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Gene Gene information from NCBI Gene database.
Entrez ID 65977
Gene name Pleckstrin homology domain containing A3
Gene symbol PLEKHA3
Synonyms (NCBI Gene)
FAPP1
Chromosome 2
Chromosome location 2q31.2
miRNA miRNA information provided by mirtarbase database.
906 Show/Hide all (906)
miRTarBase ID miRNA Experiments Reference
MIRT019877 hsa-miR-375 Microarray 20215506
MIRT021709 hsa-miR-133a-3p Microarray 21396852
MIRT506154 hsa-miR-4789-3p HITS-CLIP 21572407
MIRT506153 hsa-miR-4643 HITS-CLIP 21572407
MIRT506152 hsa-miR-5011-5p HITS-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17 Show/Hide all (17)
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0000139 Component Golgi membrane TAS
GO:0001881 Process Receptor recycling IBA
GO:0005515 Function Protein binding IPI 30659099, 32296183
GO:0005769 Component Early endosome IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607774 14338 ENSG00000116095
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9HB20
Protein name Pleckstrin homology domain-containing family A member 3 (PH domain-containing family A member 3) (Phosphatidylinositol-four-phosphate adapter protein 1) (FAPP-1) (Phosphoinositol 4-phosphate adapter protein 1)
Protein function Plays a role in regulation of vesicular cargo transport from the trans-Golgi network (TGN) to the plasma membrane (PubMed:15107860). Regulates Golgi phosphatidylinositol 4-phosphate (PtdIns(4)P) levels and activates the PtdIns(4)P phosphatase ac
PDB 2KCJ , 2MDX , 3RCP
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00169 PH 1 → 93 PH domain Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed.
Sequence
MEGVLYKWTNYLTGWQPRWFVLDNGILSYYDSQDDVCKGSKGSIKMAVCEIKVHSADNTR
MELIIPGEQHFYMKAVNAAERQRWLVALGSSKA
CLTDTRTKKEKEISETSESLKTKMSEL
RLYCDLLMQQVHTIQEFVHHDENHSSPSAENMNEASSLLSATCNTFITTLEECVKIANAK
FKPEMFQLHHPDPLVSPVSPSPVQMMKRSVSHPGSCSSERSSHSIKEPVSTLHRLSQRRR
RTYSDTDSCSDIPLEDPDRPVHCSKNTLNGDLASATIPEESRLMAKKQSESEDTLPSFSS
Sequence length 300
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
Synthesis of PIPs at the plasma membrane