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Gene Gene information from NCBI Gene database.
Entrez ID 6992
Gene name Protein phosphatase 1 regulatory inhibitor subunit 11
Gene symbol PPP1R11
Synonyms (NCBI Gene)
CFAP255HCG-VHCGVIPP3TCTE5TCTEX5
Chromosome 6
Chromosome location 6p22.1
Summary This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromoso
miRNA miRNA information provided by mirtarbase database.
586 Show/Hide all (586)
miRTarBase ID miRNA Experiments Reference
MIRT027095 hsa-miR-103a-3p Sequencing 20371350
MIRT031861 hsa-miR-16-5p Sequencing 20371350
MIRT100211 hsa-miR-424-5p HITS-CLIP 23313552
MIRT100222 hsa-miR-6838-5p HITS-CLIP 23313552
MIRT100212 hsa-miR-497-5p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17 Show/Hide all (17)
GO ID Ontology Definition Evidence Reference
GO:0001818 Process Negative regulation of cytokine production ISS
GO:0004864 Function Protein phosphatase inhibitor activity IDA 9843442
GO:0004864 Function Protein phosphatase inhibitor activity IEA
GO:0004865 Function Protein serine/threonine phosphatase inhibitor activity IBA
GO:0004865 Function Protein serine/threonine phosphatase inhibitor activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606670 9285 ENSG00000204619
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O60927
Protein name E3 ubiquitin-protein ligase PPP1R11 (EC 2.3.2.27) (Hemochromatosis candidate gene V protein) (HCG V) (Protein phosphatase 1 regulatory subunit 11) (Protein phosphatase inhibitor 3)
Protein function Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, thro
PDB 8DWK , 8DWL , 8U5G
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07491 PPI_Ypi1 25 → 81 Protein phosphatase inhibitor Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:8781118}.
Sequence
MAEAGAGLSETVTETTVTVTTEPENRSLTIKLRKRKPEKKVEWTSDTVDNEHMGRRSSKC
CCIYEKPRAFGESSTESDEEE
EEGCGHTHCVRGHRKGRRRATLGPTPTTPPQPPDPSQPP
PGPMQH
Sequence length 126
Interactions View interactions