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Gene Gene information from NCBI Gene database.
Entrez ID 170384
Gene name Protein O-fucosyltransferase 4
Gene symbol POFUT4
Synonyms (NCBI Gene)
FUCTXIFUT11
Chromosome 10
Chromosome location 10q22.2
miRNA miRNA information provided by mirtarbase database.
404 Show/Hide all (404)
miRTarBase ID miRNA Experiments Reference
MIRT017496 hsa-miR-335-5p Microarray 18185580
MIRT024743 hsa-miR-215-5p Microarray 19074876
MIRT026331 hsa-miR-192-5p Microarray 19074876
MIRT043519 hsa-miR-331-3p CLASH 23622248
MIRT041804 hsa-miR-484 CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
19 Show/Hide all (19)
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0005515 Function Protein binding IPI 25416956
GO:0005783 Component Endoplasmic reticulum IDA 39775168
GO:0005783 Component Endoplasmic reticulum IEA
GO:0005789 Component Endoplasmic reticulum membrane IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
616932 19233 ENSG00000196968
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q495W5
Protein name GDP-fucose protein O-fucosyltransferase 4 (EC 2.4.1.221) (Alpha-(1,3)-fucosyltransferase 11) (EC 2.4.1.-) (Fucosyltransferase XI) (Fuc-TXI) (FucT-XI) (Galactoside 3-L-fucosyltransferase 11) (Fucosyltransferase 11)
Protein function Protein O-fucosyltransferase that specifically catalyzes O-fucosylation of serine or threonine residues in EMI domains of target proteins, such as MMRN1, MMRN2 and EMID1 (PubMed:39775168). Attaches fucose through an O-glycosidic linkage (PubMed:
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00852 Glyco_transf_10 209 → 394 Glycosyltransferase family 10 (fucosyltransferase) C-term Family
PF17039 Glyco_tran_10_N 73 → 182 Fucosyltransferase, N-terminal Domain
Sequence
Sequence length 492
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
Lewis blood group biosynthesis