq
MIRT1270287	hsa-miR-765	CLIP-seq
MIRT2079447	hsa-miR-892a	CLIP-seq
MIRT2079441	hsa-miR-1208	CLIP-seq
MIRT1270258	hsa-miR-1265	CLIP-seq
MIRT1270259	hsa-miR-2392	CLIP-seq
MIRT1270260	hsa-miR-3121-3p	CLIP-seq
MIRT1270263	hsa-miR-324-5p	CLIP-seq
MIRT1270264	hsa-miR-3605-5p	CLIP-seq
MIRT2079442	hsa-miR-3657	CLIP-seq
MIRT1270265	hsa-miR-4436b-5p	CLIP-seq
MIRT1270267	hsa-miR-4493	CLIP-seq
MIRT1270268	hsa-miR-4534	CLIP-seq
MIRT2079443	hsa-miR-4645-3p	CLIP-seq
MIRT1270270	hsa-miR-4666-3p	CLIP-seq
MIRT2079444	hsa-miR-4669	CLIP-seq
MIRT2079445	hsa-miR-4704-3p	CLIP-seq
MIRT1270271	hsa-miR-4731-3p	CLIP-seq
MIRT1270272	hsa-miR-4801	CLIP-seq
MIRT1270273	hsa-miR-4802-5p	CLIP-seq
MIRT2079446	hsa-miR-556-3p	CLIP-seq
MIRT1270286	hsa-miR-646	CLIP-seq
MIRT1270287	hsa-miR-765	CLIP-seq
MIRT2079447	hsa-miR-892a	CLIP-seq
MIRT2079441	hsa-miR-1208	CLIP-seq
MIRT1270258	hsa-miR-1265	CLIP-seq
MIRT1270259	hsa-miR-2392	CLIP-seq
MIRT1270260	hsa-miR-3121-3p	CLIP-seq
MIRT1270263	hsa-miR-324-5p	CLIP-seq
MIRT1270264	hsa-miR-3605-5p	CLIP-seq
MIRT2079442	hsa-miR-3657	CLIP-seq
MIRT1270265	hsa-miR-4436b-5p	CLIP-seq
MIRT1270267	hsa-miR-4493	CLIP-seq
MIRT1270268	hsa-miR-4534	CLIP-seq
MIRT2079443	hsa-miR-4645-3p	CLIP-seq
MIRT1270270	hsa-miR-4666-3p	CLIP-seq
MIRT2079444	hsa-miR-4669	CLIP-seq
MIRT2079445	hsa-miR-4704-3p	CLIP-seq
MIRT1270271	hsa-miR-4731-3p	CLIP-seq
MIRT1270272	hsa-miR-4801	CLIP-seq
MIRT1270273	hsa-miR-4802-5p	CLIP-seq
MIRT2079446	hsa-miR-556-3p	CLIP-seq
MIRT1270286	hsa-miR-646	CLIP-seq
MIRT1270287	hsa-miR-765	CLIP-seq
MIRT2079447	hsa-miR-892a	CLIP-seq

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Transcription factor	Regulation	Reference
STAT3	Activation	24627483

Show/Hide all (37)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000502	Component	Proteasome complex	IDA	17323924
GO:0000502	Component	Proteasome complex	IEA
GO:0000502	Component	Proteasome complex	NAS	29636472
GO:0000502	Component	Proteasome complex	TAS	8811196
GO:0004175	Function	Endopeptidase activity	IBA
GO:0004175	Function	Endopeptidase activity	TAS
GO:0004298	Function	Threonine-type endopeptidase activity	IEA
GO:0005515	Function	Protein binding	IPI	14733938, 15231747, 17948026, 20723761, 28514442, 31473102, 32296183, 33961781, 35271311, 35858375
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	34711951
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	34711951
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	TAS
GO:0005839	Component	Proteasome core complex	IDA	34711951
GO:0005839	Component	Proteasome core complex	IEA
GO:0005839	Component	Proteasome core complex	ISS
GO:0006508	Process	Proteolysis	IDA	17540904
GO:0006508	Process	Proteolysis	IEA
GO:0006979	Process	Response to oxidative stress	IEA
GO:0008233	Function	Peptidase activity	IDA	17540904
GO:0008233	Function	Peptidase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0019774	Component	Proteasome core complex, beta-subunit complex	IBA
GO:0019774	Component	Proteasome core complex, beta-subunit complex	ISS
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IBA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IEA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	NAS	19489727
GO:0043248	Process	Proteasome assembly	TAS
GO:0051603	Process	Proteolysis involved in protein catabolic process	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867

MIM	HGNC	e!Ensembl
600306	9542	ENSG00000100804

P28074

Protein name

Proteasome subunit beta type-5 (EC 3.4.25.1) (Macropain epsilon chain) (Multicatalytic endopeptidase complex epsilon chain) (Proteasome chain 6) (Proteasome epsilon chain) (Proteasome subunit MB1) (Proteasome subunit X) (Proteasome subunit beta-5) (beta-5

Protein function

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with

PDB

4R3O , 4R67 , 5A0Q , 5GJQ , 5GJR , 5L4G , 5L5W , 5L5X , 5L5Y , 5L5Z , 5L60 , 5L61 , 5L62 , 5L63 , 5L64 , 5LE5 , 5LEX , 5LEY , 5LEZ , 5LF0 , 5LF1 , 5LF3 , 5LF4 , 5LF6 , 5LF7 , 5LN3 , 5M32 , 5T0C , 5T0G , 5T0H , 5T0I , 5T0J , 5VFO , 5VFP , 5VFQ , 5VFR , 5VFS , 5VFT , 5VFU , 6KWY , 6MSB , 6MSD , 6MSE , 6MSG , 6MSH , 6MSJ , 6MSK , 6R70 , 6REY , 6RGQ , 6WJD

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00227	Proteasome	56 → 238	Proteasome subunit	Domain

Sequence

MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGT
TTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLAR
QCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRI
SGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVRE
DGWIRVSSDNVADLHEKYSGSTP

Sequence length

263

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
MYOCARDIAL ISCHEMIA	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (24)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Arthritis	Arthritis	Pubtator	24875235	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Juvenile	Juvenile arthritis	Pubtator	24875235	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	29218236		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	36062301	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus	BEFREE	26661414		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diffuse Large B-Cell Lymphoma	Diffuse Lymphoma	BEFREE	27301795		★★★★★ ★☆☆☆☆ Found in Text Mining only
Down Syndrome	Down syndrome	Pubtator	28143565	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	24418325, 27542283	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus Cutaneous	Cutaneous lupus erythematosus	Pubtator	36049539	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	29218236		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	31562641		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28623645, 29218236		★★★★★ ★☆☆☆☆ Found in Text Mining only
Medulloblastoma	Medulloblastoma	Pubtator	36273157	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	BEFREE	30026573		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	30954557	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	35246527, 36399828	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocardial Ischemia	Myocardial Ischemia	CTD_human_DG	16214533		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neoplasms	Neoplasms	BEFREE	27301795, 29218236		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	31562641		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pterygium	Pterygium	BEFREE	30563490		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	22235146		★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	28623645		★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	28623645	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	36562811	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

PSMB5 (proteasome 20S subunit beta 5)