Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	79990
Gene name	Pleckstrin homology, MyTH4 and FERM domain containing H3
Gene symbol	PLEKHH3
Synonyms (NCBI Gene)	-
Chromosome	17
Chromosome location	17q21.2

16 Show/Hide all (16)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018704	hsa-miR-335-5p	Microarray	18185580
MIRT049030	hsa-miR-92a-3p	CLASH	23622248
MIRT1242352	hsa-miR-3647-3p	CLIP-seq
MIRT1242353	hsa-miR-3653	CLIP-seq
MIRT1242354	hsa-miR-3658	CLIP-seq
MIRT1242355	hsa-miR-495	CLIP-seq
MIRT2071393	hsa-miR-1205	CLIP-seq
MIRT2071394	hsa-miR-1236	CLIP-seq
MIRT2071395	hsa-miR-146b-3p	CLIP-seq
MIRT2071396	hsa-miR-1909	CLIP-seq
MIRT2071397	hsa-miR-3173-5p	CLIP-seq
MIRT2071398	hsa-miR-339-5p	CLIP-seq
MIRT2071399	hsa-miR-3918	CLIP-seq
MIRT2071400	hsa-miR-3926	CLIP-seq
MIRT2071401	hsa-miR-4716-5p	CLIP-seq
MIRT2071402	hsa-miR-874	CLIP-seq

GO ID	Ontology	Definition	Evidence	Reference
GO:0005615	Component	Extracellular space	HDA	22664934
GO:0005856	Component	Cytoskeleton	IEA

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q7Z736

Protein name

Pleckstrin homology domain-containing family H member 3 (PH domain-containing family H member 3)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00373	FERM_M	506 → 664	FERM central domain	Domain
PF00784	MyTH4	285 → 398	MyTH4 domain	Family
PF00788	RA	406 → 493	Ras association (RalGDS/AF-6) domain	Domain

Sequence

MPLPGGLWWLLCCRRGFTLLHRDYGDGELSGDGDEDEDEETFELRTPSPAGGGRGPLEVT
LTQPVRSGPVSNRLQSWEETWSLIPEKGLPEDDPDIVVKGWLYREPRGGGARPWLPPRRA
WFVLTRDSLDQFSSSGKGARRLGSLVLTSLCSVTGPERRRKETGLWSVTVSGRKHSVRLC
SPRQAEAERWGVALREVIASKAPLETPTQLLLRDIQESCGDPEAVALIYLRNPILRHTSG
ALYAPLLPLPYGVSAPGPGYAPLREEAVRLFLALQALEGARRPGPLMQGVLQTCRDLPAL
RDELFLQLAKQTSGPAGPPGLPATQDPAALRYWQLLTCMSCTFRPGGAVRGHLLGHLERT
EQALPDSELAEYARFIRKALGRTRGRELVPSLAEISALSQRQELLCTVHCPGAGACAVAI
DSHTTAGEVARELVGRLGLARSRNAFALYEQRGAQERALAGGTLVADVLTRFENLAAEEA
GLEDSPDSGWRLCLRLHGPLHPEGLSPDGHELPFLFEQAHALLLRGRPPPPDDTLRALAA
LRLQSLQRDFSPRVPLPRLDRLLPPPAPPREDPPRPTPRPPPSAALLAGALWSPGLAKRR
AERARRGGAGRTAGSIAREGGGGAGTAAAVLGGWKRLRGMGRAEAMAAYLALAAQCPGFG
AARYDVLELSTEPGRGAPQKLCLGLGAKAMSLSRPGETEPIHSVSYGHVAACQLMGPHTL
ALRVGESQLLLQSPQVEEIMQLVNAYLANPSPERPCSSSSPPCQDLPDTSPPSQRPGLDE
PQGQSGCLGQLQD

Sequence length

793

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CATARACT	—	GWAS catalog	31816047	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Malignant neoplasm of prostate	Prostate cancer	BEFREE	26585945		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	26585945		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sleep Apnea Obstructive	Sleep apnea	Pubtator	28520763	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

Related Genes Genes most often co-reported with PLEKHH3 across shared curated disease and pathway associations. 0 Download as csv Download as pdf
No strongly related genes found yet for PLEKHH3.

Diseases Linked via Similar Genes Diseases curated for genes most similar to PLEKHH3 (see Related Genes above), that are NOT already directly curated for PLEKHH3 itself -- a lead worth checking, not a confirmed association. 0 Download as csv Download as pdf
No additional diseases found yet through genes similar to PLEKHH3.

PLEKHH3 (pleckstrin homology, MyTH4 and FERM domain containing H3)

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