PARP16 (poly(ADP-ribose) polymerase family member 16)

Download as csv Download as pdf

Log in to bookmark this gene

Bookmark This Gene

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 54956
• Gene name: Poly(ADP-ribose) polymerase family member 16
• Gene symbol: PARP16
• Synonyms (NCBI Gene): ARTD15, C15orf30, pART15
• Chromosome: 15
• Chromosome location: 15q22.31

miRNA Show/Hide all (104)

miRTarBase ID	miRNA	Experiments	Reference
MIRT002565	hsa-miR-124-3p	Microarray	15685193
MIRT016159	hsa-miR-590-3p	Sequencing	20371350
MIRT016427	hsa-miR-193b-3p	Microarray	20304954
MIRT002565	hsa-miR-124-3p	Microarray	18668037
MIRT002565	hsa-miR-124-3p	Microarray	15685193
MIRT024865	hsa-miR-215-5p	Microarray	19074876
MIRT026485	hsa-miR-192-5p	Microarray	19074876
MIRT002565	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT566529	hsa-miR-506-3p	PAR-CLIP	20371350
MIRT002565	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT566528	hsa-miR-3714	PAR-CLIP	20371350
MIRT566527	hsa-miR-3910	PAR-CLIP	20371350
MIRT566526	hsa-miR-4323	PAR-CLIP	20371350
MIRT566525	hsa-miR-3943	PAR-CLIP	20371350
MIRT566524	hsa-miR-6769a-3p	PAR-CLIP	20371350
MIRT566523	hsa-miR-5582-5p	PAR-CLIP	20371350
MIRT566522	hsa-let-7a-5p	PAR-CLIP	20371350
MIRT566521	hsa-let-7b-5p	PAR-CLIP	20371350
MIRT566520	hsa-let-7c-5p	PAR-CLIP	20371350
MIRT566519	hsa-let-7d-5p	PAR-CLIP	20371350
MIRT566518	hsa-let-7e-5p	PAR-CLIP	20371350
MIRT566517	hsa-let-7f-5p	PAR-CLIP	20371350
MIRT566516	hsa-let-7g-5p	PAR-CLIP	20371350
MIRT566515	hsa-let-7i-5p	PAR-CLIP	20371350
MIRT566513	hsa-miR-4458	PAR-CLIP	20371350
MIRT566514	hsa-miR-4500	PAR-CLIP	20371350
MIRT566512	hsa-miR-98-5p	PAR-CLIP	20371350
MIRT566511	hsa-miR-202-3p	PAR-CLIP	20371350
MIRT440039	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440039	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT735281	hsa-miR-126-3p	qRT-PCR	32425976
MIRT002565	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT566529	hsa-miR-506-3p	PAR-CLIP	20371350
MIRT002565	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT566528	hsa-miR-3714	PAR-CLIP	20371350
MIRT566527	hsa-miR-3910	PAR-CLIP	20371350
MIRT566526	hsa-miR-4323	PAR-CLIP	20371350
MIRT566525	hsa-miR-3943	PAR-CLIP	20371350
MIRT566524	hsa-miR-6769a-3p	PAR-CLIP	20371350
MIRT566523	hsa-miR-5582-5p	PAR-CLIP	20371350
MIRT566522	hsa-let-7a-5p	PAR-CLIP	20371350
MIRT566521	hsa-let-7b-5p	PAR-CLIP	20371350
MIRT566520	hsa-let-7c-5p	PAR-CLIP	20371350
MIRT566519	hsa-let-7d-5p	PAR-CLIP	20371350
MIRT566518	hsa-let-7e-5p	PAR-CLIP	20371350
MIRT566517	hsa-let-7f-5p	PAR-CLIP	20371350
MIRT566516	hsa-let-7g-5p	PAR-CLIP	20371350
MIRT566515	hsa-let-7i-5p	PAR-CLIP	20371350
MIRT566513	hsa-miR-4458	PAR-CLIP	20371350
MIRT566514	hsa-miR-4500	PAR-CLIP	20371350
MIRT566512	hsa-miR-98-5p	PAR-CLIP	20371350
MIRT566511	hsa-miR-202-3p	PAR-CLIP	20371350
MIRT1214562	hsa-miR-1197	CLIP-seq
MIRT1214563	hsa-miR-3653	CLIP-seq
MIRT1214564	hsa-miR-3658	CLIP-seq
MIRT1214565	hsa-miR-3662	CLIP-seq
MIRT1214566	hsa-miR-4434	CLIP-seq
MIRT1214567	hsa-miR-4516	CLIP-seq
MIRT1214568	hsa-miR-4687-3p	CLIP-seq
MIRT1214569	hsa-miR-520d-5p	CLIP-seq
MIRT1214570	hsa-miR-524-5p	CLIP-seq
MIRT1214571	hsa-miR-580	CLIP-seq
MIRT1214572	hsa-miR-653	CLIP-seq
MIRT2061743	hsa-miR-214	CLIP-seq
MIRT2061744	hsa-miR-2277-3p	CLIP-seq
MIRT2061745	hsa-miR-329	CLIP-seq
MIRT2061746	hsa-miR-3619-5p	CLIP-seq
MIRT2061747	hsa-miR-362-3p	CLIP-seq
MIRT2061748	hsa-miR-3660	CLIP-seq
MIRT1214565	hsa-miR-3662	CLIP-seq
MIRT2061749	hsa-miR-4453	CLIP-seq
MIRT2061750	hsa-miR-4520a-3p	CLIP-seq
MIRT2061751	hsa-miR-4520b-3p	CLIP-seq
MIRT2061752	hsa-miR-4526	CLIP-seq
MIRT2061753	hsa-miR-4538	CLIP-seq
MIRT2061754	hsa-miR-548a-3p	CLIP-seq
MIRT2061755	hsa-miR-548e	CLIP-seq
MIRT2061756	hsa-miR-548f	CLIP-seq
MIRT2061757	hsa-miR-761	CLIP-seq
MIRT2290125	hsa-miR-1207-3p	CLIP-seq
MIRT2290126	hsa-miR-1293	CLIP-seq
MIRT2061743	hsa-miR-214	CLIP-seq
MIRT2290127	hsa-miR-3119	CLIP-seq
MIRT2290128	hsa-miR-326	CLIP-seq
MIRT2290129	hsa-miR-330-5p	CLIP-seq
MIRT2061746	hsa-miR-3619-5p	CLIP-seq
MIRT2290130	hsa-miR-3685	CLIP-seq
MIRT2290131	hsa-miR-384	CLIP-seq
MIRT2290132	hsa-miR-4291	CLIP-seq
MIRT2290133	hsa-miR-4435	CLIP-seq
MIRT2290134	hsa-miR-4483	CLIP-seq
MIRT2290135	hsa-miR-4643	CLIP-seq
MIRT2290136	hsa-miR-466	CLIP-seq
MIRT2290137	hsa-miR-4789-3p	CLIP-seq
MIRT1214571	hsa-miR-580	CLIP-seq
MIRT2061757	hsa-miR-761	CLIP-seq
MIRT2290138	hsa-miR-922	CLIP-seq
MIRT2392133	hsa-miR-103a	CLIP-seq
MIRT2392134	hsa-miR-107	CLIP-seq
MIRT2061743	hsa-miR-214	CLIP-seq
MIRT2290127	hsa-miR-3119	CLIP-seq
MIRT2392135	hsa-miR-3158-3p	CLIP-seq
MIRT2061746	hsa-miR-3619-5p	CLIP-seq
MIRT2061757	hsa-miR-761	CLIP-seq

Gene ontology (GO) Show/Hide all (41)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002181	Process	Cytoplasmic translation	IDA	8706699, 32669547, 34314702
GO:0003950	Function	NAD+ poly-ADP-ribosyltransferase activity	IBA
GO:0003950	Function	NAD+ poly-ADP-ribosyltransferase activity	IEA
GO:0003950	Function	NAD+ poly-ADP-ribosyltransferase activity	IMP	22701565, 23103912
GO:0003950	Function	NAD+ poly-ADP-ribosyltransferase activity	TAS
GO:0005515	Function	Protein binding	IPI	22701565, 25416956
GO:0005635	Component	Nuclear envelope	IBA
GO:0005635	Component	Nuclear envelope	IDA	22701565
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005783	Component	Endoplasmic reticulum	IMP	23103912
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006986	Process	Response to unfolded protein	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016757	Function	Glycosyltransferase activity	IEA
GO:0016779	Function	Nucleotidyltransferase activity	IEA
GO:0019082	Process	Viral protein processing	TAS
GO:0019900	Function	Kinase binding	IBA
GO:0019900	Function	Kinase binding	IPI	23103912
GO:0030968	Process	Endoplasmic reticulum unfolded protein response	IBA
GO:0030968	Process	Endoplasmic reticulum unfolded protein response	IMP	23103912
GO:0034355	Process	NAD+ biosynthetic process via the salvage pathway	TAS
GO:0036498	Process	IRE1-mediated unfolded protein response	IMP	23103912
GO:0043539	Function	Protein serine/threonine kinase activator activity	IBA
GO:0043539	Function	Protein serine/threonine kinase activator activity	IMP	23103912
GO:0070213	Process	Protein auto-ADP-ribosylation	IDA	25043379, 34314702
GO:0070213	Process	Protein auto-ADP-ribosylation	IMP	22701565, 23103912
GO:0071782	Component	Endoplasmic reticulum tubular network	IBA
GO:0071782	Component	Endoplasmic reticulum tubular network	IMP	22701565
GO:0140804	Function	NAD+-protein-lysine ADP-ribosyltransferase activity	IDA	25043379
GO:0140804	Function	NAD+-protein-lysine ADP-ribosyltransferase activity	IEA
GO:0140806	Function	NAD+-protein-aspartate ADP-ribosyltransferase activity	IDA	25043379, 34314702
GO:0140806	Function	NAD+-protein-aspartate ADP-ribosyltransferase activity	IEA
GO:0140807	Function	NAD+-protein-glutamate ADP-ribosyltransferase activity	IDA	25043379, 34314702
GO:0140807	Function	NAD+-protein-glutamate ADP-ribosyltransferase activity	IEA
GO:1990404	Function	NAD+-protein mono-ADP-ribosyltransferase activity	IDA	25043379
GO:1990830	Process	Cellular response to leukemia inhibitory factor	IEA
GO:2000766	Process	Negative regulation of cytoplasmic translation	IDA	34314702

Other IDs

• MIM: 620391
• HGNC: 26040
• e!Ensembl: ENSG00000138617

Protein

• UniProt ID: Q8N5Y8
• Protein name: Protein mono-ADP-ribosyltransferase PARP16 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 15) (Poly [ADP-ribose] polymerase 16) (PARP-16)
• Protein function: Intracellular mono-ADP-ribosyltransferase that plays a role in different processes, such as protein translation and unfolded protein response (UPR), through the mono-ADP-ribosylation of proteins involved in those processes (PubMed:22701565, PubM
• PDB: 4F0D , 6HXR , 6HXS , 6W65
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00644	PARP	102 → 273	Poly(ADP-ribose) polymerase catalytic domain	Family
  PF18084	ARTD15_N	11 → 90	ARTD15 N-terminal domain	Domain

• Sequence:

  MQPSGWAAAREAAGRDMLAADLRCSLFASALQSYKRDSVLRPFPASYARGDCKDFEALLA
  DASKLPNLKELLQSSGDNHKRAWDLVSWILSSKVLTIHSAGKAEFEKIQKLTGAPHTPVP
  APDFLFEIEYFDPANAKFYETKGERDLIYAFHGSRLENFHSIIHNGLHCHLNKTSLFGEG
  TYLTSDLSLALIYSPHGHGWQHSLLGPILSCVAVCEVIDHPDVKCQTKKKDSKEIDRRRA
  RIKHSEGGDIPPKYFVVTNNQLLRVKYLLVYSQKPPKRASSQLSWFSSHWFTVMISLYLL
  LLLIVSVINSSAFQHFWNRAKR

• Sequence length: 322

Pathways

Reactome Pathway:

Nicotinamide salvaging

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
SCOLIOSIS	—	GWAS catalog	30019117	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Cardiomegaly	Cardiomegaly	Pubtator	37219631	Associate	★☆☆☆☆ Found in Text Mining only
Cardiomyopathy Hypertrophic	Hypertrophic cardiomyopathy	Pubtator	37219631	Stimulate	★☆☆☆☆ Found in Text Mining only
Heart Diseases	Heart disease	Pubtator	37219631	Associate	★☆☆☆☆ Found in Text Mining only
Heart Failure	Heart failure	Pubtator	37219631	Associate	★☆☆☆☆ Found in Text Mining only
Small Cell Lung Carcinoma	Small cell lung carcinoma	Pubtator	34329582	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for PARP16.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to PARP16.