PFDN5 (prefoldin subunit 5)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 5204
• Gene name: Prefoldin subunit 5
• Gene symbol: PFDN5
• Synonyms (NCBI Gene): MM-1, MM1, PFD5
• Chromosome: 12
• Chromosome location: 12q13.13
• Summary: This gene encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The

miRNA Show/Hide all (90)

miRTarBase ID	miRNA	Experiments	Reference
MIRT028919	hsa-miR-26b-5p	Microarray	19088304
MIRT1226142	hsa-miR-1226	CLIP-seq
MIRT1226143	hsa-miR-1256	CLIP-seq
MIRT1226144	hsa-miR-3667-5p	CLIP-seq
MIRT1226145	hsa-miR-4642	CLIP-seq
MIRT1226146	hsa-miR-4731-3p	CLIP-seq
MIRT1226147	hsa-miR-4733-3p	CLIP-seq
MIRT1226148	hsa-miR-4786-3p	CLIP-seq
MIRT1226149	hsa-miR-4801	CLIP-seq
MIRT1226150	hsa-miR-671-5p	CLIP-seq
MIRT1226142	hsa-miR-1226	CLIP-seq
MIRT2066099	hsa-miR-1913	CLIP-seq
MIRT2066100	hsa-miR-2276	CLIP-seq
MIRT2066101	hsa-miR-3189-5p	CLIP-seq
MIRT2066102	hsa-miR-324-3p	CLIP-seq
MIRT2066103	hsa-miR-3657	CLIP-seq
MIRT1226147	hsa-miR-4733-3p	CLIP-seq
MIRT2066104	hsa-miR-4758-3p	CLIP-seq
MIRT2066105	hsa-miR-4772-3p	CLIP-seq
MIRT1226148	hsa-miR-4786-3p	CLIP-seq
MIRT2066106	hsa-miR-544	CLIP-seq
MIRT2066107	hsa-miR-642a	CLIP-seq
MIRT1226150	hsa-miR-671-5p	CLIP-seq
MIRT1226142	hsa-miR-1226	CLIP-seq
MIRT2066099	hsa-miR-1913	CLIP-seq
MIRT2066100	hsa-miR-2276	CLIP-seq
MIRT2066101	hsa-miR-3189-5p	CLIP-seq
MIRT2066102	hsa-miR-324-3p	CLIP-seq
MIRT2066103	hsa-miR-3657	CLIP-seq
MIRT1226144	hsa-miR-3667-5p	CLIP-seq
MIRT2293759	hsa-miR-4729	CLIP-seq
MIRT1226146	hsa-miR-4731-3p	CLIP-seq
MIRT1226147	hsa-miR-4733-3p	CLIP-seq
MIRT2066104	hsa-miR-4758-3p	CLIP-seq
MIRT2066105	hsa-miR-4772-3p	CLIP-seq
MIRT1226148	hsa-miR-4786-3p	CLIP-seq
MIRT1226149	hsa-miR-4801	CLIP-seq
MIRT2066106	hsa-miR-544	CLIP-seq
MIRT2293760	hsa-miR-548ae	CLIP-seq
MIRT2293761	hsa-miR-548aj	CLIP-seq
MIRT2293762	hsa-miR-548am	CLIP-seq
MIRT2293763	hsa-miR-548x	CLIP-seq
MIRT2066107	hsa-miR-642a	CLIP-seq
MIRT1226150	hsa-miR-671-5p	CLIP-seq
MIRT1226142	hsa-miR-1226	CLIP-seq
MIRT1226143	hsa-miR-1256	CLIP-seq
MIRT2066099	hsa-miR-1913	CLIP-seq
MIRT2066100	hsa-miR-2276	CLIP-seq
MIRT2066101	hsa-miR-3189-5p	CLIP-seq
MIRT2066102	hsa-miR-324-3p	CLIP-seq
MIRT2066103	hsa-miR-3657	CLIP-seq
MIRT1226144	hsa-miR-3667-5p	CLIP-seq
MIRT1226145	hsa-miR-4642	CLIP-seq
MIRT2293759	hsa-miR-4729	CLIP-seq
MIRT1226146	hsa-miR-4731-3p	CLIP-seq
MIRT1226147	hsa-miR-4733-3p	CLIP-seq
MIRT2066104	hsa-miR-4758-3p	CLIP-seq
MIRT2066105	hsa-miR-4772-3p	CLIP-seq
MIRT1226148	hsa-miR-4786-3p	CLIP-seq
MIRT1226149	hsa-miR-4801	CLIP-seq
MIRT2066106	hsa-miR-544	CLIP-seq
MIRT2293760	hsa-miR-548ae	CLIP-seq
MIRT2293761	hsa-miR-548aj	CLIP-seq
MIRT2293762	hsa-miR-548am	CLIP-seq
MIRT2293763	hsa-miR-548x	CLIP-seq
MIRT2066107	hsa-miR-642a	CLIP-seq
MIRT1226150	hsa-miR-671-5p	CLIP-seq
MIRT1226142	hsa-miR-1226	CLIP-seq
MIRT1226143	hsa-miR-1256	CLIP-seq
MIRT2066099	hsa-miR-1913	CLIP-seq
MIRT2066100	hsa-miR-2276	CLIP-seq
MIRT2066101	hsa-miR-3189-5p	CLIP-seq
MIRT2066102	hsa-miR-324-3p	CLIP-seq
MIRT2066103	hsa-miR-3657	CLIP-seq
MIRT1226144	hsa-miR-3667-5p	CLIP-seq
MIRT1226145	hsa-miR-4642	CLIP-seq
MIRT2293759	hsa-miR-4729	CLIP-seq
MIRT1226146	hsa-miR-4731-3p	CLIP-seq
MIRT1226147	hsa-miR-4733-3p	CLIP-seq
MIRT2066104	hsa-miR-4758-3p	CLIP-seq
MIRT2066105	hsa-miR-4772-3p	CLIP-seq
MIRT1226148	hsa-miR-4786-3p	CLIP-seq
MIRT1226149	hsa-miR-4801	CLIP-seq
MIRT2066106	hsa-miR-544	CLIP-seq
MIRT2293760	hsa-miR-548ae	CLIP-seq
MIRT2293761	hsa-miR-548aj	CLIP-seq
MIRT2293762	hsa-miR-548am	CLIP-seq
MIRT2293763	hsa-miR-548x	CLIP-seq
MIRT2066107	hsa-miR-642a	CLIP-seq
MIRT1226150	hsa-miR-671-5p	CLIP-seq

Gene ontology (GO) Show/Hide all (28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001540	Function	Amyloid-beta binding	IDA	23614719
GO:0003714	Function	Transcription corepressor activity	TAS	9792694
GO:0005515	Function	Protein binding	IPI	17728244, 21516116, 25036637, 25416956, 28514442, 31515488, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	9792694
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	16130169
GO:0005829	Component	Cytosol	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	TAS	9792694
GO:0006457	Process	Protein folding	IDA	30955883
GO:0006457	Process	Protein folding	IEA
GO:0006457	Process	Protein folding	NAS	32699605
GO:0016272	Component	Prefoldin complex	IBA
GO:0016272	Component	Prefoldin complex	IDA	23614719, 30955883
GO:0016272	Component	Prefoldin complex	IEA
GO:0016272	Component	Prefoldin complex	NAS	32699605
GO:0032991	Component	Protein-containing complex	IEA
GO:0045111	Component	Intermediate filament cytoskeleton	IDA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IMP	18281035
GO:0051082	Function	Unfolded protein binding	IDA	30955883
GO:0051082	Function	Unfolded protein binding	IEA
GO:0060041	Process	Retina development in camera-type eye	IEA
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IMP	18281035
GO:1905907	Process	Negative regulation of amyloid fibril formation	IDA	23614719
GO:1990113	Process	RNA polymerase I assembly	IBA
GO:1990114	Process	RNA polymerase II core complex assembly	IBA
GO:1990115	Process	RNA polymerase III assembly	IBA

Other IDs

• MIM: 604899
• HGNC: 8869
• e!Ensembl: ENSG00000123349

Protein

• UniProt ID: Q99471
• Protein name: Prefoldin subunit 5 (Myc modulator 1) (c-Myc-binding protein Mm-1)
• Protein function: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the tr
• PDB: 6NR8 , 6NR9 , 6NRB , 6NRC , 6NRD , 7WU7
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02996	Prefoldin	22 → 143	Prefoldin subunit	Coiled-coil

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in pancreas and skeletal muscle and moderately in other tissues.
• Sequence:

  MAQSINITELNLPQLEMLKNQLDQEVEFLSTSIAQLKVVQTKYVEAKDCLNVLNKSNEGK
  ELLVPLTSSMYVPGKLHDVEHVLIDVGTGYYVEKTAEDAKDFFKRKIDFLTKQMEKIQPA
  LQEKHAMKQAVMEMMSQKIQQLTALGAAQATAKA

• Sequence length: 154

Related Genes

No strongly related genes found yet for PFDN5.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to PFDN5.