PIN4 (peptidylprolyl cis/trans isomerase, NIMA-interacting 4)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 5303
• Gene name: Peptidylprolyl cis/trans isomerase, NIMA-interacting 4
• Gene symbol: PIN4
• Synonyms (NCBI Gene): EPVH, PAR14, PAR17, hEPVH, hPar14, hPar17
• Chromosome: X
• Chromosome location: Xq13.1
• Summary: This gene encodes a member of the parvulin subfamily of the peptidyl-prolyl cis/trans isomerase protein family. The encoded protein catalyzes the isomerization of peptidylprolyl bonds, and may play a role in the cell cycle, chromatin remodeling, and/or ri

miRNA Show/Hide all (69)

miRTarBase ID	miRNA	Experiments	Reference
MIRT040573	hsa-miR-92b-3p	CLASH	23622248
MIRT040409	hsa-miR-615-3p	CLASH	23622248
MIRT1235349	hsa-miR-1227	CLIP-seq
MIRT1235350	hsa-miR-1238	CLIP-seq
MIRT1235351	hsa-miR-139-5p	CLIP-seq
MIRT1235352	hsa-miR-141	CLIP-seq
MIRT1235353	hsa-miR-181a	CLIP-seq
MIRT1235354	hsa-miR-181b	CLIP-seq
MIRT1235355	hsa-miR-181c	CLIP-seq
MIRT1235356	hsa-miR-181d	CLIP-seq
MIRT1235357	hsa-miR-200a	CLIP-seq
MIRT1235358	hsa-miR-219-1-3p	CLIP-seq
MIRT1235359	hsa-miR-3136-5p	CLIP-seq
MIRT1235360	hsa-miR-3140-3p	CLIP-seq
MIRT1235361	hsa-miR-323b-3p	CLIP-seq
MIRT1235362	hsa-miR-3910	CLIP-seq
MIRT1235363	hsa-miR-4262	CLIP-seq
MIRT1235364	hsa-miR-4424	CLIP-seq
MIRT1235365	hsa-miR-4427	CLIP-seq
MIRT1235366	hsa-miR-4439	CLIP-seq
MIRT1235367	hsa-miR-4495	CLIP-seq
MIRT1235368	hsa-miR-4513	CLIP-seq
MIRT1235369	hsa-miR-4653-3p	CLIP-seq
MIRT1235370	hsa-miR-4691-5p	CLIP-seq
MIRT1235371	hsa-miR-4729	CLIP-seq
MIRT1235372	hsa-miR-4766-5p	CLIP-seq
MIRT1235373	hsa-miR-488	CLIP-seq
MIRT1235374	hsa-miR-489	CLIP-seq
MIRT1235375	hsa-miR-520f	CLIP-seq
MIRT1235376	hsa-miR-548an	CLIP-seq
MIRT1235377	hsa-miR-582-5p	CLIP-seq
MIRT2392552	hsa-miR-1301	CLIP-seq
MIRT2392553	hsa-miR-4267	CLIP-seq
MIRT2392554	hsa-miR-4660	CLIP-seq
MIRT2392555	hsa-miR-502-5p	CLIP-seq
MIRT2392556	hsa-miR-5047	CLIP-seq
MIRT2392557	hsa-miR-766	CLIP-seq
MIRT2439502	hsa-miR-4494	CLIP-seq
MIRT2439503	hsa-miR-4520a-3p	CLIP-seq
MIRT2439504	hsa-miR-4520b-3p	CLIP-seq
MIRT2439505	hsa-miR-4529-3p	CLIP-seq
MIRT2439506	hsa-miR-4659a-3p	CLIP-seq
MIRT2439507	hsa-miR-4659b-3p	CLIP-seq
MIRT2439508	hsa-miR-499a-5p	CLIP-seq
MIRT2439509	hsa-miR-9	CLIP-seq
MIRT2439510	hsa-miR-942	CLIP-seq
MIRT2439502	hsa-miR-4494	CLIP-seq
MIRT2439503	hsa-miR-4520a-3p	CLIP-seq
MIRT2439504	hsa-miR-4520b-3p	CLIP-seq
MIRT2439505	hsa-miR-4529-3p	CLIP-seq
MIRT2439506	hsa-miR-4659a-3p	CLIP-seq
MIRT2439507	hsa-miR-4659b-3p	CLIP-seq
MIRT2439508	hsa-miR-499a-5p	CLIP-seq
MIRT2439509	hsa-miR-9	CLIP-seq
MIRT2439510	hsa-miR-942	CLIP-seq
MIRT2594053	hsa-miR-1229	CLIP-seq
MIRT2594054	hsa-miR-342-3p	CLIP-seq
MIRT2594055	hsa-miR-377	CLIP-seq
MIRT2594056	hsa-miR-3914	CLIP-seq
MIRT2594057	hsa-miR-409-3p	CLIP-seq
MIRT1235367	hsa-miR-4495	CLIP-seq
MIRT2594058	hsa-miR-603	CLIP-seq
MIRT2594053	hsa-miR-1229	CLIP-seq
MIRT2594054	hsa-miR-342-3p	CLIP-seq
MIRT2594055	hsa-miR-377	CLIP-seq
MIRT2594056	hsa-miR-3914	CLIP-seq
MIRT2594057	hsa-miR-409-3p	CLIP-seq
MIRT1235367	hsa-miR-4495	CLIP-seq
MIRT2594058	hsa-miR-603	CLIP-seq

Gene ontology (GO) Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	IEA
GO:0003681	Function	Bent DNA binding	IDA	12144781
GO:0003690	Function	Double-stranded DNA binding	IDA	17875217
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003755	Function	Peptidyl-prolyl cis-trans isomerase activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 31515488, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	12144781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005694	Component	Chromosome	IDA
GO:0005730	Component	Nucleolus	IDA	19369196
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IDA	12144781
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IEA
GO:0005759	Component	Mitochondrial matrix	IDA	17875217
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0005819	Component	Spindle	IDA	19369196
GO:0005819	Component	Spindle	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0006364	Process	RRNA processing	IEA
GO:0006364	Process	RRNA processing	IMP	19369196
GO:0016853	Function	Isomerase activity	IEA
GO:0030684	Component	Preribosome	IDA	19369196

Other IDs

• MIM: 300252
• HGNC: 8992
• e!Ensembl: ENSG00000102309

Protein

• UniProt ID: Q9Y237
• Protein name: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (EC 5.2.1.8) (Parvulin-14) (Par14) (hPar14) (Parvulin-17) (Par17) (hPar17) (Peptidyl-prolyl cis-trans isomerase Pin4) (PPIase Pin4) (Peptidyl-prolyl cis/trans isomerase EPVH) (hEPVH) (Rotamase Pin4)
• Protein function: Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA. ; Isoform 2 binds to double-stranded DNA. {ECO:0000269|Pub
• PDB: 1EQ3 , 1FJD , 3UI4 , 3UI5 , 3UI6
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13616	Rotamase_3	23 → 131		Domain

• Tissue specificity: TISSUE SPECIFICITY: Isoform 2 is much more stable than isoform 1 (at protein level). Ubiquitous. Isoform 1 and isoform 2 are expressed in kidney, liver, blood vessel, brain, mammary gland, skeletal muscle, small intestine and submandibularis. Isoform 1 tr
• Sequence:

  MPPKGKSGSGKAGKGGAASGSDSADKKAQGPKGGGNAVKVRHILCEKHGKIMEAMEKLKS
  GMRFNEVAAQYSEDKARQGGDLGWMTRGSMVGPFQEAAFALPVSGMDKPVFTDPPVKTKF
  GYHIIMVEGRK

• Sequence length: 131

Related Genes

No strongly related genes found yet for PIN4.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to PIN4.