Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Other IDs
Entrez ID	64091
Gene name	Popeye domain cAMP effector 2
Gene symbol	POPDC2
Synonyms (NCBI Gene)	POP2
Chromosome	3
Chromosome location	3q13.33
Summary	This gene encodes a member of the POP family of proteins which contain three putative transmembrane domains. This membrane associated protein is predominantly expressed in skeletal and cardiac muscle, and may have an important function in these tissues. [

159

Show/Hide all (159)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017710	hsa-miR-335-5p	Microarray	18185580
MIRT632012	hsa-miR-4438	HITS-CLIP	23824327
MIRT632011	hsa-miR-128-3p	HITS-CLIP	23824327
MIRT632010	hsa-miR-216a-3p	HITS-CLIP	23824327
MIRT632009	hsa-miR-3681-3p	HITS-CLIP	23824327
MIRT632008	hsa-miR-5693	HITS-CLIP	23824327
MIRT632007	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT632006	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT632005	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT632004	hsa-miR-612	HITS-CLIP	23824327
MIRT632003	hsa-miR-6860	HITS-CLIP	23824327
MIRT632002	hsa-miR-5689	HITS-CLIP	23824327
MIRT632001	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT632000	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT631999	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT631998	hsa-miR-4284	HITS-CLIP	23824327
MIRT631997	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT631996	hsa-miR-4505	HITS-CLIP	23824327
MIRT631995	hsa-miR-5787	HITS-CLIP	23824327
MIRT631994	hsa-miR-5095	HITS-CLIP	23824327
MIRT631993	hsa-miR-7151-3p	HITS-CLIP	23824327
MIRT633903	hsa-miR-7977	HITS-CLIP	23824327
MIRT631992	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT632012	hsa-miR-4438	HITS-CLIP	23824327
MIRT632011	hsa-miR-128-3p	HITS-CLIP	23824327
MIRT632010	hsa-miR-216a-3p	HITS-CLIP	23824327
MIRT632009	hsa-miR-3681-3p	HITS-CLIP	23824327
MIRT632008	hsa-miR-5693	HITS-CLIP	23824327
MIRT632007	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT632006	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT632005	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT632004	hsa-miR-612	HITS-CLIP	23824327
MIRT632003	hsa-miR-6860	HITS-CLIP	23824327
MIRT632002	hsa-miR-5689	HITS-CLIP	23824327
MIRT632001	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT632000	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT631999	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT631998	hsa-miR-4284	HITS-CLIP	23824327
MIRT631997	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT631996	hsa-miR-4505	HITS-CLIP	23824327
MIRT631995	hsa-miR-5787	HITS-CLIP	23824327
MIRT631994	hsa-miR-5095	HITS-CLIP	23824327
MIRT631993	hsa-miR-7151-3p	HITS-CLIP	23824327
MIRT633903	hsa-miR-7977	HITS-CLIP	23824327
MIRT631992	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT632012	hsa-miR-4438	HITS-CLIP	23824327
MIRT632011	hsa-miR-128-3p	HITS-CLIP	23824327
MIRT632010	hsa-miR-216a-3p	HITS-CLIP	23824327
MIRT632009	hsa-miR-3681-3p	HITS-CLIP	23824327
MIRT632008	hsa-miR-5693	HITS-CLIP	23824327
MIRT632007	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT632006	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT632005	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT632004	hsa-miR-612	HITS-CLIP	23824327
MIRT632003	hsa-miR-6860	HITS-CLIP	23824327
MIRT632002	hsa-miR-5689	HITS-CLIP	23824327
MIRT632001	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT632000	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT631999	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT631998	hsa-miR-4284	HITS-CLIP	23824327
MIRT631997	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT631996	hsa-miR-4505	HITS-CLIP	23824327
MIRT631995	hsa-miR-5787	HITS-CLIP	23824327
MIRT631994	hsa-miR-5095	HITS-CLIP	23824327
MIRT631993	hsa-miR-7151-3p	HITS-CLIP	23824327
MIRT631992	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT632012	hsa-miR-4438	HITS-CLIP	23824327
MIRT632011	hsa-miR-128-3p	HITS-CLIP	23824327
MIRT632010	hsa-miR-216a-3p	HITS-CLIP	23824327
MIRT632009	hsa-miR-3681-3p	HITS-CLIP	23824327
MIRT632008	hsa-miR-5693	HITS-CLIP	23824327
MIRT632007	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT632006	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT632005	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT632004	hsa-miR-612	HITS-CLIP	23824327
MIRT632003	hsa-miR-6860	HITS-CLIP	23824327
MIRT632002	hsa-miR-5689	HITS-CLIP	23824327
MIRT632001	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT632000	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT631999	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT631998	hsa-miR-4284	HITS-CLIP	23824327
MIRT631997	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT631996	hsa-miR-4505	HITS-CLIP	23824327
MIRT631995	hsa-miR-5787	HITS-CLIP	23824327
MIRT631994	hsa-miR-5095	HITS-CLIP	23824327
MIRT631993	hsa-miR-7151-3p	HITS-CLIP	23824327
MIRT633903	hsa-miR-7977	HITS-CLIP	23824327
MIRT631992	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT632012	hsa-miR-4438	HITS-CLIP	23824327
MIRT632011	hsa-miR-128-3p	HITS-CLIP	23824327
MIRT632010	hsa-miR-216a-3p	HITS-CLIP	23824327
MIRT632009	hsa-miR-3681-3p	HITS-CLIP	23824327
MIRT632008	hsa-miR-5693	HITS-CLIP	23824327
MIRT632007	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT632006	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT632005	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT632004	hsa-miR-612	HITS-CLIP	23824327
MIRT632003	hsa-miR-6860	HITS-CLIP	23824327
MIRT632002	hsa-miR-5689	HITS-CLIP	23824327
MIRT632001	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT632000	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT631999	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT631998	hsa-miR-4284	HITS-CLIP	23824327
MIRT631997	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT631996	hsa-miR-4505	HITS-CLIP	23824327
MIRT631995	hsa-miR-5787	HITS-CLIP	23824327
MIRT631994	hsa-miR-5095	HITS-CLIP	23824327
MIRT631993	hsa-miR-7151-3p	HITS-CLIP	23824327
MIRT633903	hsa-miR-7977	HITS-CLIP	23824327
MIRT631992	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT632012	hsa-miR-4438	HITS-CLIP	23824327
MIRT632011	hsa-miR-128-3p	HITS-CLIP	23824327
MIRT632010	hsa-miR-216a-3p	HITS-CLIP	23824327
MIRT632009	hsa-miR-3681-3p	HITS-CLIP	23824327
MIRT632008	hsa-miR-5693	HITS-CLIP	23824327
MIRT632007	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT632006	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT632005	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT632004	hsa-miR-612	HITS-CLIP	23824327
MIRT632003	hsa-miR-6860	HITS-CLIP	23824327
MIRT632002	hsa-miR-5689	HITS-CLIP	23824327
MIRT632001	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT632000	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT631999	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT631998	hsa-miR-4284	HITS-CLIP	23824327
MIRT631997	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT631996	hsa-miR-4505	HITS-CLIP	23824327
MIRT631995	hsa-miR-5787	HITS-CLIP	23824327
MIRT631994	hsa-miR-5095	HITS-CLIP	23824327
MIRT631993	hsa-miR-7151-3p	HITS-CLIP	23824327
MIRT631992	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT1250264	hsa-miR-3130-3p	CLIP-seq
MIRT1250265	hsa-miR-4793-3p	CLIP-seq
MIRT1250266	hsa-miR-550a	CLIP-seq
MIRT2300732	hsa-miR-1293	CLIP-seq
MIRT2300733	hsa-miR-145	CLIP-seq
MIRT2300734	hsa-miR-1825	CLIP-seq
MIRT2300735	hsa-miR-199a-5p	CLIP-seq
MIRT2300736	hsa-miR-199b-5p	CLIP-seq
MIRT2300737	hsa-miR-224	CLIP-seq
MIRT2300738	hsa-miR-3153	CLIP-seq
MIRT2300739	hsa-miR-3614-3p	CLIP-seq
MIRT2300740	hsa-miR-3973	CLIP-seq
MIRT2300741	hsa-miR-4297	CLIP-seq
MIRT2300742	hsa-miR-4483	CLIP-seq
MIRT2300743	hsa-miR-4668-5p	CLIP-seq
MIRT2300744	hsa-miR-520g	CLIP-seq
MIRT2300745	hsa-miR-520h	CLIP-seq
MIRT2300746	hsa-miR-583	CLIP-seq
MIRT2300732	hsa-miR-1293	CLIP-seq
MIRT2300738	hsa-miR-3153	CLIP-seq
MIRT2300742	hsa-miR-4483	CLIP-seq
MIRT2300743	hsa-miR-4668-5p	CLIP-seq
MIRT2300746	hsa-miR-583	CLIP-seq
MIRT2300732	hsa-miR-1293	CLIP-seq
MIRT2300738	hsa-miR-3153	CLIP-seq
MIRT2300742	hsa-miR-4483	CLIP-seq
MIRT2300743	hsa-miR-4668-5p	CLIP-seq
MIRT2300746	hsa-miR-583	CLIP-seq

Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002027	Process	Regulation of heart rate	ISS
GO:0005886	Component	Plasma membrane	IEA
GO:0007507	Process	Heart development	IBA
GO:0007519	Process	Skeletal muscle tissue development	IBA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	10882522
GO:0030552	Function	CAMP binding	IBA
GO:0042383	Component	Sarcolemma	IBA
GO:0042383	Component	Sarcolemma	IDA	26642364
GO:0042383	Component	Sarcolemma	IEA
GO:0042391	Process	Regulation of membrane potential	IBA
GO:0051146	Process	Striated muscle cell differentiation	IBA

MIM	HGNC	e!Ensembl
605823	17648	ENSG00000121577

Q9HBU9

Protein name

Popeye domain-containing protein 2 (Popeye protein 2)

Protein function

Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhanc

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04831	Popeye	25 → 251	Popeye protein conserved region	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed predominantly in the heart and in the skeletal muscle. {ECO:0000269|PubMed:10882522, ECO:0000269|PubMed:26642364}.

Sequence

MSANSSRVGQLLLQGSACIRWKQDVEGAVYHLANCLLLLGFMGGSGVYGCFYLFGFLSAG
YLCCVLWGWFSACGLDIVLWSFLLAVVCLLQLAHLVYRLREDTLPEEFDLLYKTLCLPLQ
VPLQTYKEIVHCCEEQVLTLATEQTYAVEGETPINRLSLLLSGRVRVSQDGQFLHYIFPY
QFMDSPEWESLQPSEEGVFQVTLTAETSCSYISWPRKSLHLLLTKERYISCLFSALLGYD
ISEKLYTLNDKLFAKFGLRFDIRLPSLYHVLGPTAADAGPESEKGDEEVCEPAVSPPQAT
PTSLQQTPPCSTPPATTNFPAPPTRARLSRPDSGILASRIPLQSYSQVISRGQAPLAPTH
TPEL

Sequence length

364

Interactions

View interactions

POPDC2 (popeye domain cAMP effector 2)