PIANP (PILR alpha associated neural protein)

Download as csv Download as pdf

Log in to save this analysis

Save This Analysis

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 196500
• Gene name: PILR alpha associated neural protein
• Gene symbol: PIANP
• Synonyms (NCBI Gene): C12orf53, LEDA1, PANP, leda-1
• Chromosome: 12
• Chromosome location: 12p13.31
• Summary: This gene encodes a ligand for the paired immunoglobin-like type 2 receptor alpha, and so may be involved in immune regulation. Alternate splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Sep 2011]

miRNA Show/Hide all (26)

miRTarBase ID	miRNA	Experiments	Reference
MIRT720626	hsa-miR-6758-5p	HITS-CLIP	19536157
MIRT720624	hsa-miR-6856-5p	HITS-CLIP	19536157
MIRT720623	hsa-miR-3943	HITS-CLIP	19536157
MIRT720622	hsa-miR-28-5p	HITS-CLIP	19536157
MIRT720621	hsa-miR-3139	HITS-CLIP	19536157
MIRT720620	hsa-miR-708-5p	HITS-CLIP	19536157
MIRT720619	hsa-miR-6849-3p	HITS-CLIP	19536157
MIRT720618	hsa-miR-7152-3p	HITS-CLIP	19536157
MIRT720617	hsa-miR-4487	HITS-CLIP	19536157
MIRT720616	hsa-miR-4313	HITS-CLIP	19536157
MIRT720615	hsa-miR-6131	HITS-CLIP	19536157
MIRT720614	hsa-miR-6512-3p	HITS-CLIP	19536157
MIRT720613	hsa-miR-6720-5p	HITS-CLIP	19536157
MIRT720626	hsa-miR-6758-5p	HITS-CLIP	19536157
MIRT720624	hsa-miR-6856-5p	HITS-CLIP	19536157
MIRT720623	hsa-miR-3943	HITS-CLIP	19536157
MIRT720622	hsa-miR-28-5p	HITS-CLIP	19536157
MIRT720621	hsa-miR-3139	HITS-CLIP	19536157
MIRT720620	hsa-miR-708-5p	HITS-CLIP	19536157
MIRT720619	hsa-miR-6849-3p	HITS-CLIP	19536157
MIRT720618	hsa-miR-7152-3p	HITS-CLIP	19536157
MIRT720617	hsa-miR-4487	HITS-CLIP	19536157
MIRT720616	hsa-miR-4313	HITS-CLIP	19536157
MIRT720615	hsa-miR-6131	HITS-CLIP	19536157
MIRT720614	hsa-miR-6512-3p	HITS-CLIP	19536157
MIRT720613	hsa-miR-6720-5p	HITS-CLIP	19536157

Gene ontology (GO) Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	TAS
GO:0006950	Process	Response to stress	IEA
GO:0007214	Process	Gamma-aminobutyric acid signaling pathway	IEA
GO:0008542	Process	Visual learning	IEA
GO:0010467	Process	Gene expression	IEA
GO:0014047	Process	Glutamate secretion	IEA
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	ISS
GO:0019904	Function	Protein domain specific binding	IEA
GO:0021542	Process	Dentate gyrus development	IEA
GO:0021549	Process	Cerebellum development	IEA
GO:0035176	Process	Social behavior	IEA
GO:0048872	Process	Homeostasis of number of cells	IEA
GO:0050776	Process	Regulation of immune response	IEA
GO:0098793	Component	Presynapse	IEA

Other IDs

• MIM: 616065
• HGNC: 25338
• e!Ensembl: ENSG00000139200

Protein

• UniProt ID: Q8IYJ0
• Protein name: PILR alpha-associated neural protein (PILR-associating neural protein) (Paired immunoglobin-like type 2 receptor-associating neural protein)
• Protein function: Acts as a ligand for PILRA in neural tissues, where it may be involved in immune regulation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15298	AJAP1_PANP_C	160 → 244	AJAP1/PANP C-terminus	Family

• Tissue specificity: TISSUE SPECIFICITY: Mainly expressed in adult brain and cerebellum. Weaker expression in fetal brain and virtually no expression in spleen, heart, kidney, liver and dorsal ganglion relative to brain. {ECO:0000269|PubMed:21241660}.
• Sequence:

  MESRMWPALLLSHLLPLWPLLLLPLPPPAQGSSSSPRTPPAPARPPCARGGPSAPRHVCV
  WERAPPPSRSPRVPRSRRQVLPGTAPPATPSGFEEGPPSSQYPWAIVWGPTVSREDGGDP
  NSANPGFLDYGFAAPHGLATPHPNSDSMRGDGDGLILGEAPATLRPFLFGGRGEGVDPQL
  YVTITISIIIVLVATGIIFKFCWDRSQKRRRPSGQQGALRQEESQQPLTDLSPAGVTVLG
  AFGDSPTPTPDHEEPRGGPRPGMPHPKGAPAFQLNRIPLVNL

• Sequence length: 282

Pathways

Reactome Pathway:

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Related Genes

No strongly related genes found yet for PIANP.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to PIANP.