PEAR1 (platelet endothelial aggregation receptor 1)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 375033
• Gene name: Platelet endothelial aggregation receptor 1
• Gene symbol: PEAR1
• Synonyms (NCBI Gene): JEDI, MEGF12
• Chromosome: 1
• Chromosome location: 1q23.1
• Summary: PEAR1 is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation (Nanda et al., 2005 [PubMed 15851471]).[supplied by OMIM, Mar 2008]

miRNA Show/Hide all (131)

miRTarBase ID	miRNA	Experiments	Reference
MIRT655307	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT655306	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT655305	hsa-miR-4793-5p	HITS-CLIP	23824327
MIRT655304	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT655303	hsa-miR-4673	HITS-CLIP	23824327
MIRT655302	hsa-miR-93-3p	HITS-CLIP	23824327
MIRT655301	hsa-miR-383-5p	HITS-CLIP	23824327
MIRT655299	hsa-miR-4772-5p	HITS-CLIP	23824327
MIRT655300	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT655298	hsa-miR-8075	HITS-CLIP	23824327
MIRT655297	hsa-miR-505-5p	HITS-CLIP	23824327
MIRT655296	hsa-miR-6827-5p	HITS-CLIP	23824327
MIRT447329	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT447328	hsa-miR-1273e	PAR-CLIP	22100165
MIRT447329	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT447328	hsa-miR-1273e	PAR-CLIP	22100165
MIRT655307	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT655306	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT655305	hsa-miR-4793-5p	HITS-CLIP	23824327
MIRT655304	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT655303	hsa-miR-4673	HITS-CLIP	23824327
MIRT655302	hsa-miR-93-3p	HITS-CLIP	23824327
MIRT655301	hsa-miR-383-5p	HITS-CLIP	23824327
MIRT655299	hsa-miR-4772-5p	HITS-CLIP	23824327
MIRT655300	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT655298	hsa-miR-8075	HITS-CLIP	23824327
MIRT655297	hsa-miR-505-5p	HITS-CLIP	23824327
MIRT655296	hsa-miR-6827-5p	HITS-CLIP	23824327
MIRT447329	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT447328	hsa-miR-1273e	PAR-CLIP	22100165
MIRT447329	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT447328	hsa-miR-1273e	PAR-CLIP	22100165
MIRT1224406	hsa-miR-1275	CLIP-seq
MIRT1224407	hsa-miR-3202	CLIP-seq
MIRT1224408	hsa-miR-330-3p	CLIP-seq
MIRT1224409	hsa-miR-3934	CLIP-seq
MIRT1224410	hsa-miR-4447	CLIP-seq
MIRT1224411	hsa-miR-4472	CLIP-seq
MIRT1224412	hsa-miR-4476	CLIP-seq
MIRT1224413	hsa-miR-4525	CLIP-seq
MIRT1224414	hsa-miR-4640-5p	CLIP-seq
MIRT1224415	hsa-miR-4665-5p	CLIP-seq
MIRT1224416	hsa-miR-4723-5p	CLIP-seq
MIRT1224417	hsa-miR-4726-5p	CLIP-seq
MIRT1224418	hsa-miR-4742-5p	CLIP-seq
MIRT1224419	hsa-miR-508-5p	CLIP-seq
MIRT1224420	hsa-miR-625	CLIP-seq
MIRT1556798	hsa-miR-137	CLIP-seq
MIRT1556799	hsa-miR-3975	CLIP-seq
MIRT1556800	hsa-miR-4420	CLIP-seq
MIRT1556801	hsa-miR-4519	CLIP-seq
MIRT1224406	hsa-miR-1275	CLIP-seq
MIRT1224407	hsa-miR-3202	CLIP-seq
MIRT1224410	hsa-miR-4447	CLIP-seq
MIRT1224411	hsa-miR-4472	CLIP-seq
MIRT1224412	hsa-miR-4476	CLIP-seq
MIRT1224413	hsa-miR-4525	CLIP-seq
MIRT1224415	hsa-miR-4665-5p	CLIP-seq
MIRT1224416	hsa-miR-4723-5p	CLIP-seq
MIRT1224419	hsa-miR-508-5p	CLIP-seq
MIRT1224420	hsa-miR-625	CLIP-seq
MIRT2293238	hsa-miR-1245b-5p	CLIP-seq
MIRT2293239	hsa-miR-1260	CLIP-seq
MIRT2293240	hsa-miR-1260b	CLIP-seq
MIRT1224406	hsa-miR-1275	CLIP-seq
MIRT2293241	hsa-miR-15a	CLIP-seq
MIRT2293242	hsa-miR-15b	CLIP-seq
MIRT2293243	hsa-miR-16	CLIP-seq
MIRT2293244	hsa-miR-188-3p	CLIP-seq
MIRT2293245	hsa-miR-1913	CLIP-seq
MIRT2293246	hsa-miR-195	CLIP-seq
MIRT2293247	hsa-miR-3074-3p	CLIP-seq
MIRT2293248	hsa-miR-3130-3p	CLIP-seq
MIRT2293249	hsa-miR-3142	CLIP-seq
MIRT2293250	hsa-miR-3156-3p	CLIP-seq
MIRT1224407	hsa-miR-3202	CLIP-seq
MIRT2293251	hsa-miR-324-3p	CLIP-seq
MIRT2293252	hsa-miR-331-3p	CLIP-seq
MIRT2293253	hsa-miR-3665	CLIP-seq
MIRT1224409	hsa-miR-3934	CLIP-seq
MIRT2293254	hsa-miR-424	CLIP-seq
MIRT1556800	hsa-miR-4420	CLIP-seq
MIRT1224410	hsa-miR-4447	CLIP-seq
MIRT2293255	hsa-miR-4468	CLIP-seq
MIRT1224411	hsa-miR-4472	CLIP-seq
MIRT1224412	hsa-miR-4476	CLIP-seq
MIRT2293256	hsa-miR-4477b	CLIP-seq
MIRT2293257	hsa-miR-4512	CLIP-seq
MIRT1224413	hsa-miR-4525	CLIP-seq
MIRT1224415	hsa-miR-4665-5p	CLIP-seq
MIRT1224416	hsa-miR-4723-5p	CLIP-seq
MIRT2293258	hsa-miR-4749-3p	CLIP-seq
MIRT2293259	hsa-miR-4753-5p	CLIP-seq
MIRT2293260	hsa-miR-4793-3p	CLIP-seq
MIRT2293261	hsa-miR-497	CLIP-seq
MIRT1224419	hsa-miR-508-5p	CLIP-seq
MIRT2293262	hsa-miR-561	CLIP-seq
MIRT1224420	hsa-miR-625	CLIP-seq
MIRT2293263	hsa-miR-657	CLIP-seq
MIRT1224406	hsa-miR-1275	CLIP-seq
MIRT2392363	hsa-miR-2110	CLIP-seq
MIRT2392364	hsa-miR-3150a-3p	CLIP-seq
MIRT2392365	hsa-miR-3175	CLIP-seq
MIRT1224410	hsa-miR-4447	CLIP-seq
MIRT1224411	hsa-miR-4472	CLIP-seq
MIRT2293257	hsa-miR-4512	CLIP-seq
MIRT1224413	hsa-miR-4525	CLIP-seq
MIRT1224415	hsa-miR-4665-5p	CLIP-seq
MIRT1224416	hsa-miR-4723-5p	CLIP-seq
MIRT2392366	hsa-miR-512-5p	CLIP-seq
MIRT1224420	hsa-miR-625	CLIP-seq
MIRT2392367	hsa-miR-939	CLIP-seq
MIRT1224407	hsa-miR-3202	CLIP-seq
MIRT1224409	hsa-miR-3934	CLIP-seq
MIRT2591299	hsa-miR-3944-5p	CLIP-seq
MIRT1224412	hsa-miR-4476	CLIP-seq
MIRT1224419	hsa-miR-508-5p	CLIP-seq
MIRT2687557	hsa-miR-217	CLIP-seq
MIRT1224407	hsa-miR-3202	CLIP-seq
MIRT1224409	hsa-miR-3934	CLIP-seq
MIRT2591299	hsa-miR-3944-5p	CLIP-seq
MIRT2687558	hsa-miR-4274	CLIP-seq
MIRT2687559	hsa-miR-4418	CLIP-seq
MIRT1224412	hsa-miR-4476	CLIP-seq
MIRT1556801	hsa-miR-4519	CLIP-seq
MIRT2687560	hsa-miR-4524	CLIP-seq
MIRT1224419	hsa-miR-508-5p	CLIP-seq
MIRT2687561	hsa-miR-509-3-5p	CLIP-seq
MIRT2687562	hsa-miR-509-5p	CLIP-seq
MIRT2687563	hsa-miR-668	CLIP-seq
MIRT2687564	hsa-miR-935	CLIP-seq

Gene ontology (GO) Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001891	Component	Phagocytic cup	IEA
GO:0005515	Function	Protein binding	IPI	32296183, 36792666
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0010572	Process	Positive regulation of platelet activation	IEA
GO:0010572	Process	Positive regulation of platelet activation	IMP	36792666
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0030027	Component	Lamellipodium	IDA	36792666
GO:0030027	Component	Lamellipodium	IEA
GO:0038023	Function	Signaling receptor activity	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043491	Process	Phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA
GO:0043654	Process	Recognition of apoptotic cell	IEA
GO:0070527	Process	Platelet aggregation	IEA

Other IDs

• MIM: 610278
• HGNC: 33631
• e!Ensembl: ENSG00000187800

Protein

• UniProt ID: Q5VY43
• Protein name: Platelet endothelial aggregation receptor 1 (hPEAR1) (Multiple epidermal growth factor-like domains protein 12) (Multiple EGF-like domains protein 12)
• Protein function: Required for SVEP1-mediated platelet activation, via its interaction with SVEP1 and subsequent activation of AKT/mTOR signaling (PubMed:36792666). May be involved in the early stages of hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8VIK
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00053	Laminin_EGF	319 → 365	Laminin EGF domain	Domain
  PF00053	Laminin_EGF	622 → 667	Laminin EGF domain	Domain
  PF00053	Laminin_EGF	276 → 321	Laminin EGF domain	Domain
  PF00053	Laminin_EGF	537 → 582	Laminin EGF domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in umbilical vein endothelial cells and platelets (at protein level) (PubMed:15851471, PubMed:36792666). Expressed in coronary artery smooth muscle cells (at protein level) (PubMed:36792666). Expressed in heart, kidney, skele
• Sequence:

  MSPPLCPLLLLAVGLRLAGTLNPSDPNTCSFWESFTTTTKESHSRPFSLLPSEPCERPWE
  GPHTCPQPTVVYRTVYRQVVKTDHRQRLQCCHGFYESRGFCVPLCAQECVHGRCVAPNQC
  QCVPGWRGDDCSSECAPGMWGPQCDKPCSCGNNSSCDPKSGVCSCPSGLQPPNCLQPCTP
  GYYGPACQFRCQCHGAPCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGV
  FQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQECRCHNGGLCDRFTGQCRCAPGYTGD
  RCREECPVGRFGQDCAETCDCAPDARCFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQ
  APCTCDREHSLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQATS
  GLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVP
  CPPGTWGFSCNASCQCAHEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASRCDCD
  HSDGCDPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTCLPENGNCVCAPG
  FRGPSCQRSCQPGRYGKRCVPCKCANHSFCHPSNGTCYCLAGWTGPDCSQPCPPGHWGEN
  CAQTCQCHHGGTCHPQDGSCICPLGWTGHHCLEGCPLGTFGANCSQPCQCGPGEKCHPET
  GACVCPPGHSGAPCRIGIQEPFTVMPTTPVAYNSLGAVIGIAVLGSLVVALVALFIGYRH
  WQKGKEHHHLAVAYSSGRLDGSEYVMPDVPPSYSHYYSNPSYHTLSQCSPNPPPPNKVPG
  PLFASLQNPERPGGAQGHDNHTTLPADWKHRREPPPGPLDRGSSRLDRSYSYSYSNGPGP
  FYNKGLISEEELGASVASLSSENPYATIRDLPSLPGGPRESSYMEMKGPPSGSPPRQPPQ
  FWDSQRRRQPQPQRDSGTYEQPSPLIHDRDSVGSQPPLPPGLPPGHYDSPKNSHIPGHYD
  LPPVRHPPSPPLRRQDR

• Sequence length: 1037

Related Genes

No strongly related genes found yet for PEAR1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to PEAR1.