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Gene Gene information from NCBI Gene database.
Entrez ID 5359
Gene name Phospholipid scramblase 1
Gene symbol PLSCR1
Synonyms (NCBI Gene)
MMTRA1B
Chromosome 3
Chromosome location 3q24
miRNA miRNA information provided by mirtarbase database.
414 Show/Hide all (414)
miRTarBase ID miRNA Experiments Reference
MIRT021730 hsa-miR-132-3p Microarray 17612493
MIRT048655 hsa-miR-99a-5p CLASH 23622248
MIRT047725 hsa-miR-10a-5p CLASH 23622248
MIRT040909 hsa-miR-18a-3p CLASH 23622248
MIRT626127 hsa-miR-30a-5p HITS-CLIP 23313552
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
STAT1 Unknown 16260419
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
62 Show/Hide all (62)
GO ID Ontology Definition Evidence Reference
GO:0000287 Function Magnesium ion binding IDA 27206388
GO:0001228 Function DNA-binding transcription activator activity, RNA polymerase II-specific IDA 16091359
GO:0001618 Function Virus receptor activity IEA
GO:0001618 Function Virus receptor activity IMP 21806988
GO:0003677 Function DNA binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604170 9092 ENSG00000188313
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O15162
Protein name Phospholipid scramblase 1 (PL scramblase 1) (Ca(2+)-dependent phospholipid scramblase 1) (Erythrocyte phospholipid scramblase) (Mg(2+)-dependent nuclease) (EC 3.1.-.-) (MmTRA1b)
Protein function Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane resulting in collapse of the phospholipid a
PDB 1Y2A
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03803 Scramblase 86 → 307 Scramblase Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in platelets, erythrocyte membranes, lymphocytes, spleen, thymus, prostate, testis, uterus, intestine, colon, heart, placenta, lung, liver, kidney and pancreas. Not detected in brain and skeletal muscle. {ECO:0000269|PubMed:1
Sequence
Sequence length 318
Interactions View interactions