PRSS21 (serine protease 21)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 10942
• Gene name: Serine protease 21
• Gene symbol: PRSS21
• Synonyms (NCBI Gene): ESP-1, ESP1, TEST1, TESTISIN
• Chromosome: 16
• Chromosome location: 16p13.3
• Summary: This gene encodes a cell-surface anchored serine protease, which is a member of the trypsin family of serine proteases. The encoded protein is predicted to be active on peptide linkages involving the carboxyl group of lysine or arginine. The encoded prote

miRNA Show/Hide all (77)

miRTarBase ID	miRNA	Experiments	Reference
MIRT001346	hsa-miR-1-3p	pSILAC	18668040
MIRT021022	hsa-miR-155-5p	Proteomics	18668040
MIRT001346	hsa-miR-1-3p	Proteomics;Other	18668040
MIRT643248	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT643247	hsa-miR-8485	HITS-CLIP	23824327
MIRT643246	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT643245	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT643244	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT643243	hsa-miR-3151-3p	HITS-CLIP	23824327
MIRT643242	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT643241	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT643240	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT643239	hsa-miR-612	HITS-CLIP	23824327
MIRT643238	hsa-miR-6860	HITS-CLIP	23824327
MIRT643237	hsa-miR-661	HITS-CLIP	23824327
MIRT643236	hsa-miR-196a-3p	HITS-CLIP	23824327
MIRT643235	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT643234	hsa-miR-3192-3p	HITS-CLIP	23824327
MIRT643233	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT643232	hsa-miR-4762-3p	HITS-CLIP	23824327
MIRT543529	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT543528	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT543527	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT543526	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT543525	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT543524	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT543523	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT543522	hsa-miR-503-5p	PAR-CLIP	21572407
MIRT543521	hsa-miR-646	PAR-CLIP	21572407
MIRT543520	hsa-miR-654-3p	PAR-CLIP	21572407
MIRT543519	hsa-miR-6503-3p	PAR-CLIP	21572407
MIRT543518	hsa-miR-6830-3p	PAR-CLIP	21572407
MIRT543517	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT543516	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT543515	hsa-miR-580-3p	PAR-CLIP	21572407
MIRT543514	hsa-miR-511-5p	PAR-CLIP	21572407
MIRT543513	hsa-miR-374b-3p	PAR-CLIP	21572407
MIRT643248	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT643247	hsa-miR-8485	HITS-CLIP	23824327
MIRT643246	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT643245	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT643244	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT643243	hsa-miR-3151-3p	HITS-CLIP	23824327
MIRT643242	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT643241	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT643240	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT643239	hsa-miR-612	HITS-CLIP	23824327
MIRT643238	hsa-miR-6860	HITS-CLIP	23824327
MIRT643237	hsa-miR-661	HITS-CLIP	23824327
MIRT643236	hsa-miR-196a-3p	HITS-CLIP	23824327
MIRT643235	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT643234	hsa-miR-3192-3p	HITS-CLIP	23824327
MIRT643233	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT643232	hsa-miR-4762-3p	HITS-CLIP	23824327
MIRT543529	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT543528	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT543527	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT543526	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT543525	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT543524	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT543523	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT543522	hsa-miR-503-5p	PAR-CLIP	21572407
MIRT543521	hsa-miR-646	PAR-CLIP	21572407
MIRT543520	hsa-miR-654-3p	PAR-CLIP	21572407
MIRT543519	hsa-miR-6503-3p	PAR-CLIP	21572407
MIRT543518	hsa-miR-6830-3p	PAR-CLIP	21572407
MIRT543517	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT543516	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT543515	hsa-miR-580-3p	PAR-CLIP	21572407
MIRT543514	hsa-miR-511-5p	PAR-CLIP	21572407
MIRT543513	hsa-miR-374b-3p	PAR-CLIP	21572407
MIRT1268441	hsa-miR-2861	CLIP-seq
MIRT1268442	hsa-miR-3918	CLIP-seq
MIRT1268443	hsa-miR-3925-5p	CLIP-seq
MIRT1268444	hsa-miR-4512	CLIP-seq
MIRT1268445	hsa-miR-4685-5p	CLIP-seq
MIRT1268446	hsa-miR-589	CLIP-seq

Gene ontology (GO) Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004252	Function	Serine-type endopeptidase activity	IBA
GO:0004252	Function	Serine-type endopeptidase activity	IEA
GO:0005515	Function	Protein binding	IPI	20211623
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005737	Component	Cytoplasm	TAS	10397266
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	10397266
GO:0006508	Process	Proteolysis	IBA
GO:0006508	Process	Proteolysis	IEA
GO:0007283	Process	Spermatogenesis	IBA
GO:0008233	Function	Peptidase activity	IEA
GO:0008236	Function	Serine-type peptidase activity	IEA
GO:0008236	Function	Serine-type peptidase activity	TAS	10397266
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	9826525
GO:0016787	Function	Hydrolase activity	IEA
GO:0098552	Component	Side of membrane	IEA

Other IDs

• MIM: 608159
• HGNC: 9485
• e!Ensembl: ENSG00000007038

Protein

• UniProt ID: Q9Y6M0
• Protein name: Testisin (EC 3.4.21.-) (Eosinophil serine protease 1) (ESP-1) (Serine protease 21)
• Protein function: Could regulate proteolytic events associated with testicular germ cell maturation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00089	Trypsin	42 → 281	Trypsin	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed predominantly in premeiotic testicular germ cells, mostly late pachytene and diplotene spermatocytes.
• Sequence:

  MGARGALLLALLLARAGLRKPESQEAAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSLR
  LWDSHVCGVSLLSHRWALTAAHCFETYSDLSDPSGWMVQFGQLTSMPSFWSLQAYYTRYF
  VSNIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYIK
  EDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGDMVCAGNAQGGKDACFGDSGG
  PLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLMAQSGMSQPDPSWPLL
  FFPLLWALPLLGPV

• Sequence length: 314

Pathways

Reactome Pathway:

Post-translational modification: synthesis of GPI-anchored proteins

Related Genes

No strongly related genes found yet for PRSS21.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to PRSS21.