PCDHB2 (protocadherin beta 2)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 56133
• Gene name: Protocadherin beta 2
• Gene symbol: PCDHB2
• Synonyms (NCBI Gene): PCDH-BETA2
• Chromosome: 5
• Chromosome location: 5q31.3
• Summary: This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters.

miRNA Show/Hide all (37)

miRTarBase ID	miRNA	Experiments	Reference
MIRT671035	hsa-miR-637	HITS-CLIP	23824327
MIRT671033	hsa-miR-4284	HITS-CLIP	23824327
MIRT671034	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT671032	hsa-miR-3180	HITS-CLIP	23824327
MIRT671031	hsa-miR-3180-3p	HITS-CLIP	23824327
MIRT671030	hsa-miR-3196	HITS-CLIP	23824327
MIRT671029	hsa-miR-6816-5p	HITS-CLIP	23824327
MIRT671028	hsa-miR-1237-5p	HITS-CLIP	23824327
MIRT671027	hsa-miR-4488	HITS-CLIP	23824327
MIRT671026	hsa-miR-4697-5p	HITS-CLIP	23824327
MIRT671025	hsa-miR-6795-5p	HITS-CLIP	23824327
MIRT671024	hsa-miR-6887-5p	HITS-CLIP	23824327
MIRT671023	hsa-miR-328-5p	HITS-CLIP	23824327
MIRT671022	hsa-miR-6885-5p	HITS-CLIP	23824327
MIRT671021	hsa-miR-7977	HITS-CLIP	23824327
MIRT671020	hsa-miR-7109-5p	HITS-CLIP	23824327
MIRT671035	hsa-miR-637	HITS-CLIP	23824327
MIRT671033	hsa-miR-4284	HITS-CLIP	23824327
MIRT671034	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT671032	hsa-miR-3180	HITS-CLIP	23824327
MIRT671031	hsa-miR-3180-3p	HITS-CLIP	23824327
MIRT671030	hsa-miR-3196	HITS-CLIP	23824327
MIRT671029	hsa-miR-6816-5p	HITS-CLIP	23824327
MIRT671028	hsa-miR-1237-5p	HITS-CLIP	23824327
MIRT671027	hsa-miR-4488	HITS-CLIP	23824327
MIRT671026	hsa-miR-4697-5p	HITS-CLIP	23824327
MIRT671025	hsa-miR-6795-5p	HITS-CLIP	23824327
MIRT671024	hsa-miR-6887-5p	HITS-CLIP	23824327
MIRT671023	hsa-miR-328-5p	HITS-CLIP	23824327
MIRT671022	hsa-miR-6885-5p	HITS-CLIP	23824327
MIRT671021	hsa-miR-7977	HITS-CLIP	23824327
MIRT671020	hsa-miR-7109-5p	HITS-CLIP	23824327
MIRT1217176	hsa-miR-199a-3p	CLIP-seq
MIRT1217177	hsa-miR-199b-3p	CLIP-seq
MIRT1217178	hsa-miR-3129-5p	CLIP-seq
MIRT1217179	hsa-miR-4797-3p	CLIP-seq
MIRT1217180	hsa-miR-936	CLIP-seq

Gene ontology (GO) Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	10380929
GO:0007155	Process	Cell adhesion	IBA
GO:0007155	Process	Cell adhesion	IEA
GO:0007155	Process	Cell adhesion	TAS	10380929
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IEA
GO:0007268	Process	Chemical synaptic transmission	TAS	12231349
GO:0007399	Process	Nervous system development	IEA
GO:0007399	Process	Nervous system development	TAS	10380929
GO:0007416	Process	Synapse assembly	TAS	12231349
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	11322959
GO:0016339	Process	Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	NAS	11322959
GO:0045202	Component	Synapse	IEA
GO:0050839	Function	Cell adhesion molecule binding	IBA

Other IDs

• MIM: 606328
• HGNC: 8687
• e!Ensembl: ENSG00000112852

Protein

• UniProt ID: Q9Y5E7
• Protein name: Protocadherin beta-2 (PCDH-beta-2)
• Protein function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00028	Cadherin	249 → 340	Cadherin domain	Domain
  PF00028	Cadherin	458 → 554	Cadherin domain	Domain
  PF00028	Cadherin	140 → 235	Cadherin domain	Domain
  PF00028	Cadherin	356 → 444	Cadherin domain	Domain
  PF00028	Cadherin	577 → 665	Cadherin domain	Domain
  PF08266	Cadherin_2	32 → 114	Cadherin-like	Domain
  PF16492	Cadherin_C_2	687 → 770	Cadherin cytoplasmic C-terminal	Family

• Sequence:

  MEAGEGKERVPKQRQVLIFFVLLGIAQASCQPRHYSVAEETESGSFVANLLKDLGLEIGE
  LAVRGARVVSKGKKMHLQFDRQTGDLLLNEKLDREELCGPTEPCVLPFQVLLENPLQFFQ
  AELRIRDVNDHSPVFLDKEILLKIPESITPGTTFLIERAQDLDVGTNSLQNYTISPNFHF
  HLNLQDSLDGIILPQLVLNRALDREEQPEIRLTLTALDGGSPPRSGTALVRIEVVDINDN
  VPEFAKLLYEVQIPEDSPVGSQVAIVSARDLDIGTNGEISYAFSQASEDIRKTFRLSAKS
  GELLLRQKLDFESIQTYTVNIQATDGGGLSGTCVVFVQVMDLNDNPPELTMSTLINQIPE
  NLQDTLIAVFSVSDPDSGDNGRMVCSIQDDLPFFLKPSVENFYTLVISTALDRETRSEYN
  ITITVTDFGTPRLKTEHNITVLVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDR
  DSGTNAQVTYSLLPPQDPHLPLASLVSINADNGHLFALQSLDYEALQAFEFRVGAADRGS
  PALSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQ
  NAWLSYQLLKATEPGLFGVWAHNGEVRTARLLRERDAAKQRLVVLVKDNGEPPRSATATL
  HVLLVDGFSQPYLLLPEAAPAQAQADLLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSR
  AASVGRCSVPEGPFPGQMVDVSGTGTLSQSYQYEVCLTGGSGTNEFKFLKPIIPNFVAQG
  AERVSEANPSFRKSFEFT

• Sequence length: 798

Related Genes

No strongly related genes found yet for PCDHB2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to PCDHB2.