PIP5K1A (phosphatidylinositol-4-phosphate 5-kinase type 1 alpha)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 8394
• Gene name: Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
• Gene symbol: PIP5K1A
• Synonyms (NCBI Gene): -
• Chromosome: 1
• Chromosome location: 1q21.3

miRNA Show/Hide all (317)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021718	hsa-miR-132-3p	Microarray	17612493
MIRT046769	hsa-miR-222-3p	CLASH	23622248
MIRT039898	hsa-miR-615-3p	CLASH	23622248
MIRT039096	hsa-miR-769-3p	CLASH	23622248
MIRT037733	hsa-miR-744-5p	CLASH	23622248
MIRT036493	hsa-miR-1226-3p	CLASH	23622248
MIRT059541	hsa-miR-671-3p	PAR-CLIP	21572407
MIRT550798	hsa-miR-4324	PAR-CLIP	21572407
MIRT059543	hsa-miR-544b	PAR-CLIP	21572407
MIRT550797	hsa-miR-3928-3p	PAR-CLIP	21572407
MIRT550796	hsa-miR-8086	PAR-CLIP	21572407
MIRT059542	hsa-miR-1200	PAR-CLIP	21572407
MIRT059544	hsa-miR-3915	PAR-CLIP	21572407
MIRT181057	hsa-miR-135a-5p	PAR-CLIP	22100165
MIRT181058	hsa-miR-135b-5p	PAR-CLIP	22100165
MIRT445962	hsa-miR-4766-5p	PAR-CLIP	22100165
MIRT445961	hsa-miR-3151-3p	PAR-CLIP	22100165
MIRT445960	hsa-miR-3192-3p	PAR-CLIP	22100165
MIRT181056	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT445959	hsa-miR-4762-3p	PAR-CLIP	22100165
MIRT181057	hsa-miR-135a-5p	PAR-CLIP	22100165
MIRT181058	hsa-miR-135b-5p	PAR-CLIP	22100165
MIRT445962	hsa-miR-4766-5p	PAR-CLIP	22100165
MIRT445961	hsa-miR-3151-3p	PAR-CLIP	22100165
MIRT445960	hsa-miR-3192-3p	PAR-CLIP	22100165
MIRT181056	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT445959	hsa-miR-4762-3p	PAR-CLIP	22100165
MIRT059541	hsa-miR-671-3p	PAR-CLIP	21572407
MIRT550798	hsa-miR-4324	PAR-CLIP	21572407
MIRT059543	hsa-miR-544b	PAR-CLIP	21572407
MIRT550797	hsa-miR-3928-3p	PAR-CLIP	21572407
MIRT550796	hsa-miR-8086	PAR-CLIP	21572407
MIRT059542	hsa-miR-1200	PAR-CLIP	21572407
MIRT059544	hsa-miR-3915	PAR-CLIP	21572407
MIRT181057	hsa-miR-135a-5p	PAR-CLIP	22100165
MIRT181058	hsa-miR-135b-5p	PAR-CLIP	22100165
MIRT445962	hsa-miR-4766-5p	PAR-CLIP	22100165
MIRT445961	hsa-miR-3151-3p	PAR-CLIP	22100165
MIRT445960	hsa-miR-3192-3p	PAR-CLIP	22100165
MIRT181056	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT445959	hsa-miR-4762-3p	PAR-CLIP	22100165
MIRT181057	hsa-miR-135a-5p	PAR-CLIP	22100165
MIRT181058	hsa-miR-135b-5p	PAR-CLIP	22100165
MIRT445962	hsa-miR-4766-5p	PAR-CLIP	22100165
MIRT445961	hsa-miR-3151-3p	PAR-CLIP	22100165
MIRT445960	hsa-miR-3192-3p	PAR-CLIP	22100165
MIRT181056	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT445959	hsa-miR-4762-3p	PAR-CLIP	22100165
MIRT1235791	hsa-miR-1237	CLIP-seq
MIRT1235792	hsa-miR-1248	CLIP-seq
MIRT1235793	hsa-miR-3170	CLIP-seq
MIRT1235794	hsa-miR-4260	CLIP-seq
MIRT1235795	hsa-miR-4514	CLIP-seq
MIRT1235796	hsa-miR-4692	CLIP-seq
MIRT1235797	hsa-miR-4803	CLIP-seq
MIRT1235798	hsa-miR-545	CLIP-seq
MIRT1235799	hsa-miR-578	CLIP-seq
MIRT1235800	hsa-miR-643	CLIP-seq
MIRT1235801	hsa-miR-656	CLIP-seq
MIRT1235802	hsa-miR-885-3p	CLIP-seq
MIRT1235803	hsa-miR-1202	CLIP-seq
MIRT1235804	hsa-miR-1207-5p	CLIP-seq
MIRT1235805	hsa-miR-1227	CLIP-seq
MIRT1235806	hsa-miR-1264	CLIP-seq
MIRT1235807	hsa-miR-1273f	CLIP-seq
MIRT1235808	hsa-miR-1299	CLIP-seq
MIRT1235809	hsa-miR-141	CLIP-seq
MIRT1235810	hsa-miR-200a	CLIP-seq
MIRT1235811	hsa-miR-22	CLIP-seq
MIRT1235812	hsa-miR-23a	CLIP-seq
MIRT1235813	hsa-miR-23b	CLIP-seq
MIRT1235814	hsa-miR-23c	CLIP-seq
MIRT1235815	hsa-miR-3064-5p	CLIP-seq
MIRT1235816	hsa-miR-3065-5p	CLIP-seq
MIRT1235817	hsa-miR-31	CLIP-seq
MIRT1235818	hsa-miR-3120-3p	CLIP-seq
MIRT1235819	hsa-miR-3121-3p	CLIP-seq
MIRT1235820	hsa-miR-3133	CLIP-seq
MIRT1235821	hsa-miR-3153	CLIP-seq
MIRT1235793	hsa-miR-3170	CLIP-seq
MIRT1235822	hsa-miR-3176	CLIP-seq
MIRT1235823	hsa-miR-3180-5p	CLIP-seq
MIRT1235824	hsa-miR-3185	CLIP-seq
MIRT1235825	hsa-miR-3194-5p	CLIP-seq
MIRT1235826	hsa-miR-320a	CLIP-seq
MIRT1235827	hsa-miR-320b	CLIP-seq
MIRT1235828	hsa-miR-320c	CLIP-seq
MIRT1235829	hsa-miR-320d	CLIP-seq
MIRT1235830	hsa-miR-338-3p	CLIP-seq
MIRT1235831	hsa-miR-34a	CLIP-seq
MIRT1235832	hsa-miR-34c-5p	CLIP-seq
MIRT1235833	hsa-miR-361-3p	CLIP-seq
MIRT1235834	hsa-miR-3647-3p	CLIP-seq
MIRT1235835	hsa-miR-3651	CLIP-seq
MIRT1235836	hsa-miR-3652	CLIP-seq
MIRT1235837	hsa-miR-3653	CLIP-seq
MIRT1235838	hsa-miR-3655	CLIP-seq
MIRT1235839	hsa-miR-3658	CLIP-seq
MIRT1235840	hsa-miR-3671	CLIP-seq
MIRT1235841	hsa-miR-3691-3p	CLIP-seq
MIRT1235842	hsa-miR-3714	CLIP-seq
MIRT1235843	hsa-miR-384	CLIP-seq
MIRT1235844	hsa-miR-3908	CLIP-seq
MIRT1235845	hsa-miR-3913-3p	CLIP-seq
MIRT1235846	hsa-miR-3919	CLIP-seq
MIRT1235847	hsa-miR-3922-3p	CLIP-seq
MIRT1235848	hsa-miR-3922-5p	CLIP-seq
MIRT1235849	hsa-miR-3928	CLIP-seq
MIRT1235850	hsa-miR-3972	CLIP-seq
MIRT1235851	hsa-miR-412	CLIP-seq
MIRT1235852	hsa-miR-421	CLIP-seq
MIRT1235794	hsa-miR-4260	CLIP-seq
MIRT1235853	hsa-miR-4272	CLIP-seq
MIRT1235854	hsa-miR-4293	CLIP-seq
MIRT1235855	hsa-miR-4320	CLIP-seq
MIRT1235856	hsa-miR-4429	CLIP-seq
MIRT1235857	hsa-miR-4430	CLIP-seq
MIRT1235858	hsa-miR-4433	CLIP-seq
MIRT1235859	hsa-miR-4480	CLIP-seq
MIRT1235860	hsa-miR-449a	CLIP-seq
MIRT1235861	hsa-miR-449b	CLIP-seq
MIRT1235862	hsa-miR-4505	CLIP-seq
MIRT1235863	hsa-miR-450b-3p	CLIP-seq
MIRT1235864	hsa-miR-4511	CLIP-seq
MIRT1235795	hsa-miR-4514	CLIP-seq
MIRT1235865	hsa-miR-4530	CLIP-seq
MIRT1235866	hsa-miR-455-5p	CLIP-seq
MIRT1235867	hsa-miR-4653-3p	CLIP-seq
MIRT1235868	hsa-miR-4654	CLIP-seq
MIRT1235869	hsa-miR-4686	CLIP-seq
MIRT1235796	hsa-miR-4692	CLIP-seq
MIRT1235870	hsa-miR-4700-3p	CLIP-seq
MIRT1235871	hsa-miR-4713-3p	CLIP-seq
MIRT1235872	hsa-miR-4727-5p	CLIP-seq
MIRT1235873	hsa-miR-4731-5p	CLIP-seq
MIRT1235874	hsa-miR-4738-3p	CLIP-seq
MIRT1235875	hsa-miR-4756-3p	CLIP-seq
MIRT1235876	hsa-miR-4757-5p	CLIP-seq
MIRT1235877	hsa-miR-4763-3p	CLIP-seq
MIRT1235878	hsa-miR-4769-5p	CLIP-seq
MIRT1235879	hsa-miR-4782-5p	CLIP-seq
MIRT1235880	hsa-miR-4797-5p	CLIP-seq
MIRT1235797	hsa-miR-4803	CLIP-seq
MIRT1235881	hsa-miR-489	CLIP-seq
MIRT1235882	hsa-miR-496	CLIP-seq
MIRT1235883	hsa-miR-499-3p	CLIP-seq
MIRT1235884	hsa-miR-499a-3p	CLIP-seq
MIRT1235885	hsa-miR-505	CLIP-seq
MIRT1235886	hsa-miR-5095	CLIP-seq
MIRT1235887	hsa-miR-516b	CLIP-seq
MIRT1235888	hsa-miR-518a-5p	CLIP-seq
MIRT1235889	hsa-miR-527	CLIP-seq
MIRT1235798	hsa-miR-545	CLIP-seq
MIRT1235890	hsa-miR-548ac	CLIP-seq
MIRT1235891	hsa-miR-548ag	CLIP-seq
MIRT1235892	hsa-miR-548ai	CLIP-seq
MIRT1235893	hsa-miR-548d-3p	CLIP-seq
MIRT1235894	hsa-miR-548z	CLIP-seq
MIRT1235895	hsa-miR-596	CLIP-seq
MIRT1235896	hsa-miR-607	CLIP-seq
MIRT1235897	hsa-miR-626	CLIP-seq
MIRT1235898	hsa-miR-630	CLIP-seq
MIRT1235899	hsa-miR-635	CLIP-seq
MIRT1235900	hsa-miR-637	CLIP-seq
MIRT1235901	hsa-miR-638	CLIP-seq
MIRT1235801	hsa-miR-656	CLIP-seq
MIRT1235902	hsa-miR-665	CLIP-seq
MIRT1235903	hsa-miR-802	CLIP-seq
MIRT1235802	hsa-miR-885-3p	CLIP-seq
MIRT1235904	hsa-miR-892b	CLIP-seq
MIRT1235905	hsa-miR-940	CLIP-seq
MIRT1235792	hsa-miR-1248	CLIP-seq
MIRT1235806	hsa-miR-1264	CLIP-seq
MIRT2069396	hsa-miR-1269	CLIP-seq
MIRT2069397	hsa-miR-1269b	CLIP-seq
MIRT2069398	hsa-miR-1288	CLIP-seq
MIRT1235809	hsa-miR-141	CLIP-seq
MIRT1235810	hsa-miR-200a	CLIP-seq
MIRT2069399	hsa-miR-2115	CLIP-seq
MIRT2069400	hsa-miR-2355-5p	CLIP-seq
MIRT1235812	hsa-miR-23a	CLIP-seq
MIRT1235813	hsa-miR-23b	CLIP-seq
MIRT1235814	hsa-miR-23c	CLIP-seq
MIRT1235815	hsa-miR-3064-5p	CLIP-seq
MIRT2069401	hsa-miR-3120-5p	CLIP-seq
MIRT2069402	hsa-miR-3150b-3p	CLIP-seq
MIRT2069403	hsa-miR-3616-3p	CLIP-seq
MIRT1235834	hsa-miR-3647-3p	CLIP-seq
MIRT1235836	hsa-miR-3652	CLIP-seq
MIRT2069404	hsa-miR-3668	CLIP-seq
MIRT1235840	hsa-miR-3671	CLIP-seq
MIRT2069405	hsa-miR-3674	CLIP-seq
MIRT1235843	hsa-miR-384	CLIP-seq
MIRT1235845	hsa-miR-3913-3p	CLIP-seq
MIRT1235849	hsa-miR-3928	CLIP-seq
MIRT2069406	hsa-miR-3943	CLIP-seq
MIRT2069407	hsa-miR-3945	CLIP-seq
MIRT2069408	hsa-miR-3977	CLIP-seq
MIRT2069409	hsa-miR-409-3p	CLIP-seq
MIRT1235851	hsa-miR-412	CLIP-seq
MIRT2069410	hsa-miR-4291	CLIP-seq
MIRT2069411	hsa-miR-4310	CLIP-seq
MIRT2069412	hsa-miR-4323	CLIP-seq
MIRT1235857	hsa-miR-4430	CLIP-seq
MIRT1235862	hsa-miR-4505	CLIP-seq
MIRT1235863	hsa-miR-450b-3p	CLIP-seq
MIRT1235795	hsa-miR-4514	CLIP-seq
MIRT2069413	hsa-miR-4515	CLIP-seq
MIRT1235796	hsa-miR-4692	CLIP-seq
MIRT1235871	hsa-miR-4713-3p	CLIP-seq
MIRT2069414	hsa-miR-4724-3p	CLIP-seq
MIRT1235873	hsa-miR-4731-5p	CLIP-seq
MIRT1235874	hsa-miR-4738-3p	CLIP-seq
MIRT2069415	hsa-miR-4740-5p	CLIP-seq
MIRT1235875	hsa-miR-4756-3p	CLIP-seq
MIRT2069416	hsa-miR-4761-3p	CLIP-seq
MIRT2069417	hsa-miR-4778-3p	CLIP-seq
MIRT2069418	hsa-miR-4784	CLIP-seq
MIRT2069419	hsa-miR-483-5p	CLIP-seq
MIRT1235881	hsa-miR-489	CLIP-seq
MIRT2069420	hsa-miR-516a-3p	CLIP-seq
MIRT1235887	hsa-miR-516b	CLIP-seq
MIRT1235798	hsa-miR-545	CLIP-seq
MIRT2069421	hsa-miR-548c-3p	CLIP-seq
MIRT2069422	hsa-miR-579	CLIP-seq
MIRT1235899	hsa-miR-635	CLIP-seq
MIRT1235900	hsa-miR-637	CLIP-seq
MIRT1235901	hsa-miR-638	CLIP-seq
MIRT1235800	hsa-miR-643	CLIP-seq
MIRT2069423	hsa-miR-765	CLIP-seq
MIRT1235802	hsa-miR-885-3p	CLIP-seq
MIRT1235904	hsa-miR-892b	CLIP-seq
MIRT1235887	hsa-miR-516b	CLIP-seq
MIRT1235834	hsa-miR-3647-3p	CLIP-seq
MIRT2069410	hsa-miR-4291	CLIP-seq
MIRT2069411	hsa-miR-4310	CLIP-seq
MIRT1235873	hsa-miR-4731-5p	CLIP-seq
MIRT2456528	hsa-miR-486-3p	CLIP-seq
MIRT2594226	hsa-miR-1197	CLIP-seq
MIRT2594227	hsa-miR-1245b-3p	CLIP-seq
MIRT1235807	hsa-miR-1273f	CLIP-seq
MIRT2594228	hsa-miR-183	CLIP-seq
MIRT1235817	hsa-miR-31	CLIP-seq
MIRT1235818	hsa-miR-3120-3p	CLIP-seq
MIRT2594229	hsa-miR-3148	CLIP-seq
MIRT2069402	hsa-miR-3150b-3p	CLIP-seq
MIRT2594230	hsa-miR-3190	CLIP-seq
MIRT2594231	hsa-miR-3202	CLIP-seq
MIRT2069403	hsa-miR-3616-3p	CLIP-seq
MIRT1235837	hsa-miR-3653	CLIP-seq
MIRT1235839	hsa-miR-3658	CLIP-seq
MIRT2069404	hsa-miR-3668	CLIP-seq
MIRT2069405	hsa-miR-3674	CLIP-seq
MIRT2594232	hsa-miR-3688-3p	CLIP-seq
MIRT2594233	hsa-miR-383	CLIP-seq
MIRT1235844	hsa-miR-3908	CLIP-seq
MIRT1235845	hsa-miR-3913-3p	CLIP-seq
MIRT2069406	hsa-miR-3943	CLIP-seq
MIRT2069407	hsa-miR-3945	CLIP-seq
MIRT2069412	hsa-miR-4323	CLIP-seq
MIRT1235863	hsa-miR-450b-3p	CLIP-seq
MIRT2594234	hsa-miR-4533	CLIP-seq
MIRT1235869	hsa-miR-4686	CLIP-seq
MIRT1235871	hsa-miR-4713-3p	CLIP-seq
MIRT1235875	hsa-miR-4756-3p	CLIP-seq
MIRT2069416	hsa-miR-4761-3p	CLIP-seq
MIRT2069418	hsa-miR-4784	CLIP-seq
MIRT2069419	hsa-miR-483-5p	CLIP-seq
MIRT1235881	hsa-miR-489	CLIP-seq
MIRT2594235	hsa-miR-548aa	CLIP-seq
MIRT1235897	hsa-miR-626	CLIP-seq
MIRT1235899	hsa-miR-635	CLIP-seq
MIRT1235901	hsa-miR-638	CLIP-seq
MIRT1235800	hsa-miR-643	CLIP-seq
MIRT2594236	hsa-miR-670	CLIP-seq
MIRT2069423	hsa-miR-765	CLIP-seq
MIRT2594226	hsa-miR-1197	CLIP-seq
MIRT2594227	hsa-miR-1245b-3p	CLIP-seq
MIRT1235807	hsa-miR-1273f	CLIP-seq
MIRT2594228	hsa-miR-183	CLIP-seq
MIRT1235817	hsa-miR-31	CLIP-seq
MIRT1235818	hsa-miR-3120-3p	CLIP-seq
MIRT2594229	hsa-miR-3148	CLIP-seq
MIRT2069402	hsa-miR-3150b-3p	CLIP-seq
MIRT1235822	hsa-miR-3176	CLIP-seq
MIRT2594230	hsa-miR-3190	CLIP-seq
MIRT2594231	hsa-miR-3202	CLIP-seq
MIRT2069403	hsa-miR-3616-3p	CLIP-seq
MIRT1235837	hsa-miR-3653	CLIP-seq
MIRT1235839	hsa-miR-3658	CLIP-seq
MIRT2069404	hsa-miR-3668	CLIP-seq
MIRT2069405	hsa-miR-3674	CLIP-seq
MIRT2594232	hsa-miR-3688-3p	CLIP-seq
MIRT2594233	hsa-miR-383	CLIP-seq
MIRT1235844	hsa-miR-3908	CLIP-seq
MIRT1235845	hsa-miR-3913-3p	CLIP-seq
MIRT1235847	hsa-miR-3922-3p	CLIP-seq
MIRT2069406	hsa-miR-3943	CLIP-seq
MIRT2069407	hsa-miR-3945	CLIP-seq
MIRT2069412	hsa-miR-4323	CLIP-seq
MIRT1235863	hsa-miR-450b-3p	CLIP-seq
MIRT2594234	hsa-miR-4533	CLIP-seq
MIRT1235869	hsa-miR-4686	CLIP-seq
MIRT1235871	hsa-miR-4713-3p	CLIP-seq
MIRT1235875	hsa-miR-4756-3p	CLIP-seq
MIRT1235876	hsa-miR-4757-5p	CLIP-seq
MIRT2069416	hsa-miR-4761-3p	CLIP-seq
MIRT2069418	hsa-miR-4784	CLIP-seq
MIRT2069419	hsa-miR-483-5p	CLIP-seq
MIRT1235881	hsa-miR-489	CLIP-seq
MIRT2594235	hsa-miR-548aa	CLIP-seq
MIRT1235897	hsa-miR-626	CLIP-seq
MIRT1235899	hsa-miR-635	CLIP-seq
MIRT1235901	hsa-miR-638	CLIP-seq
MIRT1235800	hsa-miR-643	CLIP-seq
MIRT2594236	hsa-miR-670	CLIP-seq
MIRT2069423	hsa-miR-765	CLIP-seq

Gene ontology (GO) Show/Hide all (57)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000285	Function	1-phosphatidylinositol-3-phosphate 5-kinase activity	TAS
GO:0001726	Component	Ruffle	IEA
GO:0005515	Function	Protein binding	IPI	15157668, 18288197, 20660631, 30194290, 31091439
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IDA	15157668
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005847	Component	MRNA cleavage and polyadenylation specificity factor complex	IDA	18305108
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	20660631
GO:0005886	Component	Plasma membrane	IEA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006650	Process	Glycerophospholipid metabolic process	TAS	8955136
GO:0006661	Process	Phosphatidylinositol biosynthetic process	IEA
GO:0006661	Process	Phosphatidylinositol biosynthetic process	TAS
GO:0006909	Process	Phagocytosis	TAS	19889969
GO:0007165	Process	Signal transduction	TAS	8955136
GO:0008654	Process	Phospholipid biosynthetic process	IDA	15157668
GO:0010761	Process	Fibroblast migration	IEA
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016308	Function	1-phosphatidylinositol-4-phosphate 5-kinase activity	IBA
GO:0016308	Function	1-phosphatidylinositol-4-phosphate 5-kinase activity	IDA	15157668, 21477596, 22942276
GO:0016308	Function	1-phosphatidylinositol-4-phosphate 5-kinase activity	IEA
GO:0016308	Function	1-phosphatidylinositol-4-phosphate 5-kinase activity	TAS	18305108
GO:0016477	Process	Cell migration	NAS	15157668
GO:0016607	Component	Nuclear speck	IDA	18288197
GO:0016607	Component	Nuclear speck	IEA
GO:0016607	Component	Nuclear speck	TAS	19889969
GO:0016740	Function	Transferase activity	IEA
GO:0019900	Function	Kinase binding	IDA	15157668
GO:0030027	Component	Lamellipodium	IDA	15157668
GO:0030027	Component	Lamellipodium	IEA
GO:0030036	Process	Actin cytoskeleton organization	IMP	20660631
GO:0030216	Process	Keratinocyte differentiation	TAS	19889969
GO:0032587	Component	Ruffle membrane	IDA	20660631
GO:0032587	Component	Ruffle membrane	IEA
GO:0042995	Component	Cell projection	IEA
GO:0046488	Process	Phosphatidylinositol metabolic process	IEA
GO:0046488	Process	Phosphatidylinositol metabolic process	IEA
GO:0046854	Process	Phosphatidylinositol phosphate biosynthetic process	IBA
GO:0048041	Process	Focal adhesion assembly	IMP	20660631
GO:0051896	Process	Regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA
GO:0051896	Process	Regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	TAS
GO:0052742	Function	Phosphatidylinositol kinase activity	IEA
GO:0052742	Function	Phosphatidylinositol kinase activity	TAS
GO:0052810	Function	1-phosphatidylinositol-5-kinase activity	TAS
GO:0060326	Process	Cell chemotaxis	IMP	20660631
GO:0072659	Process	Protein localization to plasma membrane	IMP	20660631
GO:0090630	Process	Activation of GTPase activity	IMP	20660631
GO:0097178	Process	Ruffle assembly	IMP	20660631

Other IDs

• MIM: 603275
• HGNC: 8994
• e!Ensembl: ENSG00000143398

Protein

• UniProt ID: Q99755
• Protein name: Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1-alpha) (PtdIns(4)P-5-kinase 1 alpha) (EC 2.7.1.68) (68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha) (Phosphatidylinositol 4-phosphate 5-kinase type I alpha) (PIP5KIalpha)
• Protein function: Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transductio
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01504	PIP5K	166 → 448	Phosphatidylinositol-4-phosphate 5-Kinase	Family

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas. Detected at lower levels in brain, lung and liver. {ECO:0000269|PubMed:8955136}.
• Sequence:

  MASASSGPSSSVGFSSFDPAVPSCTLSSAASGIKRPMASEVLEARQDSYISLVPYASGMP
  IKKIGHRSVDSSGETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIF
  FPSEGSNLTPAHHYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASG
  SLFYVSSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIR
  IVVMNNLLPRSVKMHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADM
  YNALCKTLQRDCLVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALY
  STAMESIQGEARRGGTMETDDHMGGIPARNSKGERLLLYIGIIDILQSYRFVKKLEHSWK
  ALVHDGDTVSVHRPGFYAERFQRFMCNTVFKKIPLKPSPSKKFRSGSSFSRRAGSSGNSC
  ITYQPSVSGEHKAQVTTKAEVEPGVHLGRPDVLPQTPPLEEISEGSPIPDPSFSPLVGET
  LQMLTTSTTLEKLEVAESEFTH

• Sequence length: 562

Pathways

KEGG Pathway	Reactome Pathway
Inositol phosphate metabolism	Synthesis of PIPs at the plasma membrane
Metabolic pathways	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Phosphatidylinositol signaling system
Phospholipase D signaling pathway
Endocytosis
Focal adhesion
Fc gamma R-mediated phagocytosis
Regulation of actin cytoskeleton
Yersinia infection
Choline metabolism in cancer

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Intellectual developmental disorder 60 with seizures	Likely pathogenic	rs933715329	RCV003988763	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
INTELLECTUAL DEVELOPMENTAL DISORDER, AUTOSOMAL DOMINANT 60, WITH SEIZURES	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LYMPHATIC METASTASIS	—	CTD	34755307	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
URINARY BLADDER NEOPLASMS	—	CTD	34755307	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (16)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Carcinoma	Breast Carcinoma	BEFREE	30104711		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	39408874	Associate	★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	31558874		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	31558874	Associate	★☆☆☆☆ Found in Text Mining only
Endometriosis	Endometriosis	Pubtator	34546850	Associate	★☆☆☆☆ Found in Text Mining only
Episodic Kinesigenic Dyskinesia 1	Episodic Kinesigenic Dyskinesia	BEFREE	30321068		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	30104711		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	30194290		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	27588408, 31381135		★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	31558874		★☆☆☆☆ Found in Text Mining only
Metastatic Prostate Carcinoma	Metastatic Prostate Carcinoma	BEFREE	31381135		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	27588408		★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	30194290		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	27588408, 31381135		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	32169757	Stimulate	★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	34323415	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

KCNJ12 2 shared diseasesLymphatic metastasis, Urinary bladder neoplasms 2 shared evidence sourcesCTD (Lymphatic metastasis), CTD (Urinary bladder neoplasms) Related via 2 shared diseases including Lymphatic metastasis, Urinary bladder neoplasms — evidence mostly CTD. PIP5K1B 11 shared pathwaysInositol phosphate metabolism, Phosphatidylinositol signaling system, Phospholipase D signaling pathway, Endocytosis, Focal adhesion, Fc gamma R-mediated phagocytosis, Regulation of actin cytoskeleton, Yersinia infection, Choline metabolism in cancer, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, Synthesis of PIPs at the plasma membrane Related via 11 shared pathways including Inositol phosphate metabolism, Phosphatidylinositol signaling system. PIP5K1C 11 shared pathwaysInositol phosphate metabolism, Phosphatidylinositol signaling system, Phospholipase D signaling pathway, Endocytosis, Focal adhesion, Fc gamma R-mediated phagocytosis, Regulation of actin cytoskeleton, Yersinia infection, Choline metabolism in cancer, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, Synthesis of PIPs at the plasma membrane Related via 11 shared pathways including Inositol phosphate metabolism, Phosphatidylinositol signaling system. AQP3 2 shared diseasesLymphatic metastasis, Urinary bladder neoplasms 2 shared evidence sourcesCTD (Lymphatic metastasis), CTD (Urinary bladder neoplasms) Related via 2 shared diseases including Lymphatic metastasis, Urinary bladder neoplasms — evidence mostly CTD. MT1A 2 shared diseasesLymphatic metastasis, Urinary bladder neoplasms 2 shared evidence sourcesCTD (Lymphatic metastasis), CTD (Urinary bladder neoplasms) Related via 2 shared diseases including Lymphatic metastasis, Urinary bladder neoplasms — evidence mostly CTD.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
KCNJ12	2	["Lymphatic metastasis","Urinary bladder neoplasms"]	0	[]	2	["CTD (Lymphatic metastasis)","CTD (Urinary bladder neoplasms)"]
PIP5K1B	0	[]	11	["Inositol phosphate metabolism","Phosphatidylinositol signaling system","Phospholipase D signaling pathway","Endocytosis","Focal adhesion","Fc gamma R-mediated phagocytosis","Regulation of actin cytoskeleton","Yersinia infection","Choline metabolism in cancer","PI5P, PP2A and IER3 Regulate PI3K\/AKT Signaling","Synthesis of PIPs at the plasma membrane"]	0	[]
PIP5K1C	0	[]	11	["Inositol phosphate metabolism","Phosphatidylinositol signaling system","Phospholipase D signaling pathway","Endocytosis","Focal adhesion","Fc gamma R-mediated phagocytosis","Regulation of actin cytoskeleton","Yersinia infection","Choline metabolism in cancer","PI5P, PP2A and IER3 Regulate PI3K\/AKT Signaling","Synthesis of PIPs at the plasma membrane"]	0	[]
AQP3	2	["Lymphatic metastasis","Urinary bladder neoplasms"]	0	[]	2	["CTD (Lymphatic metastasis)","CTD (Urinary bladder neoplasms)"]
MT1A	2	["Lymphatic metastasis","Urinary bladder neoplasms"]	0	[]	2	["CTD (Lymphatic metastasis)","CTD (Urinary bladder neoplasms)"]

Diseases Linked via Similar Genes

Squamous cell carcinoma Linked via 2 of 5 related genesAQP3, MT1A Hypertension Linked via 1 of 5 related genesKCNJ12 Metabolic syndrome Linked via 1 of 5 related genesKCNJ12 Diabetes mellitus type 2 Linked via 1 of 5 related genesKCNJ12 Kidney disease Linked via 1 of 5 related genesPIP5K1B

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Squamous cell carcinoma	2	["AQP3","MT1A"]
Hypertension	1	["KCNJ12"]
Metabolic syndrome	1	["KCNJ12"]
Diabetes mellitus type 2	1	["KCNJ12"]
Kidney disease	1	["PIP5K1B"]