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Gene Gene information from NCBI Gene database.
Entrez ID 150696
Gene name Prominin 2
Gene symbol PROM2
Synonyms (NCBI Gene)
PROML2
Chromosome 2
Chromosome location 2q11.1
Summary This gene encodes a member of the prominin family of pentaspan membrane glycoproteins. The encoded protein localizes to basal epithelial cells and may be involved in the organization of plasma membrane microdomains. Alternative splicing results in multipl
miRNA miRNA information provided by mirtarbase database.
310 Show/Hide all (310)
miRTarBase ID miRNA Experiments Reference
MIRT517780 hsa-miR-4459 PAR-CLIP 23446348
MIRT517779 hsa-miR-665 PAR-CLIP 23446348
MIRT517778 hsa-miR-6840-3p PAR-CLIP 23446348
MIRT517777 hsa-miR-1225-3p PAR-CLIP 23446348
MIRT517776 hsa-miR-1233-3p PAR-CLIP 23446348
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
34 Show/Hide all (34)
GO ID Ontology Definition Evidence Reference
GO:0001934 Process Positive regulation of protein phosphorylation IDA 23583380
GO:0005515 Function Protein binding IPI 32296183
GO:0005886 Component Plasma membrane IEA
GO:0005886 Component Plasma membrane ISS 12514187
GO:0005902 Component Microvillus IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
617160 20685 ENSG00000155066
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8N271
Protein name Prominin-2 (PROM-2) (Prominin-like protein 2) (hPROML2)
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05478 Prominin 25 → 807 Prominin Family
Tissue specificity TISSUE SPECIFICITY: Present in saliva within small membrane particles (at protein level). Expressed in kidney, prostate, trachea, esophagus, salivary gland, thyroid gland, mammary gland adrenal gland, placenta, stomach, spinal cord and liver. In submucosa
Sequence
Sequence length 834
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
EBV-positive nodal T- and NK-cell lymphoma Likely benign ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (14)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Breast Neoplasms Breast neoplasm Pubtator 31735663 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma Renal Cell Renal cell carcinoma Pubtator 35314744 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Ciliopathies Ciliopathy Pubtator 33639936 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
LEUKOENCEPHALOPATHY, BRAIN CALCIFICATIONS, AND CYSTS LEUKOENCEPHALOPATHY, BRAIN CALCIFICATIONS, AND CYSTS BEFREE 27301951
★★★★★
★☆☆☆☆
Found in Text Mining only
Liver carcinoma Liver carcinoma BEFREE 27301951
★★★★★
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of prostate Prostate cancer BEFREE 12446606
★★★★★
★☆☆☆☆
Found in Text Mining only
Malignant Neoplasms Malignant Neoplasm BEFREE 31164716
★★★★★
★☆☆☆☆
Found in Text Mining only
Mitochondrial Diseases Mitochondrial disease Pubtator 20887790 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
nervous system disorder Nervous System Disorder BEFREE 20887790
★★★★★
★☆☆☆☆
Found in Text Mining only
Oxyphilic Adenoma Oxyphilic Adenoma LHGDN 17145811
★★★★★
★☆☆☆☆
Found in Text Mining only