PHPT1 (phosphohistidine phosphatase 1)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 29085
• Gene name: Phosphohistidine phosphatase 1
• Gene symbol: PHPT1
• Synonyms (NCBI Gene): CGI-202, HEL-S-132P, HSPC141, PHP, PHP14
• Chromosome: 9
• Chromosome location: 9q34.3
• Summary: This gene encodes an enzyme that catalyzes the reversible dephosphorylation of histidine residues in proteins. It may be involved in the dephosphorylation of G-beta and ATP citrate lyase and in negatively regulating CD4 T lymphocytes by dephosphorylation

miRNA Show/Hide all (153)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023370	hsa-miR-122-5p	Proteomics	21750653
MIRT048120	hsa-miR-197-3p	CLASH	23622248
MIRT047330	hsa-miR-181a-5p	CLASH	23622248
MIRT037322	hsa-miR-877-5p	CLASH	23622248
MIRT1232421	hsa-miR-1287	CLIP-seq
MIRT1232422	hsa-miR-1827	CLIP-seq
MIRT1232423	hsa-miR-214	CLIP-seq
MIRT1232424	hsa-miR-3135b	CLIP-seq
MIRT1232425	hsa-miR-3138	CLIP-seq
MIRT1232426	hsa-miR-3165	CLIP-seq
MIRT1232427	hsa-miR-3612	CLIP-seq
MIRT1232428	hsa-miR-3619-5p	CLIP-seq
MIRT1232429	hsa-miR-3688-5p	CLIP-seq
MIRT1232430	hsa-miR-3922-5p	CLIP-seq
MIRT1232431	hsa-miR-4293	CLIP-seq
MIRT1232432	hsa-miR-4421	CLIP-seq
MIRT1232433	hsa-miR-4435	CLIP-seq
MIRT1232434	hsa-miR-4443	CLIP-seq
MIRT1232435	hsa-miR-4456	CLIP-seq
MIRT1232436	hsa-miR-4520a-3p	CLIP-seq
MIRT1232437	hsa-miR-4690-5p	CLIP-seq
MIRT1232438	hsa-miR-4755-3p	CLIP-seq
MIRT1232439	hsa-miR-4778-5p	CLIP-seq
MIRT1232440	hsa-miR-4795-5p	CLIP-seq
MIRT1232441	hsa-miR-515-5p	CLIP-seq
MIRT1232442	hsa-miR-596	CLIP-seq
MIRT1232443	hsa-miR-604	CLIP-seq
MIRT1232444	hsa-miR-644	CLIP-seq
MIRT1232445	hsa-miR-647	CLIP-seq
MIRT1232446	hsa-miR-650	CLIP-seq
MIRT1232447	hsa-miR-663b	CLIP-seq
MIRT1232448	hsa-miR-761	CLIP-seq
MIRT2295580	hsa-miR-1207-5p	CLIP-seq
MIRT2295581	hsa-miR-1226	CLIP-seq
MIRT2295582	hsa-miR-2276	CLIP-seq
MIRT2295583	hsa-miR-3173-5p	CLIP-seq
MIRT2295584	hsa-miR-3194-5p	CLIP-seq
MIRT2295585	hsa-miR-3918	CLIP-seq
MIRT2295586	hsa-miR-4514	CLIP-seq
MIRT2295587	hsa-miR-4640-5p	CLIP-seq
MIRT1232437	hsa-miR-4690-5p	CLIP-seq
MIRT2295588	hsa-miR-4692	CLIP-seq
MIRT2295589	hsa-miR-4696	CLIP-seq
MIRT2295590	hsa-miR-4722-5p	CLIP-seq
MIRT2295591	hsa-miR-4726-5p	CLIP-seq
MIRT2295592	hsa-miR-4733-3p	CLIP-seq
MIRT2295593	hsa-miR-4763-3p	CLIP-seq
MIRT2295594	hsa-miR-485-5p	CLIP-seq
MIRT2295595	hsa-miR-940	CLIP-seq
MIRT2295580	hsa-miR-1207-5p	CLIP-seq
MIRT2295581	hsa-miR-1226	CLIP-seq
MIRT2295582	hsa-miR-2276	CLIP-seq
MIRT2295583	hsa-miR-3173-5p	CLIP-seq
MIRT2295584	hsa-miR-3194-5p	CLIP-seq
MIRT2295585	hsa-miR-3918	CLIP-seq
MIRT1232431	hsa-miR-4293	CLIP-seq
MIRT2295586	hsa-miR-4514	CLIP-seq
MIRT2295587	hsa-miR-4640-5p	CLIP-seq
MIRT1232437	hsa-miR-4690-5p	CLIP-seq
MIRT2295588	hsa-miR-4692	CLIP-seq
MIRT2295589	hsa-miR-4696	CLIP-seq
MIRT2295591	hsa-miR-4726-5p	CLIP-seq
MIRT2295592	hsa-miR-4733-3p	CLIP-seq
MIRT2295593	hsa-miR-4763-3p	CLIP-seq
MIRT2295594	hsa-miR-485-5p	CLIP-seq
MIRT1232442	hsa-miR-596	CLIP-seq
MIRT2295595	hsa-miR-940	CLIP-seq
MIRT2295582	hsa-miR-2276	CLIP-seq
MIRT2295583	hsa-miR-3173-5p	CLIP-seq
MIRT2295584	hsa-miR-3194-5p	CLIP-seq
MIRT2295589	hsa-miR-4696	CLIP-seq
MIRT2295580	hsa-miR-1207-5p	CLIP-seq
MIRT2295581	hsa-miR-1226	CLIP-seq
MIRT2593159	hsa-miR-1908	CLIP-seq
MIRT2295582	hsa-miR-2276	CLIP-seq
MIRT1232425	hsa-miR-3138	CLIP-seq
MIRT1232426	hsa-miR-3165	CLIP-seq
MIRT2295583	hsa-miR-3173-5p	CLIP-seq
MIRT2295584	hsa-miR-3194-5p	CLIP-seq
MIRT2593160	hsa-miR-3616-5p	CLIP-seq
MIRT2593161	hsa-miR-3647-5p	CLIP-seq
MIRT2295585	hsa-miR-3918	CLIP-seq
MIRT1232430	hsa-miR-3922-5p	CLIP-seq
MIRT2593162	hsa-miR-4283	CLIP-seq
MIRT1232431	hsa-miR-4293	CLIP-seq
MIRT1232432	hsa-miR-4421	CLIP-seq
MIRT1232433	hsa-miR-4435	CLIP-seq
MIRT1232435	hsa-miR-4456	CLIP-seq
MIRT2593163	hsa-miR-4484	CLIP-seq
MIRT2295586	hsa-miR-4514	CLIP-seq
MIRT1232436	hsa-miR-4520a-3p	CLIP-seq
MIRT2295587	hsa-miR-4640-5p	CLIP-seq
MIRT1232437	hsa-miR-4690-5p	CLIP-seq
MIRT2295588	hsa-miR-4692	CLIP-seq
MIRT2295589	hsa-miR-4696	CLIP-seq
MIRT2295590	hsa-miR-4722-5p	CLIP-seq
MIRT2295591	hsa-miR-4726-5p	CLIP-seq
MIRT2295592	hsa-miR-4733-3p	CLIP-seq
MIRT2593164	hsa-miR-4742-5p	CLIP-seq
MIRT1232438	hsa-miR-4755-3p	CLIP-seq
MIRT2295593	hsa-miR-4763-3p	CLIP-seq
MIRT1232439	hsa-miR-4778-5p	CLIP-seq
MIRT1232440	hsa-miR-4795-5p	CLIP-seq
MIRT2295594	hsa-miR-485-5p	CLIP-seq
MIRT1232441	hsa-miR-515-5p	CLIP-seq
MIRT2593165	hsa-miR-573	CLIP-seq
MIRT1232442	hsa-miR-596	CLIP-seq
MIRT1232443	hsa-miR-604	CLIP-seq
MIRT1232445	hsa-miR-647	CLIP-seq
MIRT2593166	hsa-miR-663	CLIP-seq
MIRT1232447	hsa-miR-663b	CLIP-seq
MIRT2593167	hsa-miR-760	CLIP-seq
MIRT2295595	hsa-miR-940	CLIP-seq
MIRT2295580	hsa-miR-1207-5p	CLIP-seq
MIRT2295581	hsa-miR-1226	CLIP-seq
MIRT2593159	hsa-miR-1908	CLIP-seq
MIRT2295582	hsa-miR-2276	CLIP-seq
MIRT1232425	hsa-miR-3138	CLIP-seq
MIRT1232426	hsa-miR-3165	CLIP-seq
MIRT2295583	hsa-miR-3173-5p	CLIP-seq
MIRT2295584	hsa-miR-3194-5p	CLIP-seq
MIRT2593160	hsa-miR-3616-5p	CLIP-seq
MIRT2593161	hsa-miR-3647-5p	CLIP-seq
MIRT2295585	hsa-miR-3918	CLIP-seq
MIRT1232430	hsa-miR-3922-5p	CLIP-seq
MIRT2593162	hsa-miR-4283	CLIP-seq
MIRT1232431	hsa-miR-4293	CLIP-seq
MIRT1232432	hsa-miR-4421	CLIP-seq
MIRT1232433	hsa-miR-4435	CLIP-seq
MIRT1232435	hsa-miR-4456	CLIP-seq
MIRT2593163	hsa-miR-4484	CLIP-seq
MIRT2295586	hsa-miR-4514	CLIP-seq
MIRT1232436	hsa-miR-4520a-3p	CLIP-seq
MIRT2295587	hsa-miR-4640-5p	CLIP-seq
MIRT1232437	hsa-miR-4690-5p	CLIP-seq
MIRT2295588	hsa-miR-4692	CLIP-seq
MIRT2295589	hsa-miR-4696	CLIP-seq
MIRT2295590	hsa-miR-4722-5p	CLIP-seq
MIRT2295591	hsa-miR-4726-5p	CLIP-seq
MIRT2295592	hsa-miR-4733-3p	CLIP-seq
MIRT2593164	hsa-miR-4742-5p	CLIP-seq
MIRT1232438	hsa-miR-4755-3p	CLIP-seq
MIRT2295593	hsa-miR-4763-3p	CLIP-seq
MIRT1232439	hsa-miR-4778-5p	CLIP-seq
MIRT1232440	hsa-miR-4795-5p	CLIP-seq
MIRT2295594	hsa-miR-485-5p	CLIP-seq
MIRT1232441	hsa-miR-515-5p	CLIP-seq
MIRT2593165	hsa-miR-573	CLIP-seq
MIRT1232442	hsa-miR-596	CLIP-seq
MIRT2593166	hsa-miR-663	CLIP-seq
MIRT1232447	hsa-miR-663b	CLIP-seq
MIRT2593167	hsa-miR-760	CLIP-seq
MIRT2295595	hsa-miR-940	CLIP-seq

Gene ontology (GO) Show/Hide all (28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004857	Function	Enzyme inhibitor activity	IDA	18656514
GO:0005515	Function	Protein binding	IPI	16713569, 18796614, 32814053
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	20501872
GO:0005829	Component	Cytosol	IEA
GO:0005886	Component	Plasma membrane	IDA
GO:0016604	Component	Nuclear body	IDA
GO:0016787	Function	Hydrolase activity	IEA
GO:0019855	Function	Calcium channel inhibitor activity	IDA	18796614
GO:0030036	Process	Actin cytoskeleton organization	IDA	27924678
GO:0030036	Process	Actin cytoskeleton organization	IMP	19344975
GO:0035774	Process	Positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISS	20501872
GO:0044325	Function	Transmembrane transporter binding	IPI	18796614
GO:0050860	Process	Negative regulation of T cell receptor signaling pathway	IMP	18796614
GO:0051015	Function	Actin filament binding	IDA	27924678
GO:0061851	Component	Leading edge of lamellipodium	IDA	27924678
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0097581	Process	Lamellipodium organization	IDA	27924678
GO:0101006	Function	Protein histidine phosphatase activity	IBA
GO:0101006	Function	Protein histidine phosphatase activity	IDA	16219293, 19138678, 20501872
GO:0101006	Function	Protein histidine phosphatase activity	IEA
GO:0101006	Function	Protein histidine phosphatase activity	IMP	18796614
GO:2000147	Process	Positive regulation of cell motility	IBA
GO:2000147	Process	Positive regulation of cell motility	IEA
GO:2000147	Process	Positive regulation of cell motility	IMP	19344975

Other IDs

• MIM: 610167
• HGNC: 30033
• e!Ensembl: ENSG00000054148

Protein

• UniProt ID: Q9NRX4
• Protein name: 14 kDa phosphohistidine phosphatase (EC 3.9.1.3) (Phosphohistidine phosphatase 1) (PHPT1) (Protein histidine phosphatase) (PHP) (Protein janus-A homolog)
• Protein function: Exhibits phosphohistidine phosphatase activity.
• PDB: 2AI6 , 2HW4 , 2NMM , 2OZW , 2OZX
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05005	Ocnus	6 → 117	Janus/Ocnus family (Ocnus)	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed abundantly in heart and skeletal muscle. {ECO:0000269|PubMed:12383260}.
• Sequence:

  MAVADLALIPDVDIDSDGVFKYVLIRVHSAPRSGAPAAESKEIVRGYKWAEYHADIYDKV
  SGDMQKQGCDCECLGGGRISHQSQDKKIHVYGYSMAYGPAQHAISTEKIKAKYPDYEVTW
  ANDGY

• Sequence length: 125

Related Genes

No strongly related genes found yet for PHPT1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to PHPT1.