PCSK4 (proprotein convertase subtilisin/kexin type 4)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 54760
• Gene name: Proprotein convertase subtilisin/kexin type 4
• Gene symbol: PCSK4
• Synonyms (NCBI Gene): PC4, SPC5
• Chromosome: 19
• Chromosome location: 19p13.3
• Summary: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein under

miRNA Show/Hide all (37)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018385	hsa-miR-335-5p	Microarray	18185580
MIRT490038	hsa-miR-3937	PAR-CLIP	23592263
MIRT490037	hsa-miR-211-3p	PAR-CLIP	23592263
MIRT490036	hsa-miR-4270	PAR-CLIP	23592263
MIRT490035	hsa-miR-4441	PAR-CLIP	23592263
MIRT490034	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT490032	hsa-miR-711	PAR-CLIP	23592263
MIRT490033	hsa-miR-6809-5p	PAR-CLIP	23592263
MIRT490031	hsa-miR-1908-5p	PAR-CLIP	23592263
MIRT490030	hsa-miR-663a	PAR-CLIP	23592263
MIRT490029	hsa-miR-6787-5p	PAR-CLIP	23592263
MIRT490038	hsa-miR-3937	PAR-CLIP	23592263
MIRT490037	hsa-miR-211-3p	PAR-CLIP	23592263
MIRT490036	hsa-miR-4270	PAR-CLIP	23592263
MIRT490035	hsa-miR-4441	PAR-CLIP	23592263
MIRT490034	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT490032	hsa-miR-711	PAR-CLIP	23592263
MIRT490033	hsa-miR-6809-5p	PAR-CLIP	23592263
MIRT490031	hsa-miR-1908-5p	PAR-CLIP	23592263
MIRT490030	hsa-miR-663a	PAR-CLIP	23592263
MIRT490029	hsa-miR-6787-5p	PAR-CLIP	23592263
MIRT1218481	hsa-miR-4258	CLIP-seq
MIRT1218482	hsa-miR-4755-3p	CLIP-seq
MIRT1218483	hsa-miR-4768-5p	CLIP-seq
MIRT1218484	hsa-miR-942	CLIP-seq
MIRT1218481	hsa-miR-4258	CLIP-seq
MIRT1218482	hsa-miR-4755-3p	CLIP-seq
MIRT1218483	hsa-miR-4768-5p	CLIP-seq
MIRT1218484	hsa-miR-942	CLIP-seq
MIRT1218481	hsa-miR-4258	CLIP-seq
MIRT1218483	hsa-miR-4768-5p	CLIP-seq
MIRT2291581	hsa-miR-550a	CLIP-seq
MIRT1218484	hsa-miR-942	CLIP-seq
MIRT1218481	hsa-miR-4258	CLIP-seq
MIRT1218482	hsa-miR-4755-3p	CLIP-seq
MIRT1218483	hsa-miR-4768-5p	CLIP-seq
MIRT1218484	hsa-miR-942	CLIP-seq

Gene ontology (GO) Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IBA
GO:0001669	Component	Acrosomal vesicle	IEA
GO:0001669	Component	Acrosomal vesicle	ISS
GO:0002080	Component	Acrosomal membrane	IEA
GO:0002080	Component	Acrosomal membrane	ISS
GO:0004252	Function	Serine-type endopeptidase activity	IBA
GO:0004252	Function	Serine-type endopeptidase activity	IEA
GO:0005515	Function	Protein binding	IPI	11164898, 32296183, 32814053
GO:0005802	Component	Trans-Golgi network	IBA
GO:0006508	Process	Proteolysis	IEA
GO:0007339	Process	Binding of sperm to zona pellucida	IEA
GO:0007339	Process	Binding of sperm to zona pellucida	ISS
GO:0007340	Process	Acrosome reaction	IEA
GO:0007340	Process	Acrosome reaction	ISS
GO:0008233	Function	Peptidase activity	IEA
GO:0008236	Function	Serine-type peptidase activity	IEA
GO:0009566	Process	Fertilization	IEA
GO:0009566	Process	Fertilization	ISS
GO:0016020	Component	Membrane	IEA
GO:0016485	Process	Protein processing	IDA	16040806
GO:0016485	Process	Protein processing	IEA
GO:0016486	Process	Peptide hormone processing	IBA
GO:0016787	Function	Hydrolase activity	IEA
GO:0022414	Process	Reproductive process	ISS
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0048240	Process	Sperm capacitation	IEA
GO:0048240	Process	Sperm capacitation	ISS

Other IDs

• MIM: 600487
• HGNC: 8746
• e!Ensembl: ENSG00000115257

Protein

• UniProt ID: Q6UW60
• Protein name: Proprotein convertase subtilisin/kexin type 4 (EC 3.4.21.-) (Proprotein convertase 4) (PC4)
• Protein function: Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues (By similarity). In males, important for ADAM2 processing as well as other acrosomal proteins with
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00082	Peptidase_S8	149 → 432	Subtilase family	Domain
  PF01483	P_proprotein	489 → 575	Proprotein convertase P-domain	Family
  PF16470	S8_pro-domain	37 → 113	Peptidase S8 pro-domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Placenta. {ECO:0000269|PubMed:16040806}.
• Sequence:

  MRPAPIALWLRLVLALALVRPRAVGWAPVRAPIYVSSWAVQVSQGNREVERLARKFGFVN
  LGPIFPDGQYFHLRHRGVVQQSLTPHWGHRLHLKKNPKVQWFQQQTLQRRVKRSVVVPTD
  PWFSKQWYMNSEAQPDLSILQAWSQGLSGQGIVVSVLDDGIEKDHPDLWANYDPLASYDF
  NDYDPDPQPRYTPSKENRHGTRCAGEVAAMANNGFCGVGVAFNARIGGVRMLDGTITDVI
  EAQSLSLQPQHIHIYSASWGPEDDGRTVDGPGILTREAFRRGVTKGRGGLGTLFIWASGN
  GGLHYDNCNCDGYTNSIHTLSVGSTTQQGRVPWYSEACASTLTTTYSSGVATDPQIVTTD
  LHHGCTDQHTGTSASAPLAAGMIALALEANPFLTWRDMQHLVVRASKPAHLQAEDWRTNG
  VGRQVSHHYGYGLLDAGLLVDTARTWLPTQPQRKCAVRVQSRPTPILPLIYIRENVSACA
  GLHNSIRSLEHVQAQLTLSYSRRGDLEISLTSPMGTRSTLVAIRPLDVSTEGYNNWVFMS
  THFWDENPQGVWTLGLENKGYYFNTGTLYRYTLLLYGTAEDMTARPTGPQVTSSACVQRD
  TEGLCQACDGPAYILGQLCLAYCPPRFFNHTRLVTAGPGHTAAPALRVCSSCHASCYTCR
  GGSPRDCTSCPPSSTLDQQQGSCMGPTTPDSRPRLRAAACPHHRCPASAMVLSLLAVTLG
  GPVLCGMSMDLPLYAWLSRARATPTKPQVWLPAGT

• Sequence length: 755

Related Genes

No strongly related genes found yet for PCSK4.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to PCSK4.