ORMDL2 (ORMDL sphingolipid biosynthesis regulator 2)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 29095
• Gene name: ORMDL sphingolipid biosynthesis regulator 2
• Gene symbol: ORMDL2
• Synonyms (NCBI Gene): HSPC160, MST095, MSTP095, adoplin-2
• Chromosome: 12
• Chromosome location: 12q13.2

miRNA Show/Hide all (118)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023785	hsa-miR-1-3p	Proteomics	18668040
MIRT696600	hsa-miR-483-5p	HITS-CLIP	23313552
MIRT696599	hsa-miR-4716-5p	HITS-CLIP	23313552
MIRT696598	hsa-miR-4324	HITS-CLIP	23313552
MIRT696597	hsa-miR-544b	HITS-CLIP	23313552
MIRT696596	hsa-miR-3653-5p	HITS-CLIP	23313552
MIRT696595	hsa-miR-3663-5p	HITS-CLIP	23313552
MIRT696594	hsa-miR-6131	HITS-CLIP	23313552
MIRT696593	hsa-miR-193b-5p	HITS-CLIP	23313552
MIRT696592	hsa-miR-6501-5p	HITS-CLIP	23313552
MIRT696591	hsa-miR-4423-5p	HITS-CLIP	23313552
MIRT696590	hsa-miR-197-3p	HITS-CLIP	23313552
MIRT696589	hsa-miR-6843-3p	HITS-CLIP	23313552
MIRT696588	hsa-miR-6848-3p	HITS-CLIP	23313552
MIRT696587	hsa-miR-744-3p	HITS-CLIP	23313552
MIRT696585	hsa-miR-5096	HITS-CLIP	23313552
MIRT696586	hsa-miR-1303	HITS-CLIP	23313552
MIRT650405	hsa-miR-320a	HITS-CLIP	23824327
MIRT650404	hsa-miR-320b	HITS-CLIP	23824327
MIRT650403	hsa-miR-320c	HITS-CLIP	23824327
MIRT650402	hsa-miR-320d	HITS-CLIP	23824327
MIRT650401	hsa-miR-4429	HITS-CLIP	23824327
MIRT650400	hsa-miR-425-5p	HITS-CLIP	23824327
MIRT650399	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT650398	hsa-miR-3117-5p	HITS-CLIP	23824327
MIRT650397	hsa-miR-9-3p	HITS-CLIP	23824327
MIRT650396	hsa-miR-188-3p	HITS-CLIP	23824327
MIRT650395	hsa-miR-1260a	HITS-CLIP	23824327
MIRT650394	hsa-miR-1260b	HITS-CLIP	23824327
MIRT650393	hsa-miR-3156-3p	HITS-CLIP	23824327
MIRT650392	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT696600	hsa-miR-483-5p	HITS-CLIP	23313552
MIRT696599	hsa-miR-4716-5p	HITS-CLIP	23313552
MIRT696598	hsa-miR-4324	HITS-CLIP	23313552
MIRT696597	hsa-miR-544b	HITS-CLIP	23313552
MIRT696596	hsa-miR-3653-5p	HITS-CLIP	23313552
MIRT696595	hsa-miR-3663-5p	HITS-CLIP	23313552
MIRT696594	hsa-miR-6131	HITS-CLIP	23313552
MIRT696593	hsa-miR-193b-5p	HITS-CLIP	23313552
MIRT696592	hsa-miR-6501-5p	HITS-CLIP	23313552
MIRT696591	hsa-miR-4423-5p	HITS-CLIP	23313552
MIRT696590	hsa-miR-197-3p	HITS-CLIP	23313552
MIRT696589	hsa-miR-6843-3p	HITS-CLIP	23313552
MIRT696588	hsa-miR-6848-3p	HITS-CLIP	23313552
MIRT696587	hsa-miR-744-3p	HITS-CLIP	23313552
MIRT696585	hsa-miR-5096	HITS-CLIP	23313552
MIRT696586	hsa-miR-1303	HITS-CLIP	23313552
MIRT650405	hsa-miR-320a	HITS-CLIP	23824327
MIRT650404	hsa-miR-320b	HITS-CLIP	23824327
MIRT650403	hsa-miR-320c	HITS-CLIP	23824327
MIRT650402	hsa-miR-320d	HITS-CLIP	23824327
MIRT650401	hsa-miR-4429	HITS-CLIP	23824327
MIRT650400	hsa-miR-425-5p	HITS-CLIP	23824327
MIRT650399	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT650398	hsa-miR-3117-5p	HITS-CLIP	23824327
MIRT650397	hsa-miR-9-3p	HITS-CLIP	23824327
MIRT650396	hsa-miR-188-3p	HITS-CLIP	23824327
MIRT650395	hsa-miR-1260a	HITS-CLIP	23824327
MIRT650394	hsa-miR-1260b	HITS-CLIP	23824327
MIRT650393	hsa-miR-3156-3p	HITS-CLIP	23824327
MIRT650392	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT1205731	hsa-miR-1206	CLIP-seq
MIRT1205732	hsa-miR-1224-5p	CLIP-seq
MIRT1205733	hsa-miR-1236	CLIP-seq
MIRT1205734	hsa-miR-1265	CLIP-seq
MIRT1205735	hsa-miR-1279	CLIP-seq
MIRT1205736	hsa-miR-297	CLIP-seq
MIRT1205737	hsa-miR-3149	CLIP-seq
MIRT1205738	hsa-miR-3153	CLIP-seq
MIRT1205739	hsa-miR-3192	CLIP-seq
MIRT1205740	hsa-miR-361-3p	CLIP-seq
MIRT1205741	hsa-miR-3689a-3p	CLIP-seq
MIRT1205742	hsa-miR-3689c	CLIP-seq
MIRT1205743	hsa-miR-375	CLIP-seq
MIRT1205744	hsa-miR-4294	CLIP-seq
MIRT1205745	hsa-miR-4307	CLIP-seq
MIRT1205746	hsa-miR-4314	CLIP-seq
MIRT1205747	hsa-miR-4450	CLIP-seq
MIRT1205748	hsa-miR-4646-5p	CLIP-seq
MIRT1205749	hsa-miR-4668-5p	CLIP-seq
MIRT1205750	hsa-miR-4751	CLIP-seq
MIRT1205751	hsa-miR-4753-3p	CLIP-seq
MIRT1205752	hsa-miR-4778-3p	CLIP-seq
MIRT1205753	hsa-miR-567	CLIP-seq
MIRT1205754	hsa-miR-635	CLIP-seq
MIRT1205755	hsa-miR-942	CLIP-seq
MIRT2287356	hsa-miR-1184	CLIP-seq
MIRT2287357	hsa-miR-1262	CLIP-seq
MIRT2287358	hsa-miR-1301	CLIP-seq
MIRT2287359	hsa-miR-22	CLIP-seq
MIRT2287360	hsa-miR-3189-3p	CLIP-seq
MIRT2287361	hsa-miR-3920	CLIP-seq
MIRT2287362	hsa-miR-4418	CLIP-seq
MIRT2287363	hsa-miR-4660	CLIP-seq
MIRT2287364	hsa-miR-4701-3p	CLIP-seq
MIRT2287365	hsa-miR-4793-5p	CLIP-seq
MIRT2287366	hsa-miR-5047	CLIP-seq
MIRT2287367	hsa-miR-509-3-5p	CLIP-seq
MIRT2287368	hsa-miR-509-5p	CLIP-seq
MIRT2287369	hsa-miR-548g	CLIP-seq
MIRT2287370	hsa-miR-938	CLIP-seq
MIRT2585590	hsa-miR-1243	CLIP-seq
MIRT2585591	hsa-miR-1270	CLIP-seq
MIRT2585592	hsa-miR-1286	CLIP-seq
MIRT2585593	hsa-miR-296-5p	CLIP-seq
MIRT2585594	hsa-miR-3169	CLIP-seq
MIRT2585595	hsa-miR-3619-3p	CLIP-seq
MIRT2585596	hsa-miR-3654	CLIP-seq
MIRT2585597	hsa-miR-4428	CLIP-seq
MIRT2585598	hsa-miR-4434	CLIP-seq
MIRT1205747	hsa-miR-4450	CLIP-seq
MIRT2585599	hsa-miR-4515	CLIP-seq
MIRT2585600	hsa-miR-4516	CLIP-seq
MIRT2585601	hsa-miR-4531	CLIP-seq
MIRT2585602	hsa-miR-4690-5p	CLIP-seq
MIRT2585603	hsa-miR-4776-5p	CLIP-seq
MIRT2585604	hsa-miR-620	CLIP-seq
MIRT2585605	hsa-miR-665	CLIP-seq

Gene ontology (GO) Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005783	Component	Endoplasmic reticulum	IDA	12093374
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0006665	Process	Sphingolipid metabolic process	IEA
GO:0006672	Process	Ceramide metabolic process	IBA
GO:0006672	Process	Ceramide metabolic process	IMP	20182505
GO:0016020	Component	Membrane	IEA
GO:0017059	Component	Serine palmitoyltransferase complex	IBA
GO:0030148	Process	Sphingolipid biosynthetic process	IBA
GO:0090156	Process	Intracellular sphingolipid homeostasis	IBA
GO:1900060	Process	Negative regulation of ceramide biosynthetic process	IMP	25691431
GO:2000303	Process	Regulation of ceramide biosynthetic process	IEA

Other IDs

• MIM: 610074
• HGNC: 16037
• e!Ensembl: ENSG00000123353

Protein

• UniProt ID: Q53FV1
• Protein name: ORM1-like protein 2 (Adoplin-2)
• Protein function: Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels (PubMed:20182505). When complexed to SPT, the binding o
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04061	ORMDL	11 → 146	ORMDL family	Family

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. Expressed in adult and fetal heart, brain, lung, liver, skeletal muscle and kidney. Expressed in adult pancreas and placenta and in fetal spleen abd thymus. {ECO:0000269|PubMed:12093374}.
• Sequence:

  MNVGVAHSEVNPNTRVMNSRGIWLAYIILVGLLHMVLLSIPFFSIPVVWTLTNVIHNLAT
  YVFLHTVKGTPFETPDQGKARLLTHWEQMDYGLQFTSSRKFLSISPIVLYLLASFYTKYD
  AAHFLINTASLLSVLLPKLPQFHGVRVFGINKY

• Sequence length: 153

Pathways

Reactome Pathway:

Sphingolipid de novo biosynthesis

Related Genes

No strongly related genes found yet for ORMDL2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ORMDL2.