PPP1R8 (protein phosphatase 1 regulatory subunit 8)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 5511
• Gene name: Protein phosphatase 1 regulatory subunit 8
• Gene symbol: PPP1R8
• Synonyms (NCBI Gene): ARD-1, ARD1, NIPP-1, NIPP1, PRO2047
• Chromosome: 1
• Chromosome location: 1p35.3
• Summary: This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform

miRNA Show/Hide all (249)

miRTarBase ID	miRNA	Experiments	Reference
MIRT037974	hsa-miR-505-5p	CLASH	23622248
MIRT037764	hsa-miR-874-3p	CLASH	23622248
MIRT714379	hsa-miR-1283	HITS-CLIP	19536157
MIRT714378	hsa-miR-3653-3p	HITS-CLIP	19536157
MIRT714377	hsa-miR-4684-5p	HITS-CLIP	19536157
MIRT714376	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT714375	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT714374	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT714379	hsa-miR-1283	HITS-CLIP	19536157
MIRT714378	hsa-miR-3653-3p	HITS-CLIP	19536157
MIRT714377	hsa-miR-4684-5p	HITS-CLIP	19536157
MIRT714376	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT714375	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT714374	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT1256984	hsa-miR-205	CLIP-seq
MIRT1256985	hsa-miR-27a	CLIP-seq
MIRT1256986	hsa-miR-27b	CLIP-seq
MIRT1256987	hsa-miR-3121-5p	CLIP-seq
MIRT1256988	hsa-miR-3130-3p	CLIP-seq
MIRT1256989	hsa-miR-362-5p	CLIP-seq
MIRT1256990	hsa-miR-4297	CLIP-seq
MIRT1256991	hsa-miR-500b	CLIP-seq
MIRT1256992	hsa-miR-501-5p	CLIP-seq
MIRT1256993	hsa-miR-513a-5p	CLIP-seq
MIRT1256994	hsa-miR-548a-3p	CLIP-seq
MIRT1256995	hsa-miR-548e	CLIP-seq
MIRT1256996	hsa-miR-548f	CLIP-seq
MIRT1256997	hsa-miR-570	CLIP-seq
MIRT1256998	hsa-miR-596	CLIP-seq
MIRT1256999	hsa-miR-139-5p	CLIP-seq
MIRT1257000	hsa-miR-2861	CLIP-seq
MIRT1257001	hsa-miR-3150a-5p	CLIP-seq
MIRT1257002	hsa-miR-3150b-5p	CLIP-seq
MIRT1257003	hsa-miR-3616-3p	CLIP-seq
MIRT1257004	hsa-miR-4272	CLIP-seq
MIRT1257005	hsa-miR-4320	CLIP-seq
MIRT1257006	hsa-miR-4512	CLIP-seq
MIRT1257007	hsa-miR-4714-3p	CLIP-seq
MIRT1257008	hsa-miR-4721	CLIP-seq
MIRT1257009	hsa-miR-4782-5p	CLIP-seq
MIRT1257010	hsa-miR-544b	CLIP-seq
MIRT1257011	hsa-miR-661	CLIP-seq
MIRT1552538	hsa-miR-4643	CLIP-seq
MIRT2075689	hsa-miR-1245b-3p	CLIP-seq
MIRT2075690	hsa-miR-1252	CLIP-seq
MIRT2075691	hsa-miR-3978	CLIP-seq
MIRT2075692	hsa-miR-4307	CLIP-seq
MIRT1552538	hsa-miR-4643	CLIP-seq
MIRT2075693	hsa-miR-4704-3p	CLIP-seq
MIRT2075694	hsa-miR-548m	CLIP-seq
MIRT2075695	hsa-miR-561	CLIP-seq
MIRT2302290	hsa-miR-214	CLIP-seq
MIRT2302291	hsa-miR-3619-5p	CLIP-seq
MIRT2302292	hsa-miR-3685	CLIP-seq
MIRT2302293	hsa-miR-384	CLIP-seq
MIRT2302294	hsa-miR-4291	CLIP-seq
MIRT2302295	hsa-miR-4459	CLIP-seq
MIRT2302296	hsa-miR-4722-5p	CLIP-seq
MIRT2302297	hsa-miR-761	CLIP-seq
MIRT2302298	hsa-miR-922	CLIP-seq
MIRT2598980	hsa-let-7a	CLIP-seq
MIRT2598981	hsa-let-7b	CLIP-seq
MIRT2598982	hsa-let-7c	CLIP-seq
MIRT2598983	hsa-let-7d	CLIP-seq
MIRT2598984	hsa-let-7e	CLIP-seq
MIRT2598985	hsa-let-7f	CLIP-seq
MIRT2598986	hsa-let-7g	CLIP-seq
MIRT2598987	hsa-let-7i	CLIP-seq
MIRT2598988	hsa-miR-1237	CLIP-seq
MIRT2598989	hsa-miR-1248	CLIP-seq
MIRT2598990	hsa-miR-1276	CLIP-seq
MIRT2598991	hsa-miR-1303	CLIP-seq
MIRT2598992	hsa-miR-134	CLIP-seq
MIRT1256999	hsa-miR-139-5p	CLIP-seq
MIRT2598993	hsa-miR-183	CLIP-seq
MIRT2598994	hsa-miR-190	CLIP-seq
MIRT2598995	hsa-miR-190b	CLIP-seq
MIRT2598996	hsa-miR-196a	CLIP-seq
MIRT2598997	hsa-miR-196b	CLIP-seq
MIRT1256984	hsa-miR-205	CLIP-seq
MIRT1257000	hsa-miR-2861	CLIP-seq
MIRT2598998	hsa-miR-298	CLIP-seq
MIRT2598999	hsa-miR-3118	CLIP-seq
MIRT1256987	hsa-miR-3121-5p	CLIP-seq
MIRT2599000	hsa-miR-3135	CLIP-seq
MIRT1257001	hsa-miR-3150a-5p	CLIP-seq
MIRT1257002	hsa-miR-3150b-5p	CLIP-seq
MIRT2599001	hsa-miR-3158-5p	CLIP-seq
MIRT2599002	hsa-miR-3164	CLIP-seq
MIRT2599003	hsa-miR-3173-3p	CLIP-seq
MIRT2599004	hsa-miR-3190	CLIP-seq
MIRT2599005	hsa-miR-3201	CLIP-seq
MIRT2599006	hsa-miR-3202	CLIP-seq
MIRT2599007	hsa-miR-3606	CLIP-seq
MIRT2599008	hsa-miR-3614-3p	CLIP-seq
MIRT1257003	hsa-miR-3616-3p	CLIP-seq
MIRT1256989	hsa-miR-362-5p	CLIP-seq
MIRT2599009	hsa-miR-365	CLIP-seq
MIRT2599010	hsa-miR-3662	CLIP-seq
MIRT2599011	hsa-miR-3681	CLIP-seq
MIRT2599012	hsa-miR-3682-5p	CLIP-seq
MIRT2599013	hsa-miR-369-3p	CLIP-seq
MIRT2599014	hsa-miR-374c	CLIP-seq
MIRT2599015	hsa-miR-378	CLIP-seq
MIRT2599016	hsa-miR-378b	CLIP-seq
MIRT2599017	hsa-miR-378c	CLIP-seq
MIRT2599018	hsa-miR-378d	CLIP-seq
MIRT2599019	hsa-miR-378e	CLIP-seq
MIRT2599020	hsa-miR-378f	CLIP-seq
MIRT2599021	hsa-miR-378h	CLIP-seq
MIRT2599022	hsa-miR-378i	CLIP-seq
MIRT2599023	hsa-miR-3913-3p	CLIP-seq
MIRT2599024	hsa-miR-422a	CLIP-seq
MIRT2599025	hsa-miR-4261	CLIP-seq
MIRT2599026	hsa-miR-4263	CLIP-seq
MIRT1257004	hsa-miR-4272	CLIP-seq
MIRT1256990	hsa-miR-4297	CLIP-seq
MIRT1257005	hsa-miR-4320	CLIP-seq
MIRT2599027	hsa-miR-4418	CLIP-seq
MIRT2599028	hsa-miR-4436b-3p	CLIP-seq
MIRT2599029	hsa-miR-4452	CLIP-seq
MIRT2599030	hsa-miR-4458	CLIP-seq
MIRT2599031	hsa-miR-4493	CLIP-seq
MIRT2599032	hsa-miR-4496	CLIP-seq
MIRT2599033	hsa-miR-4500	CLIP-seq
MIRT2599034	hsa-miR-4501	CLIP-seq
MIRT1257006	hsa-miR-4512	CLIP-seq
MIRT2599035	hsa-miR-4533	CLIP-seq
MIRT2599036	hsa-miR-4638-3p	CLIP-seq
MIRT2599037	hsa-miR-4685-5p	CLIP-seq
MIRT1257007	hsa-miR-4714-3p	CLIP-seq
MIRT1257008	hsa-miR-4721	CLIP-seq
MIRT2599038	hsa-miR-4762-5p	CLIP-seq
MIRT2599039	hsa-miR-4775	CLIP-seq
MIRT1257009	hsa-miR-4782-5p	CLIP-seq
MIRT2599040	hsa-miR-4791	CLIP-seq
MIRT2599041	hsa-miR-4796-3p	CLIP-seq
MIRT2599042	hsa-miR-4804-3p	CLIP-seq
MIRT2599043	hsa-miR-489	CLIP-seq
MIRT2599044	hsa-miR-494	CLIP-seq
MIRT1256991	hsa-miR-500b	CLIP-seq
MIRT1256992	hsa-miR-501-5p	CLIP-seq
MIRT2599045	hsa-miR-509-3-5p	CLIP-seq
MIRT2599046	hsa-miR-509-5p	CLIP-seq
MIRT2599047	hsa-miR-532-5p	CLIP-seq
MIRT1257010	hsa-miR-544b	CLIP-seq
MIRT1256994	hsa-miR-548a-3p	CLIP-seq
MIRT2599048	hsa-miR-548a-5p	CLIP-seq
MIRT2599049	hsa-miR-548ab	CLIP-seq
MIRT2599050	hsa-miR-548ak	CLIP-seq
MIRT2599051	hsa-miR-548b-5p	CLIP-seq
MIRT2599052	hsa-miR-548c-3p	CLIP-seq
MIRT2599053	hsa-miR-548c-5p	CLIP-seq
MIRT2599054	hsa-miR-548d-5p	CLIP-seq
MIRT1256995	hsa-miR-548e	CLIP-seq
MIRT1256996	hsa-miR-548f	CLIP-seq
MIRT2599055	hsa-miR-548h	CLIP-seq
MIRT2599056	hsa-miR-548i	CLIP-seq
MIRT2599057	hsa-miR-548j	CLIP-seq
MIRT2599058	hsa-miR-548n	CLIP-seq
MIRT2599059	hsa-miR-548t	CLIP-seq
MIRT2599060	hsa-miR-548w	CLIP-seq
MIRT2599061	hsa-miR-548y	CLIP-seq
MIRT2599062	hsa-miR-559	CLIP-seq
MIRT1256997	hsa-miR-570	CLIP-seq
MIRT2599063	hsa-miR-582-3p	CLIP-seq
MIRT2599064	hsa-miR-655	CLIP-seq
MIRT1257011	hsa-miR-661	CLIP-seq
MIRT2599065	hsa-miR-711	CLIP-seq
MIRT2599066	hsa-miR-760	CLIP-seq
MIRT2599067	hsa-miR-890	CLIP-seq
MIRT2599068	hsa-miR-935	CLIP-seq
MIRT2599069	hsa-miR-941	CLIP-seq
MIRT2599070	hsa-miR-98	CLIP-seq
MIRT2598980	hsa-let-7a	CLIP-seq
MIRT2598981	hsa-let-7b	CLIP-seq
MIRT2598982	hsa-let-7c	CLIP-seq
MIRT2598983	hsa-let-7d	CLIP-seq
MIRT2598984	hsa-let-7e	CLIP-seq
MIRT2598985	hsa-let-7f	CLIP-seq
MIRT2598986	hsa-let-7g	CLIP-seq
MIRT2598987	hsa-let-7i	CLIP-seq
MIRT2598988	hsa-miR-1237	CLIP-seq
MIRT2598989	hsa-miR-1248	CLIP-seq
MIRT2598990	hsa-miR-1276	CLIP-seq
MIRT2598991	hsa-miR-1303	CLIP-seq
MIRT2598992	hsa-miR-134	CLIP-seq
MIRT1256999	hsa-miR-139-5p	CLIP-seq
MIRT2598993	hsa-miR-183	CLIP-seq
MIRT2598994	hsa-miR-190	CLIP-seq
MIRT2598995	hsa-miR-190b	CLIP-seq
MIRT2598996	hsa-miR-196a	CLIP-seq
MIRT2598997	hsa-miR-196b	CLIP-seq
MIRT1257000	hsa-miR-2861	CLIP-seq
MIRT2598998	hsa-miR-298	CLIP-seq
MIRT2598999	hsa-miR-3118	CLIP-seq
MIRT1256987	hsa-miR-3121-5p	CLIP-seq
MIRT2599000	hsa-miR-3135	CLIP-seq
MIRT1257001	hsa-miR-3150a-5p	CLIP-seq
MIRT1257002	hsa-miR-3150b-5p	CLIP-seq
MIRT2599001	hsa-miR-3158-5p	CLIP-seq
MIRT2599002	hsa-miR-3164	CLIP-seq
MIRT2599003	hsa-miR-3173-3p	CLIP-seq
MIRT2599004	hsa-miR-3190	CLIP-seq
MIRT2599005	hsa-miR-3201	CLIP-seq
MIRT2599006	hsa-miR-3202	CLIP-seq
MIRT2599008	hsa-miR-3614-3p	CLIP-seq
MIRT1257003	hsa-miR-3616-3p	CLIP-seq
MIRT1256989	hsa-miR-362-5p	CLIP-seq
MIRT2599010	hsa-miR-3662	CLIP-seq
MIRT2599011	hsa-miR-3681	CLIP-seq
MIRT2599012	hsa-miR-3682-5p	CLIP-seq
MIRT2599023	hsa-miR-3913-3p	CLIP-seq
MIRT2599025	hsa-miR-4261	CLIP-seq
MIRT2599026	hsa-miR-4263	CLIP-seq
MIRT1257004	hsa-miR-4272	CLIP-seq
MIRT1257005	hsa-miR-4320	CLIP-seq
MIRT2599027	hsa-miR-4418	CLIP-seq
MIRT2599029	hsa-miR-4452	CLIP-seq
MIRT2599030	hsa-miR-4458	CLIP-seq
MIRT2599031	hsa-miR-4493	CLIP-seq
MIRT2599032	hsa-miR-4496	CLIP-seq
MIRT2599033	hsa-miR-4500	CLIP-seq
MIRT2599034	hsa-miR-4501	CLIP-seq
MIRT1257006	hsa-miR-4512	CLIP-seq
MIRT2599035	hsa-miR-4533	CLIP-seq
MIRT2688456	hsa-miR-466	CLIP-seq
MIRT1257007	hsa-miR-4714-3p	CLIP-seq
MIRT1257008	hsa-miR-4721	CLIP-seq
MIRT2599038	hsa-miR-4762-5p	CLIP-seq
MIRT2599039	hsa-miR-4775	CLIP-seq
MIRT1257009	hsa-miR-4782-5p	CLIP-seq
MIRT2599040	hsa-miR-4791	CLIP-seq
MIRT2599041	hsa-miR-4796-3p	CLIP-seq
MIRT2599042	hsa-miR-4804-3p	CLIP-seq
MIRT2599043	hsa-miR-489	CLIP-seq
MIRT2599044	hsa-miR-494	CLIP-seq
MIRT1256991	hsa-miR-500b	CLIP-seq
MIRT1256992	hsa-miR-501-5p	CLIP-seq
MIRT2599045	hsa-miR-509-3-5p	CLIP-seq
MIRT2599046	hsa-miR-509-5p	CLIP-seq
MIRT1257010	hsa-miR-544b	CLIP-seq
MIRT2599052	hsa-miR-548c-3p	CLIP-seq
MIRT2599063	hsa-miR-582-3p	CLIP-seq
MIRT1257011	hsa-miR-661	CLIP-seq
MIRT2599067	hsa-miR-890	CLIP-seq
MIRT2599068	hsa-miR-935	CLIP-seq
MIRT2599069	hsa-miR-941	CLIP-seq
MIRT2599070	hsa-miR-98	CLIP-seq

Gene ontology (GO) Show/Hide all (28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	IEA
GO:0003723	Function	RNA binding	IEA
GO:0003723	Function	RNA binding	TAS	9153239
GO:0003729	Function	MRNA binding	IBA
GO:0004518	Function	Nuclease activity	IEA
GO:0004519	Function	Endonuclease activity	IEA
GO:0004521	Function	RNA endonuclease activity	IDA	9153239, 10432294
GO:0004864	Function	Protein phosphatase inhibitor activity	IEA
GO:0004865	Function	Protein serine/threonine phosphatase inhibitor activity	IBA
GO:0004865	Function	Protein serine/threonine phosphatase inhibitor activity	TAS	7499293
GO:0005515	Function	Protein binding	IPI	11739654, 15231748, 18842582, 20516061, 22365833, 22940584, 24510904, 25416956, 25593058, 27173435, 28330616, 28514442, 31046837, 32296183, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	7499293
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0006401	Process	RNA catabolic process	TAS	9153239
GO:0008283	Process	Cell population proliferation	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0008995	Function	Ribonuclease E activity	TAS	9153239
GO:0016607	Component	Nuclear speck	IBA
GO:0016607	Component	Nuclear speck	IDA	11739654
GO:0016607	Component	Nuclear speck	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0019888	Function	Protein phosphatase regulator activity	IEA
GO:0140678	Function	Molecular function inhibitor activity	EXP	22940584

Other IDs

• MIM: 602636
• HGNC: 9296
• e!Ensembl: ENSG00000117751

Protein

• UniProt ID: Q12972
• Protein name: Nuclear inhibitor of protein phosphatase 1 (NIPP-1) (Protein phosphatase 1 regulatory inhibitor subunit 8) [Includes: Activator of RNA decay (EC 3.1.4.-) (ARD-1)]
• Protein function: Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a tr
• PDB: 3V4Y
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00498	FHA	49 → 118	FHA domain	Family

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitously expressed, with highest levels in heart and skeletal muscle, followed by brain, placenta, lung, liver and pancreas. Less abundant in kidney. The concentration and ratio between isoforms is cell-type dependent. Isoform Alph
• Sequence:

  MAAAANSGSSLPLFDCPTWAGKPPPGLHLDVVKGDKLIEKLIIDEKKYYLFGRNPDLCDF
  TIDHQSCSRVHAALVYHKHLKRVFLIDLNSTHGTFLGHIRLEPHKPQQIPIDSTVSFGAS
  TRAYTLREKPQTLPSAVKGDEKMGGEDDELKGLLGLPEEETELDNLTEFNTAHNKRISTL
  TIEEGNLDIQRPKRKRKNSRVTFSEDDEIINPEDVDPSVGRFRNMVQTAVVPVKKKRVEG
  PGSLGLEESGSRRMQNFAFSGGLYGGLPPTHSEAGSQPHGIHGTALIGGLPMPYPNLAPD
  VDLTPVVPSAVNMNPAPNPAVYNPEAVNEPKKKKYAKEAWPGKKPTPSLLI

• Sequence length: 351

Related Genes

No strongly related genes found yet for PPP1R8.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to PPP1R8.