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Gene Gene information from NCBI Gene database.
Entrez ID 55629
Gene name Proline rich nuclear receptor coactivator 2
Gene symbol PNRC2
Synonyms (NCBI Gene)
-
Chromosome 1
Chromosome location 1p36.11
miRNA miRNA information provided by mirtarbase database.
1048 Show/Hide all (1048)
miRTarBase ID miRNA Experiments Reference
MIRT571799 hsa-miR-222-3p PAR-CLIP 20371350
MIRT571798 hsa-miR-221-3p PAR-CLIP 20371350
MIRT272961 hsa-miR-6882-5p PAR-CLIP 20371350
MIRT571797 hsa-miR-5683 PAR-CLIP 20371350
MIRT571796 hsa-miR-5580-3p PAR-CLIP 20371350
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
E2F1 Repression 16181749
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16 Show/Hide all (16)
GO ID Ontology Definition Evidence Reference
GO:0000184 Process Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
GO:0000184 Process Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IDA 19150429
GO:0000184 Process Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
GO:0000932 Component P-body IBA
GO:0000932 Component P-body IDA 19150429
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
611882 23158 ENSG00000189266
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NPJ4
Protein name Proline-rich nuclear receptor coactivator 2
Protein function Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery (PubMed:19150429). May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberr
PDB 4B6H , 5KQ1 , 5KQ4
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15365 PNRC 93 → 112 Motif
Tissue specificity TISSUE SPECIFICITY: Expressed in heart, lung, muscle and brain. {ECO:0000269|PubMed:11574675}.
Sequence
MGGGERYNIPAPQSRNVSKNQQQLNRQKTKEQNSQMKIVHKKKERGHGYNSSAAAWQAMQ
NGGKNKNFPNNQSWNSSLSGPRLLFKSQANQNYAGAKFSEPPSPSVLPKPPSHWVPVSFN
PSDKEIMTFQLKTLLKVQV
Sequence length 139
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)