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Gene Gene information from NCBI Gene database.
Entrez ID 5638
Gene name Proline rich and Gla domain 1
Gene symbol PRRG1
Synonyms (NCBI Gene)
PRGP1
Chromosome X
Chromosome location Xp21.1
Summary This gene encodes a vitamin K-dependent, gamma-carboxyglutamic acid (Gla)-containing, single-pass transmembrane protein. This protein contains a Gla domain at the N-terminus, preceded by a propeptide sequence required for post-translational gamma-carboxyl
miRNA miRNA information provided by mirtarbase database.
495 Show/Hide all (495)
miRTarBase ID miRNA Experiments Reference
MIRT020483 hsa-miR-106b-5p Microarray 17242205
MIRT028084 hsa-miR-93-5p Sequencing 20371350
MIRT244944 hsa-miR-17-5p In situ hybridizationNext Generation Sequencing (NGS)qRT-PCR 26233958
MIRT244945 hsa-miR-20a-5p In situ hybridizationNext Generation Sequencing (NGS)qRT-PCR 26233958
MIRT1267821 hsa-miR-103a CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
9 Show/Hide all (9)
GO ID Ontology Definition Evidence Reference
GO:0004252 Function Serine-type endopeptidase activity IBA
GO:0005509 Function Calcium ion binding IEA
GO:0005515 Function Protein binding IPI 32296183
GO:0005576 Component Extracellular region IEA
GO:0005615 Component Extracellular space IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
300935 9469 ENSG00000130962
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O14668
Protein name Transmembrane gamma-carboxyglutamic acid protein 1 (Proline-rich gamma-carboxyglutamic acid protein 1) (Proline-rich Gla protein 1)
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00594 Gla 25 → 65 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in the spinal cord.
Sequence
MGRVFLTGEKANSILKRYPRANGFFEEIRQGNIERECKEEFCTFEEAREAFENNEKTKEF
WSTYT
KAQQGESNRGSDWFQFYLTFPLIFGLFIILLVIFLIWRCFLRNKTRRQTVTEGHI
PFPQHLNIITPPPPPDEVFDSSGLSPGFLGYVVGRSDSVSTRLSNCDPPPTYEEATGQVN
LQRSETEPHLDPPPEYEDIVNSNSASAIPMVPVVTTIK
Sequence length 218
Interactions View interactions