PCDHB3 (protocadherin beta 3)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 56132
• Gene name: Protocadherin beta 3
• Gene symbol: PCDHB3
• Synonyms (NCBI Gene): PCDH-BETA3
• Chromosome: 5
• Chromosome location: 5q31.3
• Summary: This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters.

miRNA Show/Hide all (38)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1217181	hsa-miR-1238	CLIP-seq
MIRT1217182	hsa-miR-3159	CLIP-seq
MIRT1217183	hsa-miR-320a	CLIP-seq
MIRT1217184	hsa-miR-320b	CLIP-seq
MIRT1217185	hsa-miR-320c	CLIP-seq
MIRT1217186	hsa-miR-320d	CLIP-seq
MIRT1217187	hsa-miR-323-5p	CLIP-seq
MIRT1217188	hsa-miR-330-3p	CLIP-seq
MIRT1217189	hsa-miR-374a	CLIP-seq
MIRT1217190	hsa-miR-374b	CLIP-seq
MIRT1217191	hsa-miR-3945	CLIP-seq
MIRT1217192	hsa-miR-4253	CLIP-seq
MIRT1217193	hsa-miR-4264	CLIP-seq
MIRT1217194	hsa-miR-4282	CLIP-seq
MIRT1217195	hsa-miR-4429	CLIP-seq
MIRT1217196	hsa-miR-4495	CLIP-seq
MIRT1217197	hsa-miR-4680-5p	CLIP-seq
MIRT1217198	hsa-miR-4684-5p	CLIP-seq
MIRT1217199	hsa-miR-4704-3p	CLIP-seq
MIRT1217200	hsa-miR-4708-3p	CLIP-seq
MIRT1217201	hsa-miR-4775	CLIP-seq
MIRT1217202	hsa-miR-548n	CLIP-seq
MIRT1217203	hsa-miR-590-3p	CLIP-seq
MIRT1217204	hsa-miR-606	CLIP-seq
MIRT1217205	hsa-miR-656	CLIP-seq
MIRT1217206	hsa-miR-876-3p	CLIP-seq
MIRT1217189	hsa-miR-374a	CLIP-seq
MIRT1217190	hsa-miR-374b	CLIP-seq
MIRT1217194	hsa-miR-4282	CLIP-seq
MIRT1217196	hsa-miR-4495	CLIP-seq
MIRT1217189	hsa-miR-374a	CLIP-seq
MIRT1217190	hsa-miR-374b	CLIP-seq
MIRT1217194	hsa-miR-4282	CLIP-seq
MIRT1217196	hsa-miR-4495	CLIP-seq
MIRT1217189	hsa-miR-374a	CLIP-seq
MIRT1217190	hsa-miR-374b	CLIP-seq
MIRT1217194	hsa-miR-4282	CLIP-seq
MIRT1217196	hsa-miR-4495	CLIP-seq

Gene ontology (GO) Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	10380929
GO:0007155	Process	Cell adhesion	IBA
GO:0007155	Process	Cell adhesion	IEA
GO:0007155	Process	Cell adhesion	TAS	10380929
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IEA
GO:0007268	Process	Chemical synaptic transmission	TAS	12231349
GO:0007399	Process	Nervous system development	IEA
GO:0007399	Process	Nervous system development	TAS	10380929
GO:0007416	Process	Synapse assembly	TAS	12231349
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	11322959
GO:0016339	Process	Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	NAS	11322959
GO:0045202	Component	Synapse	IEA
GO:0050839	Function	Cell adhesion molecule binding	IBA

Other IDs

• MIM: 606329
• HGNC: 8688
• e!Ensembl: ENSG00000113205

Protein

• UniProt ID: Q9Y5E6
• Protein name: Protocadherin beta-3 (PCDH-beta-3)
• Protein function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00028	Cadherin	456 → 552	Cadherin domain	Domain
  PF00028	Cadherin	247 → 338	Cadherin domain	Domain
  PF00028	Cadherin	575 → 663	Cadherin domain	Domain
  PF00028	Cadherin	138 → 233	Cadherin domain	Domain
  PF00028	Cadherin	353 → 442	Cadherin domain	Domain
  PF08266	Cadherin_2	30 → 112	Cadherin-like	Domain
  PF16492	Cadherin_C_2	685 → 768	Cadherin cytoplasmic C-terminal	Family

• Sequence:

  MEAGGERFLRQRQVLLLFVFLGGSLAGSESRRYSVAEEKEKGFLIANLAKDLGLRVEELA
  ARGAQVVSKGNKQHFQLSHQTGDLLLNEKLDREELCGPTEPCILHFQILLQNPLQFVTNE
  LRIIDVNDHSPVFFENEMHLKILESTLPGTVIPLGNAEDLDVGRNSLQNYTITPNSHFHV
  LTRSRRDGRKYPELVLDKALDPEEQPELSLTLTALDGGSPPRSGTAQINIQVLDINDNAP
  EFAQPLYEVAVLENTPVNSVIVTVSASDLDTGSFGTISYAFFHASEEIRKTFQLNPITGD
  MQLVKYLNFEAINSYEVDIEAKDGGGLSGKSTVIVQVVDVNDNPPELTLSSVNSPIPENS
  GETVLAVFSVSDLDSGDNGRVMCSIENNLPFFLKPSVENFYTLVSEGALDRETRSEYNIT
  ITITDLGTPRLKTKYNITVLVSDVNDNAPAFTQISYTLFVRENNSPALHIGSVSATDRDS
  GTNAQVTYSLLPPQDPHLPLSSLVSINADNGHLFALRSLDYEALQAFEFRVGATDRGSPA
  LSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNA
  WLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHV
  LLVDGFSQPYLPLPEAAPAQAQADLLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAA
  SVGRCSVPEGPFPGQMVDVSGTGTLSQSYQYEVCLTGGSGTNEFKFLKPIIPNFVAQGAE
  RVSEANPSFRKSFEFS

• Sequence length: 796

Related Genes

No strongly related genes found yet for PCDHB3.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to PCDHB3.