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Gene Gene information from NCBI Gene database.
Entrez ID 5613
Gene name Protein kinase cAMP-dependent X-linked catalytic subunit
Gene symbol PRKX
Synonyms (NCBI Gene)
PKX1
Chromosome X
Chromosome location Xp22.33
Summary This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein
miRNA miRNA information provided by mirtarbase database.
1318 Show/Hide all (1318)
miRTarBase ID miRNA Experiments Reference
MIRT019867 hsa-miR-375 Microarray 20215506
MIRT724463 hsa-miR-4798-3p HITS-CLIP 19536157
MIRT724462 hsa-miR-6767-3p HITS-CLIP 19536157
MIRT724461 hsa-miR-4324 HITS-CLIP 19536157
MIRT724460 hsa-miR-544b HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
36 Show/Hide all (36)
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0001525 Process Angiogenesis IEA
GO:0001525 Process Angiogenesis IMP 21684272
GO:0001935 Process Endothelial cell proliferation IEA
GO:0001935 Process Endothelial cell proliferation IMP 21684272
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
300083 9441 ENSG00000183943
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P51817
Protein name cAMP-dependent protein kinase catalytic subunit PRKX (PrKX) (Protein kinase X) (Protein kinase X-linked) (Serine/threonine-protein kinase PRKX) (EC 2.7.11.1) (Protein kinase PKX1)
Protein function Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial mo
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 49 → 303 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed (at protein level). Specifically expressed in blood by macrophages and granulocytes according to PubMed:9860982. {ECO:0000269|PubMed:15879576, ECO:0000269|PubMed:16236808, ECO:0000269|PubMed:7633447, ECO:0000269|PubMed
Sequence
Sequence length 358
Interactions View interactions