PODXL2 (podocalyxin like 2)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 50512
• Gene name: Podocalyxin like 2
• Gene symbol: PODXL2
• Synonyms (NCBI Gene): EG, PODLX2
• Chromosome: 3
• Chromosome location: 3q21.3
• Summary: This gene is a member of the CD34 family of cell surface transmembrane proteins, which are characterized by an N-terminal extracellular mucin domain, globular and stalk domains, a single pass transmembrane region, and a charged cytoplasmic tail. The encod

miRNA Show/Hide all (19)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018113	hsa-miR-335-5p	Microarray	18185580
MIRT040329	hsa-miR-615-3p	CLASH	23622248
MIRT1246407	hsa-miR-138	CLIP-seq
MIRT1246408	hsa-miR-1538	CLIP-seq
MIRT1246409	hsa-miR-3180	CLIP-seq
MIRT1246410	hsa-miR-3180-3p	CLIP-seq
MIRT1246411	hsa-miR-3196	CLIP-seq
MIRT1246412	hsa-miR-3648	CLIP-seq
MIRT1246413	hsa-miR-4466	CLIP-seq
MIRT1246414	hsa-miR-4488	CLIP-seq
MIRT1246415	hsa-miR-4632	CLIP-seq
MIRT1246416	hsa-miR-4697-5p	CLIP-seq
MIRT1246417	hsa-miR-4707-3p	CLIP-seq
MIRT1246418	hsa-miR-4745-3p	CLIP-seq
MIRT1246419	hsa-miR-4755-3p	CLIP-seq
MIRT1246420	hsa-miR-4767	CLIP-seq
MIRT1246421	hsa-miR-548q	CLIP-seq
MIRT1246422	hsa-miR-675	CLIP-seq
MIRT1246423	hsa-miR-744	CLIP-seq

Gene ontology (GO) Show/Hide all (9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	18606703, 32814053
GO:0005539	Function	Glycosaminoglycan binding	TAS	10722749
GO:0005796	Component	Golgi lumen	TAS
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	10722749
GO:0007155	Process	Cell adhesion	IEA
GO:0016020	Component	Membrane	IEA
GO:0050901	Process	Leukocyte tethering or rolling	IBA
GO:0050901	Process	Leukocyte tethering or rolling	IDA	18606703

Other IDs

• MIM: 616627
• HGNC: 17936
• e!Ensembl: ENSG00000114631

Protein

• UniProt ID: Q9NZ53
• Protein name: Podocalyxin-like protein 2 (Endoglycan)
• Protein function: Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L-selectins.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF06365	CD34_antigen	393 → 605	CD34/Podocalyxin family	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in T-cells, B-cells and monocytes. Expression is higher on memory and germinal center cells than on naive B-cells (at protein level). Highly expressed in brain. Moderately expressed in pancreas, kidney and lymphoid node. Weak
• Sequence:

  MGRLLRAARLPPLLSPLLLLLVGGAFLGACVAGSDEPGPEGLTSTSLLDLLLPTGLEPLD
  SEEPSETMGLGAGLGAPGSGFPSEENEESRILQPPQYFWEEEEELNDSSLDLGPTADYVF
  PDLTEKAGSIEDTSQAQELPNLPSPLPKMNLVEPPWHMPPREEEEEEEEEEEREKEEVEK
  QEEEEEEELLPVNGSQEEAKPQVRDFSLTSSSQTPGATKSRHEDSGDQASSGVEVESSMG
  PSLLLPSVTPTTVTPGDQDSTSQEAEATVLPAAGLGVEFEAPQEASEEATAGAAGLSGQH
  EEVPALPSFPQTTAPSGAEHPDEDPLGSRTSASSPLAPGDMELTPSSATLGQEDLNQQLL
  EGQAAEAQSRIPWDSTQVICKDWSNLAGKNYIILNMTENIDCEVFRQHRGPQLLALVEEV
  LPRHGSGHHGAWHISLSKPSEKEQHLLMTLVGEQGVVPTQDVLSMLGDIRRSLEEIGIQN
  YSTTSSCQARASQVRSDYGTLFVVLVVIGAICIIIIALGLLYNCWQRRLPKLKHVSHGEE
  LRFVENGCHDNPTLDVASDSQSEMQEKHPSLNGGGALNGPGSWGALMGGKRDPEDSDVFE
  EDTHL

• Sequence length: 605

Pathways

Reactome Pathway:

Cytosolic sulfonation of small molecules

Related Genes

No strongly related genes found yet for PODXL2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to PODXL2.