PCDHB5 (protocadherin beta 5)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 26167
• Gene name: Protocadherin beta 5
• Gene symbol: PCDHB5
• Synonyms (NCBI Gene): PCDH-BETA5
• Chromosome: 5
• Chromosome location: 5q31.3
• Summary: This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters.

miRNA Show/Hide all (24)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1217214	hsa-miR-421	CLIP-seq
MIRT1217215	hsa-miR-4670-3p	CLIP-seq
MIRT1217216	hsa-miR-4709-5p	CLIP-seq
MIRT2455992	hsa-miR-2355-3p	CLIP-seq
MIRT2455993	hsa-miR-3117-5p	CLIP-seq
MIRT2455994	hsa-miR-425	CLIP-seq
MIRT2455995	hsa-miR-4639-3p	CLIP-seq
MIRT2455996	hsa-miR-4646-3p	CLIP-seq
MIRT2455992	hsa-miR-2355-3p	CLIP-seq
MIRT2455993	hsa-miR-3117-5p	CLIP-seq
MIRT2455994	hsa-miR-425	CLIP-seq
MIRT2455995	hsa-miR-4639-3p	CLIP-seq
MIRT2455996	hsa-miR-4646-3p	CLIP-seq
MIRT2588751	hsa-miR-4694-3p	CLIP-seq
MIRT2588752	hsa-miR-522	CLIP-seq
MIRT2588753	hsa-miR-570	CLIP-seq
MIRT2455992	hsa-miR-2355-3p	CLIP-seq
MIRT2455993	hsa-miR-3117-5p	CLIP-seq
MIRT2455994	hsa-miR-425	CLIP-seq
MIRT2455995	hsa-miR-4639-3p	CLIP-seq
MIRT2455996	hsa-miR-4646-3p	CLIP-seq
MIRT2588751	hsa-miR-4694-3p	CLIP-seq
MIRT2588752	hsa-miR-522	CLIP-seq
MIRT2588753	hsa-miR-570	CLIP-seq

Gene ontology (GO) Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	37207277
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0007155	Process	Cell adhesion	IBA
GO:0007155	Process	Cell adhesion	IEA
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IEA
GO:0007268	Process	Chemical synaptic transmission	TAS	12231349
GO:0007399	Process	Nervous system development	IEA
GO:0007416	Process	Synapse assembly	TAS	12231349
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	11322959
GO:0016339	Process	Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	NAS	11322959
GO:0045202	Component	Synapse	IEA
GO:0050839	Function	Cell adhesion molecule binding	IBA

Other IDs

• MIM: 606331
• HGNC: 8690
• e!Ensembl: ENSG00000113209

Protein

• UniProt ID: Q9Y5E4
• Protein name: Protocadherin beta-5 (PCDH-beta-5)
• Protein function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00028	Cadherin	247 → 337	Cadherin domain	Domain
  PF00028	Cadherin	455 → 551	Cadherin domain	Domain
  PF00028	Cadherin	352 → 441	Cadherin domain	Domain
  PF00028	Cadherin	574 → 662	Cadherin domain	Domain
  PF00028	Cadherin	139 → 233	Cadherin domain	Domain
  PF08266	Cadherin_2	30 → 112	Cadherin-like	Domain
  PF16492	Cadherin_C_2	684 → 767	Cadherin cytoplasmic C-terminal	Family

• Sequence:

  METALAKTPQKRQVMFLAILLLLWEAGSEAVRYSIPEETESGYSVANLAKDLGLGVGELA
  TRGARMHYKGNKELLQLDIKTGNLLLYEKLDREVMCGATEPCILHFQLLLENPVQFFQTD
  LQLTDINDHAPEFPEKEMLLKIPESTQPGTVFPLKIAQDFDIGSNTVQNYTISPNSHFHV
  ATHNRGDGRKYPELVLDKALDREERPELSLTLTALDGGAPPRSGTTTIRIVVLDNNDNAP
  EFLQSFYEVQVPENSPLNSLVVVVSARDLDAGAYGSVAYALFQGDEVTQPFVIDEKTAEI
  RLKRALDFEATPYYNVEIVATDGGGLSGKCTVAIEVVDVNDNAPELTMSTLSSPTPENAP
  ETVVAVFSVSDPDSGDNGRMICSIQNDLPFLLKPTLKNFYTLVTQRTLDRESQAEYNITI
  TVTDMGTPRLKTEHNITVLVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSG
  TNAQVTYSLLPPQNPHLRLASLVSINADNGHLFALRSLDYEALQAFEFRVGATDRGSPAL
  SSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAW
  LSYQLLKATEPGLFSMWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVL
  LVDGFSQPYLPLPEAAPAQAQADSLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAAS
  VGRCSVPEGPFPGHLVDVSGTGTLSQSYHYEVCLTGDSGAGEFKFLKPIIPNLLPQGAGE
  EIGKTAAFRNSFGLN

• Sequence length: 795

Related Genes

No strongly related genes found yet for PCDHB5.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to PCDHB5.