PAK1IP1 (PAK1 interacting protein 1)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 55003
• Gene name: PAK1 interacting protein 1
• Gene symbol: PAK1IP1
• Synonyms (NCBI Gene): MAK11, PIP1, WDR84, bA421M1.5, hPIP1
• Chromosome: 6
• Chromosome location: 6p24.2

miRNA Show/Hide all (66)

miRTarBase ID	miRNA	Experiments	Reference
MIRT028619	hsa-miR-30a-5p	Proteomics	18668040
MIRT032011	hsa-miR-16-5p	Proteomics	18668040
MIRT692054	hsa-miR-634	HITS-CLIP	23313552
MIRT692053	hsa-miR-4293	HITS-CLIP	23313552
MIRT692052	hsa-miR-596	HITS-CLIP	23313552
MIRT692051	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT692050	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT692049	hsa-miR-940	HITS-CLIP	23313552
MIRT692048	hsa-miR-3929	HITS-CLIP	23313552
MIRT692047	hsa-miR-4419b	HITS-CLIP	23313552
MIRT692046	hsa-miR-4478	HITS-CLIP	23313552
MIRT692045	hsa-miR-5690	HITS-CLIP	23313552
MIRT692044	hsa-miR-665	HITS-CLIP	23313552
MIRT692043	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT692042	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT692041	hsa-miR-1827	HITS-CLIP	23313552
MIRT692040	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT692039	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT692038	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT692037	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT692036	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT692054	hsa-miR-634	HITS-CLIP	23313552
MIRT692053	hsa-miR-4293	HITS-CLIP	23313552
MIRT692052	hsa-miR-596	HITS-CLIP	23313552
MIRT692051	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT692050	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT692049	hsa-miR-940	HITS-CLIP	23313552
MIRT692048	hsa-miR-3929	HITS-CLIP	23313552
MIRT692047	hsa-miR-4419b	HITS-CLIP	23313552
MIRT692046	hsa-miR-4478	HITS-CLIP	23313552
MIRT692045	hsa-miR-5690	HITS-CLIP	23313552
MIRT692044	hsa-miR-665	HITS-CLIP	23313552
MIRT692043	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT692042	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT692041	hsa-miR-1827	HITS-CLIP	23313552
MIRT692040	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT692039	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT692038	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT692037	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT692036	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT1211215	hsa-miR-1266	CLIP-seq
MIRT1211216	hsa-miR-3074-3p	CLIP-seq
MIRT1211217	hsa-miR-3140-3p	CLIP-seq
MIRT1211218	hsa-miR-3143	CLIP-seq
MIRT1211219	hsa-miR-4270	CLIP-seq
MIRT1211220	hsa-miR-4441	CLIP-seq
MIRT1211221	hsa-miR-4518	CLIP-seq
MIRT1211222	hsa-miR-4803	CLIP-seq
MIRT1211223	hsa-miR-510	CLIP-seq
MIRT1211224	hsa-miR-512-5p	CLIP-seq
MIRT1211225	hsa-miR-513a-3p	CLIP-seq
MIRT1211226	hsa-miR-578	CLIP-seq
MIRT1211227	hsa-miR-642b	CLIP-seq
MIRT1211228	hsa-miR-656	CLIP-seq
MIRT1211216	hsa-miR-3074-3p	CLIP-seq
MIRT1211218	hsa-miR-3143	CLIP-seq
MIRT1211222	hsa-miR-4803	CLIP-seq
MIRT1211225	hsa-miR-513a-3p	CLIP-seq
MIRT1211227	hsa-miR-642b	CLIP-seq
MIRT1211228	hsa-miR-656	CLIP-seq
MIRT1211216	hsa-miR-3074-3p	CLIP-seq
MIRT1211218	hsa-miR-3143	CLIP-seq
MIRT2587028	hsa-miR-4760-3p	CLIP-seq
MIRT1211222	hsa-miR-4803	CLIP-seq
MIRT1211227	hsa-miR-642b	CLIP-seq
MIRT1211228	hsa-miR-656	CLIP-seq

Gene ontology (GO) Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000463	Process	Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA
GO:0004860	Function	Protein kinase inhibitor activity	IBA
GO:0005515	Function	Protein binding	IPI	25074804, 26871637, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IDA
GO:0005730	Component	Nucleolus	IEA
GO:0008283	Process	Cell population proliferation	IEA
GO:0009968	Process	Negative regulation of signal transduction	IEA
GO:0042254	Process	Ribosome biogenesis	IEA
GO:0042273	Process	Ribosomal large subunit biogenesis	IMP	24120868
GO:0060021	Process	Roof of mouth development	IEA
GO:1901796	Process	Regulation of signal transduction by p53 class mediator	IMP	24120868

Other IDs

• MIM: 607811
• HGNC: 20882
• e!Ensembl: ENSG00000111845

Protein

• UniProt ID: Q9NWT1
• Protein name: p21-activated protein kinase-interacting protein 1 (PAK/PLC-interacting protein 1) (hPIP1) (PAK1-interacting protein 1) (WD repeat-containing protein 84)
• Protein function: Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activa
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00400	WD40	113 → 151	WD domain, G-beta repeat	Repeat
  PF00400	WD40	73 → 109	WD domain, G-beta repeat	Repeat
  PF00400	WD40	30 → 68	WD domain, G-beta repeat	Repeat

• Tissue specificity: TISSUE SPECIFICITY: Expressed in brain, colon, heart, kidney, liver, lung, muscle, peripheral blood leukocytes, placenta, small intestine, spleen and thymus. {ECO:0000269|PubMed:11371639}.
• Sequence:

  MELVAGCYEQVLFGFAVHPEPEACGDHEQWTLVADFTHHAHTASLSAVAVNSRFVVTGSK
  DETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLISGAEDGLICIWDAKKWECLKSIK
  AHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQNAHIVEWSPRGEQYV
  VIIQNKIDIYQLDTASISGTITNEKRISSVKFLSESVLAVAGDEEVIRFFDCDSLVCLCE
  FKAHENRVKDMFSFEIPEHHVIVSASSDGFIKMWKLKQDKKVPPSLLCEINTNARLTCLG
  VWLDKVADMKESLPPAAEPSPVSKEQSKIGKKEPGDTVHKEEKRSKPNTKKRGLTGDSKK
  ATKESGLISTKKRKMVEMLEKKRKKKKIKTMQ

• Sequence length: 392

Related Genes

No strongly related genes found yet for PAK1IP1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to PAK1IP1.