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Gene Gene information from NCBI Gene database.
Entrez ID 79666
Gene name Pleckstrin homology and FYVE domain containing 2
Gene symbol PLEKHF2
Synonyms (NCBI Gene)
EAPFPHAFIN2ZFYVE18
Chromosome 8
Chromosome location 8q22.1
miRNA miRNA information provided by mirtarbase database.
569 Show/Hide all (569)
miRTarBase ID miRNA Experiments Reference
MIRT022986 hsa-miR-124-3p Microarray 18668037
MIRT024767 hsa-miR-215-5p Microarray 19074876
MIRT026780 hsa-miR-192-5p Microarray 19074876
MIRT323683 hsa-miR-1277-5p PAR-CLIP 20371350
MIRT501582 hsa-miR-6882-5p PAR-CLIP 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
15 Show/Hide all (15)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 16189514, 19060904, 21516116, 25416956, 31515488, 32296183
GO:0005768 Component Endosome IEA
GO:0005769 Component Early endosome IBA
GO:0005783 Component Endoplasmic reticulum IEA
GO:0007032 Process Endosome organization IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
615208 20757 ENSG00000175895
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9H8W4
Protein name Pleckstrin homology domain-containing family F member 2 (PH domain-containing family F member 2) (Endoplasmic reticulum-associated apoptosis-involved protein containing PH and FYVE domains) (EAPF) (PH and FYVE domain-containing protein 2) (Phafin-2) (Phaf
Protein function May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis (PubMed:18288467). {ECO:0000269|PubMed:18288467, ECO:0000269|PubMe
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00169 PH 36 → 131 PH domain Domain
PF01363 FYVE 147 → 213 FYVE zinc finger Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in placenta, ovary and small intestine, as well as in heart and pancreas. Also expressed in peripheral blood mononuclear cells and dendritic cells. {ECO:0000269|PubMed:18288467}.
Sequence
Sequence length 249
Interactions View interactions