PPP1R2 (protein phosphatase 1 regulatory inhibitor subunit 2)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 5504 |
| Gene name | Protein phosphatase 1 regulatory inhibitor subunit 2 |
| Gene symbol | PPP1R2 |
| Synonyms (NCBI Gene) |
IPP-2IPP2PPP1R2A
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| Chromosome | 3 |
| Chromosome location | 3q29 |
| Summary | Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related pseudogenes have been found throughout the human |
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miRNA
miRNA information provided by mirtarbase database.
374
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
9
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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P41236 | ||||||||||
| Protein name | Protein phosphatase inhibitor 2 (IPP-2) | ||||||||||
| Protein function | Inhibitor of protein-phosphatase 1. | ||||||||||
| Family and domains |
Pfam
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| Sequence |
MAASTASHRPIKGILKNKTSTTSSMVASAEQPRGNVDEELSKKSQKWDEMNILATYHPAD |
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| Sequence length | 205 | ||||||||||
| Interactions | View interactions | ||||||||||
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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Related Genes
Genes most often co-reported with PPP1R2 across shared curated disease and pathway associations.
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to PPP1R2 (see Related Genes above), that are NOT already directly curated for PPP1R2 itself -- a lead worth checking, not a confirmed association.
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