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Gene Gene information from NCBI Gene database.
Entrez ID 5051
Gene name Platelet activating factor acetylhydrolase 2
Gene symbol PAFAH2
Synonyms (NCBI Gene)
HSD-PLA2
Chromosome 1
Chromosome location 1p36.11
Summary This gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3
miRNA miRNA information provided by mirtarbase database.
588 Show/Hide all (588)
miRTarBase ID miRNA Experiments Reference
MIRT019805 hsa-miR-375 Microarray 20215506
MIRT274252 hsa-miR-6800-3p HITS-CLIP 19536157
MIRT713537 hsa-miR-4328 HITS-CLIP 19536157
MIRT713536 hsa-miR-339-5p HITS-CLIP 19536157
MIRT713535 hsa-miR-1914-5p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
19 Show/Hide all (19)
GO ID Ontology Definition Evidence Reference
GO:0003847 Function 1-alkyl-2-acetylglycerophosphocholine esterase activity IBA
GO:0003847 Function 1-alkyl-2-acetylglycerophosphocholine esterase activity IEA
GO:0003847 Function 1-alkyl-2-acetylglycerophosphocholine esterase activity ISS
GO:0003847 Function 1-alkyl-2-acetylglycerophosphocholine esterase activity TAS
GO:0005543 Function Phospholipid binding TAS 8955149
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602344 8579 ENSG00000158006
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q99487
Protein name Platelet-activating factor acetylhydrolase 2, cytoplasmic (EC 3.1.1.47) (PAF:lysophospholipid transacetylase) (PAF:sphingosine transacetylase) (Platelet-activating factor acetyltransferase PAFAH2) (EC 2.3.1.149) (Serine-dependent phospholipase A2) (SD-PLA
Protein function Catalyzes the hydrolyze of the acetyl group at the sn-2 position of platelet-activating factor (PAF) and its analogs, leading to their inactivation (PubMed:9494101). Hydrolyzes propionyl and butyroyl moieties approximately half as effectively as
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03403 PAF-AH_p_II 1 → 381 Platelet-activating factor acetylhydrolase, isoform II Domain
Tissue specificity TISSUE SPECIFICITY: Broadly expressed in different tissues, but high in B- and T-lymphocytes. In brain, expression is restricted to amygdala and frontal cortex. {ECO:0000269|PubMed:8955149, ECO:0000269|PubMed:9494101}.
Sequence
Sequence length 392
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Ether lipid metabolism Platelet homeostasis
Metabolic pathways