PLSCR3 (phospholipid scramblase 3)

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Gene miRNA Gene ontology Other IDs Protein Diseases linked via similar genes

Gene

• Entrez ID: 57048
• Gene name: Phospholipid scramblase 3
• Gene symbol: PLSCR3
• Synonyms (NCBI Gene): -
• Chromosome: 17
• Chromosome location: 17p13.1

miRNA Show/Hide all (107)

miRTarBase ID	miRNA	Experiments	Reference
MIRT002909	hsa-miR-124-3p	Microarray	18668037
MIRT045514	hsa-miR-149-5p	CLASH	23622248
MIRT1243241	hsa-let-7a	CLIP-seq
MIRT1243242	hsa-let-7b	CLIP-seq
MIRT1243243	hsa-let-7c	CLIP-seq
MIRT1243244	hsa-let-7d	CLIP-seq
MIRT1243245	hsa-let-7e	CLIP-seq
MIRT1243246	hsa-let-7f	CLIP-seq
MIRT1243247	hsa-let-7g	CLIP-seq
MIRT1243248	hsa-let-7i	CLIP-seq
MIRT1243249	hsa-miR-1184	CLIP-seq
MIRT1243250	hsa-miR-1207-5p	CLIP-seq
MIRT1243251	hsa-miR-1226	CLIP-seq
MIRT1243252	hsa-miR-124	CLIP-seq
MIRT1243253	hsa-miR-1267	CLIP-seq
MIRT1243254	hsa-miR-1271	CLIP-seq
MIRT1243255	hsa-miR-1301	CLIP-seq
MIRT1243256	hsa-miR-29a	CLIP-seq
MIRT1243257	hsa-miR-29b	CLIP-seq
MIRT1243258	hsa-miR-29c	CLIP-seq
MIRT1243259	hsa-miR-3125	CLIP-seq
MIRT1243260	hsa-miR-3689a-3p	CLIP-seq
MIRT1243261	hsa-miR-3689c	CLIP-seq
MIRT1243262	hsa-miR-3714	CLIP-seq
MIRT1243263	hsa-miR-3910	CLIP-seq
MIRT1243264	hsa-miR-3916	CLIP-seq
MIRT1243265	hsa-miR-3918	CLIP-seq
MIRT1243266	hsa-miR-4458	CLIP-seq
MIRT1243267	hsa-miR-4493	CLIP-seq
MIRT1243268	hsa-miR-4500	CLIP-seq
MIRT1243269	hsa-miR-4660	CLIP-seq
MIRT1243270	hsa-miR-4690-5p	CLIP-seq
MIRT1243271	hsa-miR-4715-5p	CLIP-seq
MIRT1243272	hsa-miR-4722-5p	CLIP-seq
MIRT1243273	hsa-miR-4727-3p	CLIP-seq
MIRT1243274	hsa-miR-4728-5p	CLIP-seq
MIRT1243275	hsa-miR-4763-3p	CLIP-seq
MIRT1243276	hsa-miR-4768-3p	CLIP-seq
MIRT1243277	hsa-miR-5047	CLIP-seq
MIRT1243278	hsa-miR-506	CLIP-seq
MIRT1243279	hsa-miR-541	CLIP-seq
MIRT1243280	hsa-miR-615-5p	CLIP-seq
MIRT1243281	hsa-miR-654-5p	CLIP-seq
MIRT1243282	hsa-miR-940	CLIP-seq
MIRT1243283	hsa-miR-96	CLIP-seq
MIRT1243284	hsa-miR-98	CLIP-seq
MIRT1243262	hsa-miR-3714	CLIP-seq
MIRT1243241	hsa-let-7a	CLIP-seq
MIRT1243242	hsa-let-7b	CLIP-seq
MIRT1243243	hsa-let-7c	CLIP-seq
MIRT1243244	hsa-let-7d	CLIP-seq
MIRT1243245	hsa-let-7e	CLIP-seq
MIRT1243246	hsa-let-7f	CLIP-seq
MIRT1243247	hsa-let-7g	CLIP-seq
MIRT1243248	hsa-let-7i	CLIP-seq
MIRT2688159	hsa-miR-106a	CLIP-seq
MIRT2688160	hsa-miR-106b	CLIP-seq
MIRT1243249	hsa-miR-1184	CLIP-seq
MIRT1243253	hsa-miR-1267	CLIP-seq
MIRT1243255	hsa-miR-1301	CLIP-seq
MIRT2688161	hsa-miR-17	CLIP-seq
MIRT2688162	hsa-miR-1908	CLIP-seq
MIRT2688163	hsa-miR-20a	CLIP-seq
MIRT2688164	hsa-miR-20b	CLIP-seq
MIRT2688165	hsa-miR-2467-5p	CLIP-seq
MIRT2688166	hsa-miR-2682	CLIP-seq
MIRT2688167	hsa-miR-3129-3p	CLIP-seq
MIRT2688168	hsa-miR-3146	CLIP-seq
MIRT2688169	hsa-miR-3150a-3p	CLIP-seq
MIRT2688170	hsa-miR-3175	CLIP-seq
MIRT2688171	hsa-miR-3187-3p	CLIP-seq
MIRT2688172	hsa-miR-3188	CLIP-seq
MIRT2688173	hsa-miR-3926	CLIP-seq
MIRT2688174	hsa-miR-3927	CLIP-seq
MIRT2688175	hsa-miR-3929	CLIP-seq
MIRT2688176	hsa-miR-3960	CLIP-seq
MIRT2688177	hsa-miR-3973	CLIP-seq
MIRT2688178	hsa-miR-3975	CLIP-seq
MIRT2688179	hsa-miR-4419b	CLIP-seq
MIRT2688180	hsa-miR-4435	CLIP-seq
MIRT2688181	hsa-miR-4451	CLIP-seq
MIRT1243266	hsa-miR-4458	CLIP-seq
MIRT2688182	hsa-miR-4478	CLIP-seq
MIRT2688183	hsa-miR-449c	CLIP-seq
MIRT1243268	hsa-miR-4500	CLIP-seq
MIRT2688184	hsa-miR-4527	CLIP-seq
MIRT2688185	hsa-miR-4539	CLIP-seq
MIRT2688186	hsa-miR-4640-3p	CLIP-seq
MIRT2688187	hsa-miR-4649-3p	CLIP-seq
MIRT2688188	hsa-miR-4659a-5p	CLIP-seq
MIRT2688189	hsa-miR-4659b-5p	CLIP-seq
MIRT1243269	hsa-miR-4660	CLIP-seq
MIRT2688190	hsa-miR-4701-5p	CLIP-seq
MIRT2688191	hsa-miR-485-5p	CLIP-seq
MIRT1243277	hsa-miR-5047	CLIP-seq
MIRT2688192	hsa-miR-519d	CLIP-seq
MIRT2688193	hsa-miR-520g	CLIP-seq
MIRT2688194	hsa-miR-520h	CLIP-seq
MIRT2688195	hsa-miR-548s	CLIP-seq
MIRT2688196	hsa-miR-588	CLIP-seq
MIRT1243280	hsa-miR-615-5p	CLIP-seq
MIRT2688197	hsa-miR-663	CLIP-seq
MIRT2688198	hsa-miR-885-3p	CLIP-seq
MIRT2688199	hsa-miR-93	CLIP-seq
MIRT2688200	hsa-miR-939	CLIP-seq
MIRT1243282	hsa-miR-940	CLIP-seq
MIRT1243284	hsa-miR-98	CLIP-seq

Gene ontology (GO) Show/Hide all (37)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	IMP	29337693
GO:0005509	Function	Calcium ion binding	IMP	18358005, 29337693, 31769662
GO:0005509	Function	Calcium ion binding	NAS	10930526
GO:0005515	Function	Protein binding	IPI	12649167, 16189514, 18256029, 25416956, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA	12649167, 14573790, 18491232
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	ISS
GO:0005829	Component	Cytosol	IDA	12649167
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	19333378
GO:0005886	Component	Plasma membrane	NAS	10930526
GO:0006869	Process	Lipid transport	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0006915	Process	Apoptotic process	IMP	12649167
GO:0007006	Process	Mitochondrial membrane organization	IMP	16939411
GO:0016020	Component	Membrane	IEA
GO:0017121	Process	Plasma membrane phospholipid scrambling	IBA
GO:0017121	Process	Plasma membrane phospholipid scrambling	IEA
GO:0017121	Process	Plasma membrane phospholipid scrambling	NAS	10930526
GO:0017124	Function	SH3 domain binding	IEA
GO:0017128	Function	Phospholipid scramblase activity	IBA
GO:0017128	Function	Phospholipid scramblase activity	IEA
GO:0017128	Function	Phospholipid scramblase activity	IMP	14573790, 18358005, 29337693, 31769662
GO:0017128	Function	Phospholipid scramblase activity	NAS	10930526
GO:0031966	Component	Mitochondrial membrane	IEA
GO:0032791	Function	Lead ion binding	IMP	31769662
GO:0042593	Process	Glucose homeostasis	IEA
GO:0042632	Process	Cholesterol homeostasis	IEA
GO:0042981	Process	Regulation of apoptotic process	IMP	14573790, 18358005, 18491232
GO:0045340	Function	Mercury ion binding	IMP	31769662
GO:0048306	Function	Calcium-dependent protein binding	IPI	18256029
GO:0071222	Process	Cellular response to lipopolysaccharide	IEA
GO:0090199	Process	Regulation of release of cytochrome c from mitochondria	IMP	14573790, 18358005

Other IDs

• MIM: 607611
• HGNC: 16495
• e!Ensembl: ENSG00000187838

Protein

• UniProt ID: Q9NRY6
• Protein name: Phospholipid scramblase 3 (PL scramblase 3) (Ca(2+)-dependent phospholipid scramblase 3)
• Protein function: Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of the phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer membrane of the mitochondria (PubMed:14573790, PubMed:17226776, PubMed
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03803	Scramblase	62 → 284	Scramblase	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine and peripheral blood lymphocytes. Not detected in testis, brain and liver.
• Sequence:

  MAGYLPPKGYAPSPPPPYPVTPGYPEPALHPGPGQAPVPAQVPAPAPGFALFPSPGPVAL
  GSAAPFLPLPGVPSGLEFLVQIDQILIHQKAERVETFLGWETCNRYELRSGAGQPLGQAA
  EESNCCARLCCGARRPLRVRLADPGDREVLRLLRPLHCGCSCCPCGLQEMEVQAPPGTTI
  GHVLQTWHPFLPKFSIQDADRQTVLRVVGPCWTCGCGTDTNFEVKTRDESRSVGRISKQW
  GGLVREALTDADDFGLQFPLDLDVRVKAVLLGATFLIDYMFFEKRGGAGPSAVTS

• Sequence length: 295

Related Genes

No strongly related genes found yet for PLSCR3.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to PLSCR3.