PCDHB6 (protocadherin beta 6)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 56130
• Gene name: Protocadherin beta 6
• Gene symbol: PCDHB6
• Synonyms (NCBI Gene): PCDH-BETA6
• Chromosome: 5
• Chromosome location: 5q31.3
• Summary: This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters.

miRNA Show/Hide all (13)

miRTarBase ID	miRNA	Experiments	Reference
MIRT053692	hsa-miR-181a-5p	Microarray	22942087
MIRT1217217	hsa-miR-1271	CLIP-seq
MIRT1217218	hsa-miR-1275	CLIP-seq
MIRT1217219	hsa-miR-129-5p	CLIP-seq
MIRT1217220	hsa-miR-2116	CLIP-seq
MIRT1217221	hsa-miR-3168	CLIP-seq
MIRT1217222	hsa-miR-338-5p	CLIP-seq
MIRT1217223	hsa-miR-3591-5p	CLIP-seq
MIRT1217224	hsa-miR-4255	CLIP-seq
MIRT1217225	hsa-miR-4260	CLIP-seq
MIRT1217226	hsa-miR-4665-5p	CLIP-seq
MIRT1217227	hsa-miR-564	CLIP-seq
MIRT1217228	hsa-miR-96	CLIP-seq

Gene ontology (GO) Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IEA
GO:0005509	Function	Calcium ion binding	ISS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS	10380929
GO:0007155	Process	Cell adhesion	IBA
GO:0007155	Process	Cell adhesion	IEA
GO:0007155	Process	Cell adhesion	TAS	10380929
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IEA
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	ISS
GO:0007268	Process	Chemical synaptic transmission	TAS	12231349
GO:0007399	Process	Nervous system development	IEA
GO:0007399	Process	Nervous system development	TAS	10380929
GO:0007416	Process	Synapse assembly	TAS	12231349
GO:0009988	Process	Cell-cell recognition	ISS
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	11322959
GO:0016339	Process	Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	NAS	11322959
GO:0042802	Function	Identical protein binding	ISS
GO:0045202	Component	Synapse	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0050839	Function	Cell adhesion molecule binding	IBA

Other IDs

• MIM: 606332
• HGNC: 8691
• e!Ensembl: ENSG00000113211

Protein

• UniProt ID: Q9Y5E3
• Protein name: Protocadherin beta-6 (PCDH-beta-6)
• Protein function: Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00028	Cadherin	246 → 336	Cadherin domain	Domain
  PF00028	Cadherin	454 → 550	Cadherin domain	Domain
  PF00028	Cadherin	139 → 232	Cadherin domain	Domain
  PF00028	Cadherin	573 → 661	Cadherin domain	Domain
  PF00028	Cadherin	351 → 440	Cadherin domain	Domain
  PF08266	Cadherin_2	29 → 111	Cadherin-like	Domain
  PF16492	Cadherin_C_2	683 → 766	Cadherin cytoplasmic C-terminal	Family

• Sequence:

  MMQTKVQNKKRQVAFFILLMLWGEVGSESIQYSVLEETESGTFVANLTKDLGLRVGELAS
  RGARVVFKGNRQHLQFDPQTHDLLLNEKLDREELCGSTEPCVLPFQVLLENPLQFFQASL
  RVRDINDHAPEFPAREMLLKISEITMPGKIFPLKMAHDLDTGSNGLQRYTISSNPHFHVL
  TRNRSEGRKFPELVLDKPLDREEQPQLRLTLIALDGGSPPRSGTSEIQIQVLDINDNVPE
  FAQELYEAQVPENNPLGSLVITVSARDLDAGSFGKVSYALFQVDDVNQPFEINAITGEIR
  LRKALDFEEIQSYDVDVEATDGGGLSGKCSLVVRVLDVNDNAPELTMSFFISLIPENLPE
  ITVAVFSVSDADSGHNQQVICSIENNLPFLLRPSVENFYTLVTEGALDRESRAEYNITIT
  VTDLGTPRLKTQQSITVQVSDVNDNVPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGI
  NAQVTYSLLPPQDPHLPLSSLVSINADNGHLFALRSLDYEALQSFEFRVGATDRGSPALS
  SEALVRLLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWL
  SYQLLKATELGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLL
  VDGFSQPYLPLPEAAPAQAQADSLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAASV
  GRYSVPEGPFPGHLVDVSGTGTLSQSYQYKVCLTGGSETNEFKFLKPIMPNFPPQGTERE
  MEETPTSRNSFPFS

• Sequence length: 794

Related Genes

No strongly related genes found yet for PCDHB6.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to PCDHB6.