Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	5355
Gene name	Proteolipid protein 2
Gene symbol	PLP2
Synonyms (NCBI Gene)	A4A4LSB
Chromosome	X
Chromosome location	Xp11.23
Summary	This gene encodes an integral membrane protein that localizes to the endoplasmic reticulum in colonic epithelial cells. The encoded protein can multimerize and may function as an ion channel. A polymorphism in the promoter of this gene may be linked to an

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miRTarBase ID	miRNA	Experiments	Reference
MIRT002655	hsa-miR-124-3p	Microarray	15685193
MIRT002655	hsa-miR-124-3p	Microarray	18668037
MIRT002655	hsa-miR-124-3p	Microarray	15685193
MIRT046849	hsa-miR-221-3p	CLASH	23622248
MIRT455239	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT366673	hsa-miR-1273h-3p	PAR-CLIP	23592263
MIRT366662	hsa-miR-3678-3p	PAR-CLIP	23592263
MIRT455238	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT455236	hsa-miR-4699-5p	PAR-CLIP	23592263
MIRT733287	hsa-miR-765	ImmunofluorescenceRNA-seqqRT-PCRWestern blotting	33859750
MIRT733288	hsa-miR-7-5p	ImmunofluorescenceRNA-seqqRT-PCRWestern blotting	33859750
MIRT733289	hsa-miR-150-5p	ImmunofluorescenceRNA-seqqRT-PCRWestern blotting	33859750
MIRT002655	hsa-miR-124-3p	ImmunofluorescenceRNA-seqqRT-PCRWestern blotting	33859750
MIRT455239	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT366673	hsa-miR-1273h-3p	PAR-CLIP	23592263
MIRT366662	hsa-miR-3678-3p	PAR-CLIP	23592263
MIRT455238	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT455236	hsa-miR-4699-5p	PAR-CLIP	23592263
MIRT733287	hsa-miR-765	Western blottingqRT-PCR	37495419
MIRT1243103	hsa-miR-122	CLIP-seq
MIRT1243104	hsa-miR-1254	CLIP-seq
MIRT1243105	hsa-miR-1296	CLIP-seq
MIRT1243106	hsa-miR-151-5p	CLIP-seq
MIRT1243107	hsa-miR-151b	CLIP-seq
MIRT1243108	hsa-miR-2861	CLIP-seq
MIRT1243109	hsa-miR-3116	CLIP-seq
MIRT1243110	hsa-miR-3150b-3p	CLIP-seq
MIRT1243111	hsa-miR-3173-3p	CLIP-seq
MIRT1243112	hsa-miR-3198	CLIP-seq
MIRT1243113	hsa-miR-3622a-5p	CLIP-seq
MIRT1243114	hsa-miR-3690	CLIP-seq
MIRT1243115	hsa-miR-378	CLIP-seq
MIRT1243116	hsa-miR-378b	CLIP-seq
MIRT1243117	hsa-miR-378c	CLIP-seq
MIRT1243118	hsa-miR-378d	CLIP-seq
MIRT1243119	hsa-miR-378e	CLIP-seq
MIRT1243120	hsa-miR-378f	CLIP-seq
MIRT1243121	hsa-miR-378h	CLIP-seq
MIRT1243122	hsa-miR-378i	CLIP-seq
MIRT1243123	hsa-miR-422a	CLIP-seq
MIRT1243124	hsa-miR-4309	CLIP-seq
MIRT1243125	hsa-miR-4423-3p	CLIP-seq
MIRT1243126	hsa-miR-4481	CLIP-seq
MIRT1243127	hsa-miR-4512	CLIP-seq
MIRT1243128	hsa-miR-4522	CLIP-seq
MIRT1243129	hsa-miR-4714-3p	CLIP-seq
MIRT1243130	hsa-miR-4714-5p	CLIP-seq
MIRT1243131	hsa-miR-4745-5p	CLIP-seq
MIRT1243132	hsa-miR-4751	CLIP-seq
MIRT1243133	hsa-miR-4764-3p	CLIP-seq
MIRT1243134	hsa-miR-4766-5p	CLIP-seq
MIRT1243135	hsa-miR-4784	CLIP-seq
MIRT1243136	hsa-miR-4789-3p	CLIP-seq
MIRT2071829	hsa-miR-1	CLIP-seq
MIRT2071830	hsa-miR-206	CLIP-seq
MIRT2071831	hsa-miR-296-3p	CLIP-seq
MIRT2071832	hsa-miR-3147	CLIP-seq
MIRT2071833	hsa-miR-3150a-3p	CLIP-seq
MIRT2071834	hsa-miR-3170	CLIP-seq
MIRT1243111	hsa-miR-3173-3p	CLIP-seq
MIRT2071835	hsa-miR-3175	CLIP-seq
MIRT2071836	hsa-miR-342-5p	CLIP-seq
MIRT1243113	hsa-miR-3622a-5p	CLIP-seq
MIRT2071837	hsa-miR-409-3p	CLIP-seq
MIRT1243125	hsa-miR-4423-3p	CLIP-seq
MIRT2071838	hsa-miR-4425	CLIP-seq
MIRT2071839	hsa-miR-4459	CLIP-seq
MIRT2071840	hsa-miR-4651	CLIP-seq
MIRT2071841	hsa-miR-4653-3p	CLIP-seq
MIRT2071842	hsa-miR-4664-5p	CLIP-seq
MIRT2071843	hsa-miR-4701-5p	CLIP-seq
MIRT1243132	hsa-miR-4751	CLIP-seq
MIRT2071844	hsa-miR-4777-3p	CLIP-seq
MIRT2071845	hsa-miR-4779	CLIP-seq
MIRT1243136	hsa-miR-4789-3p	CLIP-seq
MIRT2071846	hsa-miR-491-5p	CLIP-seq
MIRT2071847	hsa-miR-509-3p	CLIP-seq
MIRT2071848	hsa-miR-571	CLIP-seq
MIRT2071849	hsa-miR-583	CLIP-seq
MIRT2071850	hsa-miR-588	CLIP-seq
MIRT2071851	hsa-miR-608	CLIP-seq
MIRT2071852	hsa-miR-613	CLIP-seq
MIRT2071853	hsa-miR-642a	CLIP-seq
MIRT2071854	hsa-miR-665	CLIP-seq
MIRT2071855	hsa-miR-939	CLIP-seq
MIRT2071829	hsa-miR-1	CLIP-seq
MIRT2298960	hsa-miR-124	CLIP-seq
MIRT1243104	hsa-miR-1254	CLIP-seq
MIRT1243105	hsa-miR-1296	CLIP-seq
MIRT2071830	hsa-miR-206	CLIP-seq
MIRT1243108	hsa-miR-2861	CLIP-seq
MIRT2071831	hsa-miR-296-3p	CLIP-seq
MIRT1243109	hsa-miR-3116	CLIP-seq
MIRT2071832	hsa-miR-3147	CLIP-seq
MIRT2071833	hsa-miR-3150a-3p	CLIP-seq
MIRT2071834	hsa-miR-3170	CLIP-seq
MIRT2071835	hsa-miR-3175	CLIP-seq
MIRT2071836	hsa-miR-342-5p	CLIP-seq
MIRT2298961	hsa-miR-3622b-5p	CLIP-seq
MIRT1243114	hsa-miR-3690	CLIP-seq
MIRT1243115	hsa-miR-378	CLIP-seq
MIRT1243116	hsa-miR-378b	CLIP-seq
MIRT1243117	hsa-miR-378c	CLIP-seq
MIRT1243118	hsa-miR-378d	CLIP-seq
MIRT1243119	hsa-miR-378e	CLIP-seq
MIRT1243120	hsa-miR-378f	CLIP-seq
MIRT1243121	hsa-miR-378h	CLIP-seq
MIRT1243122	hsa-miR-378i	CLIP-seq
MIRT2071837	hsa-miR-409-3p	CLIP-seq
MIRT1243123	hsa-miR-422a	CLIP-seq
MIRT2298962	hsa-miR-4253	CLIP-seq
MIRT2298963	hsa-miR-4286	CLIP-seq
MIRT2071838	hsa-miR-4425	CLIP-seq
MIRT2071839	hsa-miR-4459	CLIP-seq
MIRT1243126	hsa-miR-4481	CLIP-seq
MIRT2298964	hsa-miR-4484	CLIP-seq
MIRT1243127	hsa-miR-4512	CLIP-seq
MIRT1243128	hsa-miR-4522	CLIP-seq
MIRT2298965	hsa-miR-4527	CLIP-seq
MIRT2298966	hsa-miR-4646-5p	CLIP-seq
MIRT2071840	hsa-miR-4651	CLIP-seq
MIRT2071841	hsa-miR-4653-3p	CLIP-seq
MIRT2071842	hsa-miR-4664-5p	CLIP-seq
MIRT2071843	hsa-miR-4701-5p	CLIP-seq
MIRT2298967	hsa-miR-4704-3p	CLIP-seq
MIRT1243129	hsa-miR-4714-3p	CLIP-seq
MIRT1243130	hsa-miR-4714-5p	CLIP-seq
MIRT2298968	hsa-miR-4731-5p	CLIP-seq
MIRT1243131	hsa-miR-4745-5p	CLIP-seq
MIRT1243133	hsa-miR-4764-3p	CLIP-seq
MIRT1243134	hsa-miR-4766-5p	CLIP-seq
MIRT2071844	hsa-miR-4777-3p	CLIP-seq
MIRT2071845	hsa-miR-4779	CLIP-seq
MIRT1243136	hsa-miR-4789-3p	CLIP-seq
MIRT2071846	hsa-miR-491-5p	CLIP-seq
MIRT2298969	hsa-miR-506	CLIP-seq
MIRT2071847	hsa-miR-509-3p	CLIP-seq
MIRT2298970	hsa-miR-548an	CLIP-seq
MIRT2071848	hsa-miR-571	CLIP-seq
MIRT2298971	hsa-miR-582-3p	CLIP-seq
MIRT2071849	hsa-miR-583	CLIP-seq
MIRT2071850	hsa-miR-588	CLIP-seq
MIRT2071851	hsa-miR-608	CLIP-seq
MIRT2071852	hsa-miR-613	CLIP-seq
MIRT2071854	hsa-miR-665	CLIP-seq
MIRT2071855	hsa-miR-939	CLIP-seq
MIRT2298960	hsa-miR-124	CLIP-seq
MIRT2071832	hsa-miR-3147	CLIP-seq
MIRT2071833	hsa-miR-3150a-3p	CLIP-seq
MIRT2071834	hsa-miR-3170	CLIP-seq
MIRT2071835	hsa-miR-3175	CLIP-seq
MIRT2071836	hsa-miR-342-5p	CLIP-seq
MIRT2071838	hsa-miR-4425	CLIP-seq
MIRT2298964	hsa-miR-4484	CLIP-seq
MIRT2071840	hsa-miR-4651	CLIP-seq
MIRT2071841	hsa-miR-4653-3p	CLIP-seq
MIRT2071842	hsa-miR-4664-5p	CLIP-seq
MIRT2071844	hsa-miR-4777-3p	CLIP-seq
MIRT2071846	hsa-miR-491-5p	CLIP-seq
MIRT2298969	hsa-miR-506	CLIP-seq
MIRT2298970	hsa-miR-548an	CLIP-seq
MIRT2071848	hsa-miR-571	CLIP-seq
MIRT2071849	hsa-miR-583	CLIP-seq
MIRT2071851	hsa-miR-608	CLIP-seq
MIRT2071853	hsa-miR-642a	CLIP-seq
MIRT2071855	hsa-miR-939	CLIP-seq

13 Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	15474493, 25416956, 30614533, 31515488, 32296183, 33961781
GO:0005783	Component	Endoplasmic reticulum	TAS	9124532
GO:0005789	Component	Endoplasmic reticulum membrane	TAS	9124532
GO:0005886	Component	Plasma membrane	IDA	15474493
GO:0006811	Process	Monoatomic ion transport	TAS	9124532
GO:0006935	Process	Chemotaxis	NAS	15474493
GO:0015075	Function	Monoatomic ion transmembrane transporter activity	TAS	9124532
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	9124532
GO:0019221	Process	Cytokine-mediated signaling pathway	NAS	15474493
GO:0019956	Function	Chemokine binding	IPI	15474493
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA

MIM	HGNC	e!Ensembl
300112	9087	ENSG00000102007

Q04941

Protein name

Proteolipid protein 2 (Differentiation-dependent protein A4) (Intestinal membrane A4 protein)

Protein function

May play a role in cell differentiation in the intestinal epithelium.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01284	MARVEL	19 → 131	Membrane-associating domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Enriched in colonic mucosa. The expression of A4 follows a gradient along the crypto-villus axis with the most abundant message occurring in the lower half of the crypt.

Sequence

MADSERLSAPGCWAACTNFSRTRKGILLFAEIILCLVILICFSASTPGYSSLSVIEMILA
AIFFVVYMCDLHTKIPFINWPWSDFFRTLIAAILYLITSIVVLVERGNHSKIVAGVLGLI
ATCLFGYDAYVTFPVRQPRHTAAPTDPADGPV

Sequence length

152

Interactions

View interactions

Related Genes Genes most often co-reported with PLP2 across shared curated disease and pathway associations. 0 Download as csv Download as pdf
No strongly related genes found yet for PLP2.

Diseases Linked via Similar Genes Diseases curated for genes most similar to PLP2 (see Related Genes above), that are NOT already directly curated for PLP2 itself -- a lead worth checking, not a confirmed association. 0 Download as csv Download as pdf
No additional diseases found yet through genes similar to PLP2.

PLP2 (proteolipid protein 2)

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