PCDHB14 (protocadherin beta 14)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 56122
• Gene name: Protocadherin beta 14
• Gene symbol: PCDHB14
• Synonyms (NCBI Gene): PCDH-BETA14
• Chromosome: 5
• Chromosome location: 5q31.3
• Summary: This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters.

miRNA Show/Hide all (39)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021560	hsa-miR-142-3p	Microarray	17612493
MIRT1217118	hsa-miR-153	CLIP-seq
MIRT1217119	hsa-miR-200b	CLIP-seq
MIRT1217120	hsa-miR-200c	CLIP-seq
MIRT1217121	hsa-miR-374c	CLIP-seq
MIRT1217122	hsa-miR-410	CLIP-seq
MIRT1217123	hsa-miR-429	CLIP-seq
MIRT1217124	hsa-miR-448	CLIP-seq
MIRT1217125	hsa-miR-491-3p	CLIP-seq
MIRT1217126	hsa-miR-548k	CLIP-seq
MIRT1217127	hsa-miR-548n	CLIP-seq
MIRT1217128	hsa-miR-655	CLIP-seq
MIRT2062672	hsa-miR-136	CLIP-seq
MIRT1217118	hsa-miR-153	CLIP-seq
MIRT2062673	hsa-miR-3120-3p	CLIP-seq
MIRT2062674	hsa-miR-3143	CLIP-seq
MIRT2062675	hsa-miR-3187-3p	CLIP-seq
MIRT2062676	hsa-miR-369-3p	CLIP-seq
MIRT2062677	hsa-miR-3908	CLIP-seq
MIRT2062678	hsa-miR-3942-5p	CLIP-seq
MIRT1217122	hsa-miR-410	CLIP-seq
MIRT2062679	hsa-miR-4435	CLIP-seq
MIRT1217124	hsa-miR-448	CLIP-seq
MIRT2062680	hsa-miR-4480	CLIP-seq
MIRT2062681	hsa-miR-4701-5p	CLIP-seq
MIRT2062682	hsa-miR-4703-5p	CLIP-seq
MIRT2062683	hsa-miR-4764-3p	CLIP-seq
MIRT2062684	hsa-miR-4766-3p	CLIP-seq
MIRT2062685	hsa-miR-4777-5p	CLIP-seq
MIRT1217125	hsa-miR-491-3p	CLIP-seq
MIRT2062686	hsa-miR-543	CLIP-seq
MIRT2062687	hsa-miR-545	CLIP-seq
MIRT1217126	hsa-miR-548k	CLIP-seq
MIRT1217127	hsa-miR-548n	CLIP-seq
MIRT2062688	hsa-miR-548p	CLIP-seq
MIRT2062689	hsa-miR-548s	CLIP-seq
MIRT2062690	hsa-miR-588	CLIP-seq
MIRT2062691	hsa-miR-885-5p	CLIP-seq
MIRT2062692	hsa-miR-889	CLIP-seq

Gene ontology (GO) Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0007155	Process	Cell adhesion	IBA
GO:0007155	Process	Cell adhesion	IEA
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IEA
GO:0007268	Process	Chemical synaptic transmission	TAS	12231349
GO:0007399	Process	Nervous system development	IEA
GO:0007416	Process	Synapse assembly	TAS	12231349
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	11322959
GO:0016339	Process	Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	NAS	11322959
GO:0045202	Component	Synapse	IEA
GO:0050839	Function	Cell adhesion molecule binding	IBA

Other IDs

• MIM: 606340
• HGNC: 8685
• e!Ensembl: ENSG00000120327

Protein

• UniProt ID: Q9Y5E9
• Protein name: Protocadherin beta-14 (PCDH-beta-14)
• Protein function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00028	Cadherin	247 → 338	Cadherin domain	Domain
  PF00028	Cadherin	456 → 552	Cadherin domain	Domain
  PF00028	Cadherin	575 → 663	Cadherin domain	Domain
  PF00028	Cadherin	352 → 442	Cadherin domain	Domain
  PF00028	Cadherin	138 → 233	Cadherin domain	Domain
  PF08266	Cadherin_2	30 → 112	Cadherin-like	Domain
  PF16492	Cadherin_C_2	685 → 768	Cadherin cytoplasmic C-terminal	Family

• Sequence:

  MEIRGALDLRKRQVLIFLVLLGLSRAGTESAHYSVAEETEIGSFVANLARDLGLGVEELS
  SREARVVSDDNKKYLHLDLLTGNLLLNEKLDRDELCGSTEPCVLHFQVVLENPLQFFRFE
  LCVKDINDHSPTFLDKEILIKISEGTTVGATFLMESAQDLDVGSNSLQNYTISPNSHFYI
  KIPDSSDRKIYPELVLDRALDYEQEAELRLTLTAVDGGSPPKSGTTLVLIKVLDINDNAP
  EFPQSLYEVQVPEDRPLGSWIATISAKDLDAGNYGKISYTFFHASEDIRKTFEINPISGE
  VNLRSPLDFEVIQSYTINIQATDGGGLSGKCTLLVKVMDINDNPPEVTISSITKRIPENA
  SETLVALFSILDQDSGDNGRMICSIQDNLPFFLKPTFKNFFTLVSEKALDRESQAEYNIT
  ITVTDLGTPRLKTEYNITVLLSDVNDNAPTFTQTSYTLFVRENNSPALHIGSVSATDRDS
  GTNAQVNYSLLPPQDRHLPLASLVSINADNGHLFALRSLDYEALQEFEFRVGATDRGSPA
  LSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNA
  WLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHV
  LLVDGFSQPYLPLPEAAPAQAQADSLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAA
  SVGRCSVPEGPFPGHLVDVSGTGTLSQSYQYEVCLTGGSGTNEFKFLKPIIPNFQVHDTG
  RNMGEIENFRNSFGLNIQ

• Sequence length: 798

Related Genes

No strongly related genes found yet for PCDHB14.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to PCDHB14.