P3H4 (prolyl 3-hydroxylase family member 4 (inactive))

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 10609
• Gene name: Prolyl 3-hydroxylase family member 4 (inactive)
• Gene symbol: P3H4
• Synonyms (NCBI Gene): LEPREL4, NO55, NOL55, SC65
• Chromosome: 17
• Chromosome location: 17q21.2
• Summary: This nucleolar protein was first characterized because it was an autoantigen in cases on interstitial cystitis. The protein, with a predicted molecular weight of 50 kDa, appears to be localized in the particulate compartment of the interphase nucleolus, w

miRNA Show/Hide all (140)

miRTarBase ID	miRNA	Experiments	Reference
MIRT741336	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT741337	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT741338	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT741339	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT741340	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT741341	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT741342	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT741343	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT741344	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT741345	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT741346	hsa-miR-1976	HITS-CLIP	23824327
MIRT741347	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT741348	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT741349	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT741350	hsa-miR-4279	HITS-CLIP	23824327
MIRT741351	hsa-miR-526b-5p	HITS-CLIP	23824327
MIRT741352	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT741353	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT741354	hsa-miR-498	HITS-CLIP	23824327
MIRT741355	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT741336	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT741337	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT741420	hsa-miR-205-3p	HITS-CLIP	23824327
MIRT741421	hsa-miR-3937	HITS-CLIP	23824327
MIRT741342	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT741343	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT741344	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT741345	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT741346	hsa-miR-1976	HITS-CLIP	23824327
MIRT741422	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT741423	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT741348	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT741349	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT741424	hsa-miR-3167	HITS-CLIP	23824327
MIRT741425	hsa-miR-876-5p	HITS-CLIP	23824327
MIRT741350	hsa-miR-4279	HITS-CLIP	23824327
MIRT741351	hsa-miR-526b-5p	HITS-CLIP	23824327
MIRT741352	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT741426	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT741336	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT741337	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT741338	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT741339	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT741340	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT741341	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT741342	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT741343	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT741344	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT741345	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT741346	hsa-miR-1976	HITS-CLIP	23824327
MIRT741347	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT741580	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT741581	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT741348	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT741349	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT741350	hsa-miR-4279	HITS-CLIP	23824327
MIRT741351	hsa-miR-526b-5p	HITS-CLIP	23824327
MIRT741352	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT741353	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT741354	hsa-miR-498	HITS-CLIP	23824327
MIRT741582	hsa-miR-4774-3p	HITS-CLIP	23824327
MIRT741583	hsa-miR-3152-5p	HITS-CLIP	23824327
MIRT741355	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT741584	hsa-miR-3664-5p	HITS-CLIP	23824327
MIRT741585	hsa-miR-6514-5p	HITS-CLIP	23824327
MIRT741586	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT741587	hsa-miR-5693	HITS-CLIP	23824327
MIRT741588	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT741589	hsa-miR-143-3p	HITS-CLIP	23824327
MIRT741590	hsa-miR-4770	HITS-CLIP	23824327
MIRT741591	hsa-miR-6088	HITS-CLIP	23824327
MIRT741592	hsa-miR-4708-5p	HITS-CLIP	23824327
MIRT741593	hsa-miR-1273f	HITS-CLIP	23824327
MIRT741594	hsa-miR-4534	HITS-CLIP	23824327
MIRT741595	hsa-miR-8082	HITS-CLIP	23824327
MIRT741596	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT741597	hsa-miR-3135b	HITS-CLIP	23824327
MIRT741598	hsa-miR-1289	HITS-CLIP	23824327
MIRT741599	hsa-miR-4294	HITS-CLIP	23824327
MIRT741600	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT741601	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT741602	hsa-miR-564	HITS-CLIP	23824327
MIRT741603	hsa-miR-3652	HITS-CLIP	23824327
MIRT741604	hsa-miR-4430	HITS-CLIP	23824327
MIRT741605	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT741606	hsa-miR-891a-3p	HITS-CLIP	23824327
MIRT741607	hsa-miR-6794-3p	HITS-CLIP	23824327
MIRT741608	hsa-miR-3198	HITS-CLIP	23824327
MIRT741609	hsa-miR-4309	HITS-CLIP	23824327
MIRT741610	hsa-miR-5698	HITS-CLIP	23824327
MIRT741336	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT741337	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT741338	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT741339	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT741340	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT741341	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT741342	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT741343	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT741344	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT741345	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT741346	hsa-miR-1976	HITS-CLIP	23824327
MIRT741347	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT741580	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT741581	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT741348	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT741349	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT741350	hsa-miR-4279	HITS-CLIP	23824327
MIRT741351	hsa-miR-526b-5p	HITS-CLIP	23824327
MIRT741352	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT741353	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT741354	hsa-miR-498	HITS-CLIP	23824327
MIRT741582	hsa-miR-4774-3p	HITS-CLIP	23824327
MIRT741583	hsa-miR-3152-5p	HITS-CLIP	23824327
MIRT741355	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT741336	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT741337	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT741342	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT741343	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT741344	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT741345	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT741346	hsa-miR-1976	HITS-CLIP	23824327
MIRT741348	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT741349	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT741350	hsa-miR-4279	HITS-CLIP	23824327
MIRT741351	hsa-miR-526b-5p	HITS-CLIP	23824327
MIRT741352	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT741354	hsa-miR-498	HITS-CLIP	23824327
MIRT741336	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT741337	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT741342	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT741343	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT741344	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT741345	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT741346	hsa-miR-1976	HITS-CLIP	23824327
MIRT741348	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT741349	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT741350	hsa-miR-4279	HITS-CLIP	23824327
MIRT741351	hsa-miR-526b-5p	HITS-CLIP	23824327
MIRT741352	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT741354	hsa-miR-498	HITS-CLIP	23824327

Gene ontology (GO) Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000794	Component	Condensed nuclear chromosome	TAS	8862517
GO:0000795	Component	Synaptonemal complex	IEA
GO:0000795	Component	Synaptonemal complex	TAS	8862517
GO:0005518	Function	Collagen binding	IBA
GO:0005730	Component	Nucleolus	TAS	8862517
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA	23959653
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0007130	Process	Synaptonemal complex assembly	TAS	8862517
GO:0017185	Process	Peptidyl-lysine hydroxylation	ISS
GO:0030199	Process	Collagen fibril organization	IBA
GO:0030199	Process	Collagen fibril organization	IEA
GO:0030199	Process	Collagen fibril organization	ISS
GO:0032964	Process	Collagen biosynthetic process	IEA
GO:0032964	Process	Collagen biosynthetic process	ISS
GO:0046849	Process	Bone remodeling	IEA
GO:0046849	Process	Bone remodeling	ISS
GO:1902494	Component	Catalytic complex	IEA

Other IDs

• MIM: 617419
• HGNC: 16946
• e!Ensembl: ENSG00000141696

Protein

• UniProt ID: Q92791
• Protein name: Endoplasmic reticulum protein SC65 (Leprecan-like protein 4) (Nucleolar autoantigen No55) (Prolyl 3-hydroxylase family member 4) (Synaptonemal complex protein SC65)
• Protein function: Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linking of collagen fibrils. Required for normal bone density and normal sk
• Tissue specificity: TISSUE SPECIFICITY: Detected in fibroblasts (at protein level) (PubMed:23959653). Detected in spleen, prostate, testis, ovary, colon, pancreas, kidney, placenta and heart (PubMed:10952778). {ECO:0000269|PubMed:10952778, ECO:0000269|PubMed:23959653}.
• Sequence:

  MARVAWGLLWLLLGSAGAQYEKYSFRGFPPEDLMPLAAAYGHALEQYEGESWRESARYLE
  AALRLHRLLRDSEAFCHANCSGPAPAAKPDPDGGRADEWACELRLFGRVLERAACLRRCK
  RTLPAFQVPYPPRQLLRDFQSRLPYQYLHYALFKANRLEKAVAAAYTFLQRNPKHELTAK
  YLNYYQGMLDVADESLTDLEAQPYEAVFLRAVKLYNSGDFRSSTEDMERALSEYLAVFAR
  CLAGCEGAHEQVDFKDFYPAIADLFAESLQCKVDCEANLTPNVGGYFVDKFVATMYHYLQ
  FAYYKLNDVRQAARSAASYMLFDPKDSVMQQNLVYYRFHRARWGLEEEDFQPREEAMLYH
  NQTAELRELLEFTHMYLQSDDEMELEETEPPLEPEDALSDAEFEGEGDYEEGMYADWWQE
  PDAKGDEAEAEPEPELA

• Sequence length: 437

Related Genes

No strongly related genes found yet for P3H4.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to P3H4.