OTOP3 (otopetrin 3)

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Gene Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 347741
• Gene name: Otopetrin 3
• Gene symbol: OTOP3
• Synonyms (NCBI Gene): -
• Chromosome: 17
• Chromosome location: 17q25.1

Gene ontology (GO) Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0015252	Function	Proton channel activity	IBA
GO:0015252	Function	Proton channel activity	IEA
GO:0015252	Function	Proton channel activity	ISS
GO:0016020	Component	Membrane	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0042802	Function	Identical protein binding	IBA
GO:0042802	Function	Identical protein binding	ISS
GO:1902600	Process	Proton transmembrane transport	IBA
GO:1902600	Process	Proton transmembrane transport	IEA
GO:1902600	Process	Proton transmembrane transport	ISS

Other IDs

• MIM: 607828
• HGNC: 19658
• e!Ensembl: ENSG00000182938

Protein

• UniProt ID: Q7RTS5
• Protein name: Proton channel OTOP3 (Otopetrin-3)
• Protein function: Proton-selective channel gated by extracellular protons.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03189	Otopetrin	252 → 483	Otopetrin	Family
  PF03189	Otopetrin	506 → 583	Otopetrin	Family
  PF03189	Otopetrin	161 → 275	Otopetrin	Family

• Sequence:

  MGRGARAAAAQSRWGRASRASVSPGRTIRSAPAVGEAQETEAAPEKENRVDVGAEERAAA
  TRPRQKSWLVRHFSLLLRRDRQAQKAGQLFSGLLALNVVFLGGAFICSMIFNKVAVTLGD
  VWILLATLKVLSLLWLLYYVASTTRRPHAVLYQDPHAGPLWVRGSLVLFGSCTFCLNIFR
  VGYDVSHIRCKSQLDLVFSVIEMVFIGVQTWVLWKHCKDCVRVQTNFTRCGLMLTLATNL
  LLWVLAVTNDSMHREIEAELGILMEKSTGNETNTCLCLNATACEAFRRGFLMLYPFSTEY
  CLICCAVLFVMWKNVGRHVAPHMGAHPATAPFHLHGAIFGPLLGLLVLLAGVCVFVLFQI
  EASGPAIACQYFTLYYAFYVAVLPTMSLACLAGTAIHGLEERELDTVKNPTRSLDVVLLM
  GAALGQMGIAYFSIVAIVAKRPHELLNRLILAYSLLLILQHIAQNLFIIEGLHRRPLWET
  VPEGLAGKQEAEPPRRGSLLELGQGLQRASLAYIHSYSHLNWKRRALKEISLFLILCNIT
  LWMMPAFGIHPEFENGLEKDFYGYQIWFAIVNFGLPLGVFYRMHSVGGLVEVYLGA

• Sequence length: 596

Related Genes

No strongly related genes found yet for OTOP3.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to OTOP3.