PAPOLB (poly(A) polymerase beta)

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Gene miRNA Gene ontology Other IDs Protein Pathways Diseases linked via similar genes

Gene

• Entrez ID: 56903
• Gene name: Poly(A) polymerase beta
• Gene symbol: PAPOLB
• Synonyms (NCBI Gene): PAPT, TPAP
• Chromosome: 7
• Chromosome location: 7p22.1

miRNA Show/Hide all (41)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1212935	hsa-miR-3149	CLIP-seq
MIRT1212936	hsa-miR-3613-5p	CLIP-seq
MIRT1212937	hsa-miR-4653-3p	CLIP-seq
MIRT1212938	hsa-miR-511	CLIP-seq
MIRT1212939	hsa-miR-576-5p	CLIP-seq
MIRT2061208	hsa-miR-101	CLIP-seq
MIRT2061209	hsa-miR-219-5p	CLIP-seq
MIRT2061210	hsa-miR-223	CLIP-seq
MIRT2061211	hsa-miR-23a	CLIP-seq
MIRT2061212	hsa-miR-23b	CLIP-seq
MIRT2061213	hsa-miR-23c	CLIP-seq
MIRT2061214	hsa-miR-383	CLIP-seq
MIRT2061215	hsa-miR-4659a-5p	CLIP-seq
MIRT2061216	hsa-miR-4659b-5p	CLIP-seq
MIRT2061217	hsa-miR-4697-3p	CLIP-seq
MIRT2061218	hsa-miR-4701-5p	CLIP-seq
MIRT2061219	hsa-miR-4782-3p	CLIP-seq
MIRT2061220	hsa-miR-494	CLIP-seq
MIRT2061221	hsa-miR-5095	CLIP-seq
MIRT2061222	hsa-miR-552	CLIP-seq
MIRT2061223	hsa-miR-588	CLIP-seq
MIRT2061224	hsa-miR-663b	CLIP-seq
MIRT2061225	hsa-miR-935	CLIP-seq
MIRT2289818	hsa-miR-1298	CLIP-seq
MIRT2061211	hsa-miR-23a	CLIP-seq
MIRT2061212	hsa-miR-23b	CLIP-seq
MIRT2061213	hsa-miR-23c	CLIP-seq
MIRT2289819	hsa-miR-376a	CLIP-seq
MIRT2289820	hsa-miR-376b	CLIP-seq
MIRT2289821	hsa-miR-4715-5p	CLIP-seq
MIRT2061221	hsa-miR-5095	CLIP-seq
MIRT2061222	hsa-miR-552	CLIP-seq
MIRT2289822	hsa-miR-664	CLIP-seq
MIRT2061225	hsa-miR-935	CLIP-seq
MIRT2061208	hsa-miR-101	CLIP-seq
MIRT2392111	hsa-miR-144	CLIP-seq
MIRT2392112	hsa-miR-3160-5p	CLIP-seq
MIRT2392113	hsa-miR-3921	CLIP-seq
MIRT2392114	hsa-miR-4653-5p	CLIP-seq
MIRT2392115	hsa-miR-4768-5p	CLIP-seq
MIRT2392116	hsa-miR-491-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003723	Function	RNA binding	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016779	Function	Nucleotidyltransferase activity	IEA
GO:0031123	Process	RNA 3'-end processing	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:1990817	Function	Poly(A) RNA polymerase activity	IBA
GO:1990817	Function	Poly(A) RNA polymerase activity	IEA

Other IDs

• MIM: 607436
• HGNC: 15970
• e!Ensembl: ENSG00000218823

Protein

• UniProt ID: Q9NRJ5
• Protein name: Poly(A) polymerase beta (PAP-beta) (EC 2.7.7.19) (Polynucleotide adenylyltransferase beta) (Testis-specific poly(A) polymerase)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01909	NTP_transf_2	74 → 175	Nucleotidyltransferase domain	Family
  PF04926	PAP_RNA-bind	366 → 435	Poly(A) polymerase predicted RNA binding domain	Domain
  PF04928	PAP_central	21 → 364	Poly(A) polymerase central domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Testis specific.
• Sequence:

  MPFPVTTQGPPQPAPPPNRYGVSSPISLAVPKETDCLLTQRLIETLRPFGVFEEEEELQR
  RILVLEKLNNLVKEWIREISESKSLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA
  PSHVDRSDFFTSFYAKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
  DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKCHNIYSNI
  LGFLGGVSWAMLVARTCQLYPNAVASTLVRKFFLVFSEWEWPNPVLLKEPEERNLNLPVW
  DPRVNPSDRYHLMPIITPAYPQQNSTYNVSISTRMVMIEEFKQGLAITHEILLSKAEWSK
  LFEAPSFFQKYKHYIVLLASASTEKQHLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS
  FPAPKENPDMEEFRTMWVIGLGLKKPDNSEILSIDLTYDIQSFTDTVYRQAVNSKMFEMG
  MKITAMHLRRKELHQLLPHHVLQDKKAHSTEGRRLTDLNDSSFDLSAGCENSMSVPSSTS
  TMKTGPLISSSQGRNSPALAVMTASVANIQATEFSLQQVNTNESSGVALNESIPHAVSQP
  AISPSPKAMVARVVSSTCLISHPDLQETQQQTYLIL

• Sequence length: 636

Pathways

KEGG Pathway:

mRNA surveillance pathway

Related Genes

No strongly related genes found yet for PAPOLB.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to PAPOLB.