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Gene Gene information from NCBI Gene database.
Entrez ID 283659
Gene name Protogenin
Gene symbol PRTG
Synonyms (NCBI Gene)
IGDCC5
Chromosome 15
Chromosome location 15q21.3
Summary This gene encodes a member of the immunoglobulin superfamily. The encoded transmembrane protein has been associated with the development of various tissues, especially neurogenesis. It has been suggested that this gene may be associated with attention def
miRNA miRNA information provided by mirtarbase database.
715 Show/Hide all (715)
miRTarBase ID miRNA Experiments Reference
MIRT051907 hsa-let-7b-5p CLASH 23622248
MIRT437375 hsa-miR-9-5p ImmunocytochemistryLuciferase reporter assayqRT-PCRWestern blot 24007463
MIRT437375 hsa-miR-9-5p ImmunocytochemistryLuciferase reporter assayqRT-PCRWestern blot 24007463
MIRT437375 hsa-miR-9-5p ImmunocytochemistryLuciferase reporter assayqRT-PCRWestern blot 24007463
MIRT437375 hsa-miR-9-5p ImmunocytochemistryLuciferase reporter assayqRT-PCRWestern blot 24007463
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
8 Show/Hide all (8)
GO ID Ontology Definition Evidence Reference
GO:0005615 Component Extracellular space HDA 22664934
GO:0005886 Component Plasma membrane IEA
GO:0016020 Component Membrane IEA
GO:0038023 Function Signaling receptor activity IEA
GO:0042802 Function Identical protein binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
613261 26373 ENSG00000166450
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q2VWP7
Protein name Protogenin (Protein Shen-Dan)
Protein function May play a role in anteroposterior axis elongation.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00041 fn3 420 → 505 Fibronectin type III domain Domain
PF00041 fn3 723 → 807 Fibronectin type III domain Domain
PF00041 fn3 518 → 603 Fibronectin type III domain Domain
PF00041 fn3 821 → 907 Fibronectin type III domain Domain
PF00041 fn3 619 → 700 Fibronectin type III domain Domain
PF07679 I-set 327 → 412 Immunoglobulin I-set domain Domain
PF07679 I-set 39 → 131 Immunoglobulin I-set domain Domain
PF13927 Ig_3 234 → 308 Domain
PF13927 Ig_3 134 → 208 Domain
Sequence
Sequence length 1150
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
CATARACT — GWAS catalog 39024449
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER — GWAS catalog 37945903
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA — GWAS catalog 37945903
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
TESTICULAR CARCINOMA — GWAS catalog 28604732, 32887889
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
TESTICULAR GERM CELL TUMOR — GWAS catalog 28604732
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (7)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Attention Deficit Disorder with Hyperactivity Attention deficit hyperactivity disorder Pubtator 19076634 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Attention deficit hyperactivity disorder Attention Deficit Hyperactivity Disorder BEFREE 19076634
★★★★★
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 40581983 Inhibit
★★★★★
★☆☆☆☆
Found in Text Mining only
Cleft Palate Cleft palate Pubtator 28425186 Stimulate
★★★★★
★☆☆☆☆
Found in Text Mining only
Degenerative polyarthritis Arthritis BEFREE 24007463
★★★★★
★☆☆☆☆
Found in Text Mining only
Dystonic Disorders Dystonia Pubtator 31190668 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Epilepsy Epilepsy Pubtator 31190668 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only