Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	5531
Gene name	Protein phosphatase 4 catalytic subunit
Gene symbol	PPP4C
Synonyms (NCBI Gene)	PP-XPP4PP4CPPH3PPP4PPX
Chromosome	16
Chromosome location	16p11.2

88 Show/Hide all (88)

miRTarBase ID	miRNA	Experiments	Reference
MIRT027866	hsa-miR-98-5p	Microarray	19088304
MIRT049792	hsa-miR-92a-3p	CLASH	23622248
MIRT045687	hsa-miR-149-5p	CLASH	23622248
MIRT044391	hsa-miR-320a	CLASH	23622248
MIRT044311	hsa-miR-106b-5p	CLASH	23622248
MIRT039997	hsa-miR-615-3p	CLASH	23622248
MIRT036330	hsa-miR-1229-3p	CLASH	23622248
MIRT1258492	hsa-miR-1297	CLIP-seq
MIRT1258493	hsa-miR-185	CLIP-seq
MIRT1258494	hsa-miR-26a	CLIP-seq
MIRT1258495	hsa-miR-26b	CLIP-seq
MIRT1258496	hsa-miR-3150a-3p	CLIP-seq
MIRT1258497	hsa-miR-3175	CLIP-seq
MIRT1258498	hsa-miR-3925-3p	CLIP-seq
MIRT1258499	hsa-miR-3928	CLIP-seq
MIRT1258500	hsa-miR-4306	CLIP-seq
MIRT1258501	hsa-miR-4465	CLIP-seq
MIRT1258502	hsa-miR-4633-3p	CLIP-seq
MIRT1258503	hsa-miR-4644	CLIP-seq
MIRT1258504	hsa-miR-4802-3p	CLIP-seq
MIRT1258505	hsa-miR-491-5p	CLIP-seq
MIRT1258506	hsa-miR-765	CLIP-seq
MIRT1258507	hsa-miR-766	CLIP-seq
MIRT1258508	hsa-miR-939	CLIP-seq
MIRT2076156	hsa-miR-1275	CLIP-seq
MIRT2076157	hsa-miR-3620	CLIP-seq
MIRT2076158	hsa-miR-3919	CLIP-seq
MIRT1258498	hsa-miR-3925-3p	CLIP-seq
MIRT2076159	hsa-miR-3943	CLIP-seq
MIRT2076160	hsa-miR-4436a	CLIP-seq
MIRT2076161	hsa-miR-4525	CLIP-seq
MIRT2076162	hsa-miR-4645-5p	CLIP-seq
MIRT2076163	hsa-miR-4650-5p	CLIP-seq
MIRT2076164	hsa-miR-4665-5p	CLIP-seq
MIRT2076165	hsa-miR-4673	CLIP-seq
MIRT2076166	hsa-miR-4723-5p	CLIP-seq
MIRT2076167	hsa-miR-4757-5p	CLIP-seq
MIRT2076168	hsa-miR-520a-5p	CLIP-seq
MIRT2076169	hsa-miR-525-5p	CLIP-seq
MIRT2076170	hsa-miR-625	CLIP-seq
MIRT2076171	hsa-miR-635	CLIP-seq
MIRT1258507	hsa-miR-766	CLIP-seq
MIRT2076172	hsa-miR-922	CLIP-seq
MIRT2076156	hsa-miR-1275	CLIP-seq
MIRT2302774	hsa-miR-128	CLIP-seq
MIRT1258492	hsa-miR-1297	CLIP-seq
MIRT1258493	hsa-miR-185	CLIP-seq
MIRT1258494	hsa-miR-26a	CLIP-seq
MIRT1258495	hsa-miR-26b	CLIP-seq
MIRT2302775	hsa-miR-27a	CLIP-seq
MIRT2302776	hsa-miR-27b	CLIP-seq
MIRT2302777	hsa-miR-296-3p	CLIP-seq
MIRT1258496	hsa-miR-3150a-3p	CLIP-seq
MIRT2302778	hsa-miR-3154	CLIP-seq
MIRT1258497	hsa-miR-3175	CLIP-seq
MIRT2302779	hsa-miR-3915	CLIP-seq
MIRT1258499	hsa-miR-3928	CLIP-seq
MIRT2076159	hsa-miR-3943	CLIP-seq
MIRT1258500	hsa-miR-4306	CLIP-seq
MIRT2302780	hsa-miR-4426	CLIP-seq
MIRT2076160	hsa-miR-4436a	CLIP-seq
MIRT2302781	hsa-miR-4443	CLIP-seq
MIRT1258501	hsa-miR-4465	CLIP-seq
MIRT2302782	hsa-miR-4466	CLIP-seq
MIRT2076161	hsa-miR-4525	CLIP-seq
MIRT2302783	hsa-miR-4640-5p	CLIP-seq
MIRT1258503	hsa-miR-4644	CLIP-seq
MIRT2302784	hsa-miR-4647	CLIP-seq
MIRT2302785	hsa-miR-4649-3p	CLIP-seq
MIRT2302786	hsa-miR-4662b	CLIP-seq
MIRT2076164	hsa-miR-4665-5p	CLIP-seq
MIRT2076166	hsa-miR-4723-5p	CLIP-seq
MIRT2302787	hsa-miR-4726-5p	CLIP-seq
MIRT2302788	hsa-miR-4737	CLIP-seq
MIRT1258504	hsa-miR-4802-3p	CLIP-seq
MIRT1258505	hsa-miR-491-5p	CLIP-seq
MIRT2076170	hsa-miR-625	CLIP-seq
MIRT2302789	hsa-miR-675	CLIP-seq
MIRT1258506	hsa-miR-765	CLIP-seq
MIRT2076172	hsa-miR-922	CLIP-seq
MIRT1258508	hsa-miR-939	CLIP-seq
MIRT2076156	hsa-miR-1275	CLIP-seq
MIRT2076160	hsa-miR-4436a	CLIP-seq
MIRT2076161	hsa-miR-4525	CLIP-seq
MIRT2076164	hsa-miR-4665-5p	CLIP-seq
MIRT2076166	hsa-miR-4723-5p	CLIP-seq
MIRT2076170	hsa-miR-625	CLIP-seq
MIRT2076172	hsa-miR-922	CLIP-seq

24 Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000724	Process	Double-strand break repair via homologous recombination	IBA
GO:0000785	Component	Chromatin	IDA	18614045
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004722	Function	Protein serine/threonine phosphatase activity	IBA
GO:0004722	Function	Protein serine/threonine phosphatase activity	IDA	18715871, 20154705
GO:0004722	Function	Protein serine/threonine phosphatase activity	IEA
GO:0004722	Function	Protein serine/threonine phosphatase activity	NAS	9837938
GO:0005515	Function	Protein binding	IPI	9647778, 10026142, 15805470, 16085932, 16769727, 17384681, 18614045, 18715871, 19156129, 26496610, 27880917, 28330616, 28514442, 32296183, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IDA
GO:0010569	Process	Regulation of double-strand break repair via homologous recombination	IMP	20154705
GO:0016787	Function	Hydrolase activity	IEA
GO:0030289	Component	Protein phosphatase 4 complex	IEA
GO:0030289	Component	Protein phosphatase 4 complex	IPI	18614045
GO:0046872	Function	Metal ion binding	IEA
GO:2000779	Process	Regulation of double-strand break repair	IMP	18614045

MIM	HGNC	e!Ensembl
602035	9319	ENSG00000149923

P60510

Protein name

Serine/threonine-protein phosphatase 4 catalytic subunit (PP4C) (Pp4) (EC 3.1.3.16) (Protein phosphatase X) (PP-X)

Protein function

Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00149	Metallophos	47 → 242	Calcineurin-like phosphoesterase	Domain

Sequence

MAEISDLDRQIEQLRRCELIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFY
DLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQI
TQVYGFYDECLRKYGSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTI
DRKQEVPHDGPMCDLLWSDPEDTTGWGVSPRGAGYLFGSDVVAQFNAANDIDMICRAHQL
VMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFEAAPQETRGIPSKK
PVADYFL

Sequence length

307

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Glucagon signaling pathway	Processing of DNA double-strand break ends

Related Genes Genes most often co-reported with PPP4C across shared curated disease and pathway associations. 0 Download as csv Download as pdf
No strongly related genes found yet for PPP4C.

Diseases Linked via Similar Genes Diseases curated for genes most similar to PPP4C (see Related Genes above), that are NOT already directly curated for PPP4C itself -- a lead worth checking, not a confirmed association. 0 Download as csv Download as pdf
No additional diseases found yet through genes similar to PPP4C.

PPP4C (protein phosphatase 4 catalytic subunit)

Bookmark This Gene