PPP4R1 (protein phosphatase 4 regulatory subunit 1)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 9989
• Gene name: Protein phosphatase 4 regulatory subunit 1
• Gene symbol: PPP4R1
• Synonyms (NCBI Gene): MEG1, PP4(Rmeg), PP4R1
• Chromosome: 18
• Chromosome location: 18p11.22
• Summary: This gene encodes one of several alternate regulatory subunits of serine/threonine protein phosphatase 4 (PP4). The protein features multiple HEAT repeats. This protein forms a complex with PP4RC. This complex may have a distinct role from other PP4 compl

miRNA Show/Hide all (301)

miRTarBase ID	miRNA	Experiments	Reference
MIRT027240	hsa-miR-101-3p	Sequencing	20371350
MIRT045435	hsa-miR-149-5p	CLASH	23622248
MIRT1258509	hsa-miR-101	CLIP-seq
MIRT1258510	hsa-miR-103a	CLIP-seq
MIRT1258511	hsa-miR-107	CLIP-seq
MIRT1258512	hsa-miR-1184	CLIP-seq
MIRT1258513	hsa-miR-1297	CLIP-seq
MIRT1258514	hsa-miR-144	CLIP-seq
MIRT1258515	hsa-miR-150	CLIP-seq
MIRT1258516	hsa-miR-2053	CLIP-seq
MIRT1258517	hsa-miR-2355-5p	CLIP-seq
MIRT1258518	hsa-miR-26a	CLIP-seq
MIRT1258519	hsa-miR-26b	CLIP-seq
MIRT1258520	hsa-miR-3064-3p	CLIP-seq
MIRT1258521	hsa-miR-3160-3p	CLIP-seq
MIRT1258522	hsa-miR-3185	CLIP-seq
MIRT1258523	hsa-miR-3194-3p	CLIP-seq
MIRT1258524	hsa-miR-323-3p	CLIP-seq
MIRT1258525	hsa-miR-33a	CLIP-seq
MIRT1258526	hsa-miR-33b	CLIP-seq
MIRT1258527	hsa-miR-3529	CLIP-seq
MIRT1258528	hsa-miR-3545-5p	CLIP-seq
MIRT1258529	hsa-miR-3591-3p	CLIP-seq
MIRT1258530	hsa-miR-3611	CLIP-seq
MIRT1258531	hsa-miR-3679-3p	CLIP-seq
MIRT1258532	hsa-miR-374c	CLIP-seq
MIRT1258533	hsa-miR-379	CLIP-seq
MIRT1258534	hsa-miR-4286	CLIP-seq
MIRT1258535	hsa-miR-433	CLIP-seq
MIRT1258536	hsa-miR-4418	CLIP-seq
MIRT1258537	hsa-miR-4445	CLIP-seq
MIRT1258538	hsa-miR-4451	CLIP-seq
MIRT1258539	hsa-miR-4465	CLIP-seq
MIRT1258540	hsa-miR-4501	CLIP-seq
MIRT1258541	hsa-miR-4528	CLIP-seq
MIRT1258542	hsa-miR-4650-3p	CLIP-seq
MIRT1258543	hsa-miR-4709-5p	CLIP-seq
MIRT1258544	hsa-miR-4727-5p	CLIP-seq
MIRT1258545	hsa-miR-4729	CLIP-seq
MIRT1258546	hsa-miR-4768-3p	CLIP-seq
MIRT1258547	hsa-miR-4769-3p	CLIP-seq
MIRT1258548	hsa-miR-509-3-5p	CLIP-seq
MIRT1258549	hsa-miR-509-5p	CLIP-seq
MIRT1258550	hsa-miR-513a-5p	CLIP-seq
MIRT1258551	hsa-miR-548aa	CLIP-seq
MIRT1258552	hsa-miR-548ac	CLIP-seq
MIRT1258553	hsa-miR-548ae	CLIP-seq
MIRT1258554	hsa-miR-548aj	CLIP-seq
MIRT1258555	hsa-miR-548am	CLIP-seq
MIRT1258556	hsa-miR-548d-3p	CLIP-seq
MIRT1258557	hsa-miR-548t	CLIP-seq
MIRT1258558	hsa-miR-548u	CLIP-seq
MIRT1258559	hsa-miR-548x	CLIP-seq
MIRT1258560	hsa-miR-548z	CLIP-seq
MIRT1258561	hsa-miR-570	CLIP-seq
MIRT1258562	hsa-miR-655	CLIP-seq
MIRT1258563	hsa-miR-665	CLIP-seq
MIRT1258564	hsa-miR-188-5p	CLIP-seq
MIRT1258565	hsa-miR-216a	CLIP-seq
MIRT1258566	hsa-miR-3125	CLIP-seq
MIRT1258567	hsa-miR-3192	CLIP-seq
MIRT1258568	hsa-miR-326	CLIP-seq
MIRT1258569	hsa-miR-330-5p	CLIP-seq
MIRT1258570	hsa-miR-3916	CLIP-seq
MIRT1258571	hsa-miR-4279	CLIP-seq
MIRT1258572	hsa-miR-4314	CLIP-seq
MIRT1258573	hsa-miR-4476	CLIP-seq
MIRT1258574	hsa-miR-4646-5p	CLIP-seq
MIRT1258575	hsa-miR-493	CLIP-seq
MIRT1258576	hsa-miR-593	CLIP-seq
MIRT1258509	hsa-miR-101	CLIP-seq
MIRT2076173	hsa-miR-1285	CLIP-seq
MIRT1258514	hsa-miR-144	CLIP-seq
MIRT2076174	hsa-miR-1587	CLIP-seq
MIRT1258564	hsa-miR-188-5p	CLIP-seq
MIRT1258565	hsa-miR-216a	CLIP-seq
MIRT2076175	hsa-miR-23a	CLIP-seq
MIRT2076176	hsa-miR-23b	CLIP-seq
MIRT2076177	hsa-miR-23c	CLIP-seq
MIRT2076178	hsa-miR-3127-3p	CLIP-seq
MIRT2076179	hsa-miR-3155	CLIP-seq
MIRT2076180	hsa-miR-3155b	CLIP-seq
MIRT1258521	hsa-miR-3160-3p	CLIP-seq
MIRT1258522	hsa-miR-3185	CLIP-seq
MIRT2076181	hsa-miR-3187-5p	CLIP-seq
MIRT1258567	hsa-miR-3192	CLIP-seq
MIRT1258568	hsa-miR-326	CLIP-seq
MIRT1258569	hsa-miR-330-5p	CLIP-seq
MIRT2076182	hsa-miR-338-3p	CLIP-seq
MIRT2076183	hsa-miR-346	CLIP-seq
MIRT1258528	hsa-miR-3545-5p	CLIP-seq
MIRT2076184	hsa-miR-3607-3p	CLIP-seq
MIRT1258530	hsa-miR-3611	CLIP-seq
MIRT2076185	hsa-miR-3652	CLIP-seq
MIRT1258531	hsa-miR-3679-3p	CLIP-seq
MIRT2076186	hsa-miR-3686	CLIP-seq
MIRT2076187	hsa-miR-374a	CLIP-seq
MIRT2076188	hsa-miR-374b	CLIP-seq
MIRT2076189	hsa-miR-377	CLIP-seq
MIRT2076190	hsa-miR-378g	CLIP-seq
MIRT2076191	hsa-miR-4297	CLIP-seq
MIRT1258572	hsa-miR-4314	CLIP-seq
MIRT1258535	hsa-miR-433	CLIP-seq
MIRT2076192	hsa-miR-4430	CLIP-seq
MIRT2076193	hsa-miR-4446-3p	CLIP-seq
MIRT2076194	hsa-miR-4486	CLIP-seq
MIRT2076195	hsa-miR-4492	CLIP-seq
MIRT2076196	hsa-miR-4498	CLIP-seq
MIRT1258540	hsa-miR-4501	CLIP-seq
MIRT2076197	hsa-miR-4505	CLIP-seq
MIRT2076198	hsa-miR-4638-3p	CLIP-seq
MIRT1258574	hsa-miR-4646-5p	CLIP-seq
MIRT2076199	hsa-miR-4656	CLIP-seq
MIRT2076200	hsa-miR-4675	CLIP-seq
MIRT2076201	hsa-miR-4720-3p	CLIP-seq
MIRT2076202	hsa-miR-4741	CLIP-seq
MIRT2076203	hsa-miR-4753-3p	CLIP-seq
MIRT2076204	hsa-miR-4778-5p	CLIP-seq
MIRT2076205	hsa-miR-484	CLIP-seq
MIRT1258575	hsa-miR-493	CLIP-seq
MIRT2076206	hsa-miR-500a	CLIP-seq
MIRT2076207	hsa-miR-512-5p	CLIP-seq
MIRT1258550	hsa-miR-513a-5p	CLIP-seq
MIRT2076208	hsa-miR-545	CLIP-seq
MIRT2076209	hsa-miR-548c-3p	CLIP-seq
MIRT1258576	hsa-miR-593	CLIP-seq
MIRT2076210	hsa-miR-612	CLIP-seq
MIRT2076211	hsa-miR-762	CLIP-seq
MIRT2076212	hsa-miR-944	CLIP-seq
MIRT1258509	hsa-miR-101	CLIP-seq
MIRT2302790	hsa-miR-1207-3p	CLIP-seq
MIRT1258514	hsa-miR-144	CLIP-seq
MIRT1258515	hsa-miR-150	CLIP-seq
MIRT2076174	hsa-miR-1587	CLIP-seq
MIRT1258522	hsa-miR-3185	CLIP-seq
MIRT1258525	hsa-miR-33a	CLIP-seq
MIRT1258526	hsa-miR-33b	CLIP-seq
MIRT1258527	hsa-miR-3529	CLIP-seq
MIRT1258528	hsa-miR-3545-5p	CLIP-seq
MIRT1258530	hsa-miR-3611	CLIP-seq
MIRT2076185	hsa-miR-3652	CLIP-seq
MIRT2076189	hsa-miR-377	CLIP-seq
MIRT2076190	hsa-miR-378g	CLIP-seq
MIRT1258533	hsa-miR-379	CLIP-seq
MIRT2076192	hsa-miR-4430	CLIP-seq
MIRT2076193	hsa-miR-4446-3p	CLIP-seq
MIRT1258538	hsa-miR-4451	CLIP-seq
MIRT2076195	hsa-miR-4492	CLIP-seq
MIRT2076196	hsa-miR-4498	CLIP-seq
MIRT1258540	hsa-miR-4501	CLIP-seq
MIRT2076197	hsa-miR-4505	CLIP-seq
MIRT2302791	hsa-miR-4520a-3p	CLIP-seq
MIRT2076198	hsa-miR-4638-3p	CLIP-seq
MIRT1258542	hsa-miR-4650-3p	CLIP-seq
MIRT2076199	hsa-miR-4656	CLIP-seq
MIRT2076200	hsa-miR-4675	CLIP-seq
MIRT2302792	hsa-miR-4701-5p	CLIP-seq
MIRT2302793	hsa-miR-4719	CLIP-seq
MIRT1258545	hsa-miR-4729	CLIP-seq
MIRT2076202	hsa-miR-4741	CLIP-seq
MIRT1258550	hsa-miR-513a-5p	CLIP-seq
MIRT2302794	hsa-miR-552	CLIP-seq
MIRT2302795	hsa-miR-588	CLIP-seq
MIRT2076211	hsa-miR-762	CLIP-seq
MIRT2076190	hsa-miR-378g	CLIP-seq
MIRT1258521	hsa-miR-3160-3p	CLIP-seq
MIRT1258522	hsa-miR-3185	CLIP-seq
MIRT1258535	hsa-miR-433	CLIP-seq
MIRT1258552	hsa-miR-548ac	CLIP-seq
MIRT1258553	hsa-miR-548ae	CLIP-seq
MIRT1258554	hsa-miR-548aj	CLIP-seq
MIRT1258555	hsa-miR-548am	CLIP-seq
MIRT1258556	hsa-miR-548d-3p	CLIP-seq
MIRT1258559	hsa-miR-548x	CLIP-seq
MIRT1258560	hsa-miR-548z	CLIP-seq
MIRT1258510	hsa-miR-103a	CLIP-seq
MIRT1258511	hsa-miR-107	CLIP-seq
MIRT1258512	hsa-miR-1184	CLIP-seq
MIRT2302790	hsa-miR-1207-3p	CLIP-seq
MIRT2599458	hsa-miR-1253	CLIP-seq
MIRT2599459	hsa-miR-1343	CLIP-seq
MIRT1258515	hsa-miR-150	CLIP-seq
MIRT2076174	hsa-miR-1587	CLIP-seq
MIRT2599460	hsa-miR-185	CLIP-seq
MIRT2599461	hsa-miR-224	CLIP-seq
MIRT1258520	hsa-miR-3064-3p	CLIP-seq
MIRT2599462	hsa-miR-3120-3p	CLIP-seq
MIRT2599463	hsa-miR-3177-5p	CLIP-seq
MIRT1258567	hsa-miR-3192	CLIP-seq
MIRT1258528	hsa-miR-3545-5p	CLIP-seq
MIRT2076184	hsa-miR-3607-3p	CLIP-seq
MIRT2076185	hsa-miR-3652	CLIP-seq
MIRT2599464	hsa-miR-3667-3p	CLIP-seq
MIRT2076186	hsa-miR-3686	CLIP-seq
MIRT2076189	hsa-miR-377	CLIP-seq
MIRT2076190	hsa-miR-378g	CLIP-seq
MIRT2599465	hsa-miR-3942-5p	CLIP-seq
MIRT2599466	hsa-miR-4266	CLIP-seq
MIRT2599467	hsa-miR-4306	CLIP-seq
MIRT1258536	hsa-miR-4418	CLIP-seq
MIRT2076192	hsa-miR-4430	CLIP-seq
MIRT2076193	hsa-miR-4446-3p	CLIP-seq
MIRT2076195	hsa-miR-4492	CLIP-seq
MIRT2599468	hsa-miR-4495	CLIP-seq
MIRT2076196	hsa-miR-4498	CLIP-seq
MIRT2076197	hsa-miR-4505	CLIP-seq
MIRT2302791	hsa-miR-4520a-3p	CLIP-seq
MIRT2076198	hsa-miR-4638-3p	CLIP-seq
MIRT2599469	hsa-miR-4642	CLIP-seq
MIRT2599470	hsa-miR-4644	CLIP-seq
MIRT2076199	hsa-miR-4656	CLIP-seq
MIRT2599471	hsa-miR-4667-3p	CLIP-seq
MIRT2076200	hsa-miR-4675	CLIP-seq
MIRT2302792	hsa-miR-4701-5p	CLIP-seq
MIRT2599472	hsa-miR-4703-5p	CLIP-seq
MIRT1258543	hsa-miR-4709-5p	CLIP-seq
MIRT2599473	hsa-miR-4711-5p	CLIP-seq
MIRT2076201	hsa-miR-4720-3p	CLIP-seq
MIRT2599474	hsa-miR-4728-3p	CLIP-seq
MIRT2076202	hsa-miR-4741	CLIP-seq
MIRT2076204	hsa-miR-4778-5p	CLIP-seq
MIRT1258548	hsa-miR-509-3-5p	CLIP-seq
MIRT1258549	hsa-miR-509-5p	CLIP-seq
MIRT2076207	hsa-miR-512-5p	CLIP-seq
MIRT1258550	hsa-miR-513a-5p	CLIP-seq
MIRT2076208	hsa-miR-545	CLIP-seq
MIRT1258552	hsa-miR-548ac	CLIP-seq
MIRT1258553	hsa-miR-548ae	CLIP-seq
MIRT1258554	hsa-miR-548aj	CLIP-seq
MIRT1258555	hsa-miR-548am	CLIP-seq
MIRT1258556	hsa-miR-548d-3p	CLIP-seq
MIRT1258558	hsa-miR-548u	CLIP-seq
MIRT1258559	hsa-miR-548x	CLIP-seq
MIRT1258560	hsa-miR-548z	CLIP-seq
MIRT2599475	hsa-miR-581	CLIP-seq
MIRT2302795	hsa-miR-588	CLIP-seq
MIRT2599476	hsa-miR-651	CLIP-seq
MIRT2076211	hsa-miR-762	CLIP-seq
MIRT1258509	hsa-miR-101	CLIP-seq
MIRT1258510	hsa-miR-103a	CLIP-seq
MIRT1258511	hsa-miR-107	CLIP-seq
MIRT1258512	hsa-miR-1184	CLIP-seq
MIRT2302790	hsa-miR-1207-3p	CLIP-seq
MIRT2599459	hsa-miR-1343	CLIP-seq
MIRT1258514	hsa-miR-144	CLIP-seq
MIRT1258515	hsa-miR-150	CLIP-seq
MIRT2076174	hsa-miR-1587	CLIP-seq
MIRT2599461	hsa-miR-224	CLIP-seq
MIRT1258520	hsa-miR-3064-3p	CLIP-seq
MIRT2599462	hsa-miR-3120-3p	CLIP-seq
MIRT2599463	hsa-miR-3177-5p	CLIP-seq
MIRT1258567	hsa-miR-3192	CLIP-seq
MIRT1258528	hsa-miR-3545-5p	CLIP-seq
MIRT2076184	hsa-miR-3607-3p	CLIP-seq
MIRT2076185	hsa-miR-3652	CLIP-seq
MIRT2599464	hsa-miR-3667-3p	CLIP-seq
MIRT2076186	hsa-miR-3686	CLIP-seq
MIRT2076189	hsa-miR-377	CLIP-seq
MIRT2076190	hsa-miR-378g	CLIP-seq
MIRT2599465	hsa-miR-3942-5p	CLIP-seq
MIRT2599466	hsa-miR-4266	CLIP-seq
MIRT1258536	hsa-miR-4418	CLIP-seq
MIRT2076192	hsa-miR-4430	CLIP-seq
MIRT2076193	hsa-miR-4446-3p	CLIP-seq
MIRT2076195	hsa-miR-4492	CLIP-seq
MIRT2599468	hsa-miR-4495	CLIP-seq
MIRT2076196	hsa-miR-4498	CLIP-seq
MIRT2076197	hsa-miR-4505	CLIP-seq
MIRT2302791	hsa-miR-4520a-3p	CLIP-seq
MIRT2076198	hsa-miR-4638-3p	CLIP-seq
MIRT2599469	hsa-miR-4642	CLIP-seq
MIRT2076199	hsa-miR-4656	CLIP-seq
MIRT2599471	hsa-miR-4667-3p	CLIP-seq
MIRT2076200	hsa-miR-4675	CLIP-seq
MIRT2302792	hsa-miR-4701-5p	CLIP-seq
MIRT2599472	hsa-miR-4703-5p	CLIP-seq
MIRT1258543	hsa-miR-4709-5p	CLIP-seq
MIRT2599473	hsa-miR-4711-5p	CLIP-seq
MIRT2076201	hsa-miR-4720-3p	CLIP-seq
MIRT2599474	hsa-miR-4728-3p	CLIP-seq
MIRT2076202	hsa-miR-4741	CLIP-seq
MIRT2076204	hsa-miR-4778-5p	CLIP-seq
MIRT2688488	hsa-miR-507	CLIP-seq
MIRT1258548	hsa-miR-509-3-5p	CLIP-seq
MIRT1258549	hsa-miR-509-5p	CLIP-seq
MIRT2076207	hsa-miR-512-5p	CLIP-seq
MIRT1258550	hsa-miR-513a-5p	CLIP-seq
MIRT2076208	hsa-miR-545	CLIP-seq
MIRT1258552	hsa-miR-548ac	CLIP-seq
MIRT1258553	hsa-miR-548ae	CLIP-seq
MIRT1258554	hsa-miR-548aj	CLIP-seq
MIRT1258555	hsa-miR-548am	CLIP-seq
MIRT1258556	hsa-miR-548d-3p	CLIP-seq
MIRT1258558	hsa-miR-548u	CLIP-seq
MIRT1258559	hsa-miR-548x	CLIP-seq
MIRT1258560	hsa-miR-548z	CLIP-seq
MIRT2688489	hsa-miR-557	CLIP-seq
MIRT2599475	hsa-miR-581	CLIP-seq
MIRT2302795	hsa-miR-588	CLIP-seq
MIRT2599476	hsa-miR-651	CLIP-seq
MIRT2076211	hsa-miR-762	CLIP-seq

Gene ontology (GO) Show/Hide all (8)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004721	Function	Phosphoprotein phosphatase activity	ISS
GO:0005515	Function	Protein binding	IPI	16085932, 18614045, 18715871, 26496610, 27880917, 33961781
GO:0005737	Component	Cytoplasm	IBA
GO:0006468	Process	Protein phosphorylation	ISS
GO:0007165	Process	Signal transduction	NAS	10026142
GO:0019888	Function	Protein phosphatase regulator activity	IBA
GO:0019888	Function	Protein phosphatase regulator activity	NAS	10026142
GO:0030289	Component	Protein phosphatase 4 complex	ISS

Other IDs

• MIM: 604908
• HGNC: 9320
• e!Ensembl: ENSG00000154845

Protein

• UniProt ID: Q8TF05
• Protein name: Serine/threonine-protein phosphatase 4 regulatory subunit 1
• Protein function: Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. Plays a role in the inhib
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02985	HEAT	213 → 244	HEAT repeat	Repeat
  PF02985	HEAT	253 → 280	HEAT repeat	Repeat
  PF15017	WRNPLPNID	451 → 520	Putative WW-binding domain and destruction box	Disordered

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed with high expression in cultured mesangial cells. Isoform 1 and isoform 2 are expressed in renal tissues. {ECO:0000269|PubMed:11729228}.
• Sequence:

  MADLSLLQEDLQEDADGFGVDDYSSESDVIIIPSALDFVSQDEMLTPLGRLDKYAASENI
  FNRQMVARSLLDTLREVCDDERDCIAVLERISRLADDSEPTVRAELMEQVPHIALFCQEN
  RPSIPYAFSKFLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERFDVETKVCPVLIEL
  TAPDSNDDVKTEAVAIMCKMAPMVGKDITERLILPRFCEMCCDCRMFHVRKVCAANFGDI
  CSVVGQQATEEMLLPRFFQLCSDNVWGVRKACAECFMAVSCATCQEIRRTKLSALFINLI
  SDPSRWVRQAAFQSLGPFISTFANPSSSGQYFKEESKSSEEMSVENKNRTRDQEAPEDVQ
  VRPEDTPSDLSVSNSSVILENTMEDHAAEASGKPLGEISVPLDSSLLCTLSSESHQEAAS
  NENDKKPGNYKSMLRPEVGTTSQDSALLDQELYNSFHFWRTPLPEIDLDIELEQNSGGKP
  SPEGPEEESEGPVPSSPNITMATRKELEEMIENLEPHIDDPDVKAQVEVLSAALRASSLD
  AHEETISIEKRSDLQDELDINELPNCKINQEDSVPLISDAVENMDSTLHYIHSDSDLSNN
  SSFSPDEERRTKVQDVVPQALLDQYLSMTDPSRAQTVDTEIAKHCAYSLPGVALTLGRQN
  WHCLRETYETLASDMQWKVRRTLAFSIHELAVILGDQLTAADLVPIFNGFLKDLDEVRIG
  VLKHLHDFLKLLHIDKRREYLYQLQEFLVTDNSRNWRFRAELAEQLILLLELYSPRDVYD
  YLRPIALNLCADKVSSVRWISYKLVSEMVKKLHAATPPTFGVDLINELVENFGRCPKWSG
  RQAFVFVCQTVIEDDCLPMDQFAVHLMPHLLTLANDRVPNVRVLLAKTLRQTLLEKDYFL
  ASASCHQEAVEQTIMALQMDRDSDVKYFASIHPASTKISEDAMSTASSTY

• Sequence length: 950

Related Genes

No strongly related genes found yet for PPP4R1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to PPP4R1.