POLR1E (RNA polymerase I subunit E)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 64425
• Gene name: RNA polymerase I subunit E
• Gene symbol: POLR1E
• Synonyms (NCBI Gene): A49, PAF53, PRAF1, RPA49
• Chromosome: 9
• Chromosome location: 9p13.2

miRNA Show/Hide all (125)

miRTarBase ID	miRNA	Experiments	Reference
MIRT692199	hsa-miR-302f	HITS-CLIP	23313552
MIRT692198	hsa-miR-1911-3p	HITS-CLIP	23313552
MIRT692197	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT692196	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT692195	hsa-miR-940	HITS-CLIP	23313552
MIRT692194	hsa-miR-15a-3p	HITS-CLIP	23313552
MIRT692193	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT692192	hsa-miR-1972	HITS-CLIP	23313552
MIRT692191	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT692190	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT692189	hsa-miR-219b-3p	HITS-CLIP	23313552
MIRT692188	hsa-miR-1827	HITS-CLIP	23313552
MIRT692187	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT692186	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT692185	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT692184	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT692183	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT692182	hsa-miR-1273e	HITS-CLIP	23313552
MIRT692181	hsa-miR-665	HITS-CLIP	23313552
MIRT692199	hsa-miR-302f	HITS-CLIP	23313552
MIRT692198	hsa-miR-1911-3p	HITS-CLIP	23313552
MIRT692197	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT692196	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT692195	hsa-miR-940	HITS-CLIP	23313552
MIRT692194	hsa-miR-15a-3p	HITS-CLIP	23313552
MIRT692193	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT692192	hsa-miR-1972	HITS-CLIP	23313552
MIRT692191	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT692190	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT692189	hsa-miR-219b-3p	HITS-CLIP	23313552
MIRT692188	hsa-miR-1827	HITS-CLIP	23313552
MIRT692187	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT692186	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT692185	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT692184	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT692183	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT692182	hsa-miR-1273e	HITS-CLIP	23313552
MIRT692181	hsa-miR-665	HITS-CLIP	23313552
MIRT1248373	hsa-miR-4438	CLIP-seq
MIRT1248374	hsa-miR-4740-3p	CLIP-seq
MIRT1248375	hsa-miR-5095	CLIP-seq
MIRT1921499	hsa-miR-4722-3p	CLIP-seq
MIRT1921499	hsa-miR-4722-3p	CLIP-seq
MIRT2073312	hsa-miR-103b	CLIP-seq
MIRT2073313	hsa-miR-3617	CLIP-seq
MIRT2073314	hsa-miR-4315	CLIP-seq
MIRT2073315	hsa-miR-4708-3p	CLIP-seq
MIRT2073316	hsa-miR-4772-3p	CLIP-seq
MIRT2073317	hsa-miR-4790-5p	CLIP-seq
MIRT2073318	hsa-miR-544	CLIP-seq
MIRT2073319	hsa-miR-607	CLIP-seq
MIRT2073320	hsa-miR-641	CLIP-seq
MIRT2073312	hsa-miR-103b	CLIP-seq
MIRT2300401	hsa-miR-106a	CLIP-seq
MIRT2300402	hsa-miR-106b	CLIP-seq
MIRT2300403	hsa-miR-1234	CLIP-seq
MIRT2300404	hsa-miR-1305	CLIP-seq
MIRT2300405	hsa-miR-1323	CLIP-seq
MIRT2300406	hsa-miR-150	CLIP-seq
MIRT2300407	hsa-miR-17	CLIP-seq
MIRT2300408	hsa-miR-20a	CLIP-seq
MIRT2300409	hsa-miR-20b	CLIP-seq
MIRT2300410	hsa-miR-302a	CLIP-seq
MIRT2300411	hsa-miR-302b	CLIP-seq
MIRT2300412	hsa-miR-302c	CLIP-seq
MIRT2300413	hsa-miR-302d	CLIP-seq
MIRT2300414	hsa-miR-302e	CLIP-seq
MIRT2300415	hsa-miR-3074-5p	CLIP-seq
MIRT2300416	hsa-miR-372	CLIP-seq
MIRT2300417	hsa-miR-373	CLIP-seq
MIRT1248373	hsa-miR-4438	CLIP-seq
MIRT2300418	hsa-miR-4679	CLIP-seq
MIRT1921499	hsa-miR-4722-3p	CLIP-seq
MIRT2300419	hsa-miR-4731-5p	CLIP-seq
MIRT2073316	hsa-miR-4772-3p	CLIP-seq
MIRT1248375	hsa-miR-5095	CLIP-seq
MIRT2300420	hsa-miR-512-3p	CLIP-seq
MIRT2300421	hsa-miR-519d	CLIP-seq
MIRT2300422	hsa-miR-520a-3p	CLIP-seq
MIRT2300423	hsa-miR-520b	CLIP-seq
MIRT2300424	hsa-miR-520c-3p	CLIP-seq
MIRT2300425	hsa-miR-520d-3p	CLIP-seq
MIRT2300426	hsa-miR-520e	CLIP-seq
MIRT2300427	hsa-miR-520g	CLIP-seq
MIRT2300428	hsa-miR-520h	CLIP-seq
MIRT2300429	hsa-miR-548c-3p	CLIP-seq
MIRT2300430	hsa-miR-548o	CLIP-seq
MIRT2073319	hsa-miR-607	CLIP-seq
MIRT2300431	hsa-miR-93	CLIP-seq
MIRT2300418	hsa-miR-4679	CLIP-seq
MIRT2597160	hsa-miR-1200	CLIP-seq
MIRT2597161	hsa-miR-1238	CLIP-seq
MIRT2597162	hsa-miR-1273f	CLIP-seq
MIRT2597163	hsa-miR-198	CLIP-seq
MIRT2597164	hsa-miR-3670	CLIP-seq
MIRT2597165	hsa-miR-4287	CLIP-seq
MIRT2597166	hsa-miR-4324	CLIP-seq
MIRT2597167	hsa-miR-4451	CLIP-seq
MIRT2597168	hsa-miR-4463	CLIP-seq
MIRT2597169	hsa-miR-4469	CLIP-seq
MIRT2597170	hsa-miR-4494	CLIP-seq
MIRT2597171	hsa-miR-4522	CLIP-seq
MIRT2597172	hsa-miR-4685-3p	CLIP-seq
MIRT2597173	hsa-miR-4691-5p	CLIP-seq
MIRT2597174	hsa-miR-4781-3p	CLIP-seq
MIRT2597175	hsa-miR-544b	CLIP-seq
MIRT2073319	hsa-miR-607	CLIP-seq
MIRT2597176	hsa-miR-615-5p	CLIP-seq
MIRT2597160	hsa-miR-1200	CLIP-seq
MIRT2597161	hsa-miR-1238	CLIP-seq
MIRT2597162	hsa-miR-1273f	CLIP-seq
MIRT2597163	hsa-miR-198	CLIP-seq
MIRT2597164	hsa-miR-3670	CLIP-seq
MIRT2597165	hsa-miR-4287	CLIP-seq
MIRT2597166	hsa-miR-4324	CLIP-seq
MIRT2597167	hsa-miR-4451	CLIP-seq
MIRT2597168	hsa-miR-4463	CLIP-seq
MIRT2597169	hsa-miR-4469	CLIP-seq
MIRT2597170	hsa-miR-4494	CLIP-seq
MIRT2597172	hsa-miR-4685-3p	CLIP-seq
MIRT2597173	hsa-miR-4691-5p	CLIP-seq
MIRT2597174	hsa-miR-4781-3p	CLIP-seq
MIRT2597175	hsa-miR-544b	CLIP-seq
MIRT2073319	hsa-miR-607	CLIP-seq
MIRT2597176	hsa-miR-615-5p	CLIP-seq

Gene ontology (GO) Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000428	Component	DNA-directed RNA polymerase complex	IEA
GO:0001179	Function	RNA polymerase I general transcription initiation factor binding	IEA
GO:0001188	Process	RNA polymerase I preinitiation complex assembly	IBA
GO:0001188	Process	RNA polymerase I preinitiation complex assembly	IEA
GO:0001650	Component	Fibrillar center	IDA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	14743216, 16809778, 24207024, 32814053, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IEA
GO:0005730	Component	Nucleolus	ISS
GO:0005736	Component	RNA polymerase I complex	IBA
GO:0005736	Component	RNA polymerase I complex	IDA	16809778, 34671025, 36271492
GO:0005736	Component	RNA polymerase I complex	IEA
GO:0006351	Process	DNA-templated transcription	IEA
GO:0006361	Process	Transcription initiation at RNA polymerase I promoter	IDA	16809778
GO:0006362	Process	Transcription elongation by RNA polymerase I	IBA
GO:0042790	Process	Nucleolar large rRNA transcription by RNA polymerase I	IDA	24207024

Other IDs

• MIM: 621031
• HGNC: 17631
• e!Ensembl: ENSG00000137054

Protein

• UniProt ID: Q9GZS1
• Protein name: DNA-directed RNA polymerase I subunit RPA49 (RNA polymerase I subunit A49) (DNA-directed RNA polymerase I subunit E) (RNA polymerase I-associated factor 1) (RNA polymerase I-associated factor 53)
• Protein function: Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates (PubMed:24207024, PubMed:34671025, PubMed:34887565, PubMed:36271492). Appe
• PDB: 7OB9 , 7OBA , 7OBB , 7VBA , 7VBB , 7VBC , 8A43
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF06870	RNA_pol_I_A49	36 → 412	A49-like RNA polymerase I associated factor	Family

• Sequence:

  MAAEVLPSARWQYCGAPDGSQRAVLVQFSNGKLQSPGNMRFTLYENKDSTNPRKRNQRIL
  AAETDRLSYVGNNFGTGALKCNTLCRHFVGILNKTSGQMEVYDAELFNMQPLFSDVSVES
  ELALESQTKTYREKMDSCIEAFGTTKQKRALNTRRMNRVGNESLNRAVAKAAETIIDTKG
  VTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNVTS
  EEILKMIEENSHCTFVIEALKSLPSDVESRDRQARCIWFLDTLIKFRAHRVVKRKSALGP
  GVPHIINTKLLKHFTCLTYNNGRLRNLISDSMKAKITAYVIILALHIHDFQIDLTVLQRD
  LKLSEKRMMEIAKAMRLKISKRRVSVAAGSEEDHKLGTLSLPLPPAQTSDRLAKRRKIT

• Sequence length: 419

Pathways

KEGG Pathway	Reactome Pathway
RNA polymerase	B-WICH complex positively regulates rRNA expression
	RNA Polymerase I Transcription Initiation
	RNA Polymerase I Promoter Escape
	RNA Polymerase I Transcription Termination

Related Genes

Sort by: Blended Diseases Pathways Evidence source

POLR1A 5 shared pathwaysRNA polymerase, RNA Polymerase I Transcription Termination, RNA Polymerase I Transcription Initiation, RNA Polymerase I Promoter Escape, B-WICH complex positively regulates rRNA expression Related via 5 shared pathways including RNA polymerase, RNA Polymerase I Transcription Termination. POLR1B 5 shared pathwaysRNA polymerase, RNA Polymerase I Transcription Termination, RNA Polymerase I Transcription Initiation, RNA Polymerase I Promoter Escape, B-WICH complex positively regulates rRNA expression Related via 5 shared pathways including RNA polymerase, RNA Polymerase I Transcription Termination. CD3EAP 4 shared pathwaysRNA Polymerase I Transcription Termination, RNA Polymerase I Transcription Initiation, RNA Polymerase I Promoter Escape, B-WICH complex positively regulates rRNA expression Related via 4 shared pathways including RNA Polymerase I Transcription Termination, RNA Polymerase I Transcription Initiation. TWISTNB 4 shared pathwaysRNA Polymerase I Transcription Termination, RNA Polymerase I Transcription Initiation, RNA Polymerase I Promoter Escape, B-WICH complex positively regulates rRNA expression Related via 4 shared pathways including RNA Polymerase I Transcription Termination, RNA Polymerase I Transcription Initiation. ZNRD1 4 shared pathwaysRNA Polymerase I Transcription Termination, RNA Polymerase I Transcription Initiation, RNA Polymerase I Promoter Escape, B-WICH complex positively regulates rRNA expression Related via 4 shared pathways including RNA Polymerase I Transcription Termination, RNA Polymerase I Transcription Initiation.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
POLR1A	0	[]	5	["RNA polymerase","RNA Polymerase I Transcription Termination","RNA Polymerase I Transcription Initiation","RNA Polymerase I Promoter Escape","B-WICH complex positively regulates rRNA expression"]	0	[]
POLR1B	0	[]	5	["RNA polymerase","RNA Polymerase I Transcription Termination","RNA Polymerase I Transcription Initiation","RNA Polymerase I Promoter Escape","B-WICH complex positively regulates rRNA expression"]	0	[]
CD3EAP	0	[]	4	["RNA Polymerase I Transcription Termination","RNA Polymerase I Transcription Initiation","RNA Polymerase I Promoter Escape","B-WICH complex positively regulates rRNA expression"]	0	[]
TWISTNB	0	[]	4	["RNA Polymerase I Transcription Termination","RNA Polymerase I Transcription Initiation","RNA Polymerase I Promoter Escape","B-WICH complex positively regulates rRNA expression"]	0	[]
ZNRD1	0	[]	4	["RNA Polymerase I Transcription Termination","RNA Polymerase I Transcription Initiation","RNA Polymerase I Promoter Escape","B-WICH complex positively regulates rRNA expression"]	0	[]

Diseases Linked via Similar Genes

Acrofacial dysostosis Linked via 1 of 5 related genesPOLR1A Burn-mckeown syndrome Linked via 1 of 5 related genesPOLR1A Cardiovascular disease Linked via 1 of 5 related genesPOLR1A Choanal atresia syndrome Linked via 1 of 5 related genesPOLR1A Desbuquois syndrome Linked via 1 of 5 related genesPOLR1A

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Acrofacial dysostosis	1	["POLR1A"]
Burn-mckeown syndrome	1	["POLR1A"]
Cardiovascular disease	1	["POLR1A"]
Choanal atresia syndrome	1	["POLR1A"]
Desbuquois syndrome	1	["POLR1A"]