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Gene Gene information from NCBI Gene database.
Entrez ID 51449
Gene name Prenylcysteine oxidase 1
Gene symbol PCYOX1
Synonyms (NCBI Gene)
PCL1
Chromosome 2
Chromosome location 2p13.3
Summary Prenylcysteine is released during the degradation of prenylated proteins. PCYOX1 catalyzes the degradation of prenylcysteine to yield free cysteines and a hydrophobic isoprenoid product (Tschantz et al., 1999 [PubMed 10585463]).[supplied by OMIM, Mar 2008
miRNA miRNA information provided by mirtarbase database.
1007 Show/Hide all (1007)
miRTarBase ID miRNA Experiments Reference
MIRT016999 hsa-miR-335-5p Microarray 18185580
MIRT020500 hsa-miR-155-5p Proteomics 18668040
MIRT028940 hsa-miR-26b-5p Microarray 19088304
MIRT655332 hsa-miR-6890-3p HITS-CLIP 23824327
MIRT655331 hsa-miR-4783-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
18 Show/Hide all (18)
GO ID Ontology Definition Evidence Reference
GO:0001735 Function Prenylcysteine oxidase activity IBA
GO:0001735 Function Prenylcysteine oxidase activity IDA 10585463, 11078725, 12186880
GO:0001735 Function Prenylcysteine oxidase activity IEA
GO:0005515 Function Protein binding IPI 32296183, 33961781
GO:0005764 Component Lysosome IDA 10585463
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
610995 20588 ENSG00000116005
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UHG3
Protein name Prenylcysteine oxidase 1 (EC 1.8.3.5) (Prenylcysteine lyase)
Protein function Prenylcysteine oxidase that cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine (PubMed:10585463, PubMed:11078725, PubMed:12186880). Only active against free prenylcysteines and not prenylcystein
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07156 Prenylcys_lyase 128 → 494 Prenylcysteine lyase Family
PF13450 NAD_binding_8 39 → 106 Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:10585463}.
Sequence
Sequence length 505
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway
Terpenoid backbone biosynthesis
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
Cervical cancer Uncertain significance ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma Uncertain significance ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (6)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Arrhythmogenic Right Ventricular Dysplasia Arrhythmogenic right ventricular cardiomyopathy Pubtator 33904367 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Cardiovascular Diseases Cardiovascular Diseases BEFREE 28930587
★★★★★
★☆☆☆☆
Found in Text Mining only
Coronary Disease Coronary artery disease Pubtator 33904367 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Diabetes Gestational Gestational diabetes Pubtator 32111749 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Liver Diseases Liver disease Pubtator 40004184 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Raynaud Disease Raynaud disease Pubtator 33904367 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only