PANX3 (pannexin 3)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 116337
• Gene name: Pannexin 3
• Gene symbol: PANX3
• Synonyms (NCBI Gene): PX3
• Chromosome: 11
• Chromosome location: 11q24.2
• Summary: The protein encoded by this gene belongs to the innexin family. Innexin family members are known to be the structural components of gap junctions. [provided by RefSeq, Jul 2008]

miRNA Show/Hide all (9)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1212461	hsa-miR-210	CLIP-seq
MIRT1212462	hsa-miR-297	CLIP-seq
MIRT1212463	hsa-miR-3201	CLIP-seq
MIRT1212464	hsa-miR-3591-5p	CLIP-seq
MIRT1212465	hsa-miR-3650	CLIP-seq
MIRT1212466	hsa-miR-3688-3p	CLIP-seq
MIRT1212467	hsa-miR-4791	CLIP-seq
MIRT1212468	hsa-miR-567	CLIP-seq
MIRT1212469	hsa-miR-648	CLIP-seq

Gene ontology (GO) Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001649	Process	Osteoblast differentiation	IEA
GO:0001649	Process	Osteoblast differentiation	ISS
GO:0005198	Function	Structural molecule activity	ISS
GO:0005262	Function	Calcium channel activity	IEA
GO:0005262	Function	Calcium channel activity	ISS
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	ISS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005921	Component	Gap junction	IEA
GO:0005921	Component	Gap junction	ISS
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006812	Process	Monoatomic cation transport	IBA
GO:0006812	Process	Monoatomic cation transport	IEA
GO:0007267	Process	Cell-cell signaling	IBA
GO:0007267	Process	Cell-cell signaling	IEA
GO:0015267	Function	Channel activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0022829	Function	Wide pore channel activity	IBA
GO:0032732	Process	Positive regulation of interleukin-1 production	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0055077	Function	Gap junction hemi-channel activity	ISS
GO:0055077	Function	Gap junction hemi-channel activity	ISS
GO:0070161	Component	Anchoring junction	IEA
GO:0070588	Process	Calcium ion transmembrane transport	IEA

Other IDs

• MIM: 608422
• HGNC: 20573
• e!Ensembl: ENSG00000154143

Protein

• UniProt ID: Q96QZ0
• Protein name: Pannexin-3
• Protein function: Regulator of osteoblast differentiation by functionning as a Ca(2+) channel in the endoplasmic reticulum which regulates calmodulin (CaM) pathways. Allows ATP release into the extracellular space and activation or purinergic receptors. {ECO:0000
• PDB: 7XL6 , 8GTR , 8GYP , 8GYT , 8HWQ , 8WZA , 9KOM , 9KRG
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00876	Innexin	34 → 262	Innexin	Family

• Sequence:

  MSLAHTAAEYMLSDALLPDRRGPRLKGLRLELPLDRIVKFVAVGSPLLLMSLAFAQEFSS
  GSPISCFSPSNFSIRQAAYVDSSCWDSLLHHKQDGPGQDKMKSLWPHKALPYSLLALALL
  MYLPVLLWQYAAVPALSSDLLFIISELDKSYNRSIRLVQHMLKIRQKSSDPYVFWNELEK
  ARKERYFEFPLLERYLACKQRSHSLVATYLLRNSLLLIFTSATYLYLGHFHLDVFFQEEF
  SCSIKTGLLSDETHVPNLITCRLTSLSIFQIVSLSSVAIYTILVPVIIYNLTRLCRWDKR
  LLSVYEMLPAFDLLSRKMLGCPINDLNVILLFLRANISELISFSWLSVLCVLKDTTTQKH
  NIDTVVDFMTLLAGLEPSKPKHLTNSACDEHP

• Sequence length: 392

Related Genes

No strongly related genes found yet for PANX3.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to PANX3.