Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	10113
Gene name	Prolactin regulatory element binding
Gene symbol	PREB
Synonyms (NCBI Gene)	SEC12
Chromosome	2
Chromosome location	2p23.3
Summary	This gene encodes a protein that specifically binds to a Pit1-binding element of the prolactin (PRL) promoter. This protein may act as a transcriptional regulator and is thought to be involved in some of the developmental abnormalities observed in patient

152 Show/Hide all (152)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022830	hsa-miR-124-3p	Microarray	18668037
MIRT052602	hsa-let-7a-5p	CLASH	23622248
MIRT051323	hsa-miR-15a-5p	CLASH	23622248
MIRT047099	hsa-miR-183-5p	CLASH	23622248
MIRT1260679	hsa-miR-103b	CLIP-seq
MIRT1260680	hsa-miR-122	CLIP-seq
MIRT1260681	hsa-miR-1273f	CLIP-seq
MIRT1260682	hsa-miR-1289	CLIP-seq
MIRT1260683	hsa-miR-1587	CLIP-seq
MIRT1260684	hsa-miR-23a	CLIP-seq
MIRT1260685	hsa-miR-23b	CLIP-seq
MIRT1260686	hsa-miR-23c	CLIP-seq
MIRT1260687	hsa-miR-3074-5p	CLIP-seq
MIRT1260688	hsa-miR-3138	CLIP-seq
MIRT1260689	hsa-miR-3918	CLIP-seq
MIRT1260690	hsa-miR-3945	CLIP-seq
MIRT1260691	hsa-miR-412	CLIP-seq
MIRT1260692	hsa-miR-4253	CLIP-seq
MIRT1260693	hsa-miR-4446-5p	CLIP-seq
MIRT1260694	hsa-miR-4477a	CLIP-seq
MIRT1260695	hsa-miR-4492	CLIP-seq
MIRT1260696	hsa-miR-4498	CLIP-seq
MIRT1260697	hsa-miR-4506	CLIP-seq
MIRT1260698	hsa-miR-4645-5p	CLIP-seq
MIRT1260699	hsa-miR-4650-5p	CLIP-seq
MIRT1260700	hsa-miR-4656	CLIP-seq
MIRT1260701	hsa-miR-4662a-5p	CLIP-seq
MIRT1260702	hsa-miR-4673	CLIP-seq
MIRT1260703	hsa-miR-4675	CLIP-seq
MIRT1260704	hsa-miR-4717-3p	CLIP-seq
MIRT1260705	hsa-miR-4722-3p	CLIP-seq
MIRT1260706	hsa-miR-4741	CLIP-seq
MIRT1260707	hsa-miR-4777-5p	CLIP-seq
MIRT1260708	hsa-miR-4800-5p	CLIP-seq
MIRT1260709	hsa-miR-5096	CLIP-seq
MIRT1260710	hsa-miR-518d-5p	CLIP-seq
MIRT1260711	hsa-miR-519b-5p	CLIP-seq
MIRT1260712	hsa-miR-519c-5p	CLIP-seq
MIRT1260713	hsa-miR-520c-5p	CLIP-seq
MIRT1260714	hsa-miR-526a	CLIP-seq
MIRT1260715	hsa-miR-577	CLIP-seq
MIRT1260716	hsa-miR-579	CLIP-seq
MIRT1260717	hsa-miR-635	CLIP-seq
MIRT1260718	hsa-miR-711	CLIP-seq
MIRT1260719	hsa-miR-762	CLIP-seq
MIRT1260720	hsa-miR-767-3p	CLIP-seq
MIRT2076704	hsa-miR-1207-3p	CLIP-seq
MIRT1260682	hsa-miR-1289	CLIP-seq
MIRT2076705	hsa-miR-1343	CLIP-seq
MIRT1260684	hsa-miR-23a	CLIP-seq
MIRT1260685	hsa-miR-23b	CLIP-seq
MIRT1260686	hsa-miR-23c	CLIP-seq
MIRT1260688	hsa-miR-3138	CLIP-seq
MIRT2076706	hsa-miR-3198	CLIP-seq
MIRT2076707	hsa-miR-3649	CLIP-seq
MIRT2076708	hsa-miR-3661	CLIP-seq
MIRT2076709	hsa-miR-378g	CLIP-seq
MIRT2076710	hsa-miR-3942-3p	CLIP-seq
MIRT1260690	hsa-miR-3945	CLIP-seq
MIRT1260691	hsa-miR-412	CLIP-seq
MIRT1260692	hsa-miR-4253	CLIP-seq
MIRT2076711	hsa-miR-4254	CLIP-seq
MIRT2076712	hsa-miR-4294	CLIP-seq
MIRT2076713	hsa-miR-4309	CLIP-seq
MIRT2076714	hsa-miR-4519	CLIP-seq
MIRT1260704	hsa-miR-4717-3p	CLIP-seq
MIRT1260708	hsa-miR-4800-5p	CLIP-seq
MIRT2076715	hsa-miR-492	CLIP-seq
MIRT2076716	hsa-miR-619	CLIP-seq
MIRT2076717	hsa-miR-631	CLIP-seq
MIRT1260717	hsa-miR-635	CLIP-seq
MIRT2076718	hsa-miR-661	CLIP-seq
MIRT1260718	hsa-miR-711	CLIP-seq
MIRT2303404	hsa-miR-105	CLIP-seq
MIRT2303405	hsa-miR-1207-5p	CLIP-seq
MIRT2303406	hsa-miR-1827	CLIP-seq
MIRT2303407	hsa-miR-193a-3p	CLIP-seq
MIRT2303408	hsa-miR-193b	CLIP-seq
MIRT1260687	hsa-miR-3074-5p	CLIP-seq
MIRT2303409	hsa-miR-3124-3p	CLIP-seq
MIRT2303410	hsa-miR-3125	CLIP-seq
MIRT2303411	hsa-miR-3155	CLIP-seq
MIRT2303412	hsa-miR-3155b	CLIP-seq
MIRT2303413	hsa-miR-3607-5p	CLIP-seq
MIRT2303414	hsa-miR-3611	CLIP-seq
MIRT2303415	hsa-miR-3612	CLIP-seq
MIRT2303416	hsa-miR-3655	CLIP-seq
MIRT2076709	hsa-miR-378g	CLIP-seq
MIRT2303417	hsa-miR-3916	CLIP-seq
MIRT2303418	hsa-miR-3928	CLIP-seq
MIRT2303419	hsa-miR-4270	CLIP-seq
MIRT2303420	hsa-miR-4441	CLIP-seq
MIRT2303421	hsa-miR-4457	CLIP-seq
MIRT1260694	hsa-miR-4477a	CLIP-seq
MIRT1260697	hsa-miR-4506	CLIP-seq
MIRT2303422	hsa-miR-4639-3p	CLIP-seq
MIRT2303423	hsa-miR-4701-5p	CLIP-seq
MIRT2303424	hsa-miR-4709-3p	CLIP-seq
MIRT1260705	hsa-miR-4722-3p	CLIP-seq
MIRT2303425	hsa-miR-4755-3p	CLIP-seq
MIRT2303426	hsa-miR-4763-3p	CLIP-seq
MIRT2303427	hsa-miR-484	CLIP-seq
MIRT2303428	hsa-miR-502-5p	CLIP-seq
MIRT2303429	hsa-miR-588	CLIP-seq
MIRT2303430	hsa-miR-650	CLIP-seq
MIRT2076718	hsa-miR-661	CLIP-seq
MIRT2303431	hsa-miR-940	CLIP-seq
MIRT1260679	hsa-miR-103b	CLIP-seq
MIRT2076704	hsa-miR-1207-3p	CLIP-seq
MIRT2599992	hsa-miR-2682	CLIP-seq
MIRT1260688	hsa-miR-3138	CLIP-seq
MIRT2599993	hsa-miR-3154	CLIP-seq
MIRT2599994	hsa-miR-34a	CLIP-seq
MIRT2599995	hsa-miR-34c-5p	CLIP-seq
MIRT2303416	hsa-miR-3655	CLIP-seq
MIRT2599996	hsa-miR-371b-3p	CLIP-seq
MIRT2599997	hsa-miR-377	CLIP-seq
MIRT1260689	hsa-miR-3918	CLIP-seq
MIRT2599998	hsa-miR-4436b-3p	CLIP-seq
MIRT2599999	hsa-miR-449a	CLIP-seq
MIRT2600000	hsa-miR-449b	CLIP-seq
MIRT2600001	hsa-miR-449c	CLIP-seq
MIRT2600002	hsa-miR-4514	CLIP-seq
MIRT2600003	hsa-miR-4641	CLIP-seq
MIRT1260701	hsa-miR-4662a-5p	CLIP-seq
MIRT2600004	hsa-miR-4692	CLIP-seq
MIRT1260708	hsa-miR-4800-5p	CLIP-seq
MIRT1260709	hsa-miR-5096	CLIP-seq
MIRT1260718	hsa-miR-711	CLIP-seq
MIRT1260679	hsa-miR-103b	CLIP-seq
MIRT2076704	hsa-miR-1207-3p	CLIP-seq
MIRT1260680	hsa-miR-122	CLIP-seq
MIRT2599992	hsa-miR-2682	CLIP-seq
MIRT1260688	hsa-miR-3138	CLIP-seq
MIRT2599993	hsa-miR-3154	CLIP-seq
MIRT2599994	hsa-miR-34a	CLIP-seq
MIRT2599995	hsa-miR-34c-5p	CLIP-seq
MIRT2303416	hsa-miR-3655	CLIP-seq
MIRT2599996	hsa-miR-371b-3p	CLIP-seq
MIRT2599997	hsa-miR-377	CLIP-seq
MIRT1260689	hsa-miR-3918	CLIP-seq
MIRT2599998	hsa-miR-4436b-3p	CLIP-seq
MIRT2599999	hsa-miR-449a	CLIP-seq
MIRT2600000	hsa-miR-449b	CLIP-seq
MIRT2600001	hsa-miR-449c	CLIP-seq
MIRT2600002	hsa-miR-4514	CLIP-seq
MIRT2600003	hsa-miR-4641	CLIP-seq
MIRT1260701	hsa-miR-4662a-5p	CLIP-seq
MIRT2600004	hsa-miR-4692	CLIP-seq
MIRT1260708	hsa-miR-4800-5p	CLIP-seq
MIRT1260709	hsa-miR-5096	CLIP-seq
MIRT1260718	hsa-miR-711	CLIP-seq

32 Show/Hide all (32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003400	Process	Regulation of COPII vesicle coating	IBA
GO:0003400	Process	Regulation of COPII vesicle coating	IDA	32358066
GO:0003677	Function	DNA binding	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IDA	32358066
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	TAS
GO:0005515	Function	Protein binding	IPI	25202031, 27170179
GO:0005634	Component	Nucleus	IDA	10194769
GO:0005634	Component	Nucleus	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	ISS
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	IBA
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	IDA	23433038
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	IDA	32358066
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	IMP	23433038
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	IMP	25202031
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	ISS
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016192	Process	Vesicle-mediated transport	IEA
GO:0042953	Process	Lipoprotein transport	ISS
GO:0042953	Process	Lipoprotein transport	ISS
GO:0048208	Process	COPII vesicle coating	IMP	23433038
GO:0048208	Process	COPII vesicle coating	TAS
GO:0051020	Function	GTPase binding	IEA
GO:0070971	Component	Endoplasmic reticulum exit site	IDA	25202031, 27170179, 28442536
GO:0090110	Process	COPII-coated vesicle cargo loading	IDA	33186557
GO:0090110	Process	COPII-coated vesicle cargo loading	ISS

MIM	HGNC	e!Ensembl
606395	9356	ENSG00000138073

Q9HCU5

Protein name

Guanine nucleotide-exchange factor SEC12 (Prolactin regulatory element-binding protein)

Protein function

Guanine nucleotide exchange factor (GEF) that regulates the assembly of the coat protein complex II/COPII in endoplasmic reticulum (ER) to Golgi vesicle-mediated transport. Selectively activates SAR1A and SAR1B by promoting the exchange of guano

PDB

5TF2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00400	WD40	144 → 182	WD domain, G-beta repeat	Repeat

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:10920239, ECO:0000269|PubMed:12735795}.

Sequence

MGRRRAPELYRAPFPLYALQVDPSTGLLIAAGGGGAAKTGIKNGVHFLQLELINGRLSAS
LLHSHDTETRATMNLALAGDILAAGQDAHCQLLRFQAHQQQGNKAEKAGSKEQGPRQRKG
AAPAEKKCGAETQHEGLELRVENLQAVQTDFSSDPLQKVVCFNHDNTLLATGGTDGYVRV
WKVPSLEKVLEFKAHEGEIEDLALGPDGKLVTVGRDLKASVWQKDQLVTQLHWQENGPTF
SSTPYRYQACRFGQVPDQPAGLRLFTVQIPHKRLRQPPPCYLTAWDGSNFLPLRTKSCGH
EVVSCLDVSESGTFLGLGTVTGSVAIYIAFSLQCLYYVREAHGIVVTDVAFLPEKGRGPE
LLGSHETALFSVAVDSRCQLHLLPSRRSVPVWLLLLLCVGLIIVTILLLQSAFPGFL

Sequence length

417

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Protein processing in endoplasmic reticulum	COPII-mediated vesicle transport
	XBP1(S) activates chaperone genes
	Cargo concentration in the ER

PREB (prolactin regulatory element binding)

Bookmark This Gene