PITHD1 (PITH domain containing 1)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 57095
• Gene name: PITH domain containing 1
• Gene symbol: PITHD1
• Synonyms (NCBI Gene): C1orf128, HT014, TXNL1CL
• Chromosome: 1
• Chromosome location: 1p36.11

miRNA Show/Hide all (264)

miRTarBase ID	miRNA	Experiments	Reference
MIRT032469	hsa-let-7b-5p	Proteomics	18668040
MIRT042313	hsa-miR-484	CLASH	23622248
MIRT186280	hsa-miR-128-3p	PAR-CLIP	20371350
MIRT186282	hsa-miR-3681-3p	PAR-CLIP	20371350
MIRT186278	hsa-miR-216a-3p	PAR-CLIP	20371350
MIRT186279	hsa-miR-27b-3p	PAR-CLIP	20371350
MIRT186277	hsa-miR-27a-3p	PAR-CLIP	20371350
MIRT471014	hsa-miR-548e-5p	PAR-CLIP	20371350
MIRT272819	hsa-miR-21-5p	PAR-CLIP	20371350
MIRT272820	hsa-miR-590-5p	PAR-CLIP	20371350
MIRT186280	hsa-miR-128-3p	PAR-CLIP	20371350
MIRT186282	hsa-miR-3681-3p	PAR-CLIP	20371350
MIRT186278	hsa-miR-216a-3p	PAR-CLIP	20371350
MIRT186279	hsa-miR-27b-3p	PAR-CLIP	20371350
MIRT186277	hsa-miR-27a-3p	PAR-CLIP	20371350
MIRT471014	hsa-miR-548e-5p	PAR-CLIP	20371350
MIRT186280	hsa-miR-128-3p	PAR-CLIP	21572407
MIRT186282	hsa-miR-3681-3p	PAR-CLIP	21572407
MIRT186278	hsa-miR-216a-3p	PAR-CLIP	21572407
MIRT186279	hsa-miR-27b-3p	PAR-CLIP	21572407
MIRT186277	hsa-miR-27a-3p	PAR-CLIP	21572407
MIRT471014	hsa-miR-548e-5p	PAR-CLIP	21572407
MIRT272819	hsa-miR-21-5p	PAR-CLIP	21572407
MIRT272820	hsa-miR-590-5p	PAR-CLIP	21572407
MIRT186280	hsa-miR-128-3p	PAR-CLIP	23592263
MIRT186282	hsa-miR-3681-3p	PAR-CLIP	23592263
MIRT186278	hsa-miR-216a-3p	PAR-CLIP	23592263
MIRT186279	hsa-miR-27b-3p	PAR-CLIP	23592263
MIRT186277	hsa-miR-27a-3p	PAR-CLIP	23592263
MIRT471014	hsa-miR-548e-5p	PAR-CLIP	23592263
MIRT471012	hsa-miR-4511	PAR-CLIP	23592263
MIRT471013	hsa-miR-888-5p	PAR-CLIP	23592263
MIRT272819	hsa-miR-21-5p	PAR-CLIP	23592263
MIRT272820	hsa-miR-590-5p	PAR-CLIP	23592263
MIRT186280	hsa-miR-128-3p	PAR-CLIP	26701625
MIRT186280	hsa-miR-128-3p	PAR-CLIP	26701625
MIRT272819	hsa-miR-21-5p	PAR-CLIP	26701625
MIRT186278	hsa-miR-216a-3p	PAR-CLIP	26701625
MIRT186278	hsa-miR-216a-3p	PAR-CLIP	26701625
MIRT186277	hsa-miR-27a-3p	PAR-CLIP	26701625
MIRT186277	hsa-miR-27a-3p	PAR-CLIP	26701625
MIRT186279	hsa-miR-27b-3p	PAR-CLIP	26701625
MIRT186279	hsa-miR-27b-3p	PAR-CLIP	26701625
MIRT186282	hsa-miR-3681-3p	PAR-CLIP	26701625
MIRT186282	hsa-miR-3681-3p	PAR-CLIP	26701625
MIRT471014	hsa-miR-548e-5p	PAR-CLIP	26701625
MIRT471014	hsa-miR-548e-5p	PAR-CLIP	26701625
MIRT272820	hsa-miR-590-5p	PAR-CLIP	26701625
MIRT186280	hsa-miR-128-3p	PAR-CLIP	20371350
MIRT186282	hsa-miR-3681-3p	PAR-CLIP	20371350
MIRT186278	hsa-miR-216a-3p	PAR-CLIP	20371350
MIRT186279	hsa-miR-27b-3p	PAR-CLIP	20371350
MIRT186277	hsa-miR-27a-3p	PAR-CLIP	20371350
MIRT471014	hsa-miR-548e-5p	PAR-CLIP	20371350
MIRT272819	hsa-miR-21-5p	PAR-CLIP	20371350
MIRT272820	hsa-miR-590-5p	PAR-CLIP	20371350
MIRT186280	hsa-miR-128-3p	PAR-CLIP	20371350
MIRT186282	hsa-miR-3681-3p	PAR-CLIP	20371350
MIRT186278	hsa-miR-216a-3p	PAR-CLIP	20371350
MIRT186279	hsa-miR-27b-3p	PAR-CLIP	20371350
MIRT186277	hsa-miR-27a-3p	PAR-CLIP	20371350
MIRT471014	hsa-miR-548e-5p	PAR-CLIP	20371350
MIRT186280	hsa-miR-128-3p	PAR-CLIP	21572407
MIRT186282	hsa-miR-3681-3p	PAR-CLIP	21572407
MIRT186278	hsa-miR-216a-3p	PAR-CLIP	21572407
MIRT186279	hsa-miR-27b-3p	PAR-CLIP	21572407
MIRT186277	hsa-miR-27a-3p	PAR-CLIP	21572407
MIRT471014	hsa-miR-548e-5p	PAR-CLIP	21572407
MIRT272819	hsa-miR-21-5p	PAR-CLIP	21572407
MIRT272820	hsa-miR-590-5p	PAR-CLIP	21572407
MIRT186280	hsa-miR-128-3p	PAR-CLIP	23592263
MIRT186282	hsa-miR-3681-3p	PAR-CLIP	23592263
MIRT186278	hsa-miR-216a-3p	PAR-CLIP	23592263
MIRT186279	hsa-miR-27b-3p	PAR-CLIP	23592263
MIRT186277	hsa-miR-27a-3p	PAR-CLIP	23592263
MIRT471014	hsa-miR-548e-5p	PAR-CLIP	23592263
MIRT471012	hsa-miR-4511	PAR-CLIP	23592263
MIRT471013	hsa-miR-888-5p	PAR-CLIP	23592263
MIRT272819	hsa-miR-21-5p	PAR-CLIP	23592263
MIRT272820	hsa-miR-590-5p	PAR-CLIP	23592263
MIRT1236299	hsa-miR-1197	CLIP-seq
MIRT1236300	hsa-miR-1203	CLIP-seq
MIRT1236301	hsa-miR-1237	CLIP-seq
MIRT1236302	hsa-miR-1248	CLIP-seq
MIRT1236303	hsa-miR-1264	CLIP-seq
MIRT1236304	hsa-miR-128	CLIP-seq
MIRT1236305	hsa-miR-140-3p	CLIP-seq
MIRT1236306	hsa-miR-21	CLIP-seq
MIRT1236307	hsa-miR-210	CLIP-seq
MIRT1236308	hsa-miR-2355-5p	CLIP-seq
MIRT1236309	hsa-miR-2682	CLIP-seq
MIRT1236310	hsa-miR-27a	CLIP-seq
MIRT1236311	hsa-miR-27b	CLIP-seq
MIRT1236312	hsa-miR-3064-3p	CLIP-seq
MIRT1236313	hsa-miR-31	CLIP-seq
MIRT1236314	hsa-miR-3117-5p	CLIP-seq
MIRT1236315	hsa-miR-3128	CLIP-seq
MIRT1236316	hsa-miR-3145-5p	CLIP-seq
MIRT1236317	hsa-miR-3148	CLIP-seq
MIRT1236318	hsa-miR-3153	CLIP-seq
MIRT1236319	hsa-miR-330-3p	CLIP-seq
MIRT1236320	hsa-miR-337-3p	CLIP-seq
MIRT1236321	hsa-miR-34a	CLIP-seq
MIRT1236322	hsa-miR-34c-5p	CLIP-seq
MIRT1236323	hsa-miR-3612	CLIP-seq
MIRT1236324	hsa-miR-3614-5p	CLIP-seq
MIRT1236325	hsa-miR-3651	CLIP-seq
MIRT1236326	hsa-miR-3673	CLIP-seq
MIRT1236327	hsa-miR-3685	CLIP-seq
MIRT1236328	hsa-miR-384	CLIP-seq
MIRT1236329	hsa-miR-425	CLIP-seq
MIRT1236330	hsa-miR-4436a	CLIP-seq
MIRT1236331	hsa-miR-4476	CLIP-seq
MIRT1236332	hsa-miR-4494	CLIP-seq
MIRT1236333	hsa-miR-449a	CLIP-seq
MIRT1236334	hsa-miR-449b	CLIP-seq
MIRT1236335	hsa-miR-449c	CLIP-seq
MIRT1236336	hsa-miR-4643	CLIP-seq
MIRT1236337	hsa-miR-4700-3p	CLIP-seq
MIRT1236338	hsa-miR-4701-5p	CLIP-seq
MIRT1236339	hsa-miR-4711-5p	CLIP-seq
MIRT1236340	hsa-miR-4712-3p	CLIP-seq
MIRT1236341	hsa-miR-4713-5p	CLIP-seq
MIRT1236342	hsa-miR-4715-3p	CLIP-seq
MIRT1236343	hsa-miR-4717-3p	CLIP-seq
MIRT1236344	hsa-miR-4719	CLIP-seq
MIRT1236345	hsa-miR-4720-5p	CLIP-seq
MIRT1236346	hsa-miR-4789-3p	CLIP-seq
MIRT1236347	hsa-miR-4799-3p	CLIP-seq
MIRT1236348	hsa-miR-542-3p	CLIP-seq
MIRT1236349	hsa-miR-549	CLIP-seq
MIRT1236350	hsa-miR-550b	CLIP-seq
MIRT1236351	hsa-miR-561	CLIP-seq
MIRT1236352	hsa-miR-582-3p	CLIP-seq
MIRT1236353	hsa-miR-588	CLIP-seq
MIRT1236354	hsa-miR-642b	CLIP-seq
MIRT1236355	hsa-miR-650	CLIP-seq
MIRT1236356	hsa-miR-875-3p	CLIP-seq
MIRT1236357	hsa-miR-890	CLIP-seq
MIRT1236358	hsa-miR-940	CLIP-seq
MIRT2069481	hsa-miR-1285	CLIP-seq
MIRT2069482	hsa-miR-196a	CLIP-seq
MIRT2069483	hsa-miR-196b	CLIP-seq
MIRT2069484	hsa-miR-204	CLIP-seq
MIRT2069485	hsa-miR-211	CLIP-seq
MIRT1236312	hsa-miR-3064-3p	CLIP-seq
MIRT1236314	hsa-miR-3117-5p	CLIP-seq
MIRT1236316	hsa-miR-3145-5p	CLIP-seq
MIRT1236317	hsa-miR-3148	CLIP-seq
MIRT2069486	hsa-miR-3187-3p	CLIP-seq
MIRT2069487	hsa-miR-3187-5p	CLIP-seq
MIRT2069488	hsa-miR-320e	CLIP-seq
MIRT1236319	hsa-miR-330-3p	CLIP-seq
MIRT1236324	hsa-miR-3614-5p	CLIP-seq
MIRT1236326	hsa-miR-3673	CLIP-seq
MIRT2069489	hsa-miR-412	CLIP-seq
MIRT1236329	hsa-miR-425	CLIP-seq
MIRT2069490	hsa-miR-4300	CLIP-seq
MIRT2069491	hsa-miR-4420	CLIP-seq
MIRT2069492	hsa-miR-4435	CLIP-seq
MIRT1236338	hsa-miR-4701-5p	CLIP-seq
MIRT1236342	hsa-miR-4715-3p	CLIP-seq
MIRT1236343	hsa-miR-4717-3p	CLIP-seq
MIRT1236348	hsa-miR-542-3p	CLIP-seq
MIRT2069493	hsa-miR-548s	CLIP-seq
MIRT1236349	hsa-miR-549	CLIP-seq
MIRT1236352	hsa-miR-582-3p	CLIP-seq
MIRT1236353	hsa-miR-588	CLIP-seq
MIRT2069494	hsa-miR-612	CLIP-seq
MIRT1236354	hsa-miR-642b	CLIP-seq
MIRT1236356	hsa-miR-875-3p	CLIP-seq
MIRT1236357	hsa-miR-890	CLIP-seq
MIRT2069495	hsa-miR-891b	CLIP-seq
MIRT2069496	hsa-miR-920	CLIP-seq
MIRT1236299	hsa-miR-1197	CLIP-seq
MIRT1236301	hsa-miR-1237	CLIP-seq
MIRT1236302	hsa-miR-1248	CLIP-seq
MIRT1236305	hsa-miR-140-3p	CLIP-seq
MIRT2296833	hsa-miR-188-5p	CLIP-seq
MIRT2069482	hsa-miR-196a	CLIP-seq
MIRT2069483	hsa-miR-196b	CLIP-seq
MIRT2069484	hsa-miR-204	CLIP-seq
MIRT2069485	hsa-miR-211	CLIP-seq
MIRT2296834	hsa-miR-2355-3p	CLIP-seq
MIRT1236312	hsa-miR-3064-3p	CLIP-seq
MIRT1236314	hsa-miR-3117-5p	CLIP-seq
MIRT1236324	hsa-miR-3614-5p	CLIP-seq
MIRT2296835	hsa-miR-3667-3p	CLIP-seq
MIRT2296836	hsa-miR-376c	CLIP-seq
MIRT2296837	hsa-miR-4323	CLIP-seq
MIRT2296838	hsa-miR-4421	CLIP-seq
MIRT1236330	hsa-miR-4436a	CLIP-seq
MIRT2296839	hsa-miR-4477b	CLIP-seq
MIRT1236336	hsa-miR-4643	CLIP-seq
MIRT2296840	hsa-miR-4646-3p	CLIP-seq
MIRT1236337	hsa-miR-4700-3p	CLIP-seq
MIRT1236338	hsa-miR-4701-5p	CLIP-seq
MIRT1236340	hsa-miR-4712-3p	CLIP-seq
MIRT1236342	hsa-miR-4715-3p	CLIP-seq
MIRT2296841	hsa-miR-4728-3p	CLIP-seq
MIRT1236346	hsa-miR-4789-3p	CLIP-seq
MIRT1236349	hsa-miR-549	CLIP-seq
MIRT1236350	hsa-miR-550b	CLIP-seq
MIRT1236353	hsa-miR-588	CLIP-seq
MIRT1236354	hsa-miR-642b	CLIP-seq
MIRT2296842	hsa-miR-676	CLIP-seq
MIRT2456538	hsa-miR-2467-3p	CLIP-seq
MIRT2456539	hsa-miR-4453	CLIP-seq
MIRT2456540	hsa-miR-4538	CLIP-seq
MIRT2456541	hsa-miR-485-5p	CLIP-seq
MIRT2456538	hsa-miR-2467-3p	CLIP-seq
MIRT2456539	hsa-miR-4453	CLIP-seq
MIRT2456540	hsa-miR-4538	CLIP-seq
MIRT2456541	hsa-miR-485-5p	CLIP-seq
MIRT1236300	hsa-miR-1203	CLIP-seq
MIRT1236303	hsa-miR-1264	CLIP-seq
MIRT2069481	hsa-miR-1285	CLIP-seq
MIRT2594265	hsa-miR-3123	CLIP-seq
MIRT2594266	hsa-miR-3129-3p	CLIP-seq
MIRT1236316	hsa-miR-3145-5p	CLIP-seq
MIRT2069487	hsa-miR-3187-5p	CLIP-seq
MIRT2069488	hsa-miR-320e	CLIP-seq
MIRT2594267	hsa-miR-331-3p	CLIP-seq
MIRT1236320	hsa-miR-337-3p	CLIP-seq
MIRT1236323	hsa-miR-3612	CLIP-seq
MIRT1236325	hsa-miR-3651	CLIP-seq
MIRT2594268	hsa-miR-3667-5p	CLIP-seq
MIRT1236327	hsa-miR-3685	CLIP-seq
MIRT2594269	hsa-miR-3692	CLIP-seq
MIRT2296836	hsa-miR-376c	CLIP-seq
MIRT1236328	hsa-miR-384	CLIP-seq
MIRT2594270	hsa-miR-3925-5p	CLIP-seq
MIRT2594271	hsa-miR-4281	CLIP-seq
MIRT2296839	hsa-miR-4477b	CLIP-seq
MIRT2594272	hsa-miR-4690-3p	CLIP-seq
MIRT2594273	hsa-miR-4704-5p	CLIP-seq
MIRT1236339	hsa-miR-4711-5p	CLIP-seq
MIRT1236342	hsa-miR-4715-3p	CLIP-seq
MIRT1236344	hsa-miR-4719	CLIP-seq
MIRT2296841	hsa-miR-4728-3p	CLIP-seq
MIRT1236346	hsa-miR-4789-3p	CLIP-seq
MIRT1236349	hsa-miR-549	CLIP-seq
MIRT1236350	hsa-miR-550b	CLIP-seq
MIRT1236351	hsa-miR-561	CLIP-seq
MIRT2594274	hsa-miR-589	CLIP-seq
MIRT2069494	hsa-miR-612	CLIP-seq
MIRT1236355	hsa-miR-650	CLIP-seq
MIRT2069495	hsa-miR-891b	CLIP-seq
MIRT1236300	hsa-miR-1203	CLIP-seq
MIRT1236320	hsa-miR-337-3p	CLIP-seq
MIRT1236323	hsa-miR-3612	CLIP-seq
MIRT1236325	hsa-miR-3651	CLIP-seq
MIRT2594268	hsa-miR-3667-5p	CLIP-seq
MIRT1236327	hsa-miR-3685	CLIP-seq
MIRT2594269	hsa-miR-3692	CLIP-seq
MIRT1236328	hsa-miR-384	CLIP-seq
MIRT2296839	hsa-miR-4477b	CLIP-seq
MIRT2594272	hsa-miR-4690-3p	CLIP-seq
MIRT2594273	hsa-miR-4704-5p	CLIP-seq
MIRT1236339	hsa-miR-4711-5p	CLIP-seq
MIRT1236342	hsa-miR-4715-3p	CLIP-seq
MIRT1236344	hsa-miR-4719	CLIP-seq
MIRT1236351	hsa-miR-561	CLIP-seq
MIRT1236355	hsa-miR-650	CLIP-seq

Gene ontology (GO) Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IBA
GO:0005737	Component	Cytoplasm	IDA	25134913
GO:0005737	Component	Cytoplasm	IEA
GO:0007286	Process	Spermatid development	IEA
GO:0007341	Process	Penetration of zona pellucida	IEA
GO:0045654	Process	Positive regulation of megakaryocyte differentiation	IEA
GO:0045654	Process	Positive regulation of megakaryocyte differentiation	IMP	25134913
GO:0045893	Process	Positive regulation of DNA-templated transcription	IDA	25134913
GO:0060255	Process	Regulation of macromolecule metabolic process	IEA
GO:0061136	Process	Regulation of proteasomal protein catabolic process	IEA
GO:0061956	Process	Penetration of cumulus oophorus	IEA
GO:0080090	Process	Regulation of primary metabolic process	IEA
GO:0097598	Component	Sperm cytoplasmic droplet	IEA

Other IDs

• MIM: 618784
• HGNC: 25022
• e!Ensembl: ENSG00000057757

Protein

• UniProt ID: Q9GZP4
• Protein name: PITH domain-containing protein 1
• Protein function: Promotes megakaryocyte differentiation by up-regulating RUNX1 expression (PubMed:25134913). Regulates RUNX1 expression by activating the proximal promoter of the RUNX1 gene and by enhancing the translation activity of an internal ribosome entry
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF06201	PITH	31 → 175	PITH domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Down-regulated in primary acute myeloid leukemia (AML) patients. {ECO:0000269|PubMed:25134913}.
• Sequence:

  MSHGHSHGGGGCRCAAEREEPPEQRGLAYGLYLRIDLERLQCLNESREGSGRGVFKPWEE
  RTDRSKFVESDADEELLFNIPFTGNVKLKGIIIMGEDDDSHPSEMRLYKNIPQMSFDDTE
  REPDQTFSLNRDLTGELEYATKISRFSNVYHLSIHISKNFGADTTKVFYIGLRGEWTELR
  RHEVTICNYEASANPADHRVHQVTPQTHFIS

• Sequence length: 211

Related Genes

No strongly related genes found yet for PITHD1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to PITHD1.