PRH2 (proline rich protein HaeIII subfamily 2)

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Gene miRNA Gene ontology Other IDs Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 5555
• Gene name: Proline rich protein HaeIII subfamily 2
• Gene symbol: PRH2
• Synonyms (NCBI Gene): PRP-1/PRP-2, Pr, pr1/Pr2
• Chromosome: 12
• Chromosome location: 12p13.2
• Summary: This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid and submandibular/sublingua

miRNA Show/Hide all (65)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018946	hsa-miR-335-5p	Microarray	18185580
MIRT1261272	hsa-miR-1238	CLIP-seq
MIRT1261273	hsa-miR-1273d	CLIP-seq
MIRT1261274	hsa-miR-1279	CLIP-seq
MIRT1261275	hsa-miR-150	CLIP-seq
MIRT1261276	hsa-miR-181a	CLIP-seq
MIRT1261277	hsa-miR-181b	CLIP-seq
MIRT1261278	hsa-miR-181c	CLIP-seq
MIRT1261279	hsa-miR-181d	CLIP-seq
MIRT1261280	hsa-miR-2052	CLIP-seq
MIRT1261281	hsa-miR-2110	CLIP-seq
MIRT1261282	hsa-miR-2117	CLIP-seq
MIRT1261283	hsa-miR-3153	CLIP-seq
MIRT1261284	hsa-miR-3163	CLIP-seq
MIRT1261285	hsa-miR-3180-5p	CLIP-seq
MIRT1261286	hsa-miR-3677-5p	CLIP-seq
MIRT1261287	hsa-miR-383	CLIP-seq
MIRT1261288	hsa-miR-4262	CLIP-seq
MIRT1261289	hsa-miR-4271	CLIP-seq
MIRT1261290	hsa-miR-4273	CLIP-seq
MIRT1261291	hsa-miR-4276	CLIP-seq
MIRT1261292	hsa-miR-4292	CLIP-seq
MIRT1261293	hsa-miR-4308	CLIP-seq
MIRT1261294	hsa-miR-4314	CLIP-seq
MIRT1261295	hsa-miR-4461	CLIP-seq
MIRT1261296	hsa-miR-4646-5p	CLIP-seq
MIRT1261297	hsa-miR-4652-3p	CLIP-seq
MIRT1261298	hsa-miR-4667-5p	CLIP-seq
MIRT1261299	hsa-miR-4668-5p	CLIP-seq
MIRT1261300	hsa-miR-4700-5p	CLIP-seq
MIRT1261301	hsa-miR-4713-5p	CLIP-seq
MIRT1261302	hsa-miR-4725-3p	CLIP-seq
MIRT1261303	hsa-miR-4772-5p	CLIP-seq
MIRT1261304	hsa-miR-5096	CLIP-seq
MIRT1261305	hsa-miR-513b	CLIP-seq
MIRT1261306	hsa-miR-520a-5p	CLIP-seq
MIRT1261307	hsa-miR-525-5p	CLIP-seq
MIRT1261308	hsa-miR-532-3p	CLIP-seq
MIRT1261309	hsa-miR-601	CLIP-seq
MIRT1261310	hsa-miR-617	CLIP-seq
MIRT1261311	hsa-miR-628-5p	CLIP-seq
MIRT1261312	hsa-miR-637	CLIP-seq
MIRT1261313	hsa-miR-203	CLIP-seq
MIRT1261314	hsa-miR-375	CLIP-seq
MIRT1261315	hsa-miR-377	CLIP-seq
MIRT2076841	hsa-miR-224	CLIP-seq
MIRT1261283	hsa-miR-3153	CLIP-seq
MIRT2076842	hsa-miR-3653	CLIP-seq
MIRT2076843	hsa-miR-3658	CLIP-seq
MIRT2076844	hsa-miR-4511	CLIP-seq
MIRT1261296	hsa-miR-4646-5p	CLIP-seq
MIRT1261299	hsa-miR-4668-5p	CLIP-seq
MIRT2076845	hsa-miR-4753-3p	CLIP-seq
MIRT2076846	hsa-miR-4782-5p	CLIP-seq
MIRT1261304	hsa-miR-5096	CLIP-seq
MIRT2076847	hsa-miR-548b-3p	CLIP-seq
MIRT1261276	hsa-miR-181a	CLIP-seq
MIRT1261277	hsa-miR-181b	CLIP-seq
MIRT1261278	hsa-miR-181c	CLIP-seq
MIRT1261279	hsa-miR-181d	CLIP-seq
MIRT1261280	hsa-miR-2052	CLIP-seq
MIRT2303540	hsa-miR-320e	CLIP-seq
MIRT2303541	hsa-miR-3909	CLIP-seq
MIRT1261288	hsa-miR-4262	CLIP-seq
MIRT2303542	hsa-miR-539	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16203048, 26091039
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	TAS	2993301

Other IDs

• MIM: 168790
• HGNC: 9367
• e!Ensembl: ENSG00000134551

Interactions View interactions

Pathways

KEGG Pathway:

Salivary secretion

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Malignant tumor of urinary bladder	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (24)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Arthrogryposis	Arthrogryposis multiplex congenita	BEFREE	26287277		★☆☆☆☆ Found in Text Mining only
Blood Coagulation Disorders	Blood Coagulation Disorders	BEFREE	30159948		★☆☆☆☆ Found in Text Mining only
Cardiomyopathies	Cardiomyopathy	BEFREE	24736382		★☆☆☆☆ Found in Text Mining only
Cardiomyopathy, Hypertrophic, Familial	Cardiomyopathy	BEFREE	10024460, 9140840, 9218526, 9503187		★☆☆☆☆ Found in Text Mining only
Cerebral Palsy	Cerebral palsy	BEFREE	30965088		★☆☆☆☆ Found in Text Mining only
Cerebrovascular accident	Stroke	BEFREE	15574195		★☆☆☆☆ Found in Text Mining only
Dental Caries	Dental caries	Pubtator	29191562	Associate	★☆☆☆☆ Found in Text Mining only
Disseminated Intravascular Coagulation	Disseminated Intravascular Coagulation	BEFREE	22728069		★☆☆☆☆ Found in Text Mining only
Fibrosis, Liver	Liver Fibrosis	BEFREE	29704446		★☆☆☆☆ Found in Text Mining only
Hyperlipoproteinemia Type IIa	Hyperlipoproteinemia	BEFREE	10024460		★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	24756636		★☆☆☆☆ Found in Text Mining only
Hypertrophic Cardiomyopathy	Hypertrophic cardiomyopathy	BEFREE	10980884, 11815426, 12386147, 12628722, 16004897, 17560888, 18374358, 19666196, 22267749, 22462493, 24888384, 28615295, 30170119, 30371160		★☆☆☆☆ Found in Text Mining only
Hypertrophic obstructive cardiomyopathy	Hypertrophic cardiomyopathy	BEFREE	10980884, 11815426, 12386147, 12628722, 16004897, 17560888, 18374358, 22267749, 28615295, 30170119, 30371160		★☆☆☆☆ Found in Text Mining only
Ischemic stroke	Ischemic Stroke	BEFREE	30383853		★☆☆☆☆ Found in Text Mining only
Lupus anticoagulant disorder	Lupus anticoagulant	BEFREE	8052955		★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial Infarction	BEFREE	21971072		★☆☆☆☆ Found in Text Mining only
Myopathy	Myopathy	BEFREE	26287277		★☆☆☆☆ Found in Text Mining only
Myositis	Myositis	BEFREE	17878394		★☆☆☆☆ Found in Text Mining only
Protein C Deficiency	Protein C Deficiency	BEFREE	1301954, 28111891		★☆☆☆☆ Found in Text Mining only
Pulmonary Fibrosis	Pulmonary Fibrosis	BEFREE	30918525		★☆☆☆☆ Found in Text Mining only
Purpura Fulminans	Purpura Fulminans	BEFREE	31524150		★☆☆☆☆ Found in Text Mining only
Septicemia	Septicemia	BEFREE	29704446		★☆☆☆☆ Found in Text Mining only
Thrombophilia	Thrombophilia	BEFREE	15978566, 1826407, 26315791, 9271815		★☆☆☆☆ Found in Text Mining only
Vertical Talus	Vertical Talus	BEFREE	10876830		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for PRH2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to PRH2.